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| Product | Description | |
|---|---|---|
| RO-3 | RO-3. Group: Biochemicals. Grades: Purified. CAS No. 1026582-88-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| RO-3 | RO-3 is a potent, CNS-penetrant, and orally active P2X 3 and P2X 2/3 antagonist with pIC 50 s of 5.9 and 7.0 for human homomultimeric P2X 3 and heteromultimeric P2X 2/3 receptors, respectively. RO-3 shows selectivity for P2X 3 and P2X 2/3 over all other functional homomultimeric P2X receptors (IC 50 >10 μM at P2X 1,2,4,5,7 ) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1026582-88-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-19978. |  |
| Ro-31-7549, Monohydrate - CAS 125313-65-7 | A cell permeable, reversible, selective protein kinase C (PKC) inhibitor (IC?? = 158 nM for rat brain PKC) that acts at the ATP binding site of PKC. Group: Fluorescence/luminescence spectroscopy. |  |
| Ro-31-8220 - CAS 138489-18-6 | A cell-permeable, reversible, competitive, and selective inhibitor of protein kinase C (PKC; IC?? = 10 nM) over CaM kinase II (IC?? = 17 μM) and protein kinase A (IC?? = 900 nM). Group: Fluorescence/luminescence spectroscopy. | |
| Ro-31-8425 - CAS 131848-97-0 | A potent, cell-permeable, reversible, ATP-competitive, and selective protein kinase C inhibitor (IC?? = 15 nM for rat brain PKC). Group: Fluorescence/luminescence spectroscopy. | |
| Ro-32-0432 - CAS 145333-02-4 | A selective cell-permeable protein kinase C inhibitor. Group: Fluorescence/luminescence spectroscopy. | |
| Ro-3306 | Ro-3306 is a potent and selective inhibitor of CDK1, with Kis of 20 nM, 35 nM and 340 nM for CDK1, CDK1/cyclin B1 and CDK2/cyclin E, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 872573-93-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12529. | |
| RO-3306 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| RO-3306 | Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Enhances Fas-mediated activation and processing of procaspase-8 in mitotic cells towards. Group: Biochemicals. Alternative Names: (5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?OS?. US Biological Life Sciences. | Worldwide |
| RO-3306, CDK 1 Inhibitor ((5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one) | Cell-permeable. A selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Arrests cell cycle at G1, S, and G2/M and induces apoptosis in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines, and suppresses phosphorylation of p53 at Ser315 and procaspase-8 at Ser387. Group: Biochemicals. Grades: Highly Purified. CAS No. 872573-93-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Bufuralol-d9 Hydrochloride (a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol-d9, Ro-3-4787-d9, Angium-d9) | A ß-Adrenergic blocker with peripheral vasodilating activity. Group: Biochemicals. Alternative Names: a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol-d9; Ro-3-4787-d9; Angium-d9. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Bufuralol, Hydrochloride (a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol, Ro-3-4787, Angium) | A ß-Adrenergic blocker with peripheral vasodilating activity. Group: Biochemicals. Alternative Names: a-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol; Ro-3-4787; Angium. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Cdk1 Inhibitor IV, RO-3306 | RO-3306 is a cell-permeable, potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). Group: Fluorescence/luminescence spectroscopy. | |
| InSolution Cdk1 Inhibitor IV, RO-3306 | The Cdk1 Inhibitor IV, RO-3306 controls the biological activity of Cdk1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione | 3,4-Di(1H-indol-3-yl)-1H-pyrrole-2,5-dione. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,3-bis(1H-Indol-3-yl)maleimide; J-004072; DTXSID30152324; BRD-K49448285-001-01-3; DS-0027; AC1L1DL8; CCG-206739; AX8117363; Ro-31-6233; Bisindolyl deriv. 3. Product Category: Heterocyclic Organic Compound. CAS No. 119139-23-0. Molecular formula: C20H13N3O2. Mole weight: 327.343g/mol. IUPACName: 3,4-bis(1H-indol-3-yl)pyrrole-2,5-dione. Canonical SMILES: C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54. Product ID: ACM119139230. Alfa Chemistry ISO 9001:2015 Certified. Categories: bisindolylmaleimide iv. |  |
| 8-OH-DPAT | 8-OH-DPAT (8-Hydroxy-DPAT) is an agonist that has selectivity for 5-HT1A receptor (pIC50 = 8.19). It was subsequently found to be a serotonin reuptake inhibitor and a 5-HT7 receptor agonist as well. Studies showed that it exhibited antidepressant, anxiolytic and other properties. Uses: Serotonin receptor agonists. Synonyms: 8-HYDROXY-2-(DI-n-PROPYLAMINO)TETRALIN; 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; CHEMBL56; Ro-31-8220 in solution; 8-Hydroxy-DPAT. Grade: 99.03 %. CAS No. 78950-78-4. Molecular formula: C16H25NO. Mole weight: 247.38. |  |
| Bufuralol-[d9] Hydrochloride | Bufuralol-[d9] Hydrochloride is the labelled analogue of Bufuralol, which is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is used for the treatment of hypertension. Synonyms: Bufuralol D9 Hydrochloride; α-[[(1,1-Dimethylethyl)-amino]methyl]-7-ethyl-2-benzofuranmethanol-d9 Hydrochloride; Ro-3-4787-d9 Hydrochloride; Angium-d9; Bufuralol-(t-butyl-d9) hydrochloride. Grade: ≥95%; ≥99% atom D. CAS No. 1173023-51-2. Molecular formula: C16H15D9ClNO2. Mole weight: 306.88. | |
