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1-PiperazineaceticAcid 2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide-d8 is deuterium labelled 1-PiperazineaceticAcid 2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide (H953060) and has been employed to characterize the in vivo and in vitro metabolic profile of PAC-1 (P132000), an anti-tumor agent that induces apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C16H14D8N4O2, Molecular Weight: 310.42. US Biological Life Sciences.
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2-PiperazineaceticAcid Dihydrochloride
2-PiperazineaceticAcid Dihydrochloride. Group: Biochemicals. Grades: Highly Purified. CAS No. 14566-74-6. Pack Sizes: 500mg. Molecular Formula: C6H14Cl2N2O2, Molecular Weight: 217.09. US Biological Life Sciences.
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(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineaceticacid
(2S,5S)-5-Benzyl-3,6-dioxo-2-piperazineaceticacid. Group: Biochemicals. Alternative Names: (2S,5S)-3,6-Dioxo-5-(phenylmethyl)-2-piperazineaceticacid; (2S-cis)-3,6-Dioxo-5-(phenylmethyl)-2-piperazineaceticacid. Grades: Highly Purified. CAS No. 5262-10-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C13H14N2O4. US Biological Life Sciences.
4-[2-(Fmoc-amino)ethyl]-1-piperazineaceticacid dihydrochloride ≥96% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 250mg, 1g, 5g. US Biological Life Sciences.
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4-Benzyl-1-piperazineaceticAcid-d8 Hydrazide
Isotope labelled 4-Benzyl-1-piperazineaceticAcid Hydrazide is an intermediate in the synthesis PAC-1 (P132000), a caspase 3 activator. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineaceticAcid-d8 Hydrazide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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4-Benzyl-1-piperazineaceticAcid Hydrazide
4-Benzyl-1-piperazineaceticAcid Hydrazide is an intermediate in the synthesis PAC-1 (P132000), a caspase 3 activator. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineaceticAcid Hydrazide. Grades: Highly Purified. CAS No. 24632-70-0. Pack Sizes: 50mg. US Biological Life Sciences.
(4-Benzylpiperazin-1-yl)acetic Acid Ethyl Ester-d8 is an isotope labelled intermediate in the synthesis of PAC-1-d8 (P132002), a caspase 3 activator. Group: Biochemicals. Alternative Names: Ethyl 2-(4-Benzylpiperazin-1-yl)acetate; Ethyl 4-Benzyl-1-piperazineacetate;4-Benzyl-1-piperazineaceticAcid Ethyl Ester; 4-(Phenylmethyl)-1-piperazineaceticAcid Ethyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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4-Boc-1-carboxymethylpiperazin-2-one
4-Boc-1-carboxymethylpiperazin-2-one. Group: Biochemicals. Alternative Names: 2-Oxo-4-Boc-1-piperazineaceticacid; 4-Carboxymethyl-3-oxo-piperazine-1-carboxylic acid tert-butyl ester. Grades: Highly Purified. CAS No. 549506-47-0. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. US Biological Life Sciences.
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AMG-747
AMG-747 is a GlyT-1 inhibitor. It has been under investigation to treat various CNS disorders that may be ameliorated by modulation of either inhibitory glycinergic or excitatory glutamatergic neurotransmission. It was used as an antipsychotic drug. It was developed by Amgen and was terminated in Cilnic phase 2. Uses: Amg-747 was used as an antipsychotic drug. Synonyms: 1-Piperazineaceticacid, 4- ( (R) -phenyl (3- (trifluoromethyl) phenyl) methyl) -; 2-[4-[ (R) -phenyl-[3- (trifluoromethyl) phenyl]methyl]piperazin-1-yl]acetic acid; Tilapertin; AMG747; AMG-747; AMG 747. Grades: >98 %. CAS No. 1000690-85-6. Molecular formula: C20H21F3N2O2. Mole weight: 378.39.
Cairomycin A
Cairomycin A is a peptide antibiotic produced by Streptomyces As-C-19, which has activity against gram-positive bacteria. Synonyms: 3,6-Dioxo-5-isopropyl-2-piperazineaceticacid; 2-Piperazineaceticacid, 5-(1-methylethyl)-3,6-dioxo-, (2S-cis)-; 2-Piperazineaceticacid, 3,6-dioxo-5-isopropyl-, (2S-cis)-. CAS No. 78859-46-8. Molecular formula: C9H14N2O4. Mole weight: 214.22.
(Carboxymethyl)-N'-methylpiperazine.
(Carboxymethyl)-N'-methylpiperazine. Group: Biochemicals. Alternative Names: 4-Methyl-1-piperazineaceticAcid; (4-Methyl-1-piperazinyl)acetic Acid; (4-Methylpiperazin-1-yl)acetic Acid; (4-Methylpiperazino) acetic Acid; 2-(4-Methylpiperazin-1-yl)acetic Acid; 4-Methylpiperazine-1-acetic Acid; 4-MethylpiperazineaceticAcid; N. Grades: Highly Purified. CAS No. 54699-92-2. Pack Sizes: 250mg. Molecular Formula: C7H14N2O2, Molecular Weight: 158.199999999999. US Biological Life Sciences.
