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| Product | Description | |
|---|---|---|
| Prion Protein (106-126) (human) (scrambled) | Prion Protein (106-126) (human) (scrambled) is a scrambled sequence of human prion protein (106-126), which is an important control for studying the biological activity of prion protein peptides. According to circular dichroism analysis, the scrambled PrP 106-126 shows a random coil structure without aggregation, and is completely degraded after incubation with proteinase K and pronase for 30 minutes at 37°C. Synonyms: H-Asn-Gly-Ala-Lys-Ala-Leu-Met-Gly-Gly-His-Gly-Ala-Thr-Lys-Val-Met-Val-Gly-Ala-Ala-Ala-OH; L-asparagyl-glycyl-L-alanyl-L-lysyl-L-alanyl-L-leucyl-L-methionyl-glycyl-glycyl-L-histidyl-glycyl-L-alanyl-L-threonyl-L-lysyl-L-valyl-L-methionyl-L-valyl-glycyl-L-alanyl-L-alanyl-L-alanine; Prion Protein Fragment 106-126 Scrambled Human; PrP (106-126) (human) (scrambled). Grades: ≥90%. CAS No. 150469-23-1. Molecular formula: C80H138N26O24S2. Mole weight: 1912.24. |  |
| Prion Protein Fragment 106-126 Human | ?90% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| Prion Protein Fragment 106-126 Scrambled Human | ?85% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| Anti-Prion Protein antibody, Mouse monoclonal | clone 8H4, purified from hybridoma cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| 2-Bromo-1-[4- (trifluoromethoxy) phenyl]ethan-1-one | 2-Bromo-1-[4- (trifluoromethoxy) phenyl]ethan-1-one is an intermediate used to prepare aminothiazoles as therapeutic leads for prion diseases. It is also used in the synthesis of pyrrolidino-tetra hydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 103962-10-3. Pack Sizes: 1g, 5g. Molecular Formula: C9H6BrF3O2, Molecular Weight: 283.04. US Biological Life Sciences. |  Worldwide |
| 6-Aminophenanthridine | 6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor agonist guanabenz. Synonyms: 6-phenanthridinamine; phenanthridin-6-amine. Grades: ≥ 95 %. CAS No. 832-68-8. Molecular formula: C13H10N2. Mole weight: 194.23. | |
| Anle138b | Anle138b is a novel fluorescent oligomer modulator and an aggregation inhibitor. In vitro, anle138b blocked the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein. Synonyms: Anle138b; Anle 138b; Anle-138b; 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole; 3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole; anle138b. CAS No. 882697-00-9. Molecular formula: C16H11BrN2O2. Mole weight: 343.17. | |
| CGP 53353 | CGP 53353, also called DAPH 2, highly selectively inhibits procarcinogenic protein kinase C-βII (PKCβII) ,and it is also an inhibitor of prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM). It inhibits de novo Aβ42 assembly in vitro. Uses: Anti-alzheimer agents; amyloid-β inhibitor. Synonyms: CGP53353; CGP 53353; CGP-53353. 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; DAPH 2; CGP-53353; 145915-60-2; DAPH-7; PKCbetaII/EGFR Inhibitor; CHEMBL7939; 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione; 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE; IN1137; 4,5-bis(4-Fluoroanilino)-phthalimide; CGP 53 353; CG53353; 4,5-Bis(4-fluoroanilino)phthalimide; 4,5-Bis[4-fluoroanilino]phthalimide; PKCbII/EGFR Inhibitor; AC1O8KXF; DAPH-2; MolMap_000016; C7866_SIGMA; SCHEMBL230492; GTPL5163; CTK8E9235; RONQPWQYDRPRGG-UHFFFAOYSA-N; HMS3229K07; HMS3269E05; ZINC600430; CGP53353; BDBM50040930; CGP 53353; DNC003638; MFCD00938569; AKOS015911570; CCG-206784; NCGC00159569-01; NCGC00159569-02; AK394840; HE005407; HE312152; ZB014534; DB-042814; FT-0643387; 5,6-bis(4-fluoroanilino)isoindole-1,3-dione; 5,6-Bis((4-fluorophenyl)amino)isoindoline-1,3-dione; 5,6-Bis-(4-fluoro-phenylamino)-isoindole-1,3-dione; BRD-K32292990-001-01-0; I14-37922; 5,6-bis[(4-fluorophenyl)amino]-2,3-dihydro-1H-isoindole-1,3-dione; CGP 53353|5,6-bis[(4-Fluorophenyl)amino]-1H-isoindole-1,3(2H)-dione. CAS No. 145915-60-2. Molecular formula: C20H13F2N3O2. Mole weight: 365.34. | |
