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| Product | Description | |
|---|---|---|
| poly(ADP-ribose) glycohydrolase | Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-D-ribose). Group: Enzymes. Enzyme Commission Number: EC 3.2.1.143. CAS No. 9068-16-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3826; poly(ADP-ribose) glycohydrolase; EC 3.2.1.143; 9068-16-0. Cat No: EXWM-3826. |  |
| ADP-HPD, Dihydrate, Ammonium Salt | ADP-HPD, Dihydrate is an amino analog of ADP-ribose that acts as a highly potent, noncompetitive, and specific inhibitor of poly(ADP-ribose) glycohydrolase (PARG; IC?? = 120 nM). Group: Fluorescence/luminescence spectroscopy. |  |
| COH34 | COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 ?M), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 906439-72-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg; 1 g. Product ID: HY-128760. |  |
| EDA-ADP - ATTO-633 | EDA-ADP ATTO-633 - a ground-breaking fluorescent probe that has forever shifted the biomedicine landscape. This astounding tool unravels enzymatic processes affiliated with ADP-ribose metabolism. Be amazed by its ability to track enzymes that regulate NAD+ homeostasis and poly(ADP-ribose) glycohydrolase activity, then discover its grandeur in the crucial roles it plays in DNA repair and apoptosis studies. Synonyms: 2'/3'-O-(2-Aminoethyl-carbamoyl)-Adenosine-5'-diphosphate, labeled with ATTO 633, Triethylammonium salt. Grades: ≥ 95 % by HPLC. Molecular formula: C13H21N7O11P2- ATTO 633 (free acid). Mole weight: 1046.29 (free acid). |  |
| Ethacridine lactate | Ethacridine lactate (Acrinol) is a widely used antiseptic and abortifacient. Ethacridine lactate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acrinol. CAS No. 1837-57-6. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B2174. | |
| Ethacridine lactate monohydrate | Ethacridine lactate (Acrinol) monohydrate is a widely used antiseptic and abortifacient. Ethacridine lactate monohydrate is effective against Staphylococcus aureus and other gram-positive cocci. Ethacridine lactate monohydrate is also a poly(ADP-ribose) glycohydrolase (PARG) inhibitor [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Acrinol monohydrate. CAS No. 6402-23-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-B0889. | |
| Oenothein B | Oenothein B is a dimeric macrocyclic ellagitannin and has widely pharmacological activities, including antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor properties. Oenothein B is a potent and specific inhibitor of poly(ADP-ribose) glycohydrolase. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 104987-36-2. Molecular formula: C68H50O44. Mole weight: 1571.1. Canonical SMILES: O[C@@H]1O[C@@H]2COC(C3=C(C4=C(C(O[C@H]2[C@@H]([C@H]1OC(C5=CC(O)=C(C(O)=C5OC6=CC(C(OC[C@H]7O[C@H]([C@@H]([C@@H]([C@H]7O8)OC(C9=CC(O)=C(C(O)=C9)O)=O)O)OC(C%10=CC(O)=C(C(O)=C%10)O)=O)=O)=C(C(O)=C6O)C%11=C(C=C(C(O)=C%11O)O)C8=O)O)=O)OC(C%12=CC(O)=C(O)C(O)=C%12)=O)=O)C=C(O)C(O)=C4O)C(O)=C(O)C(O)=C3)=O. Product ID: ACM104987362. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PDD00017272 | PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC50=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133531. | |
| PDD 00017273 | PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-21-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108360. | |
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