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| Product | Description | |
|---|---|---|
| pyruvate kinase | UTP, GTP, CTP, ITP and dATP can also act as donors. Also phosphorylates hydroxylamine and fluoride in the presence of CO2. Group: Enzymes. Synonyms: phosphoenolpyruvate kinase; phosphoenol transphosphorylase. Enzyme Commission Number: EC 2.7.1.40. CAS No. 9001-59-6. Pyruvate Kinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3070; pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase. Cat No: EXWM-3070. |  |
| Pyruvate Kinase Activator (N-(4-Chloro-3-fluorophenyl)-7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide, PKM2 Activator I) | A cell-permeable and biologically stable (t1/2 = 277.2 and 117.5 min., respectively, in human and mouse liver microsome preparation) tetrahydroquinoline-sulfonamide that enhances the donor PEP, but not the acceptor ADP, substrate affinity toward pyruvate kinase isoform PKM2 (Km = 0.4 vs. 1.9 mM with or without 10uM activator) and acts as a potent PKM2-selective activator (AC50 = 90nM using rhPKM2; ACmax = 88%), displaying much reduced activity toward PKL (<25% at 57uM) and no effect toward PKM1 or PKR. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. Molecular Formula: C??H??ClF?N?O?S, Molecular Weight: 372.8. US Biological Life Sciences. |  Worldwide |
| Pyruvate Kinase from Microorganism | Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP. Group: Enzymes. Synonyms: EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Enzyme Commission Number: EC 2.7.1.40. CAS No. 9001-59-6. Mole weight: 68 kDa (SDS-PAGE). Activity: >300U/mg. Storage: Store at -20°C. Form: White powder, lyophilized. Source: Microorganism. Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase; PK. Cat No: NATE-1720. | |
| Pyruvate kinase M2 Active from Mouse, Recombinant | Pyruvate kinase M2 (PKM2) is an isoform of pyruvate kinase that is expressed in certain differentiated cells and in proliferatively active cells. PKM2 is often overexpressed in cancer cells. Group: Enzymes. Synonyms: M2-PK tumor; OPA-interacting protein 3 (OIP-3); Pyruvate kinase 3 (PK3); Pyruvate kinase; muscle; Thyroid hormone-binding protein 1 (THBP1); Pyruvate kinase; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. CAS No. 9001-59-6. Purity: Greater than 90% (SDS-PAGE). Pyruvate Kinase. Mole weight: 58 kDa. Storage: Store at -70°C. Avoid multiple freeze-thaw cycles. Form: Aqueous solution, Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT. Source: E. coli. Species: Mouse. M2-PK tumor; OPA-interacting protein 3 (OIP-3); Pyruvate kinase 3 (PK3); Pyruvate kinase; muscle; Thyroid hormone-binding protein 1 (THBP1); Pyruvate kinase; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Cat No: NATE-0939. | |
| Pyruvate Kinase M2 from Human, Recombinant | Pyruvate kinase (PK) is an important glycolytic enzyme catalyzing the last step of glycolysis, transferring a phosphate group from phosphoenolpyruvate to ADP to yield one molecule of ATP and one molecule of pyruvate. Group: Enzymes. Synonyms: Cytosolic Thyroid hormone-binding protein (CTHBP); M2-PK; OPA-interacting protein 3 (OIP-3); PKM2; Pyruvate kinase 3 (PK3); Pyruvate kinase muscle isozyme; p58; Pyruvate kinase; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. CAS No. 9001-59-6. Pyruvate Kinase. Mole weight: 58 kDa. Activity: > 100 unit/μg protein. Storage: Store at -20°C. Form: Lyophilized powder containing phosphate buffer at pH7.5, NaCl, DTT and a carbohydrate stabilizer. Source: E. coli. Species: Human. Cytosolic Thyroid hormone-binding protein (CTHBP); M2-PK; OPA-interacting protein 3 (OIP-3); PKM2; Pyruvate kinase 3 (PK3); Pyruvate kinase muscle isozyme; p58; Pyruvate kinase; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Cat No: NATE-0938. | |
| Pyruvate Kinase, Microorganism | Pyruvate Kinase, Microorganism (PK) is a glycolytic enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PK; Fluorokinase. CAS No. 9001-59-6. Pack Sizes: 1 KU. Product ID: HY-P2806. |  |
| Pyruvate Kinase (PK),Rabbit Muscle | Pyruvate Kinase (PK),Rabbit Muscle (ATP:Pyruvate 2-0-phosphotransferase,PK) is a biological material or organic compound that can be used in life science research [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ATP:Pyruvate 2-0-phosphotransferase,PK. CAS No. 9001-59-6. Pack Sizes: 25 KU; 5 KU. Product ID: HY-P2806A. | |
| Native Bacillus stearothermophilus Pyruvate Kinase | Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP. Applications: Pyruvate kinase from bacillus stearothermophilus has been used in a study to assess evidence that the genes for phosphofructokinase and pyruvate kinase constitute an operon. 1 it has also been used in a study to investigate the importance of the lys221 active site for pyruvate kinase activity. Group: Enzymes. Synonyms: Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Enzyme Commission Number: EC 2.7.1.40. CAS No. 9001-59-6. Pyruvate Kinase. Activity: 100-300 units/mg protein. Stability: 2-8°C. Form: lyophilized powder. Source: Bacillus stearothermophilus. EC 2.7.1.40; 9001-59-6; Pyruvate kinase. Cat No: NATE-0649. | |
