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| Product | Description | |
|---|---|---|
| Rociletinib | Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686; AVL-301; CNX-419. CAS No. 1374640-70-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729. |  |
| Rociletinib | Rociletinib is a third-generation irreversible kinase inhibitor of epidermal growth factor receptor (EGFR). Rociletinib was shown to inhibit the proliferation of non-small cell lung cancer (NSCLC) cells expressing mutant EGFR. It also exhibits anti-tumor activity in NSCLC EGFR mutant xenograft models. Synonyms: CO-1686; CO1686; CO 1686; AVL-301; AVL 301; AVL301; CNX-419; CNX 419; CNX419; N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide. CAS No. 1374640-70-6. Molecular formula: C27H28F3N7O3. Mole weight: 555.562. |  |
| Rociletinib hydrobromide | Rociletinib hydrobromide (CO-1686 hydrobromide) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the K i values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CO-1686 hydrobromide; AVL-301 hydrobromide; CNX-419 hydrobromide. CAS No. 1446700-26-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15729A. | |
| CO-1686 hydrobromide | CO-1686 hydrobromide is the hydrobromide salt form of CO-1686. CO-1686, also called as Rociletinib, is an oral tyrosine kinase inhibitor that irreversibly and selectively inhibits mutation of EGFR for treating Non-small cell lung cancer.Non-small cell lun. Synonyms: N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide;hydrobromide CO-1686 (hydrobromide) CO-1686 hydrobromide HY-15729A CS-5247 KB-310894 1446700-26-0. CAS No. 1446700-26-0. Molecular formula: C27H29BrF3N7O3. Mole weight: 636.46. | |
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