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| Product | Description | |
|---|---|---|
| PPAR agonist 1 | An agonist of PPAR α and PPAR &gamma. Synonyms: Benzenepropanoic acid, α -methoxy-4-[[3-[4-[ (methylsulfonyl) oxy]phenyl]propyl]amino]-, (αS)-. CAS No. 539813-69-9. Molecular formula: C20H25NO6S. Mole weight: 407.48. |  |
| PPAR Agonist IX, GQ-16 | The PPAR Agonist IX, GQ-16 controls the biological activity of PPAR. This small molecule/inhibitor is primarily used for Biochemicals applications. Group: Fluorescence/luminescence spectroscopy. |  |
| PPAR Agonist IX, GQ-16 ((Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione) | A cell-permeable thiazolidinedione that acts as a PPARg-selective agonist (Ki=160nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARg b-sheet structure, exhibiting no detectable activity towards PPARa, PPARd, or RXRa. Although a weaker PPAPg agonist than Thiazolidinediones (TZDs) family rosiglitazone (Max. fold of transactivation induction =8.57 and 24.8 with 10uM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| PPAR-beta/delta Antagonist II, GSK3787 (4-Chloro-N-(2-((5-trifluoromethyl)-2-pyridyl) sulfonyl) ethyl) benzamide, PPARb Antagonist I, PPARd Antagonist I) | A cell-permeable pyridylsulfone that acts as a selective, high affinity PPARb (PPARd) ligand (IC50 in PPAR ligand displacement assays=200nM against human PPARb and >10uM against PPARa or PPARg) and effectively antagonizes agonist-induced, but not basal, PPARb transcription activity both in cultures in vitro (IC50=126nM in CV-1 cells) and in mice in vivo (82% and 71% inhibition of 10mg/kg GW0742-induced Adr and Angptl4 mRNA upregulation, respectively, in colon epithelium; 10mg/kg GSK3787; p.o.) by covalently modifying PPARb at Cys249. GSK3787 is also shown to exhibit weak agonistic activity toward PPARg (1.2-fold increase above basal level by 1uM GSK3787), and effectively block the more potent agonist GW1929 from further stimulation (1.5 and 3.5-fold above basal by 0.3uM GW1929 in the presence or absence of 1uM GSK3787, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 188591-46-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPARbeta/delta Antagonist, PT-S58 (PPARb Antagonist II, Methyl 3- (N- (4- (tert-butylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, PPARd Antagonist II) | A cell-permeable, diaryl sulfonamide PPARb/d subtype-specific pure competitive antagonist with an IC50 of 98nM. Antagonizes ligand binding without enabling coregulator interactions. Inhibits the PPARb/d specific agonist-induced transcriptional activity in cell cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPAR-beta/delta Inverse Agonist (Methyl 3- (N- (4- (hexylamino) -2-methoxyphenyl) sulfamoyl) thiophene-2-carboxylate, ST247) | A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR beta/delta receptor (IC50=93nM). Enhances the interaction of the PPARb/d ligand-binding domain with the co-repressor, SMRT-ID2 (EC50=10nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARb/d- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PPAR?/? Inverse Agonist | The PPAR?/? Inverse Agonist controls the biological activity of PPAR?/?. Group: Fluorescence/luminescence spectroscopy. | |
| Rosiglitazone maleate (BRL 49653, HSDB 7555, TDZ 01, Rosiglitazone XR, Avandia, PPAR Agonist X, PPARg Agonist IX) | Same activities as rosaglitazone but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells (NPCs). Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells (MSCs). Group: Biochemicals. Grades: Highly Purified. CAS No. 155141-29-0. Pack Sizes: 25mg, 100mg, 1g. Molecular Formula: C18H19N3O3S. C4H4O4. US Biological Life Sciences. | Worldwide |