| Native Pyruvate Kinase from Thermophillic bacteria | Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP. Applications: Atp regeneration in biocatalysis. Group: Enzymes. Synonyms: Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Enzyme Commission Number: EC 2.7.1.40. CAS No. 9001-59-6. Pyruvate Kinase. Storage: Store at -20°C. Form: Frozen Liquid. Source: Thermophillic bacteria. Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase. Cat No: NATE-1158. | |
| Native Rabbit Pyruvate Kinase | Pyruvate kinase is an enzyme involved in glycolysis. It catalyzes the transfer of a phosphate group from phosphoenolpyruvate (PEP) to ADP, yielding one molecule of pyruvate and one molecule of ATP. Pyruvate kinase from rabbit muscle catalyzes an atp-dependent phosphorylation of glycolate to yield 2-phosphoglycolate. Applications: Pyruvate kinase from rabbit muscle has been used in a structural study to understand the reaction mechanism of the final step in glycolysis. it has also been used in a study to investigate atp-dependent phosphorylation of α-substituted carboxylic acids. Group: Enzymes. Synonyms: Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase...7 kDa and exists as a tetramer of four equal subunits of molecular weight 57 kDa. Activity: 350-600 units/mg protein. Storage: -20°C. Form: Type I, ammonium sulfate suspension, Suspension in 3.2 M (NH4)2SO4 solution, pH 6; Type II, lyophilized powder; Type III, buffered aqueous glycerol solution, Solution in 50% glycerol containing 0.01 M phosphate, pH 7.0. Source: Rabbit muscle. Species: Rabbit. Pyruvate kinase; EC 2.7.1.40; 9001-59-6; phosphoenolpyruvate kinase; phosphoenol transphosphorylase; pyruvate kinase (phosphorylating); fluorokinase; fluorokinase (phosphorylating); pyruvic kinase; pyruvate phosphotransferase; ATP:pyruvate 2-O-phosphotransferase; PK. Cat No: NATE-0567. | |
| Native Rabbit Pyruvate Kinase/Lactic Dehydrogenase enzymes | Lactate dehydrogenase from rabbit muscle can be inhibited by ascorbate. Aldolase and actin were shown to block this inhibitory effect. Pyruvate kinase requires bivalent and monovalent cations such as Mg2+ and K+ respectively for activation to occur. Pyruvate kinase from rabbit muscle catalyzes an atp-dependent phosphorylation of glycolate to yield 2-phosphoglycolate. buffered aqueous glycerol solution, 900-1400 units/ml lactic dehydrogenase, 600-1 kda units/ml pyruvate kinase. Applications: Pyruvate kinase from rabbit muscle has been used in a study to assess nuclear magnetic relaxation studies of the conformation of adenosine 5?-triphosphate. it has also been used in a study to investigate heterogeneity of presumably homogeneous protein preparations. Group: Enzymes. Synonyms: Pyruvate Kinase/Lactic Dehydrogenase enzymes; PK/LDH enzymes. PK/LDH enzymes. Activity: 900-1400 units/mL lactic dehydrogenase; 600-1,000 units/mL pyruvate kinase. Stability: -20°C. Form: buffered aqueous glycerol solution. Source: rabbit muscle. Species: Rabbit. Pyruvate Kinase/Lactic Dehydrogenase enzymes; PK/LDH enzymes. Cat No: NATE-0568. | |
| PKM2 Activator III (N- (4- (4- (2-Methoxyphenyl) piperazine-1-carbonyl) phenyl) quinoline-8-sulfonamide, Pyruvate Kinase M2 Activator III) | A cell-permeable quinoline-sulfonamide that acts as a potent allosteric PKM2 activator both in cell-free enzymatic assays (AC50 = 17nM with 40ng PKM2/200ul) and in cultures (AC50 = 45nM in A549 cells) via a high affinity, 2:1 stoichiometric binding, effectively locking PKM2 in an active tetrameric state resistant to known intracellular negative regulators of FBP-activated PKM2 tetramer. PKM2 stimulation by compound treatment is shown to result in decreased serine biosynthesis (by 56%; 500nM for 24h) with concomitant increase in serine influx as a compensating mechanism for maintaining cellular serine level necessary for supporting A549 proliferation. Simultaneous PKM2 activation and culture serine withdrawal results in cytostatic A549 growth arrest, but not apoptosis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| [pyruvate dehydrogenase (acetyl-transferring)] kinase | The enzyme has no activating compound but is specific for its substrate. It is a mitochondrial enzyme associated with the pyruvate dehydrogenase complex in mammals. Phosphorylation inactivates EC 1.2.4.1, pyruvate dehydrogenase (acetyl-transferring). Group: Enzymes. Synonyms: PDH kinase; PDHK; PDK; PDK1; PDK2; PDK3; PDK4; pyruvate dehydrogenase kinase; pyruvate dehydrogenase kinase (phosphorylating); pyruvate dehydrogenase kinase activator protein; STK1. Enzyme Commission Number: EC 2.7.11.2. CAS No. 9074-1-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3139; [pyruvate dehydrogenase (acetyl-transferring)] kinase; EC 2.7.11.2; 9074-01-5; PDH kinase; PDHK; PDK; PDK1; PDK2; PDK3; PDK4; pyruvate dehydrogenase kinase; pyruvate dehydrogenase kinase (phosphorylating); pyruvate dehydrogenase kinase activator protein; STK1. Cat No: EXWM-3139. | |
