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| Product | Description | |
|---|---|---|
| Pyripyropene A | Pyripyropene A is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 58 nmol/L. Synonyms: (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate; (3S,4R,4aR,6S,6aS,12R,12aS,12bS)-4-(Acetoxymethyl)-12-hydroxy-4,6a,12b-trimethyl-11-oxo-9-(pyridin-3-yl)-1,2,3,4,4a,5,6,6a,11,12,12a,12b-dodecahydrobenzo[f]pyrano[4,3-b]chromene-3,6-diyl diacetate. Grades: ≥95%. CAS No. 147444-03-9. Molecular formula: C31H37NO10. Mole weight: 583.62. |  |
| Pyripyropene A ((+)-Pyripyropene A, PPPA, FO 1289A) | Antibiotic. Highly specific inhibitor of acyl-coenzyme A:cholesterol acetyltransferase 2 (ACAT2). Anti-angiogenic. Antiatherogenic and antiatherosclerotic agent. Shows cholesterol-lowering and atheroprotective activities. Group: Biochemicals. Alternative Names: (+)-Pyripyropene A, PPPA, FO 1289A. Grades: Highly Purified. CAS No. 147444-03-9. Pack Sizes: 250ug, 1mg. Molecular Formula: C31H37NO10, Molecular Weight: 583.6. US Biological Life Sciences. |  Worldwide |
| PRD-125 | PRD-125 is a potent SOAT2 inhibitor derived from pyripyropene A. Study shows that PRD-125 can suppress cholesterol diet-induced fatty liver progression in dose dependent manner and reduce the risk of atherosis in rabbit model. Uses: The potential treatment of atherosis. Synonyms: PRD-125; PRD 125; PRD125. | |
| Pyripyropene B | Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor produced by the fungus Aspergillus fumigatus FO 1289. It inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nmol/L. Synonyms: 2H,11H-Naphtho[2,1-b]pyrano[3,4-e]pyran-11-one,3,6-bis(acetyloxy)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-12-hydroxy-4,6a,12b-trimethyl-4-[(1-oxopropoxy)methyl]-9-(3-pyridinyl)-,(3S,4R,4aR,6S,6aS,12R,12aS,12bS)-. CAS No. 151519-44-7. Molecular formula: C32H39NO10. Mole weight: 597.65. | |
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