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| Product | Description | |
|---|---|---|
| Prostaglandin D2 | ?95%, synthetic. Group: Fluorescence/luminescence spectroscopychiral molecules. |  |
| Prostaglandin D2 | Prostaglandin D2 is a fatty acid compound present in the human body. Elevated levels of localized Prostaglandin D2 has been linked to hair loss and growth inhibition. It has also been seen to contribute to the activity of allergic asthma. Prostaglandin D2 is the major postagrlandin produced by mast cells and is the primary prostaglandin in the brain. It causes vasodilation, induces inflammation, and its presence in hair follicles may be partially responsible for male pattern baldness. Prostaglandin D2 is released during asthmatic and allergic reactions. Group: Biochemicals. Alternative Names: (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid; 11-Dehydroprostaglandin F2alpha, PGD2. Grades: Highly Purified. CAS No. 41598-07-6. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C20H32O5, Molecular Weight: 352.5. US Biological Life Sciences. |  Worldwide |
| Prostaglandin D2 | Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals [1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances [2]. PGD2 plays a protective role by suppressing inflammation [3]. Uses: Scientific research. Group: Natural products. Alternative Names: PGD2. CAS No. 41598-07-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101988. |  |
| Prostaglandin D2 | Prostaglandin D2 (PGD2) is the major eicosanoid product found in mast cells and brain. It has been shown to induce inflammation such as allergic asthma. Synonyms: PGD2; 11-Dehydroprostaglandin F2-alpha; (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 41598-07-6. Molecular formula: C20H32O5. Mole weight: 352.5. |  |
| Prostaglandin D2 Ethanolamide-d4 | Prostaglandin D2 Ethanolamide-d4. Group: Biochemicals. Alternative Names: N-(2-Hydroxyethyl)-11-oxo-9α,15S-dihydroxyprosta-5Z,13E-dien-1-amide-d4. Grades: Highly Purified. Pack Sizes: 50ug. Molecular Formula: C22H33D4NO5, Molecular Weight: 399.56. US Biological Life Sciences. | Worldwide |
| 13,14-dihydro-15-keto prostaglandin D2 | 13,14-dihydro-15-keto prostaglandin D2 is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway. It has been recently identified as a selective agonist for the DP2 receptor. Additionally, 13,14-dihydro-15-keto Prostaglandin D2 has been shown to inhibit ion flux in canine colonic mucosa preparation. Synonyms: 13,14-dihydro-15-keto PGD2; 11,15-dioxo-9S-hydroxy-5Z-prostenoic acid; (Z)-7-[(1R,2R,5S)-5-hydroxy-3-oxo-2-(3-oxooctyl)cyclopentyl]hept-5-enoic acid. Grades: ≥95%. CAS No. 59894-07-4. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| 15-deoxy-Δ12,14-Prostaglandin D2 | 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation ( EC 50 =8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 ( SRC-1 ) to peroxisome proliferator-activated receptor γ ( PPARγ ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells ( IC 50 =0.3 μg/ml) and inhibits ADP-induced platelet aggregation ( IC 50 =320 ng/mL). Uses: Scientific research. Group: Signaling pathways. Alternative Names: 15-Deoxy-Δ12,14-PGD2. CAS No. 85235-11-6. Pack Sizes: 1 mg (2.99 mM * 1 mL in Methyl acetate). Product ID: HY-116028. | |
| 15(R)-15-Methyl prostaglandin D2 | 15(R)-15-Methyl PGD2 is a selective, potent agonist for the CRTH2/DP2 receptor. Synonyms: 15(R)-15-methyl PGD2; 15(R)-15-methyl Prostaglandin D2. Grades: ≥95%. CAS No. 210978-26-0. Molecular formula: C21H34O5. Mole weight: 366.5. | |
| 15(R)-Prostaglandin D2 | Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor. 15(R)-15-methyl PGD2 is a surprisingly potent agonist at the DP2 receptor. Synonyms: 15(R)-PGD2; (5Z,9a,13E,15R)-9,15-Dihydroxy-11-oxoprosta-5,13-dien-1-oic acid. Grades: ≥98%. CAS No. 59894-05-2. Molecular formula: C20H32O5. Mole weight: 352.5. | |