| 10-Nitrolinoleic acid | 10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [ 3 H]Rosiglitazone for binding to PPAR-γ, with an IC 50 of 0.22 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 774603-04-2. Pack Sizes: 100 μg (3.07 mM * 100 μL in Ethanol). Product ID: HY-113473. |  |
| 1,2-DLPC | 1,2-DLPC (1,2-Dilauroyl-sn-glycero-3-phosphocholine) is a ligand for LRH-1 agonists. 1,2-DLPC is a phospholipid used in the synthesis of liposomes. 1,2-DLPC enhances fat breakdown and apoptosis in fat cells through a TNFα -dependent pathway, while also inhibiting palmitate-induced insulin resistance through PPARα -mediated inflammation in muscle cells [1] [2] [3]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: 1,2-Dilauroyl-sn-glycero-3-phosphocholine. CAS No. 18194-25-7. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-107737. | |
| 1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one | 1-(4-Methylthiophenyl)-3-(3,5-dimethyl-4-hydroxyphenyl)prop-2-en-1-one is an intermediate in synthesizing GFT-505 (G368870), which is a dual PPARα/δ agonist. Studies have shown that GFT-505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. It may also be a potential new drug candidate for treating lipid and glucose disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 824932-89-0. Pack Sizes: 100mg, 250mg. Molecular Formula: C18H18O2S. US Biological Life Sciences. | Worldwide |
| 15-deoxy-Δ12,14-Prostaglandin D2 | 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15-Deoxy-Δ12,14-PGD2. CAS No. 85235-11-6. Pack Sizes: 1 mg (2.99 mM * 1 mL in Methyl acetate). Product ID: HY-116028. | |
| 15-deoxy-Δ-12,14-Prostaglandin J2 | Selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg. Molecular Formula: C20H28O3, Method for Determining. US Biological Life Sciences. | Worldwide |
| 15-deoxy-Δ12,14-Prostaglandin J2 | 15-deoxy-Δ12,14-Prostaglandin J2 is a TRPA1 agonist and an endogenous PPARγ ligand that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM). Uses: Immunologic factors. Synonyms: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid. Grades: ≥95% by HPLC. CAS No. 87893-55-8. Molecular formula: C20H28O3. Mole weight: 316.44. | |
| 15-Deoxy-delta12,14-Prostaglandin J2 | 15-Deoxy-delta12,14-Prostaglandin J2 is an endogenous PPARγ ligand and TRPA1 agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H28O3, Molecular Weight: 316.44. US Biological Life Sciences. | Worldwide |
| 15-Deoxy-Δ-12,14-prostaglandin J2 | 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ ( EC 50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC 50 of 7 μM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2. CAS No. 87893-55-8. Pack Sizes: 1 mg (3.16 mM * 1 mL in Methyl acetate). Product ID: HY-108568. | |
| 1-Methyl-1H-benzimidazole-2-methanol | 1-Methyl-1H-benzimidazole-2-methanol acts as a reagent in the synthesis, structure-activity relationship, antibacterial and antifungal activities of benzimidazoles. Design, synthesis and computational validation of novel benzimidazole/indole-based PPARα and PPAR β partial agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 7467-35-8. Pack Sizes: 250mg, 500mg. Molecular Formula: C9H10N2O, Molecular Weight: 162.19. US Biological Life Sciences. | Worldwide |
| 1-Methylindole-2-methanol | 1-Methylindole-2-methanol is a reagent used in the synthesis of peroxisome proliferator activated receptors, PPARα and PPARγ partial agonists in the treatment of type 2 diabetes. Group: Biochemicals. Grades: Highly Purified. CAS No. 1485-22-9. Pack Sizes: 10mg, 50mg. Molecular Formula: C10H11NO, Molecular Weight: 161.199999999999. US Biological Life Sciences. | Worldwide |
