Pyruvate Dehydrogenase Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
Adaptaquin Quick inquiry Where to buy Suppliers range | Adaptaquin is an inhibitor of hypoxia-inducible factor (HIF) prolyl hydroxylase 2 (PHD2) with IC50 value of 2 μM in a reporter assay using SH-SY5Y-ODD-Luc cells. It displays neuroprotective effects and enhances functional recovery in rodent intracerebral hemorrhage models by inhibition of ATF4 dependent genes. It reduces neuronal death and behavioral deficits after intracerebral hemorrhage (ICH) in several rodent models. It blocks glutamate induced ROS production in HT-22 cells, independent of MnSOD. It stabilizes HIF-1α protein and induces expression of the HIF1-regulated genes EPO and VEGF in SH-SY5Y human neuroblastoma cells. It is used in ischemic injury research, renal anemia, and used as an antioxidant. It is also used in pyruvate dehydrogenase (PDH) related research. Synonyms: 7-[(4-Chlorophenyl)[(3-hydroxy-2-pyridinyl)amino]methyl]-8-quinolinol. Grades: ≥97% by HPLC. CAS No. 385786-48-1. Molecular formula: C21H16ClN3O2. Mole weight: 377.82. | |
DCA Quick inquiry Where to buy Suppliers range | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
Galloflavin Potassium salt Quick inquiry Where to buy Suppliers range | Galloflavin Potassium salt is an inhibitor of human lactate dehydrogenase (LDH) (Ki = 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate) with anticancer activity. Galloflavin inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Synonyms: NSC-107022 potassium; NSC 107022 potassium; NSC107022 potassium; 3,8,9,10-Tetrahydroxypyrano[3,2-c][2]benzopyran-2,6-dione potassium salt. Grades: ≥95% by HPLC. CAS No. 1780260-20-9. Molecular formula: C12H5O8K. Mole weight: 316.26. | |
JX 06 Quick inquiry Where to buy Suppliers range | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
Leelamine Quick inquiry Where to buy Suppliers range | Leelamine, a diterpene molecule, has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Leelamine is also a PDK(pyruvate dehydrogenase kinase inhibitor). Synonyms: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine; dehydroabietylamine; DEHYDROABIETYLAMINE; (+)-Dehydroabietylamine; Dehydroabiethylamine; 16496-99-4 Leelamine (hydrochloride). Grades: ≥90%. CAS No. 1446-61-3. Molecular formula: C20H31N. Mole weight: 285.5. | |
Leelamine hydrochloride Quick inquiry Where to buy Suppliers range | Leelamine is a diterpene amine exhibiting low affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It also acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Leelamine inhibits intracellular cholesterol transport and suppresses cancer cell growth. Synonyms: Lylamine hydrochloride; Dehydroabiethylamine hydrochloride; [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine hydrochloride. Grades: ≥98%. CAS No. 16496-99-4. Molecular formula: C20H31N·HCl. Mole weight: 321.9. | |
L+Lactic Acid, Calcium Salt, Pentahydrate Quick inquiry Where to buy Suppliers range | Lactic acid (2-hydroxypropanoic acid), also known as milk acid, is a chemical compound that plays a role in several biochemical processes. It was first isolated in 1780 by a Swedish chemist, Carl Wilhelm Scheele, and is a carboxylic acid with a chemical formula of C3H6O3. It has a hydroxyl group adjacent to the carboxyl group, making it an alpha hydroxy acid (AHA). In solution, it can lose a proton from the acidic group, producing the lactate ion CH3CH(OH)COO?. It is miscible with water or ethanol, and is hygroscopic. Lactic acid is chiral and has two optical isomers. One is known as L-(+)-lactic acid or (S)-lactic acid and the other, its mirror image, is D-(-)-lactic acid or (R)-lactic acid. L-(+)-Lactic acid is the biologically important isomer.In animals, L-lactate is constantly produced from pyruvate via the enzyme lactate dehydrogenase (LDH) in a process of fermentation during normal metabolism and exercise. It does not increase in concentration until the rate of lactate production exceeds the rate