| 15(S)-15-methyl Prostaglandin D2 | 15(S)-15-methyl Prostaglandin D2 is a synthetic analog of PGD2. Group: Biochemicals. Grades: Highly Purified. CAS No. 85280-90-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H34O5, Molecular Weight: 366.49. US Biological Life Sciences. | Worldwide |
| 15(S)-15-Methyl prostaglandin d2 | 15(S)-15-Methyl prostaglandin d2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9ALPHA,15S-DIHYDROXY-11-OXO-15-METHYL-PROSTA-5Z,13E-DIEN-1-OIC ACID;15(S)-15-METHYL PROSTAGLANDIN D2;(15s)-15-methyl-pgd2;(5z,9-alpha,13e,15s)-9,15-dihydroxy-15-methyl-11-oxoprosta-5,13-dien-1-oica;15-methyl-pgd2;15s)-;prosta-5,13-dien-1-oicacid,9,15-dih. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 85280-90-6. Molecular formula: C21H34O5. Mole weight: 366.49. Product ID: ACM85280906. Alfa Chemistry ISO 9001:2015 Certified. |  |
| 11-Keto fluprostenol | 11-Keto fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency. Synonyms: Fluprostenol Prostaglandin D2; (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3R)-3-hydroxy-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid. Grades: ≥98%. CAS No. 62145-07-7. Molecular formula: C23H27F3O6. Mole weight: 456.5. | |
| 13,14-Dihydro-15-keto-PGD2 | 13,14-Dihydro-15-keto-PGD2 is a metabolite of prostaglandin D2 and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 59894-07-4. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H32O5, Molecular Weight: 352.47. US Biological Life Sciences. | Worldwide |
| 15-hydroxyprostaglandin-D dehydrogenase (NADP+) | Specific for prostaglandins D [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+)]. Group: Enzymes. Synonyms: prostaglandin-D 15-dehydrogenase (NADP); dehydrogenase, prostaglandin D2; NADP-PGD2 dehydrogenase; dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate); 15-hydroxy PGD2 dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP); NADP-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin . Enzyme Commission Number: EC 1.1.1.196. CAS No. 84399-95-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0099; 15-hydroxyprostaglandin-D dehydrogenase (NADP+); EC 1.1.1.196; 84399-95-1; prostaglandin-D 15-dehydrogenase (NADP); dehydrogenase, prostaglandin D2; NADP-PGD2 dehydrogenase; dehydrogenase, 15-hydroxyprostaglandin (nicotinamide adenine dinucleotide phosphate); 15-hydroxy PGD2 dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP); NADP-dependent 15-hydroxyprostaglandin dehydrogenase; prostaglandin D2 dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; NADP-linked prostaglandin D2 dehydrogenase; 15-hydroxyprostaglandin-D dehydrogenase (NADP). Cat No: EXWM-0099. |  |
| 15-hydroxyprostaglandin dehydrogenase (NAD+) | Acts on prostaglandin E2, F2α and B1, but not on prostaglandin D2. cf. EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+) and EC 1.1.1.197 15-hydroxyprostaglandin dehydrogenase (NADP+). Group: Enzymes. Synonyms: NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I); PGDH; 11α,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase; 15-OH-PGDH; 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostanoic dehydrogenase; NAD+-specific 15-hydroxyprostaglandin dehydrogenase; prostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NAD+); (5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13. Enzyme Commission Number: EC 1.1.1.141. CAS No. 9030-87-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0045; 15-hydroxyprostaglandin dehydrogenase (NAD+); EC 1.1.1.141; 9030-87-9; NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I); PGDH; 11α,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase; 15-OH-PGDH; 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostanoic dehydrogenase; NAD+-specific 15-hydroxyprostaglandin dehydrogenase; prostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NAD+); (5Z,13E)-(15S)-11α,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase. Cat