| (1R)-(+)-2,10-Camphorsultam | (1R)-(+)-2,10-Camphorsultam has been used as a reactant in the synthesis of pyrrolidine acid analogs as potent dual PPARα/γ agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 108448-77-7. Pack Sizes: 500mg, 1g. Molecular Formula: C10H17NO2S, Molecular Weight: 215.31. US Biological Life Sciences. | Worldwide |
| 2-Chloro-5-nitro-N-4-phenylbenzamide (GW9662) | A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 µM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 µM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Group: Biochemicals. Alternative Names: GW9662. Grades: Highly Purified. CAS No. 22978-25-2. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C13H9ClN2O3. US Biological Life Sciences. | Worldwide |
| 2-Chloro-5-nitro-N-4-pyridinylbenzamide (T0070907) | A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1nM. Displays >800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85uM and 1.8uM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain. Group: Biochemicals. Alternative Names: T0070907. Grades: Highly Purified. CAS No. 313516-66-4. Pack Sizes: 5mg, 10mg, 25mg, 100mg. Molecular Formula: C12H8ClN3O3. US Biological Life Sciences. | Worldwide |
| (2-Ethoxy-4-formylphenoxy)acetic Acid | (2-Ethoxy-4-formylphenoxy)acetic Acid is synthetic reagent, vanillin derivative. It can be used as reagent/reactant for synthetic preparation. Design, synthesis, and biological evaluation of thiazolidine-2,4-dione conjugates as PPAR-γ agonists for use in diabetes treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 51264-76-7. Pack Sizes: 100mg, 500mg. Molecular Formula: C11H12O5, Molecular Weight: 224.21. US Biological Life Sciences. | Worldwide |
| ( + / -) -2-Imino-5- [4- (1- methyl cyclohexylmethoxyl) benzyl] thiazolidine-4one | Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| 2-(p-Chlorophenoxy)-2-methylpropionic acid | Clofibric acid is a PPAR agonist. Uses: Anticholesteremic agents. Synonyms: 2-(4-chlorophenoxy)-2-methylpropanoic acid. Grades: > 98 %. CAS No. 882-09-7. Molecular formula: C10H11ClO3. Mole weight: 214.65. | |
| 3-Aminosalicylic acid | 3-Aminosalicylic acid is the impurity found during the 5-Aminosalicylic acid (HY-15027) production. 5-Aminosalicylic acid is the agonist for PPARγ and the inhibitor for p21-activated kinase 1 ( PAK1 ) and NF-κB [1]. Crohn's disease, ulcerative proctitis. Uses: Scientific research. Group: Signaling pathways. CAS No. 570-23-0. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W206016. | |
| 3-?Ethoxy-?1-?propanol | 3-?Ethoxy-?1-?propanol is used in the synthesis of [1,2,4]triazolo[1,5-a]pyrimidines as anticancer agents. It is also used to prepare N-substituted [ (carboxymethyl) phenoxy]ethyl benzoxazinones as PPARγ agonists and antidiabetic (type 2) agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 111-35-3. Pack Sizes: 1g, 10g. Molecular Formula: C5H12O2, Molecular Weight: 104.15. US Biological Life Sciences. | Worldwide |
| (±)4-HDHA | (±)4-HDHA (4-Hydroxy docosahexaenoic acid) is an autoxidation product of Docosahexaenoic acid (HY-B2167) (DHA). (±)4-HDHA is a PPARγ agonist, antidiabetic and anti-inflammatory agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Hydroxy docosahexaenoic acid; (±)4-HDoHE. CAS No. 90906-40-4. Pack Sizes: 25 μg (2.90 mM * 25 μL in Methanol); 50 μg (2.90 mM * 50 μL in Methanol); 100 μg (2.90 mM * 100 μL in Methanol). Product ID: HY-130289. | |
| 4-O-Methyl honokiol | 4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis , acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. Uses: Scientific research. Group: Natural products. CAS No. 68592-15-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00450. | |
