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| Product | Description | |
|---|---|---|
| Epoxyqueuosine | Epoxyqueuosine is a crucial compound used in biomedical field for the development of drugs to study antibiotic-resistant bacterial infections. It plays a vital role in synthesizing modified queuosine, which enhances the efficacy of antibiotics against resistant pathogens. Synonyms: 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-5-[[(3,4-dihydroxy-6-oxobicyclo[3.1.0]hex-2-yl) amino]methyl]-1,7-dihydro-7-b-D-ribofuranosyl-; 7-(5-((2,3-Epoxy-4,5-dihydroxycyclopent-1-yl)amino)methyl)-7-deazaguanosine; 6-Amino-3-(((3,4-dihydroxy-6-oxabicyclo(3.1.0)hex-2-yl)amino)methyl)-1,5-dihydro-1-beta-D-ribofuranosyl-4H-pyrrolo(2,3-d)pyrimidin-4-one. Grade: ≥98%. CAS No. 107865-20-3. Molecular formula: C17H23N5O8. Mole weight: 425.39. |  |
| epoxyqueuosine reductase | This enzyme catalyses the last step in the bacterial biosynthetic pathway to queuosine, the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. Group: Enzymes. Synonyms: oQ reductase; QueG. Enzyme Commission Number: EC 1.17.99.6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1105; epoxyqueuosine reductase; EC 1.17.99.6; oQ reductase; QueG. Cat No: EXWM-1105. |  |
| Galactosyl queuosine | Galactosyl queuosine is a biomedical product used for the research of various diseases such as cancerous tumors and infectious diseases. Synonyms: galQ; O-5''-β-D-galactosylqueuosine; 4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-5-[[[(1S,4S,5R)-5-(β-D-galactopyranosyloxy)-4-hydroxy-2-cyclopenten-1-yl]amino]methyl]-3,7-dihydro-7-β-D-ribofuranosyl-; (1R,2S,5S)-2-({[2-Amino-4-oxo-7-(β-D-ribofuranosyl)-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl]methyl}amino)-5-hydroxy-3-cyclopenten-1-yl β-D-galactopyranoside; 2-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-((((1S,4S,5R)-4-hydroxy-5-(((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)cyclopent-2-en-1-yl)amino)methyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one; beta-D-galactosylqueuosine. Grade: ≥95%. CAS No. 60426-58-6. Molecular formula: C23H33N5O12. Mole weight: 571.54. | |
| tRNA-queuosine β-mannosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. Group: Enzymes. Enzyme Commission Number: EC 2.4.1.110. CAS No. 9055-6-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2337; tRNA-queuosine β-mannosyltransferase; EC 2.4.1.110; 9055-06-5. Cat No: EXWM-2337. | |
| 6-carboxytetrahydropterin synthase | Binds Zn2+. Isolated from the bacteria Bacillus subtilis and Escherichia coli. The reaction is part of the biosynthesis pathway of queuosine.The enzyme from Escherichia coli can also convert 6-pyruvoyl-5,6,7,8-tetrahydropterin and sepiapterin to 6-carboxy-5,6,7,8-tetrahydropterin. Group: Enzymes. Synonyms: CPH4 synthase; queD (gene name); ToyB; ykvK (gene name). Enzyme Commission Number: EC 4.1.2.50. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4887; 6-carboxytetrahydropterin synthase; EC 4.1.2.50; CPH4 synthase; queD (gene name); ToyB; ykvK (gene name). Cat No: EXWM-4887. | |
| 7-carboxy-7-deazaguanine synthase | Requires Mg2+. The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction. The reaction is part of the biosynthesis pathway of queuosine. Group: Enzymes. Synonyms: 7-carboxy-7-carbaguanine synthase; queE (gene name). Enzyme Commission Number: EC 4.3.99.3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5310; 7-carboxy-7-deazaguanine synthase; EC 4.3.99.3; 7-carboxy-7-carbaguanine synthase; queE (gene name). Cat No: EXWM-5310. | |
| 7-cyano-7-deazaguanine synthase | Binds Zn2+. The reaction is part of the biosynthesis pathway of queuosine. Group: Enzymes. Synonyms: preQ0 synthase; 7-cyano-7-carbaguanine synthase; queC (gene name). Enzyme Commission Number: EC 6.3.4.20. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5790; 7-cyano-7-deazaguanine synthase; EC 6.3.4.20; preQ0 synthase; 7-cyano-7-carbaguanine synthase; queC (gene name). Cat No: EXWM-5790. | |
