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Heterocyclic Organic Compound. Alternative Names: quinomycin. CAS No. 11113-76-1. Catalog: ACM11113761.
Quinomycin A (Echinomycin, Actinoleukin, Antibiotic 1491, Antibiotic 59266, Antibiotic X 948, Antibiotic X 53III)
Quiniomycin A is a cyclic depsipeptide metabolite. It has broad activity against bacteria, fungi and viruses and has found application as an antitumor agent. Quinomycin A acts by bifunctional intercalation of nucleic acids. Recent research has shown quinomycin A to be an extremely potent inhibitor of Hypoxia-inducible factor-1 (HIF-1). This transcription factor plays an essential role in tumor progression and metastasis. Related to: Qunaldopeptin. Group: Biochemicals. Alternative Names: Echinomycin, Actinoleukin, Antibiotic 1491, Antibiotic 59266, Antibiotic X 948, Antibiotic X 53III; N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester. Grades: Highly Purified. CAS No. 512-64-1. Pack Sizes: 1mg. US Biological Life Sciences.
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Quinomycin B
Quinomycin B is originally isolated from Str. sp. 732. It has a strong effect on gram-positive bacteria and HeLa cells, and also on some gram-negative bacteria. It also has a protective effect on mice inoculated with poliovirus. Synonyms: BRN 1071167; Quinomycin A,4-(N-methylalloisoleucine)-8-(N-methylalloisoleucine). CAS No. 13602-52-3. Molecular formula: C53H68N12O12S2. Mole weight: 1129.31.
Quinomycin C
Quinomycin C is originally isolated from Str. sp. 732. It has a strong effect on gram-positive bacteria and HeLa cells, and also on some gram-negative bacteria. It also has a protective effect on mice inoculated with poliovirus. Synonyms: Antibiotic U 48160; BRN 1071168. Grades: >98%. CAS No. 11001-74-4. Molecular formula: C55H72N12O12S2. Mole weight: 1157.36.
Echinomycin (Quinomycin A)
Antibiotic. Antitumor compound. Powerful, selective inhibitor of nucleic acid synthesis in vitro. Potent hypoxia-inducible factor 1 (HIF-1) DNA binding activity inhibitor. Apoptosis inducer. Antibacterial, antifungal and antiviral. Group: Biochemicals. Alternative Names: Echinomycin, Actinoleukin, Antibiotic 1491, Antibiotic 59266, Antibiotic X 948, Antibiotic X 53III; N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl L-valine (81)-lactone cyclic (37)-thioester. Grades: Highly Purified. CAS No. 512-64-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H64N12O12S2. US Biological Life Sciences.
Worldwide
Echinomycin
It is produced by the strain of Streptomyces echinatus. It has the activity of anti-gram-positive bacteria and vaginal trichomonas, and also has the effect on influenza virus and sarcoma 180 cells in vitro. Synonyms: Quinomycin A; Levomycin; N,N'-((1R,4S,7R,11S,14R,17S,20R,24S)-11,24-diisopropyl-2,4,12,15,17,25-hexamethyl-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo[12.12.3]nonacosane-7,20-diyl)bis(quinoxaline-2-carboxamide); N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic(37)-thioether; Antibiotic A 654I; NSC 13502; NSC 526417. Grades: >99% by HPLC. CAS No. 512-64-1. Molecular formula: C51H64N12O12S2. Mole weight: 1101.25.
Luzopeptin A (Antibiotic BBM-928A)
Luzopeptin is a member of the echinomycin (quinomycin A) class of antitumor and antibiotic agents that act by formation of a stable DNA complex by bis-intercalation. Luzopeptin A has also been shown to be a potent inhibitor of HIV-1 reverse transcriptase. Group: Biochemicals. Alternative Names: Antibiotic BBM-928A. Grades: Highly Purified. CAS No. 75580-37-9. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Sandramycin
Sandramycin is a high molecular weight, symmetric, cyclic depsipeptide belonging to the quinomycin class produced by Kribbella sp. Sandramycin has potent antitumor and antibacterial activity and is thought to act by bis-intercalation of DNA. Group: Biochemicals. Grades: Highly Purified. CAS No. 100940-65-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
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