| [pyruvate kinase]-phosphatase | Simultaneously dephosphorylates and activates EC 2.7.1.40 pyruvate kinase, that has been inactivated by protein kinase. Group: Enzymes. Synonyms: pyruvate kinase phosphatase. Enzyme Commission Number: EC 3.1.3.49. CAS No. 79986-25-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3653; [pyruvate kinase]-phosphatase; EC 3.1.3.49; 79986-25-7; pyruvate kinase phosphatase. Cat No: EXWM-3653. | |
| pyruvate, phosphate dikinase | It is a key enzyme in gluconeogenesis and photosynthesis that is responsible for reversing the reaction performed by pyruvate kinase in Embden-Meyerhof-Parnas glycolysis. Group: Enzymes. Synonyms: pyruvate, orthophosphate dikinase; pyruvate-phosphate dikinase (phosphorylating); pyruvate, phosphate dikinase; pyruvate-inorganic phosphate dikinase; pyruvate-phosphate dikinase; pyruvate-phosphate ligase; pyruvic-phosphate dikinase; pyruvic-phosphate ligase; pyruvate, Pi dikinase; PPDK. Enzyme Commission Number: EC 2.7.9.1. CAS No. 9027-40-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3348; pyruvate, phosphate dikinase; EC 2.7.9.1; 9027-40-1; pyruvate, orthophosphate dikinase; pyruvate-phosphate dikinase (phosphorylating); pyruvate, phosphate dikinase; pyruvate-inorganic phosphate dikinase; pyruvate-phosphate dikinase; pyruvate-phosphate ligase; pyruvic-phosphate dikinase; pyruvic-phosphate ligase; pyruvate, Pi dikinase; PPDK. Cat No: EXWM-3348. | |
| [pyruvate, phosphate dikinase] kinase | The enzymes from the plants Zea mays (maize) and Arabidopsis thaliana are bifunctional and catalyse both the phosphorylation and dephosphorylation of EC 2.7.9.1 (pyruvate, phosphate dikinase). cf. EC 2.7.4.27, [pyruvate, phosphate dikinase]-phosphate phosphotransferase. The enzyme is specific for a reaction intermediate form of EC 2.7.9.1, and phosphorylates a threonine located adjacent to the catalytic histidine. The phosphorylation only takes place if the histidine is already phosphorylated. Group: Enzymes. Synonyms: PPDK regulatory protein (ambiguous); pyruvate; phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous). Enzyme Commission Number: EC 2.7.11.32. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3153; [pyruvate, phosphate dikinase] kinase; EC 2.7.11.32; PPDK regulatory protein (ambiguous); pyruvate; phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous). Cat No: EXWM-3153. | |
| [pyruvate, phosphate dikinase]-phosphate phosphotransferase | The enzyme from the plants maize and Arabidopsis is bifunctional and also catalyses the phosphorylation of pyruvate, phosphate dikinase (EC 2.7.9.1), cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase. Group: Enzymes. Synonyms: PPDK regulatory protein (ambiguous); pyruvate, phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous); PDRP1 (gene name). Enzyme Commission Number: EC 2.7.4.27. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3209; [pyruvate, phosphate dikinase]-phosphate phosphotransferase; EC 2.7.4.27; PPDK regulatory protein (ambiguous); pyruvate, phosphate dikinase regulatory protein (ambiguous); bifunctional dikinase regulatory protein (ambiguous); PDRP1 (gene name). Cat No: EXWM-3209. | |
| [pyruvate, water dikinase] kinase | The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.4.28, ([pyruvate, water dikinase] phosphate) phosphotransferase. The enzyme is specific for a reaction intermediate form of EC 2.7.9.2, where it phosphorylates an active site histidine. It has no activity toward EC 2.7.9.1 pyruvate, phosphate dikinase (cf. EC 2.7.11.32, [pyruvate, phosphate dikinase] kinase). Group: Enzymes. Synonyms: PSRP (ambiguous); PEPS kinase. Enzyme Commission Number: EC 2.7.11.33. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3154; [pyruvate, water dikinase] kinase; EC 2.7.11.33; PSRP (ambiguous); PEPS kinase. Cat No: EXWM-3154. | |
| [pyruvate, water dikinase]-phosphate phosphotransferase | The enzyme from the bacterium Escherichia coli is bifunctional and catalyses both the phosphorylation and dephosphorylation of EC 2.7.9.2, pyruvate, water dikinase. cf. EC 2.7.11.33, [pyruvate, water dikinase] kinase. Group: Enzymes. Synonyms: PSRP (ambiguous). Enzyme Commission Number: EC 2.7.4.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3210; [pyruvate, water dikinase]-phosphate phosphotransferase; EC 2.7.4.28; PSRP (ambiguous). Cat No: EXWM-3210. | |
