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| Product | Description | |
|---|---|---|
| Reverse Transcriptase from HIV, Recombinant | Chromatographically purified heterodimer composed of 66kDa and 51kDa subunits. Supplied as a solution in 10mM potassium phosphate, pH 7.4, 1mM DTT and 20% glycerol. Primarily for AIDS research purposes; this enzyme has less fidelity than the AMV enzyme in other applications such as the preparation of cDNA from mRNA for cloning purposes. Applications: Hiv reverse transcriptase is used for research on the aids primer. however it can be substituted for amv reverse transcriptase, which is mainly used to transcribe mrna into double stranded cdna, that can be inserted into prokaryotic vectors. the enzyme can also be used with either single stranded dna or rna templates to mak...or labeling the termini of dna fragments with protruding 5' termini. the enzyme can also be used to sequence dnas by the dideoxy chain termination method of sanger when the klenow fragment of e. coli dna polymerase i, or the t7 dna polymerase yield unsatisfactory results. Group: Enzymes. Synonyms: Reverse transcriptase; RT. Enzyme Commission Number: EC 2.7.7.49. CAS No. 9068-38-6. Purity: Chromatographically purified. RT. Mole weight: 66 kDa and 51 kDa. Activity: > 5,000 units per mg protein. Storage: Store at -20°C. Form: A solution in 10mM potassium phosphate, pH 7.4, 1mM DTT and 20% glycerol. Source: E. coli. Species: HIV. Reverse transcriptase; RT. Cat No: NATE-0987. |  |
| Reverse Transcriptase from Moloney Murine Leukemia Virus, Recombinant | This Reverse Transcriptase has exceptionally strong strand displacement activity and enables efficient preparation of cDNA up to 12 kb in length. It is robust, versatile and well-suited for applications requiring full-length cDNA such as preparation of cDNA libraries and other techniques involving first strand cDNA synthesis (RT-PCR, preparation of cDNA probes, real-time quantitative RT-PCR). It can be used for performing a reverse transcription reaction with any RNA template including GC-rich templates and RNAs with high levels of secondary structure. This enzyme is a modified, recombinant MMLV (Moloney Murine Leukemia Virus) reverse transcriptase and is v...ptases tested; 4. highly specific: low rates of non-specific annealing, even on incompletely denatured rna; 5. works on challenging templates: excellent results even with gc-rich templates and templates with high levels of secondary structure 6. highly sensitive: use less of your precious rna samples; 7. demonstrated success with reverse transcription reaction times of 30 min. (60 min. for longer transcripts). Applications: Rt-pcr; first strand cdna synthesis; cdna probe preparation; synthesis of cdna libraries with a high proportion of full-length cdnas. Group: Enzymes. Synonyms: Reverse transcriptase; RT. RT. Storage: Storage at-20°C. Source: E. coli. Spec | |
| Reverse transcriptase-IN-1 | Reverse transcriptase-IN-1 (Compound 12z), a diarylbenzopyrimidine (DABP) analogue, is a potent, orally active HIV-1 nonnucleoside reverse transcriptase inhibitor. Reverse transcriptase-IN-1 has antiviral activity with EC 50 values of 3.4 nM, 4.3 nM and 3.6 nM for HIV-1 III B , E138K and K103N mutants, respectively. Reverse transcriptase-IN-1 also has an IC 50 of 13.7 nM against HIV-1 reverse transcriptase enzyme [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2380001-43-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130241. |  |
| 5X Reaction Buffer for Reverse Transcriptase, M-MLV (M-MLV-RT) | 5X Reaction Buffer for Reverse Transcriptase, M-MLV (M-MLV-RT). Group: Molecular Biology. Alternative Names: Moloney Murine Leukemia Virus; RNA-dependant DNA Polymerase. Grades: Molecular Biology Grade. Pack Sizes: 1ml. US Biological Life Sciences. |  Worldwide |
| Native Avian myeloblastosis virus AMV-Reverse Transcriptase | A Reverse transcriptase (RT) is an enzyme used to geneRate complementary DNA (cDNA) from an RNA template, a process termed reverse transcription. It is mainly associated with retroviruses. However, non-retroviruses also use RT (for example, the hepatitis B virus, a member of the Hepadnaviridae, which are dsDNA-RT viruses, while retroviruses are ssRNA viruses). RT inhibitors are widely used as antiretroviral drugs. RT activities are also associated with the replication of chromosome ends (telomerase) and some mobile genetic elements (retrotransposons). Applications: Amv reverse transcriptase synthesizes dna complementary (cdna) to rna templates. a dna primer complementary to the rna template and a divalent cation, either mg or mn, are required for initiation of transcription. this enzyme is commonly used to make cdnas from mrna for eventual cloning or for use as probes. Group: Enzymes. Synonyms: DNA nucleotidyltransferase (RNA-directed); reverse transcripta. Enzyme Commission Number: EC 2.7.7.49. CAS No. 9068-38-6. RT. Storage: -70°C. Source: Avian myeloblastosis virus. DNA nucleotidyltransferase (RNA-directed); reverse transcriptase; revertase; RNA-dependent deoxyribonucleate nucleotidyltransferase; RNA revertase; RNA-dependent DNA polymerase; RNA-instructed DNA polymerase; RT; EC 2.7.7.49; 9068-38-6. Cat No: NATE-0073. | |