| 4-Oxo docosahexaenoic acid | 4-Oxo docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. Synonyms: 4-oxo DHA. Grades: ≥90%. CAS No. 845673-74-7. Molecular formula: C22H30O3. Mole weight: 342.5. | |
| 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione | 5-(4-Chlorobenzylidene)-2,4-thiazolidinedione, a well-researched organic compound, exhibits remarkable promise in treating diabetes mellitus type 2 owing to its ability to function as an agonist for peroxisome proliferator-activated receptor gamma (PPAR-γ). PPAR-γ is implicated in the modulation of glucose and lipid metabolism. Beyond its anti-diabetic attributes, this compound has been the subject of inquiry for its potential anti-cancer properties. The chemical's therapeutic significance is evidenced by the numerous investigations conducted on its biological activity. Synonyms: 5-(4-Chloro-benzylidene)-thiazolidine-2,4-dione; 2,4-Thiazolidinedione, 5-[(4-chlorophenyl)methylene]-. CAS No. 24138-83-8. Molecular formula: C10H6ClNO2S. Mole weight: 239.673. | |
| 5-Aminosalicylic acid | 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB. Uses: 5-aminosalicylic acid is a peroxidase substrate suitable for use in elisa procedures. this substrate produces a soluble end product that is brown in color and can be read spectrophotometrically at 450 nm. the reaction may be stopped with 3 n naoh and read at 550 nm. Additional or Alternative Names: 5-AS, 5-Amino-2-hydroxybenzoic acid, Mesalamine. Product Category: Amino Acids. Appearance: Solid. CAS No. 89-57-6. Molecular formula: H2NC6H3-2-(OH)CO2H. Mole weight: 153.14. Purity: 0.98. IUPACName: 5-Amino-2-hydroxybenzoic acid. Canonical SMILES: Nc1ccc(O)c(c1)C(O)=O. Density: 1.3585 g/cm³. ECNumber: 201-919-1. Product ID: ACM89576-1. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 5-Aminosalicylic Acid | 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 ( PAK1 ) and NF-κB. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN). Uses: Scientific research. Group: Natural products. Alternative Names: Mesalamine; 5-ASA; Mesalazine. CAS No. 89-57-6. Pack Sizes: 500 mg; 1 g; 5 g; 25 g; 50 g. Product ID: HY-15027. | |
| 9-Octadecynoic acid | 9-Octadecynoic acid is a DNA binding agent with a dissociation constant of 1.8 mM. 9-Octadecynoic acid is also an agonist for peroxisome proliferator-activated receptor γ ( PPARγ ) [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 506-24-1. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W341997. | |
| AdipoR agonist 1 | AdipoR agonist 1 (Compound 112254) is an agonist for adiponectin receptor ( AdipoR ), which activates the transcriptional regulators like peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). AdipoR agonist 1 is utilized in preventive doping research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 949745-75-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-130479. | |
| AdipoRon hydrochloride | AdipoRon hydrochloride is the hydrochloride salt and water-soluble derivative of AdipoRon, which is a potent and selective agonist of adiponectin receptors AdipoR1 and AdipoR2 with Kd values of 1.8 and 3.1 μM respectively. It activates PPAR-α and AMPK pathways in the liver and muscle. It ameliorates dyslipidemia, insulin resistance and glucose intolerance in db/db mice. It is a promising treatment for obesity-related diseases such as type 2 diabetes. It is orally active antidiabetic agent. Synonyms: 2-(4-Benzyoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1781835-20-8. Molecular formula: C27H29N2O3Cl. Mole weight: 464.98. | |
| Aleglitazar | Aleglitazar is a potent dual agonist of peroxisome proliferator-activated receptor (PPAR) α/&gamma. Synonyms: RO-0728804; RO 0728804; RO0728804; RG-1439; R-1439; R 1439; R1439; Aleglitazar. Grades: >98%. CAS No. 475479-34-6. Molecular formula: C24H23NO5S. Mole weight: 437.51. | |
