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| Product | Description | |
|---|---|---|
| Ponatinib | Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC 50 s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl , PDGFRα , VEGFR2 , FGFR1 , and Src , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AP24534. CAS No. 943319-70-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12047. |  |
| Ponatinib-[d8] | Ponatinib-[d8] is the labelled analogue of Ponatinib, which is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0. 37 nM, 1. 1 nM, 1. 5 nM, 2. 2 nM and 5. 4 nM, respectively. Synonyms: Ponatinib D8; 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl-2,2,3,3,5,5,6,6-d8)methyl]-3-(trifluoromethyl)phenyl]-benzamide. Grade: 95% by HPLC; 95% atom D. CAS No. 1562993-37-6. Molecular formula: C29H19D8F3N6O. Mole weight: 540.61. |  |
| Ponatinib, Free Base (AP24534) | Ponatinib is a novel potent, orally available small molecule multitargeted kinase inhibitor. Ponatinib inhibits both native and mutant BCR-ABL. Ponatinib is used in the treatment of chronic myeloid leukemia (CML) with BCR-ABL kinase inhibitors. Ponatinib is the active ingredient in the drug product sold under the trade name Iclusig®, currently approved in at least one country for use in patients with chronic myeloid leukemia (CML) and Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia. Group: Biochemicals. Alternative Names: 3- (2-Imidazo[1, 2-b]pyridazin-3-ylethynyl) -4-methyl-N-[4-[ (4-methyl-1-piperazinyl) methyl]-3- (trifluoromethyl) phenyl]benzamide; AP 24534; Iclusig. Grades: Highly Purified. CAS No. 943319-70-8. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C29H27F3N6O, Molecular Weight: 532.56. US Biological Life Sciences. |  Worldwide |
| Ponatinib hydrochloride | Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC 50 s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl , PDGFRα , VEGFR2 , FGFR1 , and Src , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AP24534 hydrochloride. CAS No. 1114544-31-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108766. | |
| Ponatinib Impurity 2 | Ponatinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 1-(dibromomethyl)-4-nitro-2-(trifluoromethyl)benzene. CAS No. 122947-77-7. Molecular formula: C8H4Br2F3NO2. Mole weight: 362.93. Catalog: APB122947777. |  |
| Ponatinib Impurity 5 | Ponatinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1255099-13-8. Molecular formula: C11H10O2. Mole weight: 174.2. Catalog: APB1255099138. | |
| Ponatinib Impurity 8 | Ponatinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1001203-03-7. Molecular formula: C10H8O2. Mole weight: 160.17. Catalog: APB1001203037. | |
| Ponatinib Tris-Hydrochloride | Ponatinib Tris-Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1232836-25-7. Molecular formula: C29H30Cl3F3N6O. Mole weight: 641.95. Catalog: APB1232836257. | |
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