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| Product | Description | |
|---|---|---|
| Prostaglandin J2 | Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K i s of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC 50 value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: PGJ2. CAS No. 60203-57-8. Pack Sizes: 500 μg (14.95 mM * 100 μL in Methyl acetate). Product ID: HY-113366. |  |
| Prostaglandin J2 | Prostaglandin J2 (PGJ2) is a metabolite of PGD2, exhibiting antimitotic and antiproliferative effects. It inhibits platelet aggregation with IC50 value of 5-10 nM. Uses: Antineoplastic agents. Synonyms: PGJ2; 9-Deoxy-delta-9-prostaglandin D2; 9-Deoxy-delta-9-pgd2; (Z)-7-[(1S,5R)-5-[(E,3S)-3-hydroxyoct-1-enyl]-4-oxocyclopent-2-en-1-yl]hept-5-enoic acid. Grades: ≥95%. CAS No. 60203-57-8. Molecular formula: C20H30O4. Mole weight: 334.5. |  |
| 15-deoxy-Δ-12,14-Prostaglandin J2 | Selective PPARγ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg. Molecular Formula: C20H28O3, Method for Determining. US Biological Life Sciences. |  Worldwide |
| 15-deoxy-Δ12,14-Prostaglandin J2 | 15-deoxy-Δ12,14-Prostaglandin J2 is a TRPA1 agonist and an endogenous PPARγ ligand that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC50 = 7 μM). Uses: Immunologic factors. Synonyms: (5Z,12E,14E)-11-Oxo-prosta-5,9,12,14-tetraen-1-oic acid. Grades: ≥95% by HPLC. CAS No. 87893-55-8. Molecular formula: C20H28O3. Mole weight: 316.44. | |
| 15-Deoxy-delta12,14-Prostaglandin J2 | 15-Deoxy-delta12,14-Prostaglandin J2 is an endogenous PPARγ ligand and TRPA1 agonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 87893-55-8. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C20H28O3, Molecular Weight: 316.44. US Biological Life Sciences. | Worldwide |
| 15-Deoxy-Δ-12,14-prostaglandin J2 | 15-Deoxy-Δ-12,14-prostaglandin J2 (15d-PGJ2) is a cyclopentenone prostaglandin and a metabolite of PGD2. 15-Deoxy-Δ-12,14-prostaglandin J2 is a selective PPARγ ( EC 50 of 2 μM) and a covalent PPARδ agonist. 15-Deoxy-Δ-12,14-prostaglandin J2 promotes efficient differentiation of C3H10T1/2 fibroblasts to adipocytes with an EC 50 of 7 μM [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 15d-PGJ2; 15-Deoxy-Δ12,14-PGJ2. CAS No. 87893-55-8. Pack Sizes: 1 mg (3.16 mM * 1 mL in Methyl acetate). Product ID: HY-108568. | |
| 15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester | 15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 μM in a murine chimera system. Synonyms: 15-deoxy-Δ12,14-PGJ2-2-glycerol ester; 1,3-dihydroxypropan-2-yl (Z)-7-[(1S,5E)-5-[(Z)-oct-2-enylidene]-4-oxocyclopent-2-en-1-yl]hept-5-enoate. Grades: ≥98%. Molecular formula: C23H34O5. Mole weight: 390.5. | |
| Delta-12-Prostaglandin J2 | Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Δ12-PGJ2. CAS No. 87893-54-7. Pack Sizes: 100 μg (2.99 mM * 100 μL in Methyl acetate). Product ID: HY-113505. | |
| CAY10410 | CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. It was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. CAY10410 was not cytotoxic at up to 25 μM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 μM. Synonyms: 9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2. Grades: ≥98% (isomer mixture). CAS No. 596104-94-8. Molecular formula: C20H30O3. Mole weight: 318.5. | |
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