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Quinacrine dihydrochloride is the dihydrochloride salt of the 9-aminoacridine derivative quinacrine with potential antineoplastic and antiparasitic activities. Quinacrine may inhibit the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB), which may result in the induction of tumor suppressor p53 transcription, the restoration of p53-dependent apoptotic pathways, and tumor cell apoptosis. Continuous NF-kappaB signaling, present in many tumors and in chronic inflammatory processes, promotes the expression of antiapoptotic proteins and cytokines while downregulating the expression of proapoptotic proteins, such as p53. Synonyms: atabrine dihydrochloride; mepacrine dihydrochoride; SN 390. CAS No. 69-05-6. Molecular formula: C23H30ClN3O.2HCl. Mole weight: 472.88.
Quinacrine hydrochloride hydrate
Quinacrine hydrochloride hydrate (Mepacrine hydrochloride hydrate) is an antimalarial agent, which possess anticancer effect both in vitro and vivo. Quinacrine hydrochloride hydrate suppresses NF-κB and activates p53 signaling, which results in the induction of the apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mepacrine hydrochloride hydrate; SN-390 hydrochloride hydrate. CAS No. 6151-30-0. Pack Sizes: 100 mg. Product ID: HY-13735B.