No: EXWM-0045. | |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) | Acts on prostaglandins E2, F2α and B1, but not on prostaglandin D2 [cf. EC 1.1.1.141 15-hydroxyprostaglandin dehydrogenase (NAD+) and EC 1.1.1.196 15-hydroxyprostaglandin-D dehydrogenase (NADP+)]. May be identical with EC 1.1.1.189 prostaglandin-E2 9-reductase. Group: Enzymes. Synonyms: NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP). Enzyme Commission Number: EC 1.1.1.197. CAS No. 54989-39-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0100; 15-hydroxyprostaglandin dehydrogenase (NADP+); EC 1.1.1.197; 54989-39-8; NADP-dependent 15-hydroxyprostaglandin dehydrogenase; NADP-linked 15-hydroxyprostaglandin dehydrogenase; NADP-specific 15-hydroxyprostaglandin dehydrogenase; type II 15-hydroxyprostaglandin dehydrogenase; 15-hydroxyprostaglandin dehydrogenase (NADP). Cat No: EXWM-0100. | |
| 1-Descarboxy Ketorolac-d4 | 1-Descarboxy Ketorolac-d4 is labelled 1-Descarboxy Ketodolac (D289435) which is an impurity in the synthesis of (R)-Ketorolac (K235600). The (S)-enantiomer is about 60 times more potent than (R)-enantiomer. Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C14H9D4NO, Molecular Weight: 215.28. US Biological Life Sciences. | Worldwide |
| 2-Fluoro-5- (ethoxycarbonylmethyl) phenylboronic Acid, Pinacol Ester | 2-Fluoro-5- (ethoxycarbonylmethyl) phenylboronic Acid, Pinacol Ester acts as a reagent in the preparation of tetra hydroisoquinolines as prostaglandin D2 receptor modulators useful in treatment and prevention of prostaglandin-mediated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1198615-88-1. Pack Sizes: 25mg, 50mg. Molecular Formula: C16H22BFO4, Molecular Weight: 308.149999999999. US Biological Life Sciences. | Worldwide |
| AM-211 | This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary disease) and asthma, but no recent results has been published. Uses: Chronic obstructive pulmonary disease(copd) and asthma. Synonyms: AM-211; AM 211; AM211; 2-(2'-((3-benzyl-1-ethylureido)methyl)-6-methoxy-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)acetic acid,1263077-74-2 (AM-211 sodium). Grades: 98%. CAS No. 1175526-27-8. Molecular formula: C27H27F3N2O4. Mole weight: 500.51. | |
| AM-211 sodium | This active molecular is a potent Prostaglandin D2 receptor antagonists and has been in phase I clinical trials for both COPD (chronic obstructive pulmonary disease) and asthma, but no recent results has been published. Uses: Chronic obstructive pulmonary disease(copd) and asthma. Synonyms: UNII-8SV621U288;1175526-27-8(Free acid); AM-211 sodium; AM 211 sodium; AM211 sodium. Grades: 98%. CAS No. 1263077-74-2. Molecular formula: C27H26F3N2O4Na. Mole weight: 522.50. | |
| BW 246C | The prostaglandin D2 (PGD2) receptors are the members of G protein-coupled receptors. PGD2 receptors include the following proteins prostaglandin D2 receptor 1 (DP1) and prostaglandin D2 receptor 2 (DP2). BW 246C is a DP receptor agonist. BW 246C is the less active C-8 diastereomer of the DP receptor agonist BW 245C. The activity of BW 245C is 70-fold greater than that of BW 246C. Synonyms: 8-epi BW 245C. Grades: ≥98%. CAS No. 65705-83-1. Molecular formula: C19H32N2O5. Mole weight: 368.5. | |
| BW A868C | Prostaglandin D2 (PGD2) has been widely distributed in rat brain, spinal cord and pituitary and may act as a neuromodulator in the central nervous system. BW A868C is a novel, selective and potent competitive antagonist of PGD2. BW A868C antagonizes the prostaglandin D2 and BW 245C-induced activation of human platelet adenylate cyclase. BW A868C antagonizes the accumulation of cAMP in rabbit non-pigmented ciliary epithelial cells. However, it has virtually no effect on human TP, IP, EP1, EP2, and FP receptors. Synonyms: BWA-868C; BWA868C. Grades: ≥98%. CAS No. 118675-50-6. Molecular formula: C25H37N3O5. Mole weight: 459.6. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grades: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