| Emrusolmin | Emrusolmin (Anle138b), an oligomeric aggregation inhibitor, blocks the formation of pathological aggregates of prion protein (PrPSc) and of α-synuclein (α-syn). Emrusolmin strongly inhibits oligomer accumulation, neuronal degeneration, and disease progression in vivo. Emrusolmin has low toxicity and an excellent oral bioavailability and blood-brain-barrier penetration. Emrusolmin blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Anle138b. CAS No. 882697-00-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101855. |  |
| Native Tritirachium album Proteinase K | Proteinase K is a stable and highly reactive serine protease. Evidence from crystal and molecular structure studies indicates the enzyme belongs to the subtilisin family with an active-site catalytic triad (Asp39-His69-Ser224). It is stable in a broad range of environments:pH, buffer salts, detergents (SDS), and temperature. In the presence of 0.1-0.5% SDS, proteinase K retains activity and will digest a variety of proteins and nucleases in DNA preparations without compromising the integrity of the isolated DNA. Applications: Proteinase k is useful for the proteolytic inactivation of nucleases during the isolation of dna and rna. it is used for the removal of endotoxins bo... used to facilitate the access of probes to rrna using fish techniques to detect pathogenic staphylococcus aureus. useful for the proteolytic inactivation of nucleases during the isolation of dna and rna. removes endotoxins that bind to cationic proteins such as lysozyme and ribonuclease a. reported useful for the isolation of hepatic, yeast, and mung bean mitochondria determination of enzyme localization on membranes treatment of paraffin embedded tissue sections to expose antigen binding sites for antibody labeling. digestion of proteins from brain tissue samples for prions in transmissible spongiform encephalopathies (tse) research. Group: Enzymes. Synonyms: Tritirachiu |  |
| PrP 106-126 (human) | Prion Protein 106-126 (human), a peptide fragment of the cellular prion protein PrP, is used as a model to investigate neurodegeneration in prion diseases. It exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Synonyms: Prion Protein Fragment 106-126 Human; Prion Protein 106-126 (human); Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly; L-lysyl-L-threonyl-L-asparagyl-L-methionyl-L-lysyl-L-histidyl-L-methionyl-L-alanyl-glycyl-L-alanyl-L-alanyl-L-alanyl-L-alanyl-glycyl-L-alanyl-L-valyl-L-valyl-glycyl-glycyl-L-leucyl-glycine. Grades: ≥95%. CAS No. 148439-49-0. Molecular formula: C80H138N26O24S2. Mole weight: 1912.24. | |
| TCS PrP Inhibitor 13 | TCS PrP Inhibitor 13 is an antiprion agent that inhibits protease-resistant prion protein (PrP-res) accumulation in two types of prion-infected mouse neuroblastoma (N2a) cell lines (IC50 = 3 nM). It was also shown to cause the inhibition of PrP expression and a decrease of proliferation and survival in schwannoma cell lines. Synonyms: 2,4-Dihydro-5-(4-nitrophenyl)-2-phenyl-3H-pyrazol-3-one; 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one. Grades: ≥98% by HPLC. CAS No. 34320-83-7. Molecular formula: C15H11N3O3. Mole weight: 281.27. | |
| WAY-641966 | WAY-641966 is an anti-prion agent. Synonyms: WAY 641966; WAY641966. CAS No. 259870-32-1. Molecular formula: C20H16N4. Mole weight: 312.4. | |
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