| Aleglitazar | Aleglitazar (R1439) is a potent dual PPARα/γ agonist, with IC 50 s of 38 nM and 19 nM for human PPARa and PPARγ, respectively. Aleglitazar can be used for the research of type II diabetes [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R1439; RO0728804. CAS No. 475479-34-6. Pack Sizes: 10 mM * 1 mL; 1 mg. Product ID: HY-14728. | |
| AM3102 | AM3102 is an oleoylethanolamide (OEA) analog. AM3102 is an endogenous high-affinity PPAR-alpha agonist. AM3102 resists enzymatic hydrolysis, activates PPAR-alpha with high potency in vitro, and persistently reduces feeding when administered in vivo either parenterally or orally [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 213182-22-0. Pack Sizes: 5 mg. Product ID: HY-129683. | |
| Amorfrutin B | Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki=19 nM and EC50=73 nM) that was first isolated from A. fruticosa. Amorfrutin B has low nanomolar binding affinity to pparγ and micromolar binding to the isotypes pparα and pparβ/δ, the binding affinity constant to ppargamma is 12 times lower than amorfrutin a, antidiabetic agent, glucose-lowering agent, antimicrobial agent. It binds to PPARα with 2.6 μM and PPARβ/δ with Ki values of 1.7 μM. Amorfrutin is a glucose-lowering agent and can improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity. Synonyms: Amorfrutin B; 78916-42-4; CHEMBL2337127; 3-[(2E)-3,7-dimethylocta-2,6-dienyl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)benzoic acid; 3-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2-hydroxy-4-methoxy-6-(2-phenylethyl)-benzoicacid; SCHEMBL10039861; Amorfrutin B, >=85% (NMR); BDBM50428826; AKOS040734349; Q27467732; 3-[(2E)-3,7-DIMETHYLOCTA-2,6-DIEN-1-YL]-2-HYDROXY-4-METHOXY-6-(2-PHENYLETHYL)BENZOIC ACID. Grades: ≥97%. CAS No. 78916-42-4. Molecular formula: C26H32O4. Mole weight: 408.5. | |
| Ankaflavin | Ankaflavin, isolated from Monascus-Fermented red rice, is an orally active PPARγ agonist. Ankaflavin exhibits selective cytotoxic effect and induces cell death through apoptosis on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 50980-32-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N6642. | |
| Arhalofenate | Arhalofenateis, also known as JNJ-39659100 and MBX102, as an uricosuric agent it is a selective, partial PPAR-γ agonist. Synonyms: 2-acetamidoethyl (2R)-2-(4-chlorophenyl)-2-[3-(trifluoromethyl)phenoxy]acetate; JNJ-39659100; JNJ39659100; JNJ 39659100; MBX102; MBX-102; MBX 102; Arhalofenate. Grades: >98%. CAS No. 24136-23-0. Molecular formula: C19H17ClF3NO4. Mole weight: 415.79. | |
| Astaxanthin | Potent antioxidant carotenoid. Free radical scavenger. Reduces oxidative stress. Anticancer compound. Anti-inflammatory. Blocks NF-kappaB activatin. Anti-hypertensive. Cardiovascular protective. Improves neuronal stem cell potential. Neuroprotective. Inhibits tumor invasion. Apoptosis inducer. Increases insulin sensitivity. Attenuates diabetes associated coagulatory, oxidative and inflammatory stress PPAR-alpha agonist and PPAR-gamma antagonist. Shows positive effects on obesity and insulin resistance. Hepatoprotective. Group: Biochemicals. Alternative Names: 3,3'-Dihydroxy-b,b-carotene-4,4'-dione; 3,3'-Dhydroxy-4,4'-diketo-b-carotene; Ovoester; NSC635689; CCRIS 7118, HSDB 7468. Grades: Highly Purified. CAS No. 472-61-7. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C??H??O?, Molecular Weight: 596.84. US Biological Life Sciences. | Worldwide |
