Pyruvate Kinase Suppliers USA
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Product | Description | |
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Pyruvate Kinase Activator (N-(4-Chloro-3-fluorophenyl)-7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide, PKM2 Activator I) Quick inquiry Where to buy Suppliers range | A cell-permeable and biologically stable (t1/2 = 277.2 and 117.5 min., respectively, in human and mouse liver microsome preparation) tetrahydroquinoline-sulfonamide that enhances the donor PEP, but not the acceptor ADP, substrate affinity toward pyruvate kinase isoform PKM2 (Km = 0.4 vs. 1.9 mM with or without 10uM activator) and acts as a potent PKM2-selective activator (AC50 = 90nM using rhPKM2; ACmax = 88%), displaying much reduced activity toward PKL (<25% at 57uM) and no effect toward PKM1 or PKR. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?S, Molecular Weight: 372.8. US Biological Life Sciences. | Worldwide |
PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) Quick inquiry Where to buy Suppliers range | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione Quick inquiry Where to buy Suppliers range | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 μM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. Synonyms: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Grades: > 98 %. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.34. | |
Alkannin Quick inquiry Where to buy Suppliers range | Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). It inhibits proliferation, migration and invasion of human Huh7 and Hep3B2.1-7 hepatocellular carcinoma cells via regulation of miR92a. Synonyms: 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (S)-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-pentenyl]-; 1,4-Naphthoquinone, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (-)-; 5,8-Dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione; Alkanet extract; Alkanet extract, inspissated; Alkanna red; Anchusa acid; Anchusin; C.I. 75530; C.I. Natural Red 20. Grades: ≥95%. CAS No. 23444-65-7. Molecular formula: C16H16O5. Mole weight: 288.30. | |
DASA-58 Quick inquiry Where to buy Suppliers range | DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Synonyms: DASA-58; DASA 58; DASA58. Grades: 98%. CAS No. 1203494-49-8. Molecular formula: C19H23N3O6S2. Mole weight: 453.53. | |
DCA Quick inquiry Where to buy Suppliers range | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
D-Fructose-13C6 1,6-Bisphosphate Sodium Salt Hydrate Quick inquiry Where to buy Suppliers range | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-13C6 1,6-Bis(dihydrogen phosphate); D-Fructose-13C6 1,6-Biphosphate; D-Fructose-13C6 1,6-Bisphosphate; D-Fructose-13C6 1,6-Diphosphate; Diphosphofructose-13C6; Esafosfan-13C6; Esafosfina-13C6; FDP-13C6; Fosfructose-13C6; Fructose-13C6 1,6-Bis(dihydrogen phosphate); Fructose-13C6 1,6-Bisphosphate; Fructose-13C6 1,6-Diphosphate; Harden-Young Ester-13C6. Molecular formula: [13C]6H14O12P2 xH2O xNa. Mole weight: 346.06. | |
D-Fructose-13C6 1,6-Bisphosphate Sodium Salt Hydrate Quick inquiry Where to buy Suppliers range | Isotope labelled Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an allosteric activator of pyruvate kinase. Group: Biochemicals. Alternative Names: D-Fructose-13C6 1,6-Bis(dihydrogen phosphate); D-Fructose-13C6 1,6-Biphosphate; D-Fructose-13C6 1,6-Bisphosphate; D-Fructose-13C6 1,6-Diphosphate; Diphosphofructose-13C6; Esafosfan-13C6; Esafosfina-13C6; FDP-13C6; Fosfructose-13C6; Fructose-13C6 1,6-Bis(dihydrogen phosphate); Fructose-13C6 1,6-Bisphosphate; Fructose-13C6 1,6-Diphosphate; Harden-Young Ester-13C6. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
D-Fructose 1,6-Bisphosphate Sodium Salt Hydrate Quick inquiry Where to buy Suppliers range | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose, 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate;D-Fructose, 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate; D-Fructose 1,6-bisphosphate Sodium Salt Hydrate; D-Fructose 1,6-diphosphate Sodium Salt Hydrate; Diphosphofructose Sodium Salt Hydrate; Esafosfan Sodium Salt Hydrate; Esafosfina Sodium Salt Hydrate; FDP Sodium Salt Hydrate; Fosfructose Sodium Salt Hydrate; Fructose 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate; Fructose 1,6-bisphosphate Sodium Salt Hydrate; Fructose 1,6-diphosphate Sodium Salt Hydrate; Harden-Young ester Sodium Salt Hydrate. CAS No. 41012-14-0. Molecular formula: C6H14O12P2 xH2O xNa. Mole weight: 340.12. | |
