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| Product | Description | |
|---|---|---|
| PPI-2458 | PPI-2458 is a potent, orally active, selective and irreversible inhibitor of methionine aminopeptidase-2 ( MetAP-2 ). PPI-2458 can be used for arthritis and lymphoma research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 431077-35-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-13731. |  |
| PPI-2458 | PPI-2458 is a synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. Synonyms: PPI 2458; PPI2458; Metapro; NSC-720735. CAS No. 431077-35-9. Molecular formula: C22H36N2O6. Mole weight: 424.54. |  |
| Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid | Boc-(S)-2-amino-3-hydroxy-3-methylbutanoic acid is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir, an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection. Synonyms: Boc-L-Ser(3,3-dimethyl)-OH; (S)-Boc-β,β-dimethyl-serine; N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-threonine; N-[(1,1-Dimethylethoxy)carbonyl]-3-hydroxy-L-valine; (S)-2-(tert-Butoxycarbonylamino)-3-hydroxy-3-methylbutanoic Acid; n-boc-(s)-2-amino-3-hydroxy-3-methylbutanoic acid; (S)-2-N-Boc-amino-3-hydroxy-3-methylbutyric acid; (S)-N-Boc-2-Amino-3-hydroxy-3-methylbutanoic acid; L-Valine, N-[(1,1-dimethylethoxy)carbonyl]-3-hydroxy-; L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-3-methyl-; N-(tert-butoxycarbonyl)-3-hydroxy-L-valine; (2S)-2-(N-tert-Butoxycarbonyl)amino-3-hydroxy-3-methylbutanoic acid; N-boc-3-hydroxy-L-valine. Grades: ≥ 98% (Assay). CAS No. 102507-13-1. Molecular formula: C10H19NO5. Mole weight: 233.26. | |
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