| 3,4-Di(3-indolyl)-1H-pyrrole-2,5-dione | Bisindolylmaleimide IV (BIM IV) is an inhibitor of pyruvate phosphate dikinase (PPDK). It is a cell-permeable potent and somewhat selective inhibitor of PKC with IC50 of 87 nM. BIM IV is a cell-permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 μM. It also inhibits protein kinase A (PKA) with an IC50 of 2.7 μM. Synonyms: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione; 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Grades: > 98 %. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.34. |  |
| acetate kinase (diphosphate) | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is diphosphate:acetate phosphotransferase. This enzyme is also called pyrophosphate-acetate phosphotransferase. This enzyme participates in pyruvate metabolism. Group: Enzymes. Synonyms: pyrophosphate-acetate phosphotransferase. Enzyme Commission Number: EC 2.7.2.12. CAS No. 57657-58-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3170; acetate kinase (diphosphate); EC 2.7.2.12; 57657-58-6; pyrophosphate-acetate phosphotransferase. Cat No: EXWM-3170. | |
| Alkannin | Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). It inhibits proliferation, migration and invasion of human Huh7 and Hep3B2.1-7 hepatocellular carcinoma cells via regulation of miR92a. Synonyms: 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (S)-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-pentenyl]-; 1,4-Naphthoquinone, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (-)-; 5,8-Dihydroxy-6-[(1S)-1-hydroxy-4-methyl-3-penten-1-yl]-1,4-naphthalenedione; Alkanet extract; Alkanet extract, inspissated; Alkanna red; Anchusa acid; Anchusin; C.I. 75530; C.I. Natural Red 20. Grades: ≥95%. CAS No. 23444-65-7. Molecular formula: C16H16O5. Mole weight: 288.30. | |
| DASA-58 | DASA-58 is a specific and potent Pyruvate kinase M2 (PKM2) activator. Synonyms: DASA-58; DASA 58; DASA58. Grades: 98%. CAS No. 1203494-49-8. Molecular formula: C19H23N3O6S2. Mole weight: 453.53. | |
| DCA | DCA is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. DCA also induces apoptosis and reverses the KV1.5 channels downregulation in cancer. Synonyms: Sodium dichloroacetate; Sodium 2,2-dichloroacetate; Dichloroacetic acid sodium salt. CAS No. 2156-56-1. Molecular formula: C2HCl2NaO2. Mole weight: 150.92. | |
| D-Fructose-13C6 1,6-Bisphosphate Sodium Salt Hydrate | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-13C6 1,6-Bis(dihydrogen phosphate); D-Fructose-13C6 1,6-Biphosphate; D-Fructose-13C6 1,6-Bisphosphate; D-Fructose-13C6 1,6-Diphosphate; Diphosphofructose-13C6; Esafosfan-13C6; Esafosfina-13C6; FDP-13C6; Fosfructose-13C6; Fructose-13C6 1,6-Bis(dihydrogen phosphate); Fructose-13C6 1,6-Bisphosphate; Fructose-13C6 1,6-Diphosphate; Harden-Young Ester-13C6. Molecular formula: [13C]6H14O12P2 xH2O xNa. Mole weight: 346.06. | |
| D-Fructose-13C6 1,6-Bisphosphate Sodium Salt Hydrate | Isotope labelled Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an allosteric activator of pyruvate kinase. Group: Biochemicals. Alternative Names: D-Fructose-13C6 1,6-Bis(dihydrogen phosphate); D-Fructose-13C6 1,6-Biphosphate; D-Fructose-13C6 1,6-Bisphosphate; D-Fructose-13C6 1,6-Diphosphate; Diphosphofructose-13C6; Esafosfan-13C6; Esafosfina-13C6; FDP-13C6; Fosfructose-13C6; Fructose-13C6 1,6-Bis(dihydrogen phosphate); Fructose-13C6 1,6-Bisphosphate; Fructose-13C6 1,6-Diphosphate; Harden-Young Ester-13C6. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| D-Fructose 1,6-Bisphosphate Sodium Salt Hydrate | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose, 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate;D-Fructose, 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate; D-Fructose 1,6-bisphosphate Sodium Salt Hydrate; D-Fructose 1,6-diphosphate Sodium Salt Hydrate; Diphosphofructose Sodium Salt Hydrate; Esafosfan Sodium Salt Hydrate; Esafosfina Sodium Salt Hydrate; FDP Sodium Salt Hydrate; Fosfructose Sodium Salt Hydrate; Fructose 1,6-bis(dihydrogen phosphate) Sodium Salt Hydrate; Fructose 1,6-bisphosphate Sodium Salt Hydrate; Fructose 1,6-diphosphate Sodium Salt Hydrate; Harden-Young ester Sodium Salt Hydrate. CAS No. 41012-14-0. Molecular formula: C6H14O12P2 xH2O xNa. Mole weight: 340.12. | |
| D-Fructose-1,6-diphosphate trisodium salt octahydrate | UsesCardioprotectant for ischemic disorders.;UsesD-Fructose-1,6-bisphosphate (FBP), a common metabolic sugar, is the precursor of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic pathway. It is an allosteric activator of enzymes such as pyruvate kinase and a substrate used to identify and characterize enzymes such as fructose-1,6-bisphosphate aldolase(s) and fructose-1, 6-bisphosphatase(s). FBP is studied as a neuroprotective agent in brain injury. Synonyms: D-Fructose-1,6-bisphosphate trisodium salt octahydrate. CAS No. 81028-91-3. Molecular formula: C6H11Na3O12P2 8H2O. Mole weight: 550.18. | |
