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Regorafenib Inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Group: Biochemicals. Alternative Names: 4- [4- [ [ [ [4-Chloro-3- (trifluoromethyl) phenyl] amino] carbonyl] amino] -3-fluorophenoxy] -N-methyl-2-pyridinecarboxamide; 4-[4-[N’- (4-Chloro-3-trifluoromethylphenyl) ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; BAY 73-4506; Fluoro-Sorafenib; Stivarga. Grades: Highly Purified. CAS No. 755037-03-7. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 482.82. US Biological Life Sciences. USBiological 8
Worldwide
Regorafenib Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 , respectively. Regorafenib shows very robust antitumor and antiangiogenic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506. CAS No. 755037-03-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10331. MedChemExpress MCE
Regorafenib-d3 2H Labeled Compounds. CAS No. 1255386-16-3. Mole weight: 485.83. Catalog: ACM1255386163. Alfa Chemistry. 4
Regorafenib EP Impurity A Regorafenib EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. CAS No. 757251-39-1. Molecular Formula: C13H12FN3O2. Mole Weight: 261.26. Catalog: APB757251391. Alfa Chemistry Analytical Products 3
Regorafenib EP Impurity B Regorafenib EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2141961-84-2. Molecular Formula: C15H14FN3O3. Mole Weight: 303.29. Catalog: APB2141961842. Alfa Chemistry Analytical Products 2
Regorafenib EP Impurity D An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4,4'-(((carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide). CAS No. 2438857-80-6. Molecular formula: C27H22F2N6O5. Mole weight: 548.50. BOC Sciences 8
Regorafenib EP Impurity D Regorafenib EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2438857-80-6. Molecular Formula: C27H22F2N6O5. Mole Weight: 548.51. Catalog: APB2438857806. Alfa Chemistry Analytical Products 2
Regorafenib Hydrochloride Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 with IC 50 s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506 hydrochloride. CAS No. 835621-07-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13308. MedChemExpress MCE
Regorafenib Hydrochloride Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1. Synonyms: BAY73-4506 hydrochloride. Grades: >98%. CAS No. 835621-07-3. Molecular formula: C21H16Cl2F4N4O3. Mole weight: 519.28. BOC Sciences 8
Regorafenib Impurity 1 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C25H19F2N5O4. Mole weight: 491.46. BOC Sciences 7
Regorafenib Impurity 10 Regorafenib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2098799-12-1. Molecular Formula: C19H17FN4O3. Mole Weight: 368.37. Catalog: APB2098799121. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 13 Regorafenib Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2909-32-2. Molecular Formula: C14H14N2O. Mole Weight: 226.28. Catalog: APB2909322. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 14 Regorafenib Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 835621-12-0. Molecular Formula: C20H13ClF4N4O4. Mole Weight: 484.79. Catalog: APB835621120. Alfa Chemistry Analytical Products 3
Regorafenib Impurity 15 Regorafenib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1343498-72-5. Molecular Formula: C20H13ClF4N4O3. Mole Weight: 468.79. Catalog: APB1343498725. Alfa Chemistry Analytical Products
Regorafenib Impurity 16 Regorafenib Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1343498-71-4. Molecular Formula: C21H15ClF4N4O4. Mole Weight: 498.82. Catalog: APB1343498714. Alfa Chemistry Analytical Products
Regorafenib Impurity 17 Regorafenib Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2545933-24-0. Molecular Formula: C25H22FN5O4. Mole Weight: 475.48. Catalog: APB2545933240. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 18 (Sorafenib Impurity 8) Regorafenib Impurity 18 (Sorafenib Impurity 8). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1379324-09-0. Molecular Formula: C7H6Cl2N2O. Mole Weight: 205.04. Catalog: APB1379324090. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 2 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H16F4N4O3. Mole weight: 448.38. BOC Sciences 7