| Telomerare Reverse Transcriptase (hTRT) (653-661) | Human telomerase reverse transcriptase is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Synonyms: hTRT (653-661). |  |
| 11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]. diazepin-6-one | 11-Cyclopropyl-5,11-dihydro-4-(hydroxymethyl)-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one, is a metabolite of Nevirapine (N391275), which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. It is also an antiviral. Group: Biochemicals. Alternative Names: 12-Hydroxy Nevirapine. Grades: Highly Purified. CAS No. 133627-24-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 11-Cyclopropyl-5, 11-dihydro-4-[[ (methylsulfonyl) oxy]methyl]-6H-dipyrido[3, 2-b: 2', 3'-e][1, 4]diazepin-6-one | 11-Cyclopropyl-5, 11-dihydro-4-[[ (methylsulfonyl) oxy]methyl]-6H-dipyrido[3, 2-b: 2', 3'-e][1, 4]diazepin-6-one is an intermediate in synthesizing Nevirapine-d1 (N391279), an isotope labelled Nevirapine (N391275), which acts as a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 1046462-02-5. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H16N4O4S. US Biological Life Sciences. | Worldwide |
| 11-Cyclopropyl-5, 11-dihydro-4-[[ (methylsulfonyl) oxy]methyl]-6H-dipyrido[3, 2-b: 2', 3'-e][1, 4]diazepin-6-one-d2 | 11-Cyclopropyl-5, 11-dihydro-4-[[ (methylsulfonyl) oxy]methyl]-6H-dipyrido[3, 2-b: 2', 3'-e][1, 4]diazepin-6-one is an intermediate in synthesizing Nevirapine-d2 (N391276), an isotope labelled Nevirapine (N391275), which acts as a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C16H14D2N4O4S. US Biological Life Sciences. | Worldwide |
| 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil | 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-b-L-ribofuranosyl)-uracil, a pharmacological compound renowned for its potent antiviral properties, is extensively employed as a therapeutic agent in the management of human immunodeficiency virus (HIV) infections. Its mechanism of action entails the inhibition of reverse transcriptase, a pivotal enzyme indispensable for viral replication. Synonyms: 1-(2',3'-Dideoxy-2',3'-didehydro-2'-fluoro-5'-O-trityl-β-L-ribofuranosyl)-uracil. Molecular formula: C28H23FN2O4. Mole weight: 470.49. | |
| 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine | 1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)thymine is a nucleoside analogue used in antiviral research. It's primarily used in research of antiretroviral therapies, specifically combating HIV due to its ability to inhibit reverse transcriptase, a key enzyme in HIV replication. Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxy-2'-fluoro-5-methyl-b-D-arabinouridine; 1-{5-O-[Bis-(4-Methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-D-arabinofuranosyl}-5-methyl-2,4(1H,3H)-pyrimidinedione; 5'-O-(dimethoxytrityl)-2'-β-fluorothymidine. Grades: ≥98% by HPLC. CAS No. 144822-48-0. Molecular formula: C31H31FN2O7. Mole weight: 562.59. | |
| 1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose | 1,2-Di-O-acetyl-5-O-benzoyl-3-deoxy-3-fluoro-D-ribofuranose is a biomedical intermediate often utilized in the synthesis of antiviral drugs. Its derivatives demonstrate potential activity against diseases like HIV and Hepatitis B by inhibition of reverse transcriptase. Synonyms: (3S,4S,5R)-5-((Benzoyloxy)methyl)-4-fluorotetrahydrofuran-2,3-diyl diacetate. CAS No. 159099-24-8. Molecular formula: C16H17FO7. Mole weight: 340.3. | |
| 12-Hydroxy Nevirapine 12-O- β-D-Glucuronide | 12-Hydroxy Nevirapine 12-O- β-D-Glucuronide is the O-glucuronide derivative of 12-Hydroxy Nevirapine (C988365); a metabolite of Nevirapine (N391275) which is a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Also antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 245500-95-2. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C21H22N4O8, Molecular Weight: 458.42. US Biological Life Sciences. | Worldwide |