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Cetirizine EP Impurity B Dihydrochloride
Cetirizine EP Impurity B Dihydrochloride is an impurity of Cetirizine, a second-generation antihistamine used to treat allergic rhinitis, dermatitis, and urticaria. Synonyms: 4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineaceticAcid Dihydrochloride; De(carboxymethoxy)Cetirizine Acetic Acid Dihydrochloride; Levocetirizine Impurity 3 DiHCl. Grades: 98%. CAS No. 1000690-91-4. Molecular formula: C19H23Cl3N2O2. Mole weight: 417.76.
CVT-3369
CVT-3369 is an impurity of Ranolazine, which is a medication used to treat heart-related chest pain. Synonyms: RS-91347; 4-[2-Hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineaceticAcid; Ranolazine Impurity 16; CVT 3369; CVT3369; RS 91347; RS91347; 1-Piperazineaceticacid, 4-(2-hydroxy-3-(2-methoxyphenoxy)propyl)-. Grades: 98%. CAS No. 172430-48-7. Molecular formula: C16H24N2O5. Mole weight: 324.37.
Dasatinib Carboxylic Acid
An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: 4-[6-[[5-[[ (2-Chloro-6-methylphenyl) amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineaceticAcid. Grades: Highly Purified. CAS No. 910297-53-9. Pack Sizes: 1mg. US Biological Life Sciences.
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Dasatinib Carboxylic Acid
Dasatinib Carboxylic Acid is an oxidative metabolite of Dasatinib (M6 metabolite), used in the treatment of cancers and immune diseases. Synonyms: 4-[6-[[5-[[(2-Chloro-6-methylphenyl)amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineaceticAcid. Grades: > 95%. CAS No. 910297-53-9. Molecular formula: C22H24ClN7O3S. Mole weight: 501.99.
Dasatinib Carboxylic Acid Ethyl Ester
Protected Dasatinib Carboxylic Acid. An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. Group: Biochemicals. Alternative Names: 4-[6-[[5-[[ (2-Chloro-6-methylphenyl) amino]carbonyl]-2-thiazolyl]amino]-2-methyl-4-pyrimidinyl]-1-piperazineaceticAcid Ethyl Ester. Grades: Highly Purified. CAS No. 910297-62-0. Pack Sizes: 2.5mg. US Biological Life Sciences.
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N- (Ethoxycarbonylmethyl) piperazine
N- (Ethoxycarbonylmethyl) piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents. Group: Biochemicals. Alternative Names: 1-PiperazineaceticAcid Ethyl Ester; 2-(Piperazin-1-yl)acetic Acid Ethyl Ester; 4- (Carboethoxymethyl) piperazine; Ethyl 1-piperazineacetate; Ethyl 1-Piperazinylacetate; Ethyl 2-(piperazin-1-yl)acetate; Ethyl 2-Piperazinoacetate; Ethyl Piperazinoacetate; N- (Carboethoxymethyl) piperazine; N- (Ethoxycarbonylmethyl) piperazine; Piperazin-1-ylacetic Acid Ethyl Ester. Grades: Highly Purified. CAS No. 40004-08-8. Pack Sizes: 100mg. US Biological Life Sciences.
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PAC1
PAC1. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineaceticacid [ [2-hydroxy-3- (2-propenyl) phenyl] methylene] hydrazide. Grades: Highly Purified. CAS No. 315183-21-2. Pack Sizes: 2g, 5g, 10g, 25g, 50g. Molecular Formula: C23H28N4O2. US Biological Life Sciences.
Worldwide
PAC-1
PAC-1. Group: Biochemicals. Alternative Names: 4-(Phenylmethyl)-1-piperazineaceticAcid (2E) -2- [ [2-Hydroxy-3- (2-propen-1-yl) phenyl] methylene] hydrazide. Grades: Highly Purified. CAS No. 1044929-62-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C23H28N4O2. US Biological Life Sciences.
Worldwide
PAC-1
PAC-1 is known as the first procaspase activating compound, which selectively induces apoptosis, or cell suicide, in cancerous cells. PAC-1 has shown good results in mouse models and is being further evaluated for use in humans. In 2010 a published study showed PAC-1 to be safe to research dogs, and a second study published later that same year reported that a PAC-1 derivative (called S-PAC-1) was well tolerated in a small Phase I Clinical Trial of pet dogs with lymphoma. Even at low doses of S-PAC-1, tumors regressed in 1/6 dogs, and the disease was stabilized (no additional tumor growth) in 3/6 dogs. Synonyms: 1-Piperazineaceticacid, 4-(phenylmethyl)-, 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide; 1-Piperazineaceticacid, 4-(phenylmethyl)-, [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide; PAC 1; PAC1; Procaspase activating compound 1. Grades: >98%. CAS No. 315183-21-2. Molecular formula: C23H28N4O2. Mole weight: 392.49.
O-Desaryl Ranolazine, a piperazine derivative, has been found to be a ranolazine metabolite which is a partial fatty acid oxidation inhibitor and could be used as an anti-myocardial ischemia agent. Uses: A metabolite of ranolazine. Synonyms: 4-(2,3-Dihydroxypropyl)-N-(2,6-dimethylphenyl)-1-piperazineacetamide; RS 88640; CVT-2512; Ranolazine Impurity 4; CVT-2512; CVT 2512; CVT2512; RS 88640; RS-88640; UNII-04210SF62M. Grades: 98%. CAS No. 172430-46-5. Molecular formula: C17H27N3O3. Mole weight: 321.41.
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