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| Product | Description | |
|---|---|---|
| Dinactin | A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: GNF-Pf-90; Antibiotic 170t; NSC63925; 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo(32.2.1.17, 10.116, 19.125, 28)tetracontane-3, 12, 21, 30-tetrone, 5,23-diethyl-2,11,14,20,29,32-hexamethyl-(VAN) (8CI). Grades: >95% by HPLC. CAS No. 20261-85-2. Molecular formula: C42H68O12. Mole weight: 764.98. |  |
| Dinactin (Antibiotic AKD 1C, Antibiotic S 3466A) | Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-g. Dinactin has not previously been available for intensive investigation. Group: Biochemicals. Alternative Names: Antibiotic AKD 1C, Antibiotic S 3466A. Grades: Highly Purified. CAS No. 20261-85-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Monactin | A member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium; inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and IFN-&gamma. It is also resistant to gram-positive bacteria and mycobacteria. Synonyms: 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo[32.2.1.17, 10.116, 19.125, 28]tetracontane-3, 12, 21, 30-tetrone, 5-ethyl-2, 11, 14, 20, 23, 29, 32-heptamethyl-, (1R, 2R, 5R, 7R, 10S, 11S, 14S, 16S, 19R, 20R, 23R, 25R, 28S, 29S, 32S, 34S)-; Akd-1B. Grades: >95% by HPLC. CAS No. 7182-54-9. Molecular formula: C41H66O12. Mole weight: 750.95. | |
| Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B) | Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Group: Biochemicals. Alternative Names: 5-demethyl-5-ethylnonactin, Antibiotic AKD 1B. Grades: Highly Purified. CAS No. 7182-54-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Nigericin | Nigericin, derived from S. hygroscopicus, is an antibiotic potassium ionophore. It exchanges K+ for H+ across biological membranes. Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis. Synonyms: 2-[6-[[2-[5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid; Antibiotic K178; Antibiotic X464; Azalomycin M; Helexin C, Polyetherin A. Grades: >98%. CAS No. 28380-24-7. Molecular formula: C40H68O11. Mole weight: 724.96. | |
| Nonactin | Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is somewhat confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purifed to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Group: Biochemicals. Grades: Highly Purified. CAS No. 6833-84-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Nonactin | The smallest member of the macrotetrolide complex produced by a range of streptomyces species; a monovalent cation ionophore with high selectivity for ammonium and potassium. It is resistant to gram-positive bacteria, mycobacteria and fungi, and it also inhibits L cells. Synonyms: Werramycin-A; NSC 52141; BRN 0076434; 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo(32.2.1.17, 10.116, 19.125, 28)tetracontane-3, 12, 21, 30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-(8CI). Grades: >99% by HPLC. CAS No. 6833-84-7. Molecular formula: C40H64O12. Mole weight: 736.93. | |
| Salinomycin | Salinomycin is a polyether ionophore with broad spectrum Gram +ve and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used in animal health for control of coccidia and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is > 100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active. Group: Biochemicals. Grades: Highly Purified. CAS No. 53003-10-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Salinomycin | Salinomycin (Procoxacin), a polyether potassium ionophore antibiotic, selectively inhibits the growth of gram-positive bacteria. Salinomycin is a potent inhibitor of Wnt/β-catenin signaling, blocks Wnt-induced LRP6 phosphorylation. Salinomycin shows selective activity against human cancer stem cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Procoxacin. CAS No. 53003-10-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15597. |  |
| Tetranactin | It is a member of the macrotetrolide complex produced by a range of streptomyces sp. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Unlike the other macrotetrolides, tetranactin exhibits potent insecticidal activity. It is a glycoprotein transportation inhibitor, an immunosuppressant, an antiproliferative and an antiallergic agent. Synonyms: 5,14,23,32-Tetrademethyl-5,14,23,32-tetraethylnonactin; S-3466-C; 4, 13, 22, 31, 37, 38, 39, 40-Octaoxapentacyclo[32.2.1.17, 10.116, 19.125, 28]tetracontane-3, 12, 21, 30-tetrone, 5,14,23,32-tetraethyl-2,11,20,29-tetramethyl-, (1R, 2R, 5R, 7R, 10S, 11S, 14S, 16S, 19R, 20R, 23R, 25R, 28S, 29S, 32S, 34S)-. Grades: >95% by HPLC. CAS No. 33956-61-5. Molecular formula: C44H72O12. Mole weight: 793.04. | |
| Tetranactin | Tetranactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp. Like the other members of the macrotetrolide family, tetranactin is thought to act as a monvalent cation ionophore with high selectivity for ammonium and potassium. Unlike the other macrotetrolides, tetranactin is reported to exhibit potent insecticidal activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 33956-61-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Trinactin | Trinactin is a tetracyclic lactone compound produced by Streptomyces. It is a monovalent cation ionophore with high selectivity to ammonium and potassium. It can inhibit the proliferation of T cells induced by IL-2, and inhibit the production of cytokines at nanomolar levels of IL-2, IL-4, IL-5 and interferon-&gamma. Synonyms: AKD-1D; S 3466B. Grades: >95% by HPLC. CAS No. 7561-71-9. Molecular formula: C43H70O12. Mole weight: 779.0. | |
| Trinactin (Antibiotic AKD-1D, Antibiotic S 3466B) | Trinactin is a member of the macrotetrolide complex produced by a range of Streptomyces sp. Early literature reported that trinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Trinactin inhibited T-cell proliferation induced by IL-2 and cytokine production at nonomolar levels for IL-2, IL-4, IL-5 and interferon-gamma. Trinactin has not previously been available for intensive investigation. Group: Biochemicals. Alternative Names: Antibiotic AKD-1D, Antibiotic S 3466B. Grades: Highly Purified. CAS No. 7561-71-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Valinomycin | A hydrophobic cyclodepsipeptide with potent antitumour activity; a highly selective potassium ionophore; a biosensor to detect potassium efflux. Synonyms: Potassium ionophore I; valino; Valinomicin; NSC122023; Antibiotic N-329 B; cyclo[-D-O-Val-D-Val-L-O-Ala-L-Val]3; BRN 0078657; (3R, 6R, 9S, 12S, 15R, 18R, 21S, 24S, 27R, 30R, 33S, 36S)-3, 6, 9, 15, 18, 21, 27, 30, 33-Nonaisopropyl-12, 24, 36-trimethyl-1, 7, 13, 19, 25, 31-hexaoxa-4, 10, 16, 22, 28, 34-hexaazacyclohexatriacontane-2, 5, 8, 11, 14, 17, 20, 23, 26, 29, 32,35-dodecone. Grades: >95% by HPLC. CAS No. 2001-95-8. Molecular formula: C54H90N6O18. Mole weight: 1111.32. | |
| Valinomycin | Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, Valinomycin has found application in biosensors. Group: Biochemicals. Grades: Highly Purified. CAS No. 2001-95-8. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Valinomycin | Valinomycin is a potassium-specific ionophore, the valinomycin-K + complex can be incorporated into biological bilayer membranes with the hydrophobic surface of valinomycin, destroys the normal K + gradient across the membrane, and as a result kills the cells, incorporating into liposomes can significantly reduces the cytotoxicity and enhances the targeting effect. Valinomycin exhibits antibiotic , antifungal, antiviral, antitumor and insecticidal efficacy, thus can be used for relevant research [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: NSC 122023. CAS No. 2001-95-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N6693. | |
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