| 1- (2- ( (tert-Butyldimethylsilyl) oxy) -5-chlorophenyl) -2, 2, 2-trifluoroethanone | 1- (2- ( (tert-Butyldimethylsilyl) oxy) -5-chlorophenyl) -2, 2, 2-trifluoroethanone is an intermediate in the synthesis of Efavirenz De(1-amino-3-oxo)-1-oxo-3-amine, which is an analog of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250mg, 500mg. Molecular Formula: C14H18ClF3O2Si. US Biological Life Sciences. | Worldwide |
| 1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine | 1-(3-beta-Amino-2,3-dideoxy-beta-D-threopenta-furanosyl)thymine is a nucleoside analogue used in the treatment of HIV-1 infected patients in combination with other antiretroviral drugs. It specifically targets the reverse transcriptase enzyme of the virus, preventing it from replicating and reducing viral load. Synonyms: 3'-beta-Amino-3'-deoxy thymidine; Thymidine, 3'-amino-3'-deoxy-; 1-((2R,4R,5S)-4-Amino-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(3'-amino-2',3'-dideoxy-β-D-xylofuranosyl)thymidine; 1-(3-Amino-2,3-dideoxy-β-D-threo-pentofuranosyl)thymine. Grades: ≥95%. CAS No. 73971-79-6. Molecular formula: C10H15N3O4. Mole weight: 241.24. | |
| 1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine | 1-(3-beta-Azido-2,3-dideoxy-5-O-trityl-beta-D-threopenta-furanosyl)thymine is a potent antiviral drug used in the treatment of HIV/AIDS and hepatitis B virus infections. It works by inhibiting the reverse transcriptase enzyme, preventing the virus from replicating and spreading within the body. Research has also shown promising results in using this compound as a potential treatment for certain types of cancers. Synonyms: 3'-beta-Azido-3'-deoxy-5'-O-trityl thymidine; 1-[3'-azido-2',3'-dideoxy-5'-(triphenylmethyl)-β-D-threo-pentofuranosyl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-((2R,4R,5S)-4-azido-5-((trityloxy)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 3'-β-Azido-3'-deoxy-5'-O-trityl thymidine. Grades: ≥95%. CAS No. 66503-47-7. Molecular formula: C29H27N5O4. Mole weight: 509.56. | |
| 1,3-Bis(methoxymethyl)-2-nitrobenzene | 1,3-Bis(methoxymethyl)-2-nitrobenzene is an intermediate in the synthesis of 2,6-Dihydroxymethyl Rilpivirine (D446615), which is an analog of Rilpivirine (R509800) a novel non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. An anti-HIV agent. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 50mg. Molecular Formula: C10H13NO4. US Biological Life Sciences. | Worldwide |
| 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phos-phino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil | 1-[(5E)-3-O-[(Bis-diisopropylamino)(2-cyanoethoxy)phos-phino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]uracil, a potent agent for the treatment of human immunodeficiency virus (HIV) infections, functions as a viral replication inhibitor by suppressing the reverse transcriptase enzyme. Its intricate molecular structure reflects the sophisticated nature of modern pharmaceuticals, which require cutting-edge research and development to ultimately undo the feats of viruses and other elusive adversaries. Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(5E)-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-. Grades: ≥95%. CAS No. 2361324-80-1. Molecular formula: C24H40N4O9P2. Mole weight: 590.54. | |
| 1-[(5E)-5,6-Dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-β-D-ribo-hex-5-enofuranosyl]uracil | The nucleoside analogue, 1-[(5E)-5,6-dideoxy-6-(diethoxyphosphinyl)-2-O-(2-methoxyethyl)-β-D-ribo-hex-5-enofuranosyl]uracil, is a potent antiviral weapon against both HIV and hepatitis B. By inhibiting viral reverse transcriptase, it has the power to eliminate viral replication and halt spreading within the body. Its effectiveness is further amplified when used in tandem with other antiretroviral drugs, which substantially reduces the risk of drug resistance. Grades: ≥95%. Molecular formula: C17H27N2O9P. Mole weight: 434.38. | |
| 1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-β-D-ribo-hex-5-enofuranosyl)uracil | 1-[(5E)-5,6-Dideoxy-6-phosphono-2-O-methyl-β-D-ribo-hex-5-enofuranosyl)uracil, an inhibitor derived amidst nucleoside analogues, is widely employed to counteract hepatitis B virus contagion, reflecting its potential to quash the reverse transcriptase enzyme's functionality, ultimately mitigating the virus's replication ability and, in turn, reducing the viral load in the body. Its efficacy, when combined with other antiviral drugs, exponentially augments its curative prowess, making it the go-to option for preemptive treatment of prolonged hepatitis B. Grades: ≥95%. CAS No. 2095417-50-6. Molecular formula: C11H15N2O8P. Mole weight: 334.22. | |