of lactate removal which is governed by a number of factors including: monocarboxylate transporters, concentration and isoform of LDH and oxidative capacity of tissues. The concentration of blood lactate is usually 1-2 mmol/L at rest, but can rise to over 20 mmol/L during intense exertion. Industrially, lactic acid fermentation is performed by Lactobacillus bacteria, among others. These bacteria can operate in the mouth; the acid they produce is responsible for the tooth decay known as caries.In medicine, lactate is one of the main components of Ringer's lactate or lactated Ringer's solution (Compound Sodium Lactate or Hartmann's Solution in the UK). This intravenous fluid consists of sodium and potassium cations, with lactate and chloride anions, in solution with distilled water in concentration so as to be isotonic compared to human blood. It is most commonly used for fluid resuscitation after blood loss due to trauma, surgery, or a burn injury. Group: Biochemicals. Alternative Names: Lactic Acid Calcium Salt (2:1) Pentahydrate; Propanoic Acid 2-Hydroxycalcium Salt Pentahydrate; Calcium Lactate Pentahydrate; Puracal DC. Grades: USP. CAS No. 5743-47-5. Pack Sizes: 100g, 250g, 500g, 1Kg, 2.5Kg. Molecular Formula: C6H10O6 Ca 5H2O, Molecular Weight: 308.29. US Biological Life Sciences. | Worldwide |
Oxalacetic Acid (Oxaloacetic acid) Quick inquiry Where to buy Suppliers range | A four carbon dicarboxylic acid that is an intermediate in the citric acid cycle and glucogenesis. It has been shown to inhibit succinate dehydrogenase. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in the: gluconeogenesis, urea cycle, glyoxylate cycle, amino acid synthesis, fatty acid synthesis and citric acid cycle. Gluconeogenesis[1] is a metabolic pathway consisting of a series of eleven enzyme-catalyzed reactions, resulting in the generation of glucose from non-carbohydrates substrates. The beginning of this process takes place in the mitochondrial matrix, where pyruvate molecules are found. A pyruvate molecule is carboxylated by a pyruvate carboxylase enzyme, activated by a molecule each of ATP and water. This reaction results in the formation of oxaloacetate. NADH reduces oxaloacetate to malate. This transformation is needed to transport the molecule out of the mitochondria. On Group: Biochemicals. Alternative Names: Oxobutanedioic Acid; Oxalacetic Acid; 2-Ketosuccinic acid; 2-Oxobutanedioic acid; 2-Oxosuccinic Acid; Ketosuccinic Acid; NSC 284205; NSC 77688; OAA; Oxaloacetic Acid; Oxaloethanoic Acid; Oxosuccinic Acid; α-Ketosuccinic Acid. Grades: Reagent Grade. CAS No. 328-42-7. Pack Sizes: 25g, 50g, 100g, 250g. Molecular Formula: C?H?O?, Molecular Weight: 132.07. US Biological Life Sciences. | Worldwide |
pdGp Quick inquiry Where to buy Suppliers range | pdGp, also known as pyruvate dehydrogenase kinase, is a remarkably efficacious and highly targeted inhibitor of the glycogen phosphorylase (Gp). Synonyms: 2'- Deoxyguanosine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 16174-59-7. Molecular formula: C10H15N5O10P2. Mole weight: 427.2. | |
Ribavirin 2,3,5-Tri-O-acetyl Quick inquiry Where to buy Suppliers range | As a purine nucleoside analog, protected Ribavirin inhibits inosine monophosphate dehydrogenase. It could be used as an antiviral agent. This compound is suitable for pyruvate dehydrogenase (PDH) related research. Synonyms: 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1,2,4-triazole-3-carboxamide; Tri-O-acetylribavirin; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-1H-1,2,4-triazole-3-carboxamide. CAS No. 40372-03-0. Molecular formula: C14H18N4O8. Mole weight: 370.31. | |
Sodium Oxamate Quick inquiry Where to buy Suppliers range | Sodium oxamate is an inhibitor of lactate dehydrogenase (LDH), a key regulator of glycolysis, reversibly catalyzing the conversion of pyruvate to lactate. Synonyms: Sodium 2-amino-2-oxoacetate; Oxamic acid sodium salt. Grades: ≥95%. CAS No. 565-73-1. Molecular formula: C2H2NO3·Na. Mole weight: 111. |