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| Product | Description | |
|---|---|---|
| Reveromycin A | Reveromycin A, a benzoquinoid antibiotic isolated from the genus Streptomyces , is a selective inhibitor of protein synthesis in eukaryotic cells. Reveromycin A inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Reveromycin A has antiproliferative activity against tumor cell lines and antifungal activity [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 134615-37-5. Pack Sizes: 1 mg. Product ID: HY-129337. |  |
| Reveromycin A | Reveromycin A, the dominant analogue of a complex of spiroketals isolated from a Streptomyces sp., is an inhibitor of the mitogenic activity of epidermal growth factor (EGF). It is a G1 phase cell cycle inhibitor, selectively inhibiting isoleucyl-tRNA synthetase. Reveromycin A displays antiproliferative behavior against human cell lines KB and K562 as well as potent antifungal activity. More recently it has been shown to inducing apoptosis in osteoclasts thus inhibiting bone resorption. Group: Biochemicals. Grades: Highly Purified. CAS No. 134615-37-5. Pack Sizes: 250ug. US Biological Life Sciences. |  Worldwide |
| Reveromycin A | The dominant analogue of complex of spiroketals isolated from streptomyces sp. It is an inhibitor of the mitogenic activity of EGF and a G1 phase cell cycle inhibitor. It selectively inhibits isoleucyl-trna synthetase. It has anti-proliferation effect on human cell lines KB and K562, and has potent antifungal activity. Synonyms: (-)-Reveromycin A; [2S-[2α(1E, 3E), 3β, 6α[8S*(2E, 4E, 6R*, 7R*, 8E), 9R*]]]-butanedioic acid mono[3-butyl-8-(9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl)-2-(4-carboxy-3-methyl-1,3-butadienyl)-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester; Butanedioic Acid Mono[(2S,3R,6S,8R,9S)-3-butyl-8-[(2E,4E,6S,7S,8E)-9-carboxy-6-hydroxy-3,7-dimethyl-2,4,8-nonatrienyl]-2-[(1E,3E)-4-carboxy-3-methyl-1,3-butadienyl]-9-methyl-1,7-dioxaspiro[5.5]undec-3-yl] Ester. Grades: >99% by HPLC. CAS No. 134615-37-5. Molecular formula: C36H52O11. Mole weight: 660.79. |  |
| Reveromycin B | Reveromycin B is an much less active analogue of reveromycin A formed by rearrangement of the 6to6 spiroketal to a 5to6 spiroketal. Lacking much of the biological activity of reveromycin A, the reveromycin B is a useful negative control in resolving the mode of action of this class. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-68-4. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Reveromycin B | Reveromycin B is a polyketide antibiotic isolated from Streptomyces, which can inhibit mitotic activity. Synonyms: BDBM50217842; ZINC49871994. Grades: >98% by HPLC. CAS No. 144860-68-4. Molecular formula: C36H52O11. Mole weight: 660.79. | |
| Reveromycin C | Reveromycin C is a minor analogue of the reveromycin complex isolated from a Streptomyces sp. Published information suggests that reveromycin C exhibits comparable potency to reveromycin A, its butyl homologue. In Microbial Screening Technologies in-house screens Reveromycins C and A had similar biological profiles but Reveromycin C was generally more potent. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-69-5. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
| Reveromycin C | Reveromycin C is a polyketide isolated from Streptomyces. It is an antibiotic inhibitor with mitotic activity that responds to EGF. Grades: >95% by HPLC. CAS No. 144860-69-5. Molecular formula: C37H54O11. Mole weight: 674.82. | |
| Reveromycin D | Reveromycin D is a bacterial metabolite isolated from Streptomyces. It inhibits EGF-induced mitotic activity in Balb/MK cells and has pH-dependent antifungal activity against Candida albicans. Grades: >95% by HPLC. CAS No. 144860-70-8. Molecular formula: C37H54O11. Mole weight: 674.82. | |
| Reveromycin D | Reveromycin D, the isopentyl analogue, is a minor component of the reveromycin complex isolated from a Streptomyces sp. Published information on reveromycin D suggests that it is more active than its straight chain analogue, reveromycin C. Group: Biochemicals. Grades: Highly Purified. CAS No. 144860-70-8. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
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