| D-Fructose-2-13C 1,6-Bisphosphate Tetrasodium Salt Hydrate | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-2-13C 1,6-Bis(dihydrogen phosphate); D-Fructose-2-13C 1,6-Biphosphate; D-Fructose-2-13C 1,6-Bisphosphate; D-Fructose-2-13C 1,6-Diphosphate; Diphosphofructose-2-13C; Esafosfan-2-13C; Esafosfina-2-13C; FDP-2-13C; Fosfructose-2-13C; Fructose-2-13C 1,6-Bis(dihydrogen phosphate); Fructose-2-13C 1,6-Bisphosphate; Fructose-2-13C 1,6-Diphosphate; Harden-Young Ester-2-13C. Molecular formula: C5[13C]H10Na4O12P2 xH2O. Mole weight: 429.03. | |
| D-Fructose-6-13C 1,6-Bisphosphate Tetrasodium Salt Hydrate | Fructose1,6-bisphosphate is an intermediate that lies within the glycolysis metabolic pathway and is also an pyruvate kinase allosteric activator. Synonyms: D-Fructose-6-13C 1,6-Bis(dihydrogen phosphate); D-Fructose-6-13C 1,6-Biphosphate; D-Fructose-6-13C 1,6-Bisphosphate; D-Fructose-6-13C 1,6-Diphosphate; Diphosphofructose-6-13C; Esafosfan-6-13C; Esafosfina-6-13C; FDP-6-13C; Fosfructose-6-13C; Fructose-6-13C 1,6-Bis(dihydrogen phosphate); Fructose-6-13C 1,6-Bisphosphate; Fructose-6-13C 1,6-Diphosphate; Harden-Young Ester-6-13C. Molecular formula: C5[13C]H10Na4O12P2 xH2O. Mole weight: 429.03. | |
| DL-Serine | Serine is a non-essential amino acid and a natural ligand and allosteric activator of pyruvate kinase M2. Synonyms: Serine; Serine, DL-; (±)-Serine; 2-Azaniumyl-3-hydroxypropanoate; DL-Ser; NSC 9960. Grades: ≥95%. CAS No. 302-84-1. Molecular formula: C3H7NO3. Mole weight: 105.09. | |
| Etavopivat | Etavopivat is a potent, selective, and orally active erythrocyte pyruvate kinase ( PKR ) activator. Etavopivat has potent antisickling effects that can be used in studies of sickle cell disease and other haemoglobinopathies [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FT-4202. CAS No. 2245053-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139573. | |
| Glycerokinase from Cellulomonas sp. | Glycerol kinase is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis. Glycerol kinase catalyzes tge MgATP-dependent phosphorylation of glycerol to produce sn-glycerol-3-phosphate and is the rate limiting enzyme in the utilization of glycerol. It is also subject to feedback regulation by fructose-1,6-bisphosphate. Phosphoryl moiety of atp to one of the primary hydroxyl group of glycerol, forming sn-glycerol-3-p. the enzyme has the highest specificity for glycerol, and also phosphorylates dihydroxyacetone and glyceraldehyde (table 1,2). mg++ is essentially required for the reaction. Applications: This enzyme is useful for enzymatic deter...se, g3o-301, g3o-311, g3o-321) or pyruvate kinase (pyk-301) and lactate dehydrogenase (lcd-209, lcd-211), lipoprotein lipase (lpl-311, lpl-314) in clinical analysis. Group: Enzymes. Synonyms: EC 2.7.1.30; glycerokinase; GK; ATP:glycerol-3-phosphotransferase; glycerol kinase (phosphorylating); glyceric kinase; 9030-66-4. Enzyme Commission Number: EC 2.7.1.30. CAS No. 9030-66-4. Activity: 20 U/mg-solid or more. Storage: -20°C. Form: Lyophilized powder containing phosphate buffer salts and sodium gluconate. Source: Cellulomonas sp. EC 2.7.1.30; glycerokinase; GK; ATP:glycerol-3-phosphotransferase; glycerol kinase (phosphorylating); glyceric kinase; 9030-66-4. Cat No: NATE-0287. | |
| Glycerokinase from Microorganism | Glycerol kinase is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis. Glycerol kinase catalyzes tge MgATP-dependent phosphorylation of glycerol to produce sn-glycerol-3-phosphate and is the rate limiting enzyme in the utilization of glycerol. It is also subject to feedback regulation by fructose-1,6-bisphosphate. Applications: This enzyme is useful for enzymatic determination of glycerol and triglyceride when coupled with glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate oxidase or pyruvate kinase and lactate dehydrogenase, lipoprotein lipase in clinical analysis. Group: Enzymes. Synonyms: glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Enzyme Commission Number: EC 2.7.1.30. CAS No. 9030-66-4. Activity: 30 U/mg-solid or more. Appearance: White amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Cat No: DIA-149. | |
| Glycometabolism Compound Library | 708 glycometabolism-related comounds, can be used for HTS and HCT; - Targets contain GLUTs?Hexokinase?HK??Pyruvate Kinase?PK??phosphofructokinase?PFK??IDH1/2?LDH?AMPK, etc. ; - Detailed compound information with structure, target, and biological activity description; - NMR and HPLC/LCMS validated to ensure high purity and quality. - All compounds are in stock. Uses: Scientific use. Product Category: L2520. Categories: Glycometabolism Compounds Libraries. |  |