D-Fructose-1,6-diphosphate trisodium salt octahydrate Quick inquiry Where to buy Suppliers range | UsesCardioprotectant for ischemic disorders.;UsesD-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Synonyms: D-Fructose-1,6-bisphosphate trisodium salt octahydrate. CAS No. 81028-91-3. Molecular formula: C6H11Na3O12P2 8H2O. Mole weight: 550.18. | |
D-Fructose-2-13C 1,6-Bisphosphate Tetrasodium Salt Hydrate Quick inquiry Where to buy Suppliers range | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-2-13C 1,6-Bis(dihydrogen phosphate); D-Fructose-2-13C 1,6-Biphosphate; D-Fructose-2-13C 1,6-Bisphosphate; D-Fructose-2-13C 1,6-Diphosphate; Diphosphofructose-2-13C; Esafosfan-2-13C; Esafosfina-2-13C; FDP-2-13C; Fosfructose-2-13C; Fructose-2-13C 1,6-Bis(dihydrogen phosphate); Fructose-2-13C 1,6-Bisphosphate; Fructose-2-13C 1,6-Diphosphate; Harden-Young Ester-2-13C. Molecular formula: C5[13C]H10Na4O12P2 xH2O. Mole weight: 429.03. | |
D-Fructose-6-13C 1,6-Bisphosphate Tetrasodium Salt Hydrate Quick inquiry Where to buy Suppliers range | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-6-13C 1,6-Bis(dihydrogen phosphate); D-Fructose-6-13C 1,6-Biphosphate; D-Fructose-6-13C 1,6-Bisphosphate; D-Fructose-6-13C 1,6-Diphosphate; Diphosphofructose-6-13C; Esafosfan-6-13C; Esafosfina-6-13C; FDP-6-13C; Fosfructose-6-13C; Fructose-6-13C 1,6-Bis(dihydrogen phosphate); Fructose-6-13C 1,6-Bisphosphate; Fructose-6-13C 1,6-Diphosphate; Harden-Young Ester-6-13C. Molecular formula: C5[13C]H10Na4O12P2 xH2O. Mole weight: 429.03. | |
DL-Serine Quick inquiry Where to buy Suppliers range | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Synonyms: Serine; Serine, DL-; (±)-Serine; 2-Azaniumyl-3-hydroxypropanoate; DL-Ser; NSC 9960. Grades: ≥95%. CAS No. 302-84-1. Molecular formula: C3H7NO3. Mole weight: 105.09. | |
Glycometabolism Compound Library Quick inquiry Where to buy Suppliers range | 708 glycometabolism-related comounds, can be used for HTS and HCT; - Targets contain GLUTs?Hexokinase?HK??Pyruvate Kinase?PK??phosphofructokinase?PFK??IDH1/2?LDH?AMPK, etc. ; - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. - All compounds are in stock. Uses: Scientific use. Product Category: L2520. Categories: Glycometabolism Compounds Libraries. | |
Guanosine 5'-diphosphate Quick inquiry Where to buy Suppliers range | Pyruvate kinase substrate. Synonyms: GDP; ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; Guanosine diphosphate; 2-amino-9-{5-O-[hydroxy(phosphonooxy)phosphoryl]-β-D-ribofuranosyl}-9H-purin-6-ol; Guanosine 5'-(trihydrogen diphosphate). Grades: ≥95% by HPLC. CAS No. 146-91-8. Molecular formula: C10H15N5O11P2. Mole weight: 443.20. | |
Guanosine 5'-Diphosphate Disodium Salt Quick inquiry Where to buy Suppliers range | Pyruvate kinase substrate. Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors. Group: Biochemicals. Alternative Names: 5'-GDP·2Na; Guanosine 5'-diphosphoric acid disodium salt. Grades: Highly Purified. CAS No. 7415-69-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C10H13N5O11P2·2Na, Molecular Weight: 487.17. US Biological Life Sciences. | Worldwide |
Guanosine 5'-diphosphate sodium salt Quick inquiry Where to buy Suppliers range | A pyruvate kinase substrate. Synonyms: Guanosine 5'-diphosphate sodium salt; 43139-22-6; MFCD00070121; DTXSID101036037; Guanosine-5'-diphosphate sodium salt; sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogendiphosphate. Molecular formula: C10H15N5O11P2·xNa. Mole weight: 443.20 (free acid). | |
JX 06 Quick inquiry Where to buy Suppliers range | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
Kemptide Quick inquiry Where to buy Suppliers range | Kemptide, a synthetic heptapeptide, acts as a specific substrate for cAMP-dependent protein kinase (PKA) and is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. Synonyms: H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-glycine; (5S,8S,11S,14S,17S,20S)-20-amino-14,17-bis(3-guanidinopropyl)-8-(hydroxymethyl)-5-isobutyl-11,22-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazatricosan-1-oic acid. Grades: ≥97% by HPLC. CAS No. 65189-71-1. Molecular formula: C32H61N13O9. Mole weight: 771.91. | |