| Azelaoyl PAF | Azelaoyl-PAF is an alkyl phosphatidylcholine and is a component of the lipid pool within oxidized low-density lipoprotein (oxLDL) particles, which contain low molecular weight species. It is a potent PPARγ agonist which competes for the thiazolidinedione binding site. Synonyms: 1-hexadecyl-2-azelaoyl-sn-glycero-3-phosphocholine; C16-09:0 (COOH) PC; 1-O-hexadecyl-2-nonadioyl-sn-glycero-3-phosphocholine; 1-O-Hexadecyl-2-O-(9-carboxyoctanoyl)-sn-glyceryl-3-phosphocholine. Grades: >99%. CAS No. 354583-69-0. Molecular formula: C33H66NO9P. Mole weight: 651.85. | |
| Balaglitazone | Balaglitazone is a selective partial PPARγ agonist with an EC 50 of 1.351 μM for human PPAR&gamma. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DRF 2593; NN 2344. CAS No. 199113-98-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16086. | |
| BAY-5516 | BAY-5516 is a inverse-agonist o PPAR G, with the IC 50 value of 6.1±3.6 nM that has anti-tumor effect [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2891706-79-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-160160. | |
| Bezafibrate | Bezafibrate is an agonist of PPAR , with EC 50 s of 50 μM, 60 μM, 20 μM for human PPARα , PPARγ and PPARδ , and 90 μM, 55 μM, 110 μM for murine PPARα , PPARγ and PPARδ , respectively; Bezafibrate is used as an hypolipidemic agent. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BM15075. CAS No. 41859-67-0. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-B0637. | |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| BMS-687453 | BMS-687453 is a potent and selective peroxisome proliferator activated receptor PPARα agonist. with an IC50 of 10 nM for human PPARalpha and approximately 410-fold selectivity vs human PPARgamma in PPAR-GAL4 transactivation assays. Synonyms: BMS-687453; BMS 687453; BMS687453. Grades: 98%. CAS No. 1000998-59-3. Molecular formula: C22H21ClN2O6. Mole weight: 444.87. | |
| BMS711939 | BMS711939 is a selective and potent peroxisome proliferator-activated receptor α(PPARα) agonist with EC50 value of 4 nM for human PPAR&alpha. It is >1000-fold selectivity vs human PPARγ with EC50 value of 4.5 μM and PPARδ with EC50 value of > 100 μM in PPAR-GAL4 transactivation assays. It shows excellent in vivo efficacy and safety profiles in preclinical studies. It was chosen for further preclinical evaluation. Uses: Bms711939 was chosen for further preclinical evaluation. Synonyms: BMS-711939; BMS 711939; BMS711939. Glycine, N-((5-((2-(4-chlorophenyl)-5-methyl-4-oxazolyl)methoxy)-2-fluorophenyl)methyl)-N-(methoxycarbonyl)-; 2-[[5-[[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methoxy]-2-fluorophenyl]methyl-methoxycarbonylamino]acetic acid. Grades: >98 %. CAS No. 1000998-62-8. Molecular formula: C22H20ClFN2O6. Mole weight: 462.86. | |
| Bocidelpar | Bocidelpar, also known as ASP0367 or MA-0211, is a peroxisome proliferator-activated receptor (PPAR) delta agonist. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Bocidelpar; ASP0367; SP-0367 ; SP 0367; MA-0211; MA 0211; MA0211. Product Category: Agonists. Appearance: Solid powder. CAS No. 2095128-20-2. Molecular formula: C25H27F3N2O3. Mole weight: 460.5. Purity: >98%. IUPACName: (3R)-3-methyl-6-[2-({5-methyl-2-[4-(trifluoromethyl)phenyl]-1H-imidazol-1-yl}methyl)phenoxy]hexanoic acid. Canonical SMILES: O=C(O)C[C@H](C)CCCOC1=CC=CC=C1CN2C(C)=CN=C2C3=CC=C(C(F)(F)F)C=C3. Product ID: ACM2095128202. Alfa Chemistry ISO 9001:2015 Certified. | |
| Candesartan | Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CV 11974. CAS No. 139481-59-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-B0205. | |