| Guanosine 5'-diphosphate | Pyruvate kinase substrate. Synonyms: GDP; ((2R,3S,4R,5R)-5-(2-Amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; Guanosine diphosphate; 2-amino-9-{5-O-[hydroxy(phosphonooxy)phosphoryl]-β-D-ribofuranosyl}-9H-purin-6-ol; Guanosine 5'-(trihydrogen diphosphate). Grades: ≥95% by HPLC. CAS No. 146-91-8. Molecular formula: C10H15N5O11P2. Mole weight: 443.20. | |
| Guanosine 5'-Diphosphate Disodium Salt | Pyruvate kinase substrate. Guanosine-5'-diphosphate disodium salt is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors. It is also used to study cell signaling processes mediate by guanine nucleotide exchange factors. Group: Biochemicals. Alternative Names: 5'-GDP·2Na; Guanosine 5'-diphosphoric acid disodium salt. Grades: Highly Purified. CAS No. 7415-69-2. Pack Sizes: 1g, 2g, 5g, 10g, 25g. Molecular Formula: C10H13N5O11P2·2Na, Molecular Weight: 487.17. US Biological Life Sciences. | Worldwide |
| Guanosine 5'-diphosphate sodium salt | A pyruvate kinase substrate. Synonyms: Guanosine 5'-diphosphate sodium salt; 43139-22-6; MFCD00070121; DTXSID101036037; Guanosine-5'-diphosphate sodium salt; sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogendiphosphate. Molecular formula: C10H15N5O11P2·xNa. Mole weight: 443.20 (free acid). | |
| Iminostilbene | Iminostilbene is a chemical precursor of carbamazepine. Additionally, Iminostilbene is an orally active inhibitor of PKM2 (Pyruvate Kinase M2) and COX2 (Cyclooxygenase-2). Iminostilbene exerts its effects by inhibiting PKM2 and its interaction with HIF-1α and STAT3 , reducing COX2 and iNOS expression, and decreasing LPS-induced release of IL-1β , IL-6 , TNF-α , and MCP-1 , thereby suppressing macrophage-mediated inflammatory responses and improving myocardial ischemia/reperfusion (MI/R) injury. Iminostilbene holds promise for research in inflammation regulation, cardiovascular diseases (such as MI/R injury), and macrophage-mediated immune-related diseases [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 256-96-2. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-N7064. | |
| JX 06 | JX 06 is a potent, selective and covalent pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor with IC50 values of 49, 101 and 313 nM for PDK1, PDK2 and PDK3, respectively. It suppresses A549 lung cancer cell proliferation in vitro and reduces tumor volume of A549 xenografts in mice. Synonyms: JX-06; JX06; Bis(morpholinothiocarbonyl) Disulfide; 4, 4'- (Dithiodicarbonothioyl) bis[morpholine]; 4-Morpholinethiocarbonyl Disulfide; Dimorpholinethiuram Disulfide; Disulfide, bis(4-Morpholinylthioxomethyl); NSC 402538; bis(Oxydi-2,1-ethanediyl)-thiuram Disulfide. Grades: ≥98% by HPLC. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.51. | |
| JX-06 | JX-06 is a potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). JX06 Selectively Inhibits Pyruvate Dehydrogenase Kinase PDK1 by a Covalent Cysteine Modification. JX06, as a selective covalent inhibitor of PDK1 in cells, forms a disulfide bond with the thiol group of a conserved cysteine residue (C240) based on recognition of a hydrophobic pocket adjacent to the ATP pocket of the PDK1 enzyme. Uses: Designed for use in research and industrial production. Additional or Alternative Names: JX-06; JX 06; JX06. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 729-46-4. Molecular formula: C10H16N2O2S4. Mole weight: 324.49. Purity: >98%. IUPACName: Bis(morpholinothiocarbonyl) disulfide. Canonical SMILES: S=C(SSC(N1CCOCC1)=S)N2CCOCC2. Product ID: ACM729464. Alfa Chemistry ISO 9001:2015 Certified. Categories: JP-06. |  |
| Kemptide | Kemptide, a synthetic heptapeptide, acts as a specific substrate for cAMP-dependent protein kinase (PKA) and is shown to be a basic serine-containing heptapeptide corresponding to a sequence from pig liver pyruvate kinase. Synonyms: H-Leu-Arg-Arg-Ala-Ser-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-L-seryl-L-leucyl-glycine; (5S,8S,11S,14S,17S,20S)-20-amino-14,17-bis(3-guanidinopropyl)-8-(hydroxymethyl)-5-isobutyl-11,22-dimethyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazatricosan-1-oic acid. Grades: ≥97% by HPLC. CAS No. 65189-71-1. Molecular formula: C32H61N13O9. Mole weight: 771.91. | |
| Kemptide Phospho-Ser5 | Kemptide (Phospho-Ser5), a phosphate acceptor peptide, serves as a specific substrate for cAMP-dependent protein kinase (PKA). Synonyms: Leu-Arg-Arg-Ala-pSer-Leu-Gly; H-Leu-Arg-Arg-Ala-Ser(PO3H2)-Leu-Gly-OH; L-leucyl-L-arginyl-L-arginyl-L-alanyl-O-phosphono-L-seryl-L-leucyl-glycine; phosphokemptide; Kinase Domain of Pyruvate Kinase porcine. Grades: ≥95%. Molecular formula: C32H62N13O12P. Mole weight: 851.89. | |
