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Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR ( muscarinic acetylcholine receptor ) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LS 519; Pirenzepin dihydrochloride; Gastrozepin dihydrochloride. CAS No. 29868-97-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-17037.
Pirenzepine, dihydrochloride
Pirenzepine, dihydrochloride. Group: Biochemicals. Alternative Names: 5,11-Dihydro-11-[2-(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzo-diazepin-6-one dihydrochloride; Duogastral; Durapirenz. Grades: Highly Purified. CAS No. 29868-97-1. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C19H23Cl2N5O2. US Biological Life Sciences.
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Pirenzepine Dihydrochloride
An antagonist selective for mAChR subtype M1. Used for studying the functional roles of M1 receptors in both central and peripheral nervous systems. Group: Biochemicals. Grades: Highly Purified. CAS No. 28797-61-7. Pack Sizes: 100mg. Molecular Formula: C??H??N?O? 2HCl. US Biological Life Sciences.
11, 11'- (2, 2'- (Piperazine-1, 4-diyl)bis (acetyl))bis (5H-benzo[e]pyrido[3, 2-b][1, 4]diazepin-6 (11H)-one)-d8 is an labelled dimer impurity of labelled Pirenzepine (P508502), an antiulcerative agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C32H20D8N8O4, Molecular Weight: 596.669999999999. US Biological Life Sciences.
Worldwide
Coluracetam
MKC-231 (10(-10)-10(-6) moll) significantly increased high affinity choline uptake (HACU) when it was incubated with the hippocampal synaptosomes of ethylcholine mustard aziridinium ion (AF64A) treated rats, but not of normal rats. MKC-231 did not affect the AChE activity, [3H]- quinuclidinyl benzilate binding, and [3H]-pirenzepine binding. Oral administration of MKC-231 (1-10 mg/kg) significantly improved the learning deficits in the Morris' water maze of AF64A-treated rats, but it did not produce any significant side effects, like tremor, salivation or hypothermia, which were observed in rats treated with high doses of tacrine [1]. In acute behavioral experiments, MKC-231 and THA had no significant effect on AF64A-induced memory deficits at any doses tested (0.3, 1.0 and 3.0 mg/kg), whereas Dup 996, at a dose of 1.0 mg/kg, significantly improved memory deficits. In chronic experiments, MKC-231 improved memory deficit at all doses tested (0.3, 1.0, or 3.0 mg/kg p.o., once daily for 11 days) and Dup 996 did so only at a dose of 3.0 mg/kg, whereas THA did not improve memory deficit at any doses tested. Synonyms: Coluracetam; BCI-540; MKC-231; BCI 540; MKC 231; BCI540; MKC231. Grades: >98%. CAS No. 135463-81-9. Molecular formula: C19H23N3O3. Mole weight: 341.4.
Nuvenzepine
Nuvenzepine, a new pirenzepine-analog, is an mAChR antagonist, administered intraduodenally, displayed a long-lasting and dose-dependent inhibition of neostigmine-induced intestinal motility in anaesthetized cats. Synonyms: 11-(1-methylpiperidine-4-carbonyl)-6H-pyrido[3,2-c][1,5]benzodiazepin-5-one; 11-(N-methylisonipecotyl)-6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one; DF 545; DF-545; nuvenzepine. CAS No. 96487-37-5. Molecular formula: C19H20N4O2. Mole weight: 336.39.
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