| 1-Phenoxy-2-propanol | 1-Phenoxy-2-propanol is a useful synthetic intermediate. It was used in the preparation of acylarylthiocarbamates as nonnucleoside reverse transcriptase inhibitors. Group: Biochemicals. Alternative Names: (±)-1-Phenoxy-2-propanol; 2-Phenoxy-1-methylethanol; NSC 24015; Phenoxyisopropanol; Propylene phenoxetol; rac-1-Phenoxy-2-propanol; β-Phenoxyisopropanol. Grades: Highly Purified. CAS No. 770-35-4. Pack Sizes: 25g, 100g. Molecular Formula: C?H??O?, Molecular Weight: 152.19. US Biological Life Sciences. | Worldwide |
| 1-Phenoxy-d5-2-propanol | 1-Phenoxy-d5-2-propanol is the labeled analogue of 1-Phenoxy-2-propanol (P301700), a useful synthetic intermediate. It was used in the preparation of acylarylthiocarbamates as nonnucleoside reverse transcriptase inhibitors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 50mg, 500mg. Molecular Formula: C9H7D5O2, Molecular Weight: 157.22. US Biological Life Sciences. | Worldwide |
| [ [ (1R) -2- (6-Amino-9H-purin-9-yl) -1-methylethoxy] methyl] monophenylester | [ [ (1R) -2- (6-Amino-9H-purin-9-yl) -1-methylethoxy] methyl] monophenylester is an antiviral agent and a Tenofovir (T018500) intermediate. Tenofovir is an acyclic phosphonate nucleotide analogue and reverse transcriptase inhibitor, used as an anti-HIV agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 379270-35-6. Pack Sizes: 250mg, 1g. Molecular Formula: C15H18N5O4P. US Biological Life Sciences. | Worldwide |
| (1R, 2R) -2- methyl cyclopropanecarboxylic Acid | (1R, 2R) -2- methyl cyclopropanecarboxylic Acid, is an intermediate used for the synthesis of (1R,2R)-trans-1-(Chloromethyl)-2-methylcyclopropane (C369820). It can also be used for the preparation of Luzopeptin A-C and Quinoxapeptin A-C, acting as potent inhibitors of HIV-1 reverse transcriptase. Group: Biochemicals. Grades: Highly Purified. CAS No. 10487-86-2. Pack Sizes: 500mg, 5g. Molecular Formula: C5H8O2, Molecular Weight: 100.12. US Biological Life Sciences. | Worldwide |
| (1R,2S,5R)-Menthol-5R-hydroxy-[1,3]-oxathiolane-2R-carboxylate | (1R,2S,5R)-Menthol-5R-hydroxy-[1,3]-oxathiolane-2R-carboxylate is an intermediate of Lamivudine, a potent nucleoside reverse transcriptase inhibitor and antiviral agent. Lamivudine has also been used for treatment of chronic hepatitis B. Synonyms: (2S,5R)-5-Hydroxy[1,3]oxathiolane-2-carboxylic Acid L-Menthol Ester; (1R,2S,5R)-Menthol-5R-hydroxy Acid 2-Isopropyl-5-methyl-cyclohexyl Ester; HME; Lamivudine Impurity 8; (1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl (2R,5R)-5-hydroxy-1,3-oxathiolane-2-carboxylate; 1,3-Oxathiolane-2-carboxylic acid, 5-hydroxy-, (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester, (2R,5R)-. Grades: 98%. CAS No. 147126-62-3. Molecular formula: C14H24O4S. Mole weight: 288.40. | |
| (1R, 3R, 4R)- Entecavir | An isomer of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: (1R,3R,4R)-Entecavir ; 2-Amino-9-[(1R,3R,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylidene cyclopentyl]-6,9-dihydro-3H-purin-6-one. Grades: > 95%. CAS No. 1367369-76-3. Molecular formula: C12H15N5O3. Mole weight: 277.29. | |
| (1R, 3S, 4R)-ent-Entecavir | An isomer of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 2-Amino-1,9-dihydro-9-[(1R,3S,4R)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-Purin-6-one. Grades: > 95%. CAS No. 188399-46-4. Molecular formula: C12H15N5O3. Mole weight: 277.29. | |
| (1R, 3S, 4S)-Entecavir | An isomer of Entecavir. Entecavir is a reverse transcriptase inhibitor. It prevents the hepatitis B virus from multiplying and reduces the amount of virus in the body. Synonyms: 2-Amino-9-[(1R, 3S, 4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidene cyclopentyl]-6,9-dihydro-3H-purin-6-one. Grades: > 95%. Molecular formula: C12H15N5O3. Mole weight: 277.29. | |
| (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester | (1R, 4R) -4-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate in synthesizing trans-Abacavir Dihydrochloride (A104995), which is an impurity of Abacavir. Abacavir (A104990) is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 168958-19-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C12H19NO4. US Biological Life Sciences. | Worldwide |
| (1R,4R)-rel-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester Hydrochloride | (1R,4R)-rel-4-Amino-2-cyclopentene-1-carboxylic Acid Methyl Ester is an intermediate used in the synthesis of the HIV reverse transcriptase inhibitor ziagen. Group: Biochemicals. Grades: Highly Purified. CAS No. 77745-26-7. Pack Sizes: 10mg, 25mg. Molecular Formula: C7H12ClNO2. US Biological Life Sciences. | Worldwide |
| (1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol | (1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol is an intermediate used in the synthesis of ent-Abacavir, which is an enantiomer of Abacavir. Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. CAS No. 216481-88-8. Molecular formula: C11H12ClN5O. Mole weight: 265.7. | |