Kemptide Phospho-Ser5 Quick inquiry Where to buy Suppliers range | Kemptide (Phospho-Ser5), a phosphate acceptor peptide, serves as a specific substrate for cAMP-dependent protein kinase (PKA). Synonyms: Leu-Arg-Arg-Ala-pSer-Leu-Gly; H-Leu-Arg-Arg-Ala-Ser(PO3H2)-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-O-phosphono-L-seryl-L-leucyl-glycine; phosphokemptide; Kinase Domain of Pyruvate Kinase porcine. Grades: ≥95%. Molecular formula: C32H62N13O12P. Mole weight: 851.89. | |
Leelamine Quick inquiry Where to buy Suppliers range | Leelamine, a diterpene molecule, has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Leelamine is also a PDK(pyruvate dehydrogenase kinase inhibitor). Synonyms: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine; dehydroabietylamine; DEHYDROABIETYLAMINE; (+)-Dehydroabietylamine; Dehydroabiethylamine; 16496-99-4 Leelamine (hydrochloride). Grades: ≥90%. CAS No. 1446-61-3. Molecular formula: C20H31N. Mole weight: 285.5. | |
Leelamine hydrochloride Quick inquiry Where to buy Suppliers range | Leelamine is a diterpene amine exhibiting low affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It also acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Leelamine inhibits intracellular cholesterol transport and suppresses cancer cell growth. Synonyms: Lylamine hydrochloride; Dehydroabiethylamine hydrochloride; [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine hydrochloride. Grades: ≥98%. CAS No. 16496-99-4. Molecular formula: C20H31N·HCl. Mole weight: 321.9. | |
Metabolism Compound Library Quick inquiry Where to buy Suppliers range | A unique collection of 2350 metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening. - Targeting multiple metabolic pathways such as gluconeogenesis, lipid metabolism, nucleotide metabolism; targets include GLUT, Hexokinase, Pyruvate Kinase; ATGL, MAGL, FAAH and other metabolism-related popular targets. - Structural diversity, significant drug potency and cell penetration. - Detailed specifications, compound structure, target information, activity description, etc. - NMR, HPLC/LCMS and other detection techniques to ensure correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L2560. Categories: Metabolism Compounds Libraries. | |
pdGp Quick inquiry Where to buy Suppliers range | pdGp, also known as pyruvate dehydrogenase kinase, is a remarkably efficacious and highly targeted inhibitor of the glycogen phosphorylase (Gp). Synonyms: 2'- Deoxyguanosine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 16174-59-7. Molecular formula: C10H15N5O10P2. Mole weight: 427.2. | |
PKR-IN-1 Quick inquiry Where to buy Suppliers range | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Synonyms: PKR-IN-1; PKM2 activator 1020; PKM2 activator; Mitapivat. Grades: >98%. CAS No. 1260075-17-9. Molecular formula: C24H26N4O3S. Mole weight: 450.55. | |
PKR-IN-2 Quick inquiry Where to buy Suppliers range | PKR-IN-2 is a pyruvate kinase (PKR) activator. IC50: PKR (R510Q) <100 nM. Synonyms: N-[4-[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]phenyl]quinoxaline-5-sulfonamide PKR-IN-2 SCHEMBL16049613. CAS No. 1628428-01-2. Molecular formula: C24H28N4O4S. Mole weight: 468.57. | |
TEPP-46 Quick inquiry Where to buy Suppliers range | TEPP-46, an effective sensitizer of recombinant pyruvate kinase M2, has been found to decrease the formation of tumor in a mouse xenograft model. IC50: 92 nM (AC50). Uses: Tepp-46 has been found to decrease the formation of tumor in a mouse xenograft model. Synonyms: ML265; ML-265; ML 265; CID44246499; CID-44246499; CID 44246499; NCGC00186528; NCGC 00186528; NCGC-00186528; TEPP46; TEPP 46; TEPP-46; 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5h-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one; ML265; TEPP 46; MLS006010294. Grades: 95%. CAS No. 1221186-53-3. Molecular formula: C17H16N4O2S2. Mole weight: 372.46. | |
TLN-232 Quick inquiry Where to buy Suppliers range | TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: TLN 232; TLN232; CAP-232; CAP 232; CAP232; H-D-Phe-Cys(1)-D-Trp-Lys-Cys(1)-Thr-NH2. CAS No. 158899-10-6. Molecular formula: C36H49N9O7S2. Mole weight: 783.96. |