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Reboxetine, also called as Vestra, 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate, exists as two enantiomers, (R,R)-(-)- and (S,S)-(+)-reboxetine. Ti is a selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and ADD/ADHD which has been approved for treatment of major depression. In vitro: it inhibits noradrenaline reuptake in vitro to a similar extent to the tricyclic antidepressant desmethylimipramine and does not inhibit the activity of the following isozymes of cytochrome P450: CYP1A2, CYP2C9, CYP2C19, and CYP2E1; In vivo: Reboxetine does not affect dopamine or serotonin reuptake and it has low in vivo and in vitro affinity for adrenergic, cholinergic, histaminergic, dopaminergic and serotonergic receptors.Besides, it inhibits both CYP2D6 and CYP3A4 with low binding affinities, but has shown no effect on the in vivo clearance of drugs metabolized by these enzymes. Inhibits (±)-epibatidine-induced Ca(2+) influx in human (h) muscle embryonic (hα1β1γδ) and adult (hα1β1εδ) AChRs in a non-competitive manner , with potencies IC50= 3.86±0.49 and 1.92±0.48 μM, respectively. Uses: A selective norepinephrine reuptake inhibitor used in the treatment of clinical depression, panic disorder and add/adhd, it has been approved for treatment of major depression. Synonyms: Norebox; 2-((2-ethoxyphenoxy)benzyl)morpholine methanesulfonate; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R,R)-Reboxetine. Grades: ≥ 95.0%. CAS No. 98769-81-4. Molecular formula: C19H23NO3. Mole weight: 313.39.
Reboxetine-d5, Mesylate
Labelled Reboxetine, a selective noradrenaline reuptake inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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Reboxetine mesylate
Reboxetine mesylate (FCE20124 mesylate) is a potent, selective, and specific noradrenaline reuptake inhibitor (NARI) for the research of depression. Reboxetine mesylate inhibits the uptake of norepinephrine, with a K i of 8 nM [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FCE20124 mesylate; PNU155950E mesylate. CAS No. 98769-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14560C.
Reboxetine mesylate
Reboxetine mesylate. Group: Biochemicals. Grades: Purified. CAS No. 98769-84-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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Reboxetine Mesylate
Reboxetine is a norepinephrine reuptake inhibitor with Ki of 8.2 nM. Synonyms: PNU 155950E. Grades: >98%. CAS No. 98769-84-7. Molecular formula: C19H23NO3·CH4O3S. Mole weight: 409.5.
Reboxetine, Mesylate
A selective noradrenaline reuptake inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
A potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and >10000nM for rat NET, SERT and DAT, respectively). Displays >1000-fold selectivity over alpha-adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 71620-89-8. Pack Sizes: 10mg. US Biological Life Sciences.
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5-Hydroxy Reboxetine-d5
5-Hydroxy Reboxetine-d5. Group: Biochemicals. Alternative Names: 4-Ethoxy-3- [ (S) - (2S) -2-morpholinyl phenyl methoxy] phenol-d5. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C19H18D5NO4, Molecular Weight: 334.42. US Biological Life Sciences.
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Esreboxetine succinate
Esreboxetine succinate is a selective norepinephrine reuptake inhibitor. It was under development by Pfizer for the treatment of neuropathic pain and fibromyalgia. Uses: Esreboxetine succinate was used for the treatment of neuropathic pain and fibromyalgia. Synonyms: (S,S)-reboxetine succinate; (+) - (2S) -2- ( (S) - (2-Ethoxyphenoxy) phenylmethyl) morpholine hydrogen butanedioate. Grades: 98%. CAS No. 635724-55-9. Molecular formula: C23H29NO7. Mole weight: 431.48.
