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| Product | Description | |
|---|---|---|
| Regorafenib | Inhibits PDGFR tyrosine kinase with IC50=83nM. It is useful for the treatment of inflammation and as an anti-proliferative agent. Group: Biochemicals. Alternative Names: 4- [4- [ [ [ [4-Chloro-3- (trifluoromethyl) phenyl] amino] carbonyl] amino] -3-fluorophenoxy] -N-methyl-2-pyridinecarboxamide; 4-[4-[N- (4-Chloro-3-trifluoromethylphenyl) ureido]-3-fluorophenoxy]pyridine-2-carboxylic Acid Methylamide; BAY 73-4506; Fluoro-Sorafenib; Stivarga. Grades: Highly Purified. CAS No. 755037-03-7. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C??H??ClF?N?O?, Molecular Weight: 482.82. US Biological Life Sciences. |  Worldwide |
| Regorafenib | Regorafenib (BAY 73-4506) is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 , respectively. Regorafenib shows very robust antitumor and antiangiogenic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506. CAS No. 755037-03-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10331. |  |
| Regorafenib EP Impurity D | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4,4'-(((carbonylbis(azanediyl))bis(3-fluoro-4,1-phenylene))bis(oxy))bis(N-methylpicolinamide). CAS No. 2438857-80-6. Molecular formula: C27H22F2N6O5. Mole weight: 548.50. |  |
| Regorafenib Hydrochloride | Regorafenib Hydrochloride (BAY 73-4506 hydrochloride) is a multi-target inhibitor for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 with IC 50 s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506 hydrochloride. CAS No. 835621-07-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13308. | |
| Regorafenib Hydrochloride | Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1, VEGFR2, VEGFR3, PDGFRβ, Kit, RET and Raf-1. Synonyms: BAY73-4506 hydrochloride. Grades: >98%. CAS No. 835621-07-3. Molecular formula: C21H16Cl2F4N4O3. Mole weight: 519.28. | |
| Regorafenib Impurity 1 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C25H19F2N5O4. Mole weight: 491.46. | |
| Regorafenib Impurity 2 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H16F4N4O3. Mole weight: 448.38. | |
| Regorafenib Impurity 27 | Regorafenib Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1333390-56-9. Molecular formula: C14H9ClF4N2O2. Mole weight: 348.68. Catalog: APB1333390569. |  |
| Regorafenib Impurity 3 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H15ClF4N4O3. Mole weight: 482.83. | |
| Regorafenib Impurity 4 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C20H18FN5O3. Mole weight: 395.4. | |
| Regorafenib Impurity 5 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C27H22F2N6O5. Mole weight: 548.51. | |
| Regorafenib Impurity 6 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 6; Regorafenib metabolite M6; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinic acid; ZU2HG2Y956; UNII-ZU2HG2Y956; 2-Pyridinecarboxylic acid, 4- (4- ( ( ( (4-chloro-3- (trifluoromethyl) phenyl) amino) carbonyl) amino) -3-fluorophenoxy) -; 4- (4- ( (4-Chloro-3- (trifluoromethyl) phenyl) carbamoylamino) -3-fluoro-phenoxy) pyridine-2-carboxylic acid; 4-[4-[[4-chloro-3- (trifluoromethyl) phenyl]carbamoylamino]-3-fluorophenoxy]pyridine-2-carboxylic acid; SCHEMBL4609009; 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy) picolinic acid. Grades: > 95%. CAS No. 1187945-05-6. Molecular formula: C20H12ClF4N3O4. Mole weight: 469.78. | |
| Regorafenib Impurity 62 | Regorafenib Impurity 62. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1855006-12-0. Molecular formula: C20H18FN5O3. Mole weight: 395.39. Catalog: APB1855006120. | |
| Regorafenib Impurity 7 | An impurity of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C36H24Cl2F7N5O5. Mole weight: 810.52. | |
| Regorafenib monohydrate | Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC 50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3 , PDGFRβ , Kit , RET and Raf-1 , respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAY 73-4506 monohydrate. CAS No. 1019206-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10331A. | |
| Regorafenib monohydrate | Regorafenib monohydrate is a multitargetedinhibitor of tyrosine kinase with IC50 values of 13nM, 4.2nM, 46nM, 2.5nM, 28nM, 19nM, 202nM, 22nM, 7nM, 1.5nM and 311nM, respectively for VEGFR-1, mVEGFR-2, mVEGFR-3, Raf-1, BRAF WT, BRAFV600E, FGFR-1, PDGFR-β, c-KIT, RET and TIE2. Synonyms: BAY 73-4506. Grades: >98%. CAS No. 1019206-88-2. Molecular formula: C21H17ClF4N4O4. Mole weight: 500.83. | |
| Regorafenib monohydrate impurity B [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 02; 4-(4-acetamido-3-fluorophenoxy)-N-methylpicolinamide. CAS No. 2141961-84-2. Molecular formula: C15H14FN3O3. Mole weight: 303.29. | |
