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| Product | Description | |
|---|---|---|
| Roflumilast | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopyapi standardsenzyme activators, inhibitors & substratespharmaceutical toxicology. Alternative Names: Daxas, 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide, BYK 20869, BY 217, Roflumilast,3-(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)-benzamide, B 9302-107. |  |
| Roflumilast | Roflumilast (APTA-2217) is a selective PDE4 inhibitor with IC 50 s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1 , PDEA4 , PDEB1 , and PDEB2 , respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APTA-2217; BYK 20869; B9302-107. CAS No. 162401-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15455. |  |
| Roflumilast | Roflumilast has anti-inflammatory effects and is under development as an orally administered drug for the treatment of inflammatory conditions of the lungs such as asthma, and chronic obstructive pulmonary disease (COPD). While Roflumilast was found to be effective in clinical trials, it produced several dose-limiting side effects including nausea, diarrhoea and headache, and development is continuing in an attempt to minimise the incidence of side effects while retaining clinical efficacy. Synonyms: BY217; BY-217; BY 217; B 9302-107; B9302-107; B-9302-107; BYK 20869; BYK-20869; BYK20869; Daxas; Daliresp. Grade: 99%. CAS No. 162401-32-3. Molecular formula: C17H14Cl2F2N2O3. Mole weight: 403.207. |  |
| Roflumilast | Selective phosphodiesterase 4 (PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease. Group: Biochemicals. Alternative Names: 3- (Cyclopropylmethoxy) -N- (3, 5-dichloro-4-pyridinyl) -4- (difluoromethoxy) benzamide; B 9302-107; BY 217; BYK 20869. Grades: Highly Purified. CAS No. 162401-32-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg. Molecular Formula: C17H14Cl2F2N2O3, Form: Supplied as a white to off-white. US Biological Life Sciