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| Product | Description | |
|---|---|---|
| 3-?[(1,?3-?Benzodioxol-?5-?ylamino)?sulfonyl]?-?methyl ester 2-?thiophenecarboxylic acid | 3-?[(1,?3-?Benzodioxol-?5-?ylamino)?sulfonyl]?-?methyl ester 2-?thiophenecarboxylic acid is an anti-viral compound that activate the RIG-I pathway which is involved in regulating the innate immune response to RNA virus infections. Group: Biochemicals. Grades: Highly Purified. CAS No. 895261-32-2. Pack Sizes: 250mg, 1g. Molecular Formula: C13H11NO6S2, Molecular Weight: 341.36. US Biological Life Sciences. |  Worldwide |
| dApCpp | dApCpp, a derivative of adenosine, serves as a valuable substrate for kinase assays. It plays a pivotal role in extensively conducted studies on PKR and RIG-I. Alongside its conventional usage, dApCpp serves as a stable counterpart to ATP, GTP, and UTP to facilitate both in vitro enzymatic assays and in silico enzymatic modeling experiments. Its structured similarity to ATP, GTP, and UTP further accentuates its relevance in the aforementioned endeavors. Synonyms: (dAMPCPP); 2'-Deoxyadenosine-5'-[(α,β)-methyleno]triphosphate, Sodium salt. Grades: ≥ 95% by HPLC. CAS No. 138998-91-1. Molecular formula: C11H18N5O11P3 (free acid). Mole weight: 489.21 (free acid). |  |
| Inarigivir ammonium | Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101954A. |  |
| KIN1148 | KIN1148, a small-molecule IRF3 agonist, associates with and activates recombinant RIG-I protein in cell-free assays. KIN1148 is a novel influenza vaccine adjuvant found to enhance flu vaccine efficacy. Synonyms: KIN-1148; KIN 1148; KIN1148; N-([1,3]thiazolo[5,4-e][1,3]benzothiazol-2-yl)naphthalene-2-carboxamide. Grades: ≥98% (HPLC). CAS No. 1428729-56-9. Molecular formula: C19H11N3OS2. Mole weight: 361.44. | |
| Polyinosinic-polycytidylic acid | Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors ( RIG-I and MDA5 ). Polyinosinic-polycytidylic acid can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid can directly trigger cancer cells to undergo apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Poly(I:C). CAS No. 24939-03-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107202. | |
| Polyinosinic-polycytidylic acid sodium | Polyinosinic-polycytidylic acid (Poly(I:C)) sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gene I (RIG-I)-like receptors ( RIG-I and MDA5 ). Polyinosinic-polycytidylic acid sodium can be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Polyinosinic-polycytidylic acid sodium can directly trigger cancer cells to undergo apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Poly(I:C) sodium. CAS No. 42424-50-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135748. | |
| Resiquimod (R-848, S 28463) | Immune response modifier. Potent antitumor and antiviral compound. Stimulates antibody secretion and cytokine production. Used as adjuvant to increase the effectiveness of vaccines. Potent and selective synthetic ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in human. Activates immune cells via the TLR7/TLR8 MyD88-dependent signaling pathway and leads to the induction of NF-kappaB. NLRP3/NALP3 inflammasome activator, independent of TLRs and RIG-I. Upregulator of the opioid growth factor receptor. Used in the treatment of skin lesions such as herpes simplex virus. Group: Biochemicals. Alternative Names: 1-[4-Amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; 4-Amino-2- (ethoxymethyl) -1- (2-hydroxyisobutyl) imidazo[4, 5-c]quinoline; 4-Amino-2-ethoxymethyl-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol; R 848; Resiquimod; S 28463. Grades: Highly Purified. CAS No. 144875-48-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?, Molecular Weight: 314.4. US Biological Life Sciences. | Worldwide |
| RIG012 | RIG012 is a potent RIG-I inhibitor with an IC50 of 0.71 ?M using the NADH-coupled ATPase assay. RIG012 inhibits IFN-? and ISG hRsad2 expression[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2642218-43-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147124. | |
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