A stereoisomer of Reboxetine.Reboxetine is a norepinephrine reuptake inhibitor. It can be used for the treatment of unipolar depression, although it has also been used off-label for panic disorder and ADHD. Uses: Adrenergic uptake inhibitors. Synonyms: Reboxetine; 71620-89-8; 98769-81-4; Reboxetine [INN]; 105017-38-7; (2R)-2-[(R)-(2-ethoxyphenoxy)-phenylmethyl]morpholine; 947S0YZ36I; Reboxetine (INN); Norebox; (2r)-2-[ (R)- (2-Ethoxyphenoxy) (Phenyl)methyl]morpholine; Reboxitine; Morpholine, 2-[(R)-(2-ethoxyphenoxy)phenylmethyl]-, (2R)-rel-; (R)-2- ( (R)- (2-ethoxyphenoxy) (phenyl)methyl)morpholine; Morpholine, 2-((R)-(2-ethoxyphenoxy)phenylmethyl)-, (2R)-rel-; Reboxetine [INN:BAN]; UNII-947S0YZ36I; R,R-reboxetine; Reboxe- tine; HSDB 7701; Edronax (TN); (R)-2- ( (R)- (2-ethoxyphenoxy) (phenyl)methyl)morpholine methanesulfonate. Grades: > 95%. CAS No. 105017-38-7. Molecular formula: C19H23NO3. Mole weight: 313.4.
(S, R)-Reboxetine
A stereoisomer of Reboxetine.Reboxetine is a norepinephrine reuptake inhibitor. It can be used for the treatment of unipolar depression, although it has also been used off-label for panic disorder and ADHD. Grades: > 95%. CAS No. 868686-70-8. Molecular formula: C19H23NO3. Mole weight: 313.4.
(S,S)-Reboxetine
A stereoisomer of Reboxetine.Reboxetine is a norepinephrine reuptake inhibitor. It can be used for the treatment of unipolar depression, although it has also been used off-label for panic disorder and ADHD. Synonyms: [S-(R*,R*)]-2-[(2-Ethoxyphenoxy)phenylmethyl]-morpholine; (S,S)-(+)-Reboxetine; Esreboxetine; (2S)-2-[(S)-(2-Ethoxyphenoxy)phenylmethyl]-morpholine. Grades: > 95%. CAS No. 98819-76-2. Molecular formula: C19H23NO3. Mole weight: 313.4.
2-Bromo-4- ( (tert-butyldimethylsilyl) oxy) phenol is an intermediate in synthesizing rac 5-Hydroxy Reboxetine Hydrochloride (H953470), which is an hydroxylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C12H19BrO2Si. US Biological Life Sciences.
(2R)-2-Benzoyl-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing rac 5-Hydroxy Reboxetine Hydrochloride (H953470), which is an hydroxylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 869088-60-8. Pack Sizes: 25mg, 50mg. Molecular Formula: C16H21NO4. US Biological Life Sciences.
(2R)-2-[(S)-hydroxyphenylmethyl]-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing rac 5-Hydroxy Reboxetine Hydrochloride (H953470), which is an hydroxylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 1030837-58-1. Pack Sizes: 10mg, 25mg. Molecular Formula: C16H23NO4. US Biological Life Sciences.
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(2R) -2-[ (S) -[ (Methylsulfonyl) oxy]phenylmethyl]-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester
(2R) -2-[ (S) -[ (Methylsulfonyl) oxy]phenylmethyl]-4-morpholinecarboxylic Acid 1,1-Dimethylethyl Ester is an intermediate in synthesizing rac 5-Hydroxy Reboxetine Hydrochloride (H953470), which is an hydroxylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 1030837-66-1. Pack Sizes: 5mg, 10mg. Molecular Formula: C17H25NO6S, Molecular Weight: 371.45. US Biological Life Sciences.
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(2RS,3RS)-1-Amino-3-(2-ethoxy-d5-phenoxy)-2-hydroxy-3-phenylpropane, Methanesulfonate Salt
A labeled intermediate in the synthesis of Reboxetine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
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(2RS,3RS)-1-Amino-3-(2-ethoxyphenoxy)-2-hydroxy-3-phenylpropane, Methanesulfonate Salt
An intermediate in the synthesis of Reboxetine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
An intermediate in the synthesis of Reboxetine. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
3-Bromo-4-ethoxy-phenol
3-Bromo-4-ethoxy-phenol is an intermediate in synthesizing rac 5-Hydroxy Reboxetine Hydrochloride (H953470), which is an hydroxylated metabolite of Reboxetine (R142000), a selective noradrenaline reuptake inhibitor and an antidepressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 1216224-85-9. Pack Sizes: 5mg, 10mg. Molecular Formula: C8H9BrO2. US Biological Life Sciences.
Worldwide
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