Rat Liver Enzyme Suppliers USA
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Product | Description | |
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Acaterin Quick inquiry Where to buy Suppliers range | Acarbose is an acyl-CoA isolated from Pseudomonas species. A92. In the presence of oxidized low-density lipoprotein in macrophages J744, the synthesis of cholesterol enzymes is inhibited, with an IC50 of 45 μmol/L, and the IC50 for inhibiting ACAT in rat liver microsomes is 120 μmol/L. Inhibition of ACAT is non-competitive Sexual. Synonyms: (2R)-4-[(1R)-1-hydroxyoctyl]-2-methyl-2H-furan-5-one; 3-(1-Hydroxyoctyl)-5-methyl-2(5H)-furanone. Grades: >98%. CAS No. 144398-20-9. Molecular formula: C13H22O3. Mole weight: 226.31. | |
β-cyano-L-alanine Quick inquiry Where to buy Suppliers range | β-cyano-L-alanine is a reversible inhibitor of the H2S-synthesizing enzyme CSE. It blocks H2S synthesis in rat liver preparations with an IC50 value of 6.5 μM and increases blood pressure in anaesthetized rats induced with hemorrhagic shock by inhibiting endogenous H2S synthesis. Synonyms: BCA; beta-cyano-L-alanine; 3-Cyano-L-alanine; L-3-Cyanoalanine. Grades: ≥ 98% (TLC). CAS No. 6232-19-5. Molecular formula: C4H6N2O2. Mole weight: 114.1. | |
Carfilzomib Quick inquiry Where to buy Suppliers range | Carfilzomib is an irreversible proteasome inhibitor and antineoplastic agent that is used in treatment of refractory multiple myeloma. Carfilzomib is associated with a low rate of serum enzyme elevations during treatment and has been implicated to rare instances of clinically apparent, acute liver injury some of which have been fatal. Uses: API. CAS No. 868540-17-4. Product ID: 10-101-326. | |
D-Eritadenine Quick inquiry Where to buy Suppliers range | D-Eritadenine is an adenosine analog and a potent, reversible inhibitor of S-adenosylhomocysteine hydrolase. Dietary administration of D-eritadenine (50 mg/kg) increases liver microsomal phosphatidylethanolamine concentration and decreases liver microsomal Δ6 desaturase activity and plasma cholesterol levels in rats. Uses: Enzyme inhibitors. Synonyms: (αR,βR)-6-Amino-α,β-dihydroxy-9H-purine-9-butanoic Acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic Acid; 4-(6-Aminopurin-9-yl)-4-deoxy-D-erythronic Acid; Lentinacin; Lentysine; 4-(9-Adenyl)-D-erythro-2,3-dihydroxybutyric Acid; Eritadenine; Lentysine; Lentinacin. Grades: ≥95%. CAS No. 23918-98-1. Molecular formula: C9H11N5O4. Mole weight: 253.21. | |
DL-Propargyl glycine hydrochloride Quick inquiry Where to buy Suppliers range | DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 μM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock. Synonyms: PAG; 2-Aminopent-4-ynoic acid hydrochloride; AK323755; AK110719. Grades: ≥95%. CAS No. 16900-57-5. Molecular formula: C5H7NO2·HCl. Mole weight: 149.6. | |
Eniluracil Quick inquiry Where to buy Suppliers range | Eniluracil, also known as GW776 and GW776C85, is an orally active and irreversible inhibitor of dihydropyrimidine dehydrogenase. Eniluracil inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil (5-FU) in the liver. Co-administration of ethynyluracil permits the oral administration of 5-FU. Uses: Enzyme inhibitors. Synonyms: 5-ethynyluracil; 5-ethynylpyrimidine-2,4(1H,3H)-dione; 5-Ethynyl-2-hydroxypyrimidin-4(1H)-one; GW776; GW-776; GW 776. CAS No. 59989-18-3. Molecular formula: C6H4N2O2. Mole weight: 136.11. | |
Histrelin Quick inquiry Where to buy Suppliers range | Histrelin is a gonadotropin releasing hormone (GnRH) agonist that is a potent inhibitor of production of testosterone (in men) and estrogen (in women) and is used predominantly to treat advanced prostate cancer. Histrelin is associated with a low rate of transient serum enzyme elevations during therapy, but has not been linked convincingly to cases of clinically apparent acute liver injury. Uses: Peptide Inhibitors. CAS No. 76712-82-8. Product ID: R1965. | |
Nafenopin Quick inquiry Where to buy Suppliers range | Nafenopin is a hypolipidemic agent, a peroxisome proliferator, on the activities of rat liver glutathione-requiring enzymes and catalase in comparison to the action of phenobarbital. Uses: A hypolipidemic agent. Synonyms: 2-Methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid. Grades: ≥98%. CAS No. 3771-19-5. Molecular formula: C20H22O3. Mole weight: 310.39. | |
Pentostatin Quick inquiry Where to buy Suppliers range | Pentostatin is a purine analogue and antineoplastic agent used in the therapy of hairy cell leukemia and T cell lymphomas. Pentostatin is associated with a low rate of serum enzyme elevations during therapy and has been linked to rare instances of severe acute liver injury with jaundice. Uses: Microbial Fermentation Products. CAS No. 53910-25-1. Product ID: MFP-022. | |
TUG-770 Quick inquiry Where to buy Suppliers range | TUG-770 displayed excellent physicochemical and in vitro ADME properties, with good aqueous solubility, good chemical stability, low lipophilicity, and decreased plasma protein binding (PPB). TUG-770 furthermore showed excellent stability toward human liver microsomes (HLM), no inhibition of selected CYP-enzymes implicated in drug-drug interactions, no P-glycoprotein (P-gp) inhibition, and good permeability in the Caco-2 cell assay. Examination of TUG-770 in an acute intraperitoneal glucose tolerance test (IPGTT) in normal mice revealed a good dose dependent response with maximal reduction in glucose level reached at 50 mg/kg. The effect of TUG-770 was fully sustained after 29 days of daily oral treatment. Additional evaluation of TUG-770 in rats confirmed a significant glucose lowering effect for the high doses already after 10 min and for all doses after 30 min. Synonyms: TUG-770; TUG 770; TUG770. Grades: >98%. CAS No. 1402601-82-4. Molecular formula: C19H14FNO2. Mole weight: 307.32. | |
YM-53601 Quick inquiry Where to buy Suppliers range | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. |