| CAY10595 | Chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) is a G-protein coupled receptor that binds to the ligand prostaglandin D2 (PGD2).The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. CAY10595 is a mixture of isomers which acts as a potent CRTH2/DP2 receptor antagonist with Ki of 10 nM. Synonyms: CAY 10595; CAY-10595. Grades: ≥97%. CAS No. 916047-16-0. Molecular formula: C20H13Cl2FN2O5. Mole weight: 451.2. | |
| CAY10597 | The biological effects of prostaglandin D2 (PGD2) are transduced by at least two 7-transmembrane G protein-coupled receptors, designated DP1 and CRTH2/DP2. CAY10597, as a racemic mixture, is a potent CRTH2/DP2 receptor antagonist that binds to the human receptor with a Ki value of 37 nM. The R enantiomer is slightly more potent exhibiting Ki values of 23 and 22 nM at the human and murine CRTH2/DP2 receptor, respectively. Synonyms: CAY 10597; CAY-10597. Grades: ≥98%. CAS No. 916046-55-4. Molecular formula: C20H14ClFN2O5. Mole weight: 416.8. | |
| Delta-12-Prostaglandin J2 | Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Δ12-PGJ2. CAS No. 87893-54-7. Pack Sizes: 100 μg (2.99 mM * 100 μL in Methyl acetate). Product ID: HY-113505. | |
| Fevipiprant | Fevipiprant (QAW039, NVP-QAW039) is s an orally active, selective, reversible prostaglandin D2 (DP2) receptor antagonist with an K d value of 1.14 nM. Fevipiprant has the potential for the research of bronchial asthma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: QAW039; NVP-QAW039. CAS No. 872365-14-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16768. | |
| MK 0524 sodium salt | MK 0524 sodium salt is a potent and selective prostaglandin D2 (PGD2) receptor 1 (DP1) antagonist with Ki values to be 0.57 nM and 750 nM for DP1 and DP2 receptors, respectively. Synonyms: MK 0524 sodium salt; MK0524 sodium salt; MK-0524 sodium salt; Laropiprant sodium; 2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid sodium. Grades: 99%. CAS No. 572874-50-1. Molecular formula: C21H18ClFNNaO4S. Mole weight: 457.88. | |
| Prosta-5,13-dien-1-oicacid,9,15-dihydroxy-11-methylene-,(5z,9a,13e,15s)- | Prosta-5,13-dien-1-oicacid,9,15-dihydroxy-11-methylene-,(5z,9a,13e,15s)-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 11-DEOXY-11-METHYLENE PROSTAGLANDIN D2;9ALPHA,15S-DIHYDROXY-11-METHYLENE-PROSTA-5Z,13E-DIEN-1-OIC ACID. Product Category: Heterocyclic Organic Compound. Appearance: A solution in methyl acetate. CAS No. 100648-29-1. Molecular formula: C21H34O4. Mole weight: 350.49. Purity: 0.96. IUPACName: 7-[5-hydroxy-2-(3-hydroxyoct-1-enyl)-3-methylidenecyclopentyl]hept-5-enoic acid. Canonical SMILES: CCCCCC(C=CC1C(C(CC1=C)O)CC=CCCCC(=O)O)O. Product ID: ACM100648291. Alfa Chemistry ISO 9001:2015 Certified. | |
| prostaglandin-F synthase | Reduces prostaglandin D2 and prostaglandin H2 to prostaglandin F2; prostaglandin D2 is not an intermediate in the reduction of prostaglandin H2. Also catalyses the reduction of a number of carbonyl compounds, such as 9,10-phenanthroquinone and 4-nitroacetophenone. Group: Enzymes. Synonyms: prostaglandin-D2 11-reductase; reductase, 15-hydroxy-11-oxoprostaglandin; PGD2 11-ketoreductase; PGF2α synthetase; prostaglandin 11-ketoreductase; prostaglandin D2-ketoreductase; prostaglandin F synthase; prostaglandin F synthetase; synthetase, prostaglandin F2α; PGF synthetase; NADPH-dependent prostaglandin D2 11-keto reductase; prostaglandin 11-keto reductase. Enzyme Commission Number: EC 1.1.1.188. CAS No. 55976-95-9. PGF synthetase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0090; prostaglandin-F synthase; EC 1.1.1.188; 55976-95-9; prostaglandin-D2 11-reductase; reductase, 15-hydroxy-11-oxoprostaglandin; PGD2 11-ketoreductase; PGF2α synthetase; prostaglandin 11-ketoreductase; prostaglandin D2-ketoreductase; prostaglandin F synthase; prostaglandin F synthetase; synthetase, prostaglandin F2α; PGF synthetase; NADPH-dependent prostaglandin D2 11-keto reductase; prostaglandin 11-keto reductase. Cat No: EXWM-0090. | |