| ((1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl Formate | ((1R,4S)-4-(2-Amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methyl Formate is an impurity of Abacavir (A105000), a nucleoside reverse transcriptase inhibitor (NRTI) used for treating HIV infection. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 50mg. Molecular Formula: C12H12ClN5O2, Molecular Weight: 293.709999999999. US Biological Life Sciences. | Worldwide |
| 1'-rac-4'S-Emtricitabine 5'-O-Benzoyl | 1'-rac-4'S-Emtricitabine 5'-O-Benzoyl is a protected intermediate in the synthesis of ent-Emtricitabine, a reverse transcriptase inhibitor that is effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Molecular formula: C15H14FN3O4S. Mole weight: 351.35. | |
| 1-rac-4S-Emtricitabine 5-O-Benzoyl | 1-rac-4S-Emtricitabine 5-O-Benzoyl is an protected intermediate in the synthesis of ent-Emtricitabine (E525005), a reverse transcriptase inhibitor that is effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (1R-cis)-N-[2-amino-4-chloro-6-[[4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-pyrimidinyl]-formamide | (1R-cis)-N-[2-amino-4-chloro-6-[[4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-pyrimidinyl]-formamide is an intermediate used in the synthesis of the HIV reverse transcriptase inhibitor ziagen. Group: Biochemicals. Grades: Highly Purified. CAS No. 171887-04-0. Pack Sizes: 25mg, 50mg. Molecular Formula: C11H14ClN5O2, Molecular Weight: 283.709999999999. US Biological Life Sciences. | Worldwide |
| (1S,2R,4R)-1-Isopropyl-2,4-dimethylcyclohexyl-emtricitabine Uracil Carboxylate | It is the uracil impurity of the parent compound Emtricitabine, a reverse transcriptase inhibitor. Synonyms: 5-Fluoro-1-(2'-L-menthyloxycarbonyl-1'-3'-oxathiolan-5'-yl)-cytosine; (2R,5S)-(1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl 5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate; (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl (2R,5S)-5-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-1,3-oxathiolane-2-carboxylate. Grades: ≥95%. CAS No. 1422361-25-8. Molecular formula: C18H25FN2O5S. Mole weight: 400.46. | |
| (1Z)-Rilpivirine | (1Z)-Rilpivirine is a stereoisomer of Rilpivirine (R509800) which is a non-nucleoside reverse transcriptase inhibitor. Rilpivirine seems to be well tolerated with less CNS disturbance than Efavirenz, and has non-teratogenic potential. Group: Biochemicals. Grades: Highly Purified. CAS No. 500287-94-5. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H18N6, Molecular Weight: 366.42. US Biological Life Sciences. | Worldwide |
| 2- (2- (2- ( (tert-Butyldimethylsilyl) oxy) ethyl) -5-chlorophenyl) -4-cyclopropyl-1, 1, 1-trifluorobut-3-yn-2-ol | 2- (2- (2- ( (tert-Butyldimethylsilyl) oxy) ethyl) -5-chlorophenyl) -4-cyclopropyl-1, 1, 1-trifluorobut-3-yn-2-ol is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C21H28ClF3O2Si. US Biological Life Sciences. | Worldwide |
| 2,2,2-Trifluoroethanol-1,1-d2 | Isotope labelled 2,2,2-Trifluoroethanol (T790175), is used in the synthesis of competitive inhibitors for phospholipase A2. Used in the preparation of a key Efavirenz (E425000) intermediate, a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. CAS No. 132248-58-9. Pack Sizes: 100mg, 250mg. Molecular Formula: C2HD2F3O, Molecular Weight: 102.05. US Biological Life Sciences. | Worldwide |
| 2- ( (2- ( (4-Cyanophenyl) amino) pyrimidin-4-yl) amino) -5- (2-cyanovinyl) -3-methylbenzoic Acid Methyl Ester | 2- ( (2- ( (4-Cyanophenyl) amino) pyrimidin-4-yl) amino) -5- (2-cyanovinyl) -3-methylbenzoic Acid Methyl Ester is an impurity in the synthesis of analogs of Rilpivirine (R509800), a novel non-nucleoside reverse transcriptase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C23H18N6O2. US Biological Life Sciences. | Worldwide |
| 2- (2- ( (tert-Butyldimethylsilyl) oxy) ethyl) -5-chlorobenzoic Acid Trifluoromethyl Ester | 2- (2- ( (tert-Butyldimethylsilyl) oxy) ethyl) -5-chlorobenzoic Acid Trifluoromethyl Ester is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H22ClF3O3Si. US Biological Life Sciences. | Worldwide |
| 2,3,4,6-Tetra-O-benzoyl-D-mannopyranose | 2,3,4,6-Tetra-O-benzoyl-D-mannopyranose is a commonly used synthetic reagent in the biomedical industry. Mainly utilized in the development of anti-HIV drugs, it assists in inhibiting reverse transcriptase to slow the virus's replication process. Synonyms: D-Mannopyranose, 2,3,4,6-tetrabenzoate; 2-O,3-O,4-O,6-O-Tetrabenzoyl-D-mannopyranose; (2R,3R,4S,5S)-2-((benzoyloxy)methyl)-6-hydroxytetrahydro-2H-pyran-3,4,5-triyl tribenzoate. Grades: ≥95%. CAS No. 627466-98-2. Molecular formula: C34H28O10. Mole weight: 596.58. | |