| Candesartan (Standard) | Candesartan (Standard) is the analytical standard of Candesartan. This product is intended for research and analytical applications. Candesartan (CV 11974) is an orally active angiotensin II AT1-Receptor blocker and PPAR-γ agonist. Candesartan has potent and long-lasting antihypertensive effects. Candesartan can be used for the research of hypertension, chronic heart failure (CHF) and Traumatic brain injury (TBI) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CV 11974 (Standard). CAS No. 139481-59-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0205R. | |
| CAY10506 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10506 is a PPARγ agonist, which is a nuclear transcription factor that controls lipid homeostasis and glucose metabolism. It is a hybrid lipoic acid (anti-diabetic drugs of the thiazolidinedione) TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM. Synonyms: CAY 10506; CAY-10506. Grades: ≥98%. CAS No. 292615-75-9. Molecular formula: C20H26N2O4S3. Mole weight: 454.6. | |
| CAY10514 | 8(S)-HETE is a strong activator of peroxisome proliferator-activated receptors α (PPARα) and a weak activator of peroxisome proliferator-activated receptors γ (PPARγ). CAY10514 is an aromatic analog of 8(S)-HETE, which acts as a dual agonist of PPARα and PPARγ with EC50 values of 0.173 and 0.642 μM, respectively. Synonyms: Methyl-8-hydroxy-8-(2-pentyl-oxyphenyl)-oct-5-ynoate. Grades: ≥98%. CAS No. 868526-38-9. Molecular formula: C20H28O4. Mole weight: 332.4. | |
| CAY10573 | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/&delta. CAY10573 is a PPAR agonist that displays potent binding at PPARα, γ, and δ with IC50 values of 113, 50, and 223 nM, respectively. It shows stronger binding and functional activity for PPARγ than the antidiabetic compound rosiglitazone (IC50 = 92 nM; EC50 = 220 nM). Synonyms: CAY 10573; CAY-10573. Grades: ≥98%. CAS No. 853652-40-1. Molecular formula: C33H31NO5. Mole weight: 521.6. | |
| CAY10592 | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of nuclear hormone receptor superfamily comprising of the following three subtypes: PPARα, PPARγ, and PPARβ/&delta. CAY10592 is a full PPARδ agonist with EC50 of 30 nM in a fatty acid oxidation assay of rat L6 muscle cells with desirable oral pharmacokinetic properties. Synonyms: CAY 10592; CAY-10592. Grades: ≥98%. CAS No. 685139-10-0. Molecular formula: C23H17Br2ClO3S. Mole weight: 568.7. | |
| CAY10599 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at PPARγ with an EC50 of 0.05 μM. It shows high selectivity for the PPARγ receptor over PPARβ (EC50 > 10 μM) or PPARα (EC50 = 3.99 μM). Synonyms: CAY 10599; CAY-10599. Grades: ≥98%. CAS No. 1143573-33-4. Molecular formula: C38H41NO5. Mole weight: 591.7. | |
| CAY10638 | Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. Thiazolidinediones (TZDs) are a class of PPARγ agonists that have potent 15-PGDH inhibitory activity. CAY10638 is a TZD derivative that inhibits 15-PGDH activity with IC50 of 31 nM. Synonyms: CAY 10638; CAY-10638. Grades: ≥98%. CAS No. 1221413-57-5. Molecular formula: C16H13NO3S2. Mole weight: 331.4. | |
| Cefminox sodium | Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits a broad spectrum of antibacterial activity [1]. Cefminox sodium (MT-141) also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ , upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium (MT-141) also prevents pulmonary arterial hypertension [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MT-141. CAS No. 75498-96-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128932. | |
| Chiglitazar | Chiglitazar (Carfloglitazar) is a PPARα/γ dual agonist, with EC 50 s of 1.2, 0.08, 1.7 μM for PPARα, PPARγ and PPARδ, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Carfloglitazar. CAS No. 743438-45-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106266. | |
