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| Product | Description | |
|---|---|---|
| Pyr3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Pyr3 | Pyr3, a pyrazole derivative, is a selective antagonist of the TRP canonical 3 channel (TRPC3) which can function as a receptor-operated channel. It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM. Synonyms: Pyr3; Pyr-3; Pyr 3; 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1160514-60-2. Molecular formula: C16H11Cl3F3N3O3. Mole weight: 456.63. |  |
| Pyr3 | Pyr3. Group: Biochemicals. Grades: Purified. CAS No. 1160514-60-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| (Pyr3)-Amyloid β-Protein (3-40) | (Pyr3)-Amyloid β-Protein (3-40), a pyroglutamate-modified amyloid-β peptide extracted from Aβ40 and Aβ42, is a potential key player in the pathology of Alzheimer's disease (AD) due to its abundance in the brain, high aggregation propensity, stability and cytotoxicity. Synonyms: Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH; L-pyroglutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valine. Grades: ≥95%. CAS No. 161818-04-8. Molecular formula: C187H283N51O53S. Mole weight: 4125.68. | |
| (Pyr3)-Amyloid β-Protein (3-42) | (Pyr3)-Amyloid β-Protein (3-42) , an indispensible resource in the research of compound, assumes a pivotal role in the tireless pursuit of drug advancement pertaining to the grave predicament of Alzheimer's disease. Through its meticulously engineered sequence modification, it remarkably homes in on and actively impedes the pernicious aggregation of Amyloid β-Protein—a pivotal protagonist in the intricate pathogenesis of said affliction. Synonyms: (Glp3) β-Amyloid (3-42); Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH; L-pyroglutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-seryl-glycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valyl-glycyl-L-seryl-L-asparagyl-L-lysyl-glycyl-L-alanyl-L-isoleucyl-L-isoleucyl-glycyl-L-leucyl-L-methionyl-L-valyl-glycyl-glycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine. Grades: 95%. CAS No. 183449-57-2. Molecular formula: C196H299N53O55S1. Mole weight: 4309.92. | |
| Amyloid β-Protein (3-42) | With the development of AD, N-terminal truncation of Aβ42 may be formed in increased amounts. Amyloid β-Protein (3-42) is a precursor of Pyr-peptide. The resistance of (Pyr3)-Aβ 3-42 positive plaque to age-dependent degradation may be due to its high stability and aggregation tendency. Synonyms: Aβ (3-42); H-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH. Grades: ≥95%. CAS No. 157884-74-7. Molecular formula: C196H301N53O56S. Mole weight: 4327.94. | |
| CRAC Channel Inhibitor III, Pyr6 (N-(4-(3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)-3-fluoroisonicotinamide) | A cell-permeable pyrazole derivative that acts as a selective blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 490nM by Fura-2), while exhibiting much reduced potency against the transient receptor potential cation channel TRPC3-medated ROCE (receptor-operated Ca2+ entry) upon carbachol stimulation in TRPC3-expressing HEK293 cells (IC50 = 18.46uM; by Fura-2). A great complement to Pyr2, Pyr3, and Pyr10 in Ca2+ signaling studies. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H?F?N?O, Primary Target: Orai3. US Biological Life Sciences. | Worldwide |
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