| preQ1 synthase | The reaction occurs in the reverse direction. This enzyme catalyses one of the early steps in the synthesis of queuosine (Q-tRNA), and is followed by the action of EC 2.4.2.29, queuine tRNA-ribosyltransferase. Queuosine is found in the wobble position of tRNAGUN in Eukarya and Bacteria and is thought to be involved in translational modulation. The enzyme is not a GTP cyclohydrolase, as was thought previously based on sequence-homology studies. Group: Enzymes. Synonyms: YkvM; QueF; preQ0 reductase; preQ0 oxidoreductase; 7-cyano-7-deazaguanine reductase; queuine synthase (incorrect as queuine is not the product); queuine:NADP+ oxidoreductase (incorrect as queuine is not the product). Enzyme Commission Number: EC 1.7.1.13. CAS No. 1256460-80-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1606; preQ1 synthase; EC 1.7.1.13; 1256460-80-6; YkvM; QueF; preQ0 reductase; preQ0 oxidoreductase; 7-cyano-7-deazaguanine reductase; queuine synthase (incorrect as queuine is not the product); queuine:NADP+ oxidoreductase (incorrect as queuine is not the product). Cat No: EXWM-1606. | |
| Queuine | Queuine is a hypermodified nucleobase , which is modified to queuosine. Queuine, as an important micronutrient, can be used for the research of diseases associated with human gut microbiome [1]. Uses: Scientific research. Group: Natural products. CAS No. 72496-59-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N10574. |  |
| Queuine dihydrochloride | Queuine dihydrochloride is a super-modified nucleobase, modified to queuosine dihydrochloride. Queuine dihydrochloride is an important micronutrient that can be used in the study of human intestinal microbial-related diseases [1]. Uses: Scientific research. Group: Natural products. CAS No. 86496-18-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N10574A. | |
| S-adenosylmethionine:tRNA ribosyltransferase-isomerase | The reaction is a combined transfer and isomerization of the ribose moiety of S-adenosyl-L-methionine to the modified guanosine base in the wobble position in tRNAs specific for Tyr, His, Asp or Asn. It is part of the queuosine biosynthesis pathway. Group: Enzymes. Synonyms: QueA enzyme; queuosine biosynthesis protein QueA. Enzyme Commission Number: EC 2.4.99.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2701; S-adenosylmethionine:tRNA ribosyltransferase-isomerase; EC 2.4.99.17; QueA enzyme; queuosine biosynthesis protein QueA. Cat No: EXWM-2701. | |
| tRNA-guanosine34 transglycosylase | Certain prokaryotic and eukaryotic tRNAs contain the modified base queuine at position 34. In eukaryotes queuine is salvaged from food and incorporated into tRNA directly via a base-exchange reaction, replacing guanine. In eubacteria, which produce queuine de novo, the enzyme catalyses the exchange of guanine with the queuine precursor preQ1, which is ultimately modified to queuosine. The eubacterial enzyme can also use an earlier intermediate, preQ0, to replace guanine in unmodified tRNATyr and tRNAAsn. This enzyme acts after EC 1.7.1.13, preQ1 synthase, in the queuine-biosynthesis pathway. Group: Enzymes. Synonyms: guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguou. Enzyme Commission Number: EC 2.4.2.29. CAS No. 72162-89-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2656; tRNA-guanosine34 transglycosylase; EC 2.4.2.29; 72162-89-1; guanine insertion enzyme (ambiguous); tRNA transglycosylase (ambiguous); Q-insertase (ambiguous); queuine34 transfer ribonucleate ribosyltransferase; transfer ribonucleate glycosyltransferase (ambiguous); tRNA guanine34 transglycosidase; queuine tRNA-ribosyltransferase (ambiguous); TGT; [tRNA]-guanine34:queuine tRNA-D-ribosyltransferase; transfer ribonucleic acid guanine34 transglycosylase. Cat No: EXWM-2656. | |
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