| Ciglitazone | Ciglitazone is a potent and selective PPARγ agonist ( EC 50 =3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ADD-3878; U-63287. CAS No. 74772-77-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W011220. | |
| Ciglitazone | Ciglitazone is a selective agonist at peroxisome proliferator-activated receptor γ (PPARγ) with an EC50 value of 3 μM in vitro. It is at least 33-fold selective over PPARα and &delta. It shows antihyperglycemic activity in genetically obese C57 B1/6 ob/ob mice and is used as an antihyperglycemic agent. Uses: Hypoglycemic agents. Synonyms: ADD 3878; ADD-3878; ADD3878; Ciglitazona; U 63287; U-63287; U63287; ADD 3878; ADD-3878; ADD3878; (+/-) -5-[4- (1-methylcyclohexylmethoxy) benzyl]thiazolidine-2, 4-dione; ADD-3878; 5-[[4-[ (1-Methylcyclohexyl) methoxy]phenyl]methyl]-2, 4-thiazolidinedione. Grades: ≥99% by HPLC. CAS No. 74772-77-3. Molecular formula: C18H23NO3S. Mole weight: 333.44. | |
| Ciglitazone | Selective PPARgamma agonist (EC50=3uM). Hypoglycemic agent. Angiogenesis inhibitor. Anti-inflammatory. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 74772-77-3. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C18H23NO3S. US Biological Life Sciences. | Worldwide |
| Ciglitazone ( ( + / -) -5- [4- (1- methyl cyclohexylmethoxy) benzyl] thiazolidine-2, 4-dione, ADD-3878) | Displays antihyperglycemic activity in genetically obese mice. It is a selective PPARg agonist. Group: Biochemicals. Alternative Names: ( + / -) -5- [4- (1- methyl cyclohexylmethoxy) benzyl] thiazolidine-2, 4-dione; ADD-3878. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ciglitazone ( (±) -5- [4- (1- methyl cyclohexylmethoxy) benzyl] thiazolidine-2, 4-dione, ADD-3878) | An antidiabetic drug. A thiazolidinedione (TDZ) type of antihyperglycemic agent. It displays antihyperglycemic activity in genetically obese C57 Bl/6 ob/ob mice and is a selective PPARγ agonist (EC50 = 3uM). Group: Biochemicals. Alternative Names: (±) -5- [4- (1- methyl cyclohexylmethoxy) benzyl] thiazolidine-2, 4-dione. Grades: Highly Purified. CAS No. 74772-77-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Ciglitazone - CAS 74772-77-3 | A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPAR? agonist (EC?? = 3 μM). Group: Fluorescence/luminescence spectroscopy. | |
| Clofibrate | Clofibrate is an agonist of PPAR , with EC 50 s of 50 μM, ~500 μM for murine PPARα and PPARγ, and 55 μM, ~500 μM for human PPARα and PPARγ, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 637-07-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-B0287. | |
| CP 775146 | CP 775146 is a high affinity PPARα agonist and show hypolipidemic activity in vivo. Synonyms: CP-775146; CP 775146; CP775146. 2-Methyl-2-[3-[(3S)-1-[2-[4-(1-methylethyl)phenyl]acetyl]-3-piperidinyl]phenoxy]-propanoic acid. Grades: ≥99% by HPLC. CAS No. 702680-17-9. Molecular formula: C26H33NO4. Mole weight: 423.54. | |
| CP-775146 | A potent and selective PPARα agonist. It exhibits hypolipidemic activity in vivo. Group: Biochemicals. Alternative Names: 2-Methyl-2- [3- [ (3S) -1- [ [4- (1-methylethyl) phenyl] acetyl] -3-piperidinyl] phenoxy] propanoic Acid; CP 775146; (S) -2-[3-[1-[ (4-Isopropylphenyl) acetyl]piperidin-3-yl]phenoxy]-2-methylpropionic Acid; PF-06340672. Grades: Highly Purified. CAS No. 702680-17-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CP-775146 | CP-775146 is a selective PPARα agonist that binds strongly to the PPARα ligand. CP-775146 efficiently alleviates obesity-induced liver damage, prevents lipid accumulation by activating the liver fatty acid β-oxidation pathway [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 702680-17-9. Pack Sizes: 5 mg. Product ID: HY-108571. | |
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