| Regorafenib monohydrate impurity C [EP] | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-(3-Fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpyridine-2-carboxamide; 4-(3-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)amino)phenoxy)-N-methylpicolinamide. CAS No. 1855006-12-0. Molecular formula: C20H18FN5O3. Mole weight: 395.39. | |
| Regorafenib N-β-D-Glucuronide Methyl Ester | Regorafenib N-β-D-Glucuronide Methyl Ester, an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, is a derivative of Regorafenib. It is a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. as well as useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2S,3S,4S,5R,6R)-Methyl 6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate. Molecular formula: C28H25ClF4N4O9. Mole weight: 672.97. | |
| Regorafenib N-β-D-Glucuronide (Pyridine)-N-oxide | A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C27H23ClF4N4O10. Mole weight: 647.95. | |
| Regorafenib N-β-D-Glucuronide Sodium Salt | A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: (2S,3S,4S,5R,6R)-6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid Sodium Salt. Grades: > 95%. Molecular formula: C27H22ClF4N4NaO9. Mole weight: 680.92. | |
| Regorafenib N-Beta-D-Glucuronide Sodium Salt | Regorafenib N-Beta-D-Glucuronide Sodium Salt. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,3S,4S,5R,6R)-6-(1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)ureido)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid Sodium Salt. IUPAC Name: sodium;(2S,3S,4S,5R,6R)-6-[4-chloro-N-[[2-fluoro-4-[[2-(methylcarbamoyl)-4-pyridyl]oxy]phenyl]carbamoyl]-3-(trifluoromethyl)anilino]-3,4,5-trihydroxy-tetrahydropyran-2-carboxylate. Molecular formula: C27H22ClF4N4O9.Na. Mole weight: 680.92. Catalog: APS002935. SMILES: [Na+].CNC(=O)c1cc(Oc2ccc(NC(=O)N([C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O)C(=O)[O-])c4ccc(Cl)c(c4)C(F)(F)F)c(F)c2)ccn1. Format: Neat. | |
| Regorafenib N-Oxide (M2 Metabolite) | A metabolite of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-11-9. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. | |
| Hydroxyregorafenib | A derivative of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Grades: > 95%. Molecular formula: C21H15ClF4N4O4. Mole weight: 498.82. | |
| N-Desmethyl Regorafenib | N-Desmethyl Regorafenib is a metabolite of Regorafenib. Regorafenib is useful for the treatment of inflammation and as an anti-proliferative agent. Uses: A metabolite of regorafenib. Synonyms: BAY-751098; BAY 751098; BAY751098; Regorafenib metabolite M4;UNII-58I22S7HYD;4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)picolinamide. Grades: 98%. CAS No. 1343498-72-5. Molecular formula: C20H13ClF4N4O3. Mole weight: 468.79. | |
| N-Desmethyl Regorafenib N-Oxide (M5 Metabolite) | A metabolite of Regorafenib.Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: 4-[4-[[[[4-Chloro-3- (trifluoromethyl) phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-2-pyridinecarboxamide 1-Oxide. Grades: > 95%. CAS No. 835621-12-0. Molecular formula: C20H13ClF4N4O4. Mole weight: 484.79. | |
| 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-hydroxyphenyl)urea | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Urea Impurity; Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2-fluoro-4-hydroxyphenyl)-. CAS No. 1333390-56-9. Molecular formula: C14H9ClF4N2O2. Mole weight: 348.68. | |
| 5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester | 5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50 = 83 nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R, 3R, 4S, 5S, 6S)-2- ( (4-Chloro-3- (trifluoromethyl)phenyl) (chlorocarbonyl)amino)-6- (methoxycarbonyl)tetrahydro-2H-pyran-3, 4, 5-triyl Triacetate. Molecular formula: C21H20Cl2F3NO10. Mole weight: 574.29. | |
| 5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester | 5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R,3R,4S,5S,6S)-2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C20H21ClF3NO9. Mole weight: 511.83. | |
| ethyl (2-fluoro-4-((2-(methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate | An impurity of Regorafenib. Regorafenib is a multi-kinase inhibitor which targets angiogenic, stromal and oncogenic receptor tyrosine kinase. It shows anti-angiogenic activity due to its dual targeted VEGFR2-TIE2 tyrosine kinase inhibition. Synonyms: Regorafenib Impurity 06. CAS No. 2514957-39-0. Molecular formula: C16H16FN3O4. Mole weight: 333.31. | |
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