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| Product | Description | |
|---|---|---|
| quinolinate synthase | An iron-sulfur protein that requires a [4Fe-4S] cluster for activity. Quinolinate synthase catalyses the second step in the de novo biosynthesis of NAD+ from aspartate in some bacteria, with EC 1.4.3.16 (L-aspartate oxidase) catalysing the first step and EC 2.4.2.19 [nicotinate-nucleotide diphosphorylase (carboxylating)] the third step. In Escherichia coli, two of the residues that are involved in the [4Fe-4S] cluster binding appear to undergo reversible disulfide-bond formation that regulates the activity of the enzyme. Group: Enzymes. Synonyms: NadA; QS; quinolinate synthetase. Enzyme Commission Number: EC 2.5.1.72. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2810; quinolinate synthase; EC 2.5.1.72; NadA; QS; quinolinate synthetase. Cat No: EXWM-2810. |  |
| L-aspartate oxidase | A flavoprotein (FAD). L-Aspartate oxidase catalyses the first step in the de novo biosynthesis of NAD+ in some bacteria. O2 can be replaced by fumarate as electron acceptor, yielding succinate. The ability of the enzyme to use both O2 and fumarate in cofactor reoxidation enables it to function under both aerobic and anaerobic conditions. Iminosuccinate can either be hydrolysed to form oxaloacetate and NH3 or can be used by EC 2.5.1.72, quinolinate synthase, in the production of quinolinate. The enzyme is a member of the succinate dehydrogenase/fumarate-reductase family of enzymes. Group: Enzymes. Synonyms: NadB; Laspo; AO. Enzyme Commission Number: EC 1.4.3.16. CAS No. 69106-47-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1472; L-aspartate oxidase; EC 1.4.3.16; 69106-47-4; NadB; Laspo; AO. Cat No: EXWM-1472. | |
| (αR, βS)-rel-Bedaquiline | (αR, βS)-rel-Bedaquiline is a promising diarylquinoline candidate in clinical development for the treatment of tuberculosis. (αR, βS)-rel-Bedaquiline inhibits mycobacterial ATP synthase and displays high activity against both drug-susceptible and multidrug-resistant strains of Mycobacterium tuberculosis. Group: Biochemicals. Alternative Names: (αR, βS)-rel-6-Bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl- β-phenyl-3-quinolineethanol. Grades: Highly Purified. CAS No. 654653-93-7. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Baxdrostat | Baxdrostat is an aldosterone synthase inhibitor. Synonyms: N-[(8R)-4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl]propanamide; (R)-N-(4-(1-methyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-5,6,7,8-tetrahydroisoquinolin-8-yl)propionamide; N-[(8R)-4-(1-Methyl-2-oxo-1,2,3,4-tetrahydro-6-quinolinyl)-5,6,7,8-tetrahydro-8-isoquinolinyl]propanamide; Propanamide, N-[(8R)-5,6,7,8-tetrahydro-4-(1,2,3,4-tetrahydro-1-methyl-2-oxo-6-quinolinyl)-8-isoquinolinyl]-. CAS No. 1428652-17-8. Molecular formula: C22H25N3O2. Mole weight: 363.45. |  |
| FASN-IN-4 | FAS-IN-1, a diazaspiro derivative, has been found to be a fatty acid synthase inhibitor that probably have potential biological usage in anticancer study. Uses: Fas-in-1 has been found to be a fatty acid synthase inhibitor that probably have potential biological usage in anticancer study. Synonyms: FAS-IN-1; 1375105-96-6; FASN-IN-4; CHEMBL2147032; 4-cyclopropyl-9-(4-quinolin-7-ylphenyl)sulfonyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one; SCHEMBL4541971; OGGOWHOQMIINAZ-UHFFFAOYSA-N; BCP28627; BDBM50391837; AKOS030526462; CS-3932; 4-Cyclopropyl-9-((4-(quinolin-7-yl)phenyl)sulfonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-one; NCGC00485940-01; DA-63380; HY-12648; A906146; 4-cyclopropyl-9-{[4-(7-quinolinyl)phenyl]sulfonyl}-1-oxa-4,9-diazaspiro[5.5]undecan-3-one. Grade: 98%. CAS No. 1375105-96-6. Molecular formula: C26H27N3O4S. Mole weight: 477.58. | |
| Tetrahydrobiopterin (THB) dihydrochloride | Tetrahydrobiopterin (THB) dihydrochloride is an activating Nitric Oxide Synthase (NOS)cofactor used in a variety of applications. The compound is also a known cofactor for the monooxygenases that hydroxylates phenylalanine, tyrosine, and tryptophan. Synthesis of THB has been documented to be the rate limiting step in the metabolism of phenylalanine and the biosynthesis of neurotransmiter amines. In mice, Quinolinic acid (sc-203226) induced convulsions were potentiated with Tetrahydrobiopterin dihydrochloride demonstrating that endogenous NO may be involved in stimulating the NMDA receptors. When hypertensive mice were fed THB, but were not introduced to hydralazine or tetrahydroneopterin, they displayed improved cardiac THB stores, phosphorylated phospholamban levels, and diastolic dysfunction. The compound has also been observed as an essential cofactor in the hydroxylation process in mammalian brains. Applications: An activating nos cofactor. Group: Coenzymes. Synonyms: (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride. CAS No. 69056-38-8. Purity: ≥98%. Mole weight: 314.17. Appearance: Powder. Form: Solid. (6R)-5,6,7,8-Tetrahydro-L-biopterin dihydrochloride; Tetrahydrobiopterin (THB) dihydrochloride; 69056-38-8. Cat No: COEC-024. | |
| Viridicatol | Viridicatol is a fungal metabolite found in various Penicillium species as well as Phoma. It suppresses the expression of COX-2 and inducible nitric oxide synthase (iNOS) and inhibits production of nitric oxide and prostaglandin E2 (PGE2) in LPS-stimulated RAW 264.7 and BV2 cells. Synonyms: 2(1H)-Quinolinone, 3-hydroxy-4-(3-hydroxyphenyl)-; Carbostyril, 3-hydroxy-4-(m-hydroxyphenyl)-; 3-hydroxy-4-(3-hydroxyphenyl)carbostyril; 4-(3-Hydroxyphenyl)-2,3-quinolinediol. Grade: ≥95%. CAS No. 14484-44-7. Molecular formula: C15H11NO3. Mole weight: 253.25. | |
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