| Bufuralol hydrochloride | Bufuralol (Ro-34787) is a β-adrenoceptor blocker with partial peripheral vasodilating activity and is potentially useful for the treatment of hypertension. It is primarily metabolized by cytochrome P450 (CYP) isoform CYP2D6, with CYP1A2 and CYP2C19 also contributing to 1'-hydroxylation. Most beta blockers are aryloxypropanolamine-based, in this rare exception, the benzofuran oxygen is part of a ring instead of derived from the epichlorohydrin precursor. Synonyms: Ro 3-4787. Grade: ≥95%. CAS No. 60398-91-6. Molecular formula: C16H23NO2·HCl. Mole weight: 297.8. | |
| Cilazapril | Cilazapril is a very potent and highly effective angiotensin-converting enzyme inhibitor (ACE inhibitor). It is used for the treatment of hypertension and congestive heart failure. lt is a monoethyl ester. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat by non-specific esterases. It is known that the diacid form is more potent. It has been listed. Uses: Cilazapri is used for the treatment of hypertension and congestive heart failure. Synonyms: Cilazapril; Ro 34-2848; Ro-34-2848; Ro34-2848. 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate; 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, (1S,9S)-; 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-, [1S-[1α,9α(R*)]]-; Ro 31-2848; (1S,9S)-9-[(S)-1-Ethoxycarbonyl-3-phenylpropylamino]-10-oxoperhydropyridazino[1,2-a][1,2]diazepine-1-carboxylic acid; Inhibace; Vascace; Cilazaprilum; (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid. Grade: >98%. CAS No. 88768-40-5. Molecular formula: C22H31N3O5. Mole weight: 417.50. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC1; MKC 1; MKC-1; R 440; R-440; R440; Ro 317453; Ro-317453; Ro317453. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. Purity: >98%. IUPACName: 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Canonical SMILES: O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC([N+]([O-])=O)=C5)NC3=O. Product ID: ACM125313920. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mk 153 Shoulder-Launched Multipurpose Assault Weapon. | |
| MKC-1 | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro-31-7453. CAS No. 125313-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13691. | |
| 1-Methoxy-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol | 1-Methoxy-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 1-methoxy-3-(2-methyl-5-nitro-imidazol-1-yl)-propan-2-ol; Roll-3696; 1-methoxy-3-(2-methyl-5-nitroimidazol-1-yl)propan-2-ol. Product Category: Heterocyclic Organic Compound. CAS No. 60174-20-1. Molecular formula: C8H13N3O4. Mole weight: 215.207 g/mol. Purity: 0.96. IUPACName: 1-(2-hydroxy-3-methoxypropyl)-2-methyl-5-nitroimidazole. Product ID: ACM60174201. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ablukast | Ablukast is a leuktriene receptor antagonist that acts as an anti-asthmatic. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ablukast; Ro 23-3544; Ro-23-3544; Ro23-3544; Ro 233544; Ro-233544; Ro233544; Ro 23-3544/000. Product Category: Antagonists. Appearance: Solid powder. CAS No. 96566-25-5. Molecular formula: C28H34O8. Mole weight: 498.57. Purity: >98%. IUPACName: 2H-1-Benzopyran-2-carboxylic acid, 6-acetyl-7-((5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentyl)oxy)-3,4-dihydro-, (+-)-. Canonical SMILES: O=C(C1CCC2=CC(C(C)=O)=C(OCCCCCOC3=CC=C(C(C)=O)C(O)=C3CCC)C=C2O1)O. Product ID: ACM96566255-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ro5-3335 | Ro5-3335, a benzodiazepine, acts as an inhibitor of core binding factor (CBF) leukemia. Ro5-3335 is a RUNX1-CBF? interaction inhibitor that represses RUNX1/CBFB-dependent transactivation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 30195-30-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-108470. | |
| Ro5-3335 | Ro5-3335 Inhibitor. Uses: Scientific use. Product Category: T4687. CAS No. 30195-30-3. |  |
| ROC-325 | ROC-325 is a potent and orally active autophagy inhibitor with a strong anticancer activity. ROC-325 induces the deacidification of lysosomes, accumulation of autophagosomes, and disrupted autophagic flux. ROC-325 also induces renal cell carcinoma apoptosis [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1859141-26-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103706. | |
| WUN40378 | WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of Ro 24-7429. Uses: Designed for use in research and industrial production. Additional or Alternative Names: WUN40378; WUN 40378; WUN-40378; Ro5-3335 analog; Ro 5-3335 analog; Ro 5-3335 analog; Ro 24-7429 analog; Ro 24-7429 analog; Ro24-7429 analog. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2328140-37-8. Molecular formula: C13H10FN3O. Mole weight: 243.24. Purity: >98%. IUPACName: 7-fluro-1,3-dihydro-5-(1H-pyrrol-2yl)-2H-1,4-benzodiazepin-2-one. Canonical SMILES: O=C1NC2=CC=C(F)C=C2C(C3=CC=CN3)=NC1. Product ID: ACM2328140378. Alfa Chemistry ISO 9001:2015 Certified. | |
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