| Leelamine | Leelamine, a diterpene molecule, has weak affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Leelamine is also a PDK(pyruvate dehydrogenase kinase inhibitor). Synonyms: [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine; dehydroabietylamine; DEHYDROABIETYLAMINE; (+)-Dehydroabietylamine; Dehydroabiethylamine; 16496-99-4 Leelamine (hydrochloride). Grades: ≥90%. CAS No. 1446-61-3. Molecular formula: C20H31N. Mole weight: 285.5. | |
| Leelamine | Leelamine is an orally active pyruvate dehydrogenase kinase ( PDK ) inhibitor with an IC 50 value of 9.5 μM, showing a blood glucose lowering effect in the diabetic mouse. Leelamine is also a weak agonist of cannabinoid receptors CB1 and CB2. Leelamine decreases mitotic activity, prostate-specific antigen expression and induces Apoptosis to cell death in cancer cells [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1446-61-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W005629. | |
| Leelamine hydrochloride | Leelamine is a diterpene amine exhibiting low affinity for the human central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It also acts as an inhibitor of pyruvate dehydrogenase kinase (PDK). Leelamine inhibits intracellular cholesterol transport and suppresses cancer cell growth. Synonyms: Lylamine hydrochloride; Dehydroabiethylamine hydrochloride; [(1R,4aS,10aR)-1,4a-dimethyl-7-propan-2-yl-2,3,4,9,10,10a-hexahydrophenanthren-1-yl]methanamine hydrochloride. Grades: ≥98%. CAS No. 16496-99-4. Molecular formula: C20H31N·HCl. Mole weight: 321.9. | |
| Lipoamide | Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide. CAS No. 940-69-2. Pack Sizes: 100 mg; 500 mg. Product ID: HY-B1142. | |
| Metabolism Compound Library | A unique collection of 2350 metabolic pathway-related bioactive small molecule compounds for high-throughput, high-content screening. - Targeting multiple metabolic pathways such as gluconeogenesis, lipid metabolism, nucleotide metabolism; targets include GLUT, Hexokinase, Pyruvate Kinase; ATGL, MAGL, FAAH and other metabolism-related popular targets. - Structural diversity, significant drug potency and cell penetration. - Detailed specifications, compound structure, target information, activity description, etc. - NMR, HPLC/LCMS and other detection techniques to ensure correct structure and high purity of the product and reduce false positives. Uses: Scientific use. Product Category: L2560. Categories: Metabolism Compounds Libraries. | |
| Mitapivat | Mitapivat (AG-348) is an orally active pyruvate kinase allosteric activator. Mitapivat increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes, shows the potential to restore the activity of PK (pyruvate kinase) -deficient glycolytic pathways. Mitapivat can be used in study of PK deficiency [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-348. CAS No. 1260075-17-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12689. | |
| Native Microorganism Glycerol Kinase | The activity of glycerol kinase is found widely in nature. In microorganisms GK makes possible the utilization of glycerol as a carbon source. In mammals the enzyme represents a juncture of sugar and fat metabolism; The enzyme is important to the clinical chemist in the determination of glycerol. GK is also useful in the assay of glyceraldehydes and dihydroxyacetone following their quantitative reduction to glycerol with sodium borohydride. Applications: This enzyme is useful for enzymatic determination of glycerol and triglyceride when coupled with glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate oxidase or pyruvate kinase and lactate dehydrogenase, lipoprotein lipase in clinical analysis. Group: Enzymes. Synonyms: glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Enzyme Commission Number: EC 2.7.1.30. CAS No. 9030-66-4. GK. Mole weight: approx. 220 kDa (by gel filtration). Activity: Grade? 30 U/mg-solid or more. Stability: Stable at-20°C. Appearance: White amorphous powder, lyophilized. Form: Freeze dried powder. Source: Microorganism. glycerokinase; GK; ATP: glycerol-3-phosphotransferase; glycerol kinase phosphorylating; glyceric kinase; EC 2.7.1.30. Cat No: DIA-149. | |
| pdGp | pdGp, also known as pyruvate dehydrogenase kinase, is a remarkably efficacious and highly targeted inhibitor of the glycogen phosphorylase (Gp). Synonyms: 2'- Deoxyguanosine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 16174-59-7. Molecular formula: C10H15N5O10P2. Mole weight: 427.2. | |
| PKR activator 3 | PKR activator 3 is a pyruvate kinase isoform PKR activator extracted from patent WO2014139144A1, compound 160. PKR activator 3 can be used for the research of PKR function related diseases, including cancer, diabetes, obesity, autoimmune disorders, and benign prostatic hyperplasia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628428-01-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19702. | |