| 2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine | 2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxycytidine is a chemical compound with potential applications in research of viral infections due to its inhibition of reverse transcriptase, an enzyme used by viruses, including HIV, to replicate within host cells. Synonyms: 2,3'-Anhydro-5'-O-benzoyl-N4-benzoyl-2'-deoxy-D-cytidine. Molecular formula: C23H21N3O5. Mole weight: 419.44. | |
| 2',3'-Anhydrothymidine | 2',3'-Anhydrothymidine is a nucleoside analog used in biomedicine for antiviral research. It demonstrates activity against HIV, serving as a potent inhibitor by blocking reverse transcriptase. Synonyms: 1-(2,3-Anhydro-b-D-lyxofuranosyl)-thymine. CAS No. 14486-22-7. Molecular formula: C10H12N2O5. Mole weight: 240.21. | |
| 2',3'-Dideoxy-2',2'-difluorocytidine | 2',3'-Dideoxy-2',2'-difluorocytidinea potent antiviral agentfinds clinical application in the management of HIV and hepatitis B virus (HBV) infections. By impeding the reverse transcriptase enzyme, it effectively hampers viral replication. This nucleoside analogue demonstrates a remarkable affinity for viral polymerases, ensuring minimal toxicity to host cells. Synonyms: 4-amino-1-((2R,5S)-3,3-difluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. CAS No. 124708-94-7. Molecular formula: C9H11F2N3O3. Mole weight: 247.20. | |
| 2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine | 2',3'-Dideoxy-2',3'-didehydro-2'-fluorocytidine, a remarkable and potent antiviral marvel, emerges as a beacon of promise in the battle against the formidable adversaries HIV and hepatitis B. Acting with surgical precision, this miraculous agent exclusively targets and obstructs the reverse transcriptase enzyme, abruptly arresting viral replication and decisively quelling the burdensome viral load. Synonyms: 2,3-Ddfc; 2'-Fd4C. CAS No. 122757-53-3. Molecular formula: C9H10FN3O3. Mole weight: 227.19. | |
| 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-cytidine | It is a nucleoside reverse transcriptase inhibitor (NRTI) with the potential to inhibit HIV-1 replication. Uses: Anti-hiv agents. Synonyms: FddddC; Dexelvucitabine; 5-Fluoro-1-(2',3'-dideoxy-2',3'-didehydro-b-D-arabinofuranosyl)-cytosine; Reverset; DFC; 4-Amino-5-fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-2(1H)-pyrimidinone. Grades: ≥95%. CAS No. 134379-77-4. Molecular formula: C9H10FN3O3. Mole weight: 227.19. | |
| 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine | 2',3'-Dideoxy-2',3'-didehydro-5-fluoro-uridine is a synthetic nucleoside analogue with potential antiviral activity. It's primarily utilized in theresearch of HIV, halting virus replication by interfering with the enzyme reverse transcriptase. Synonyms: FddddU; NSC 125562; 5-Fluoro-1-[(2R,5S)-5-(hydroxymethyl)-2,5-dihydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione. Grades: ≥95%. CAS No. 15379-29-0. Molecular formula: C9H9FN2O4. Mole weight: 228.18. | |
| 2',3'-Dideoxy-3',5-difluorocytidine | 2',3'-Dideoxy-3',5-difluorocytidine is a potent antiviral drug used in the treatment of HIV and AIDS. It inhibits the reverse transcriptase enzyme, preventing the conversion of viral RNA to DNA. This drug is an effective option for patients with viral resistance to other antivirals, offering hope in managing these infections effectively. Synonyms: 4-amino-5-fluoro-1-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one. CAS No. 134379-78-5. Molecular formula: C9H11F2N3O3. Mole weight: 247.20. | |
| 2',3'-Dideoxyadenosine-5'-monothiophosphate | 2',3'-Dideoxyadenosine-5'-monothiophosphate is a vital compound used in the biomedicine industry. Acting as a nucleotide analogue, it inhibits viral reverse transcriptase and DNA polymerase, thus displaying antiviral activity against various retroviruses. Synonyms: 2',3'-Dideoxyadenosine-5'-monothiophosphate; 1266500-93-9; SCHEMBL20028990; SCHEMBL21636992; SCHEMBL22990586. Grades: ≥ 95% (HPLC). CAS No. 1266500-93-9. Molecular formula: C10H14N5O4PS. Mole weight: 331.29. | |
| 2',3'-Dideoxyadenosine-5'-O-(1-Thiotriphosphate) | 2',3'-Dideoxyadenosine-5'-O-(1-Thiotriphosphate) is a biomedically significant reagent used to investigate the intricate mechanisms of DNA synthesis and repair. As a non-hydrolyzable analog of adenosine triphosphate (ATP), it is implicated in inhibiting the activity of reverse transcriptase - a vital aspect of HIV/AIDS treatment. With its remarkable affinity and specificity towards RNA polymerase and other enzymes central to DNA metabolism, this powerful tool is a prized asset for researchers in the biomedical field. Synonyms: Alpha Thiol ddATP; 1-Thio-ddATP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H16N5O10P3S. Mole weight: 491.20. | |
