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| Product | Description | |
|---|---|---|
| Piperlongumine | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Piperlongumine | Piperlongumine. Group: Biochemicals. Grades: Purified. CAS No. 20069-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Piperlongumine | Piperlongumine is a alkaloid [1] , possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities [2]. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines [1]. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Piplartine. CAS No. 20069-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2329. |  |
| Piperlongumine | Piperlongumine is a alkaloid, possesses ant-inflammatory, antibacterial, antiangiogenic, antioxidant, antitumor, and antidiabetic activities. Piperlongumine induces ROS, and induces apoptosis in cancer cell lines. Piperlongumine shows anti-cardiac fibrosis activity, suppresses myofibroblast transformation via suppression of the ERK1/2 signaling pathway. Piperlongumin could be used in the study of migrasome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-[(E)-3-(3,4,5-Trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one. Product Category: Inhibitors. CAS No. 20069-09-4. Molecular formula: C17H19NO5. Mole weight: 317.34. Purity: 98%+. Density: 1.223 g/cm³. Product ID: ACM20069094. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PIPERLONGUMINE | Piperlongumine, also known as Piplartine , is a biologically active alkaloid/amide from peppers, as from long pepper (Piper longum L. - Piperaceae). Long pepper is one of the most widely used in Ayurvedic medicine, which is used to treat many diseases, including tumors. The reported pharmacological activities of piplartine include cytotoxic, genotoxic, antitumor, antiangiogenic, antimetastatic, antiplatelet aggregation, antinociceptive, anxiolytic, antidepressant, anti-atherosclerotic, antidiabetic, antibacterial, antifungal, leishmanicidal, trypanocidal, and schistosomicidal activities. Among the multiple pharmacological effects of piplartine, its anticancer property is the most promising. Therefore, the preclinical anticancer potential of piplartine has been extensively investigated, which recently resulted in one patent. This compound is selectively cytotoxic against cancer cells by induction of oxidative stress, induces genotoxicity, as an alternative strategy to killing tumor cells, has excellent oral bioavailability in mice, inhibits tumor growth in mice, and presents only weak systemic toxicity. Synonyms: Piplartine; 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone; (E)-5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone; Piplartin; (E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one; NSC-794671. Grade: ≥98%. CAS No. 20069-09-4. Mole |  |
| Piperlongumine (Piplartine, 5,6-Dihydro-1-(1-oxo-3-trans-2-propenyl)-2-pyridinone) | Cytotoxic against tumor cell lines. Induces necrosis and apoptosis in cancer cells. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation. Shows significant anxiolytic and antidepressant activities. Promotes adipogenesis of 3T3-L1 cells. Induces in vivo and in vitro mutagenicity in eukaryotic models. Selectively kills cancer cells by targeting the stress response to ROS. Shows in vitro schistosomicidal activity. Group: Biochemicals. Alternative Names: Piplartine, 5,6-Dihydro-1-(1-oxo-3--trans-2-propenyl)-2-pyridinone. Grades: Highly Purified. CAS No. 20069-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Piperlongumine (Piplartine, (E) -1- (3- (3, 4, 5-Trimethoxyphenyl) acryloyl) -5, 6-dihydropyridin-2 (1H) -one) | A cell-permeable, orally bioavailable natural product isolated from the plant species, Piper longum L, which selectively induces cell death in cancer cells that express both wild-type and mutant p53, dose-dependently from 1-15uM, but not in primary normal cells and non-transformed immortalized cells. It significantly enhances wild-type p53 and PUMA expression, and inhibits the expression of several pro-survival proteins, including BCL2, surviving, and XIAP, in various types of cancer cells, but not in normal cells. It elicits ROS and apoptosis in several human cancer cells (EJ, MDA-MB-231, U2OS and MDA-MB-435), possibly through interaction with oxidative stress responders such as GSTP1 and CBR1, and can be reversed by NAC (3mM) in EJ cells. Additionally, it exhibits anti-tumor effects and inhibits the formation of blood vessels in xenograft-tumor mice without obvious toxicity, and inhibits tumor growth and their associated metastases in a MMTV-PyVT breast cancer transgenic mouse model Group: Biochemicals. Grades: Highly Purified. CAS No. 20069-09-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3,5-Didemethoxy Piperlongumine | 3,5-Didemethoxy Piperlongumine. Group: Biochemicals. Alternative Names: 5,6-Dihydro-1-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-2(1H)-pyridinone. Grades: Highly Purified. CAS No. 1246095-66-8. Pack Sizes: 50mg. Molecular Formula: C15H15NO3, Molecular Weight: 257.279999999999. US Biological Life Sciences. | Worldwide |
| Piperlonguminine | Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows various biological properties, including anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 5950-12-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-126562. | |
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