Regorafenib Impurity 20 Regorafenib Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 370-50-3. Molecular Formula: C15H8Cl2F6N2O. Mole Weight: 417.13. Catalog: APB370503. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 21 Regorafenib Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 9448-54-5. Molecular Formula: C9H7ClF3NO2. Mole Weight: 253.61. Catalog: APB9448545. Alfa Chemistry Analytical Products 3
Regorafenib Impurity 27 Regorafenib Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1333390-56-9. Molecular Formula: C14H9ClF4N2O2. Mole Weight: 348.68. Catalog: APB1333390569. Alfa Chemistry Analytical Products
Regorafenib Impurity 29 Regorafenib Impurity 29. Uses: For analytical and research use. Group: Impurity standards. CAS No. 352277-93-1. Molecular Formula: C12H13ClF3NO2. Mole Weight: 295.69. Catalog: APB352277931. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 3 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H15ClF4N4O3. Mole weight: 482.83. BOC Sciences 7
Regorafenib Impurity 4 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C20H18FN5O3. Mole weight: 395.4. BOC Sciences 7
Regorafenib Impurity 5 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C27H22F2N6O5. Mole weight: 548.51. BOC Sciences 7
Regorafenib Impurity 50 Regorafenib Impurity 50. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6636-55-1. Molecular Formula: C7H6ClNO2. Mole Weight: 171.58. Catalog: APB6636551. Alfa Chemistry Analytical Products 3
Regorafenib Impurity 51 Regorafenib Impurity 51. Uses: For analytical and research use. Group: Impurity standards. CAS No. 98273-19-9. Molecular Formula: C7H5Cl2NO2. Mole Weight: 206.02. Catalog: APB98273199. Alfa Chemistry Analytical Products 4
Regorafenib Impurity 58 Regorafenib Impurity 58. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2126178-55-8. Molecular Formula: C2013CH12D3ClF4N4O3. Mole Weight: 486.83. Catalog: APB2126178558. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 6 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) -3-fluorophenoxy) -; 4- (4- ( (4-Chloro-3- (trifluoromethyl) phenyl) carbamoylamino) -3-fluoro-phenoxy) pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3- (trifluoromethyl) phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. Grades: > 95%. CAS No. 1187945-05-6. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. BOC Sciences 8
Regorafenib Impurity 60 Regorafenib Impurity 60. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2232228-54-3. Molecular Formula: C27H23ClF4N4O9. Mole Weight: 658.94. Catalog: APB2232228543. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 62 Regorafenib Impurity 62. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1855006-12-0. Molecular Formula: C20H18FN5O3. Mole Weight: 395.39. Catalog: APB1855006120. Alfa Chemistry Analytical Products
Regorafenib Impurity 63 Regorafenib Impurity 63. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2098799-13-2. Molecular Formula: C35H23Cl2F7N6O5. Mole Weight: 811.49. Catalog: APB2098799132. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 67 Regorafenib Impurity 67. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1446410-29-2. Molecular Formula: C8H10ClN3O. Mole Weight: 199.64. Catalog: APB1446410292. Alfa Chemistry Analytical Products
Regorafenib Impurity 7 An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C36H24Cl2F7N5O5. Mole weight: 810.52. BOC Sciences 7
Regorafenib Impurity 7 Regorafenib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 835621-11-9. Molecular Formula: C21H15ClF4N4O4. Mole Weight: 498.82. Catalog: APB835621119. Alfa Chemistry Analytical Products 3
Regorafenib Impurity 74 Regorafenib Impurity 74. Uses: For analytical and research use. Group: Impurity standards. CAS No. 50528-86-4. Molecular Formula: C8H3ClF3NO. Mole Weight: 221.56. Catalog: APB50528864. Alfa Chemistry Analytical Products 2
Regorafenib Impurity 9 Regorafenib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2188236-16-8. Molecular Formula: C21H16F4N4O3. Mole Weight: 448.38. Catalog: APB2188236168. Alfa Chemistry Analytical Products 2
Regorafenib monohydrate Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 , respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506 monohydrate. CAS No. 1019206-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10331A. MedChemExpress MCE
Regorafenib monohydrate Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Synonyms: BAY 73-4506. Grades: >98%. CAS No. 1019206-88-2. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. BOC Sciences 8