| PKR-IN-1 | Activator of pyruvate kinase isoenzyme M2 (PKM2), an enzyme involved in glycolysis. Since all tumor cells exclusively express the embryonic M2 isoform of PK, it is hypothesized that PKM2 is a potential target for cancer therapy. Modulation of PKM2 might also be effective in the treatment of obesity, diabetes, autoimmune conditions, and antiproliferation-dependent diseases. Synonyms: PKR-IN-1; PKM2 activator 1020; PKM2 activator; Mitapivat. Grades: >98%. CAS No. 1260075-17-9. Molecular formula: C24H26N4O3S. Mole weight: 450.55. | |
| PKR-IN-2 | PKR-IN-2 is a pyruvate kinase (PKR) activator. IC50: PKR (R510Q) <100 nM. Synonyms: N-[4-[4-hydroxy-4-(2-methylpropyl)piperidine-1-carbonyl]phenyl]quinoxaline-5-sulfonamide PKR-IN-2 SCHEMBL16049613. CAS No. 1628428-01-2. Molecular formula: C24H28N4O4S. Mole weight: 468.57. | |
| PS10 | PS10 is a novel, potent and ATP-competitive pan- PDK inhibitor, inhibits all PDK isoforms with IC 50 of 0.8 μM, 0.76 μM, 2.1 μM and 21.3 μM for PDK2, PDK4, PDK1, and PDK3, respectively. PS10 shows high affinity for PDK2 ( K d = 239 nM) than for Hsp90 (K d = 47 μM) [1]. PS10 improves glucose tolerance, stimulates myocardial carbohydrate oxidation in diet-induced obesity. PS10 has the potential for the investigation of diabetic cardiomyopathy [2].PDK: pyruvate dehydrogenase kinase. Uses: Scientific research. Group: Signaling pathways. CAS No. 1564265-82-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-121744. | |
| Shikonin | Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC 50 of 6.5 μM [1]. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor [2] and can also inhibit TNF-α and NF-κB pathway [3]. Shikonin decreases exosome secretion through the inhibition of glycolysis [4]. Shikonin inhibits AIM2 inflammasome activation [7]. Uses: Scientific research. Group: Natural products. Alternative Names: C.I. 75535; Isoarnebin 4. CAS No. 517-89-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N0822. | |
| Shikonin | Shikonin is a major component of a Chinese herbal medicine named zicao. Shikonin is a potent TMEM16A chloride channel inhibitor with an IC50 of 6.5 μM. Shikonin is a specific pyruvate kinase M2 (PKM2) inhibitor and can also inhibit TNF-α and NF-κB pathway. Shikonin decreases exosome secretion through the inhibition of glycolysis. Shikonin inhibits AIM2 inflammasome activation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: C.I. 75535. Product Category: Inhibitors. CAS No. 517-89-5. Molecular formula: C16H16O5. Mole weight: 288.3. Purity: 0.98. Product ID: ACM517895. Alfa Chemistry ISO 9001:2015 Certified. | |
| Tebapivat | Tebapivat (PKR activator 2) is a potent pyruvate kinase-R (PKR) activator extracted from patent WO2019035863A1, compound 385 [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AG-946; PKR activator 2. CAS No. 2283422-04-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-135884. | |
| TEPP-46 | TEPP-46, an effective sensitizer of recombinant pyruvate kinase M2, has been found to decrease the formation of tumor in a mouse xenograft model. IC50: 92 nM (AC50). Uses: Tepp-46 has been found to decrease the formation of tumor in a mouse xenograft model. Synonyms: ML265; ML-265; ML 265; CID44246499; CID-44246499; CID 44246499; NCGC00186528; NCGC 00186528; NCGC-00186528; TEPP46; TEPP 46; TEPP-46; 6-[(3-aminophenyl)methyl]-4,6-dihydro-4-methyl-2-(methylsulfinyl)-5h-thieno[2',3':4,5]pyrrolo[2,3-d]pyridazin-5-one; ML265; TEPP 46; MLS006010294. Grades: 95%. CAS No. 1221186-53-3. Molecular formula: C17H16N4O2S2. Mole weight: 372.46. | |
| TEPP-46 | TEPP-46 (ML-265) is a potent and selective pyruvate kinase M2 (PKM2) activator with an AC 50 of 92 nM, showing little or no effect on PKM1, PKL and PKR [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ML-265. CAS No. 1221186-53-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18657. | |
| TLN-232 | TLN-232, also known as CAP-232, is a synthetic cyclic heptapeptide with potential antineoplastic activity. Pyruvate kinase (PK) inhibitor TLN-232 targets pyruvate kinase M2 (M2PK), which may disrupt tumor cell anaerobic glycolysis. M2PK is a dimeric isoform of PK and the predominant PK isoform found in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). Synonyms: TLN 232; TLN232; CAP-232; CAP 232; CAP232; H-D-Phe-Cys(1)-D-Trp-Lys-Cys(1)-Thr-NH2. CAS No. 158899-10-6. Molecular formula: C36H49N9O7S2. Mole weight: 783.96. | |
| TM-1 | TM-1 is a potent inhibitor of pyruvate dehydrogenase kinase ( PDHK1 ). TM-1 inhibits PDHK1 and PDHK2 with IC 50 s of 2.97 μM and 5.2 μM, respectively. TM-1 blocks pyruvate dehydrogenase complex (PDHC) phosphorylation, and inhibits cell proliferation [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 921099-13-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-136882. | |
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