| 2',3'-Dideoxyadenosine 5'-Triphosphate | ddATP is an inhibitor of reverse transcriptases from retroviruses, such as HIV-1 and visna (Kis = 20 and 37 nM, respectively). ddATP is commonly used to terminate chain extension produced by the Taq polymerase for its competitive effect with dATP in cells. Uses: Ddatp is an inhibitor of reverse transcriptases from retroviruses. Synonyms: [[(2S,5R)-5-(6-aminopurin-9-yl)-2-oxolanyl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate; [[(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate. Grades: ≥ 98 % by HPLC. CAS No. 24027-80-3. Molecular formula: C10H16N5O11P3. Mole weight: 475.18. | |
| 2',3'-Dideoxyadenosine-5'-Triphosphate | 2',3'-Dideoxyadenosine-5'-Triphosphate is a nucleoside triphosphate analogue commonly used in biomedical research to study polymerases and reverse transcriptases. It can be incorporated into DNA or RNA strands, resulting in chain termination and inhibition of replication. Additionally, 2',3'-Dideoxyadenosine-5'-Triphosphate has potential antiviral properties and has been studied as a treatment for HIV and hepatitis B. Synonyms: ddATP. Grades: ≥95% by AX-HPLC. Molecular formula: C10H16N5O11P3. Mole weight: 475.10. | |
| 2',3'-Dideoxycytidine-5'-O-(1-Thiotriphosphate) | 2',3'-Dideoxycytidine-5'-O-(1-Thiotriphosphate), often referred to as ddCTP, is a crucial analog used in the biomedical field. This potent inhibitor of reverse transcriptase has been lauded for its effectiveness in hindering viral replication. Specifically, ddCTP is frequently utilized in the treatment of HIV and AIDS due to its ability to stop the reverse transcriptase enzyme from catalyzing the formation of DNA from RNA. Synonyms: Alpha Thiol ddCTP; 1-Thio-ddCTP. Grades: ≥90% by AX-HPLC. Molecular formula: C9H16N3O11P3S. Mole weight: 467.23. | |
| 2',3'-Dideoxyguanosine-5'-O-(1-Thiotriphosphate) | 2',3'-Dideoxyguanosine-5'-O-(1-Thiotriphosphate), a potent nucleotide analog, serves as a promising biomedical product towards combatting multiple viral infections such as human immunodeficiency virus (HIV) and hepatitis C virus (HCV). Not only does this chain-terminating inhibitor effectively target viral reverse transcriptase and RNA polymerase, but it also displays promising results in cancer treatment and cell signaling research. Its potential to revolutionize antiviral therapy warrants further exploration. Synonyms: Alpha Thiol ddGTP; 1-Thio-ddGTP. Grades: ≥90% by AX-HPLC. Molecular formula: C10H16N5O11P3S. Mole weight: 507.25. | |
| 2',3'-Dideoxyguanosine (ddG) | 2',3'-Dideoxyguanosine (ddG) is a potent inhibitor of reverse transcriptase, used in the research of HIV. This biomolecule halts HIV replication by terminating the DNA chain during replication. Grades: ≥ 98% by HPLC. Molecular formula: C10H13N5O3. Mole weight: 251.24. | |
| 2',3'-Dideoxyinosine-5'-monophosphate sodium salt | 2',3'-Dideoxyinosine-5'-monophosphate sodium salt, a remarkable pharmaceutical compound, emerges as a pivotal player in the battle against human immunodeficiency virus (HIV) infection. Exhibiting its prowess as an antiviral agent, this compound effectively thwarts the replication of the virus by inhibiting the reverse transcriptase enzyme. Synonyms: Didanosine 5'-monophosphate sodium salt. Molecular formula: C10H11N4O6P·Na2. Mole weight: 360.17. | |
| 2',3'-Dideoxyinosine-5'-Triphosphate | 2',3'-Dideoxyinosine-5'-Triphosphate, a nucleoside analogue predominantly employed for investigating facets of DNA and RNA replication, impeding reverse transcriptases, and regulating DNA polymerases, exhibits immense potential as an efficient therapeutic agent against a host of viral infections, such as HIV. Synonyms: ddITP; Didanosine triphosphate. Grades: ≥90% by AX-HPLC. Molecular formula: C10H15N4O12P3. Mole weight: 476.10. | |
| 2',3'-Dideoxyinosine-5'-triphosphate triethylammonium salt | 2',3'-Dideoxyinosine-5'-triphosphate triethylammonium salt, a paramount chemical compound employed in biomedical research, exhibits its significance. Functioning as a nucleotide analogue, it proficiently impedes the reverse transcriptase activity of HIV, the causative agent of AIDS. Its versatile attributes have merited its application in the creation of antiviral medications, specifically designed to combat HIV/AIDS and tackle associated ailments. Synonyms: Didanosine 5'-triphosphate sodium salt. CAS No. 122406-02-4. Molecular formula: C10H15N4O12P3. Mole weight: 476.17. | |