Regorafenib monohydrate impurity B [EP] An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 02; 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide. CAS No. 2141961-84-2. Molecular formula: C15H14FN3O3. Mole weight: 303.29. BOC Sciences 8
Regorafenib monohydrate impurity C [EP] An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpyridine-2-carboxamide; 4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide. CAS No. 1855006-12-0. Molecular formula: C20H18FN5O3. Mole weight: 395.39. BOC Sciences 8
Regorafenib N-β-D-Glucuronide Methyl Ester Regorafenib N-β-D-Glucuronide Methyl Ester, an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib. It is a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. as well as useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2S,3S,4S,5R,6R)-Methyl 6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate. Molecular formula: C28H25ClF4N4O9. Mole weight: 672.97. BOC Sciences 11
Regorafenib N-β-D-Glucuronide (Pyridine)-N-oxide A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C27H23ClF4N4O10. Mole weight: 647.95. BOC Sciences 7
Regorafenib N-β-D-Glucuronide Sodium Salt A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: (2S,3S,4S,5R,6R)-6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid Sodium Salt. Grades: > 95%. Molecular formula: C27H22ClF4N4NaO9. Mole weight: 680.92. BOC Sciences 7
Regorafenib N-Beta-D-Glucuronide Sodium Salt Regorafenib N-Beta-D-Glucuronide Sodium Salt. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4S,5R,6R)-6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid Sodium Salt. IUPAC Name: sodium;(2S,3S,4S,5R,6R)-6-[4-chloro-N-[[2-fluoro-4-[[2-(methylcarbamoyl)-4-pyridyl]oxy]phenyl]carbamoyl]-3-(trifluoromethyl)anilino]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylate. Molecular Formula: C27H22ClF4N4O9.Na. Mole Weight: 680.92. Catalog: APS002935. SMILES: [Na+]. CNC (=O)c1cc (Oc2ccc (NC (=O)N ([C@@H]3O[C@@H] ([C@@H] (O)[C@H] (O)[C@H]3O)C (=O)[O-])c4ccc (Cl)c (c4)C (F) (F)F)c (F)c2)ccn1. Format: Neat. Alfa Chemistry Analytical Products
Regorafenib N-Oxide (M2 Metabolite) A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-11-9. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. BOC Sciences 8
Hydroxyregorafenib A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. BOC Sciences 7
N-Desmethyl Regorafenib N-Desmethyl Regorafenib is a metabolite of Regorafenib. Regorafenib is useful for the treatment of inflammation and as an anti-proliferative agent. Uses: A metabolite of regorafenib. Synonyms: BAY-751098; BAY 751098; BAY751098; Regorafenib metabolite M4;UNII-58I22S7HYD;4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinamide. Grades: 98%. CAS No. 1343498-72-5. Molecular formula: C20H13ClF4N4O3. Mole weight: 468.79. BOC Sciences 6
N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) A metabolite of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-12-0. Molecular formula: C20H13ClF4N4O4. Mole weight: 484.79. BOC Sciences 7
Sorafenib Impurity 5 (Regorafenib Impurity 5) Sorafenib Impurity 5 (Regorafenib Impurity 5). Uses: For analytical and research use. Group: Impurity standards. CAS No. 320-51-4. Molecular Formula: C7H5ClF3N. Mole Weight: 195.57. Catalog: APB320514. Alfa Chemistry Analytical Products 3
1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Urea Impurity; Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2-fluoro-4-hydroxyphenyl)-. CAS No. 1333390-56-9. Molecular formula: C14H9ClF4N2O2. Mole weight: 348.68. BOC Sciences 8
5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester 5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50 = 83 nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R, 3R, 4S, 5S, 6S)-2- ( (4-Chloro-3- (trifluoromethyl)phenyl) (chlorocarbonyl)amino)-6- (methoxycarbonyl)tetrahydro-2H-pyran-3, 4, 5-triyl Triacetate. Molecular formula: C21H20Cl2F3NO10. Mole weight: 574.29. BOC Sciences 12
5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester 5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R,3R,4S,5S,6S)-2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C20H21ClF3NO9. Mole weight: 511.83. BOC Sciences 11
ethyl (2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 06. CAS No. 2514957-39-0. Molecular formula: C16H16FN3O4. Mole weight: 333.31. BOC Sciences 8

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