| Prostaglandin F Synthase from human, Recombinant | PGF synthase catalyzes the conversions of 4-androstene-3,17-dione to testosterone, estrone to 17β-estradiol, prostaglandin H2 to PGF2α, and PGD2 to 9α,11β-PGF2. Prostaglandin (PG) F2 is synthesized via three pathways. Applications: Prostaglandin f synthase (pgf synthase) is a member of the aldo-keto reductase superfamily of proteins which catalyze the conversion of aldehydes and ketones to thier corresponding alcohols. prostaglandin f synthase is used in cancer research since it is upregulated in many cancers such as breast and prostate cancer. pgf synthase is also used to study kidney and renal cell carcinoma. Group: Enzymes. Synonyms: prostaglandin-D2 11-reduc. Enzyme Commission Number: EC 1.1.1.188. CAS No. 55976-95-9. Purity: > 90% (SDS-PAGE). PGF synthetase. Mole weight: mol wt ~37 kDa. Storage: -70°C. Source: E. coli. Species: Human. prostaglandin-D2 11-reductase; reductase, 15-hydroxy-11-oxoprostaglandin; PGD2 11-ketoreductase; PGF2α synthetase; prostaglandin 11-ketoreductase; prostaglandin D2-ketoreductase; prostaglandin F synthase; prostaglandin F synthetase; synthetase, prostaglandin F2α; prostaglandin-D2 11-reductase; PGF synthetase; NADPH-dependent prostaglandin D2 11-keto reductase; prostaglandin 11-keto reductase; prostaglandin-F synthase; EC 1.1.1.188; 55976-95-9. Cat No: NATE-0552. | |
| Prostaglandin J2 | Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: PGJ2. CAS No. 60203-57-8. Pack Sizes: 500 μg (14.95 mM * 100 μL in Methyl acetate). Product ID: HY-113366. | |
| Prostaglandin J2 | Prostaglandin J2 (PGJ2) is a metabolite of PGD2, exhibiting antimitotic and antiproliferative effects. It inhibits platelet aggregation with IC50 value of 5-10 nM. Uses: Antineoplastic agents. Synonyms: PGJ2; 9-Deoxy-delta-9-prostaglandin D2; 9-Deoxy-delta-9-pgd2; (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid. Grades: ≥95%. CAS No. 60203-57-8. Molecular formula: C20H30O4. Mole weight: 334.5. | |
| prostamide/prostaglandin F2α synthase | The enzyme contains a thioredoxin-type disulfide as a catalytic group. Prostamide H2 and prostaglandin H2 are the best substrates; the latter is converted to prostaglandin F2&alpha. The enzyme also reduces tert-butyl hydroperoxide, cumene hydroperoxide and H2O2, but not prostaglandin D2 or prostaglandin E2. Group: Enzymes. Synonyms: prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Enzyme Commission Number: EC 1.11.1.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0502; prostamide/prostaglandin F2α synthase; EC 1.11.1.20; prostamide/PGF synthase; prostamide F synthase; prostamide/prostaglandin F synthase; tPGF synthase. Cat No: EXWM-0502. | |
| S 5751 | S 5751 is a potent and orally bioactive antagonist of prostaglandin D2 (PGD2) receptor DP1 (Ki values 1.6 and 24.2 nM for human DP and TP receptors, respectively). S 5751 is identified as a potential treatment of allergic diseases. Uses: Potential antiallergic drug. Synonyms: S-5751; S5751; S 5751; (Z)-7-[(1S,3S,4R,5R)-4-[(5-hydroxy-1-benzothiophene-3-carbonyl)amino]-6,6-dimethyl-3-bicyclo[3.1.1]heptanyl]hept-5-enoic acid. Grades: 99%. CAS No. 209268-36-0. Molecular formula: C25H31NO4S. Mole weight: 441.58. | |
| Tranilast | Tranilast (MK-341) acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 ( PGD2 , IC 50 = 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects [1]. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-341; SB 252218. CAS No. 53902-12-8. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg. Product ID: HY-B0195. | |
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