| 2',3'-Dideoxyinosine-5'-triphosphate trisodium salt | 2',3'-Dideoxyinosine-5'-triphosphate trisodium salt is a potent adversary for HIV reverse transcriptase, occupiing a position in the research of antiretroviral therapeutic applications designed to curb HIV infections. Synonyms: Sodium ((2S,5R)-5-(6-hydroxy-9H-purin-9-yl)tetrahydrofuran-2-yl)methyl hydrogentriphosphate. CAS No. 137629-34-6. Molecular formula: C10H12N4Na3O12P3. Mole weight: 542.11. | |
| 2-(4-Bromophenyl)-acetamidine | 2-(4-Bromophenyl)-acetamidine is a bromo-substituted analog of 2-Phenylacetamidine; a useful synthetic intermediate used in the synthesis of non-nucleoside reverse transcriptase inhibitors. 2-Phenylacetamidine is also used to prepare naltrexone-derived pyrido- and pyrimidomorphinans. Group: Biochemicals. Grades: Highly Purified. CAS No. 59104-21-1. Pack Sizes: 1g, 10g. Molecular Formula: C8H9BrN2, Molecular Weight: 213.07. US Biological Life Sciences. | Worldwide |
| 2,4-Dichloro-6-methyltriazine | 2,4-Dichloro-6-methyltriazine is a reagent used to prepare triazinyl-amines as inhibitors of HIV-1 reverse transcriptase. It is also used in the synthesis of anilinotriazine corticotropin releasing hormone antagonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 1973-4-2. Pack Sizes: 500mg, 1g. Molecular Formula: C4H3Cl2N3, Molecular Weight: 163.99. US Biological Life Sciences. | Worldwide |
| 2,4-Difluorobenzylamine | 2,4-Difluorobenzylamine acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarbox yl ic acids as HIV reverse transcriptase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 72235-52-0. Pack Sizes: 1g, 5g. Molecular Formula: C7H7F2N, Molecular Weight: 143.13. US Biological Life Sciences. | Worldwide |
| 2,4-Dimethyl-6-nitroaniline | 2,4-Dimethyl-6-nitroaniline is used as a reagent in the synthetic preparation of 1,2-bis-substituted benzimidazoles as nonnucleoside HIV-1 reverse transcriptase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 1635-84-3. Pack Sizes: 500mg, 1g. Molecular Formula: C8H10N2O2, Molecular Weight: 166.18. US Biological Life Sciences. | Worldwide |
| 2,4-Dithiothymidine | 2,4-Dithiothymidine is intrinsically a chemical kin of Thymidine, routinely finding employment in research geared toward antiviral solutions. It stipulates a substantial propitious capacity in ameliorating maladies of viral origin, notably HIV, via the inhibition of HIV-1 reverse transcriptase thereby potentially throwing into disarray the virus's vital event sequence. Synonyms: 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dithione. CAS No. 28585-52-6. Molecular formula: C10H14N2O3S2. Mole weight: 274.36. | |
| 2-(5-Chloro-2-(2-hydroxyethyl)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol | 2-(5-Chloro-2-(2-hydroxyethyl)phenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol is an analog of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C15H14ClF3O2. US Biological Life Sciences. | Worldwide |
| 2- (5-Chloro-2- (4-methoxybenzamido) phenyl) -4-cyclopropyl-1, 1, 1-trifluorobut-3-yn-2-yl 4-Methoxybenzoate | 2- (5-Chloro-2- (4-methoxybenzamido) phenyl) -4-cyclopropyl-1, 1, 1-trifluorobut-3-yn-2-yl 4-Methoxybenzoate is an impurity of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2',5'-Dideoxycytidine | 2',5'-Dideoxycytidine is a potent antiviral compound commonly used in the research of HIV infection and AIDS. It works by inhibiting the reverse transcriptase enzyme, thereby blocking viral replication. This nucleoside analogue specifically targets the reverse transcriptase of the HIV virus. Synonyms: 2',5'-Dideoxy-D-cytidine. Grades: ≥ 98% (HPLC). CAS No. 5174-25-4. Molecular formula: C9H13N3O3. Mole weight: 211.22. | |
| 2',5'-Dideoxyguanosine | 2',5'-Dideoxyguanosine, a powerful antiviral agent employed for combatting HIV and AIDS, exerts its effect through the inhibition of the reverse transcriptase enzyme, effectively impeding viral replication processes. Moreover, this pharmaceutical agent displays remarkable potential in facilitating investigations into the intricate mechanisms underlying a myriad of viral infections, thereby offering invaluable insights into the field of viral pathology. Synonyms: 2',5'-Dideoxy-D-guanosine. Molecular formula: C10H13N5O3. Mole weight: 251.25. | |
| 2',5'-Dideoxyinosine | 2',5'-Dideoxyinosine is an nucleoside reverse transcriptase inhibitor. Its mechanistic tenacity roots in impeding the reverse transcriptase enzyme, thus ensnaring the pernicious replication propensities of the viral entity. Synonyms: DIDEOXYINOSINE; 2',5'-Dideoxy-D-inosine. CAS No. 72448-59-0. Molecular formula: C10H12N4O3. Mole weight: 236.23. | |
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