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| Product | Description | |
|---|---|---|
| R112 | R112 Inhibitor. Uses: Scientific use. Product Category: T3185. CAS No. 575474-82-7. |  |
| R112 | R112 is a fast and reversible inhibitor of spleen tyrosine kinase ( Syk ) kinase. R112 inhibits Syk kinase activity with an IC 50 value of 226 nM and a Ki value of 96 nM. R112 inhibits IgE-FcεRI signaling pathway. R112 can be used for the research of allergic rhinitis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 575474-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16420. |  |
| R112 | R112 is a Syk inhibitor. R112 inhibited degranulation induced by anti-IgE cross-linking in mast cells (tryptase release, effective concentration for 50% inhibition [EC(50)] = 353 nmol/L) or basophils (histamine release, EC(50) = 280 nmol/L), and by allergen (dust mite) in basophils (histamine release, EC(50) = 490 nmol/L). R112 also blocked leukotriene C4 production and all proinflammatory cytokines tested. Subsequent molecular characterization indicated that R112 is an ATP-competitive spleen tyrosine kinase (Syk) inhibitor (inhibitory constant [K(I)] = 96 nmol/L). R112 was able to completely inhibit all three IgE-induced mast cell functions: degranulation, lipid mediator production, and cytokine production. R112 and its analogues offer a new modality in the treatment of allergic rhinitis. Synonyms: R112; R 112; R-112. CAS No. 575474-82-7. Molecular formula: C16H13FN4O2. Mole weight: 312.3. |  |
| R1128 A | R1128 A is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 A for partially purified rat uterine cytosol receptor was 11 x 10(-7) M. Synonyms: R1128A; R-1128A. CAS No. 135161-96-5. Molecular formula: C17H14O5. Mole weight: 298.29. | |
| R1128 B | R1128 B is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 B for partially purified rat uterine cytosol receptor was 1.2 x 10(-7) M. Synonyms: R1128B; R-1128B. CAS No. 135161-97-6. Molecular formula: C18H16O5. Mole weight: 312.3. | |
| R1128 C | R1128 C is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 C for partially purified rat uterine cytosol receptor was 2.6 x 10(-7) M. Synonyms: R1128C; R-1128C. CAS No. 135161-98-7. Molecular formula: C19H18O5. Mole weight: 326.3. | |
| R1128 D | R1128 D is a non-steroidal estrogen-receptor antagonist produced by Streptomyces sp. No. 1128. The IC50 value of R1128 D for partially purified rat uterine cytosol receptor was 2.7 x 10(-7) M. Synonyms: R1128D; R-1128D. CAS No. 135161-99-8. Molecular formula: C19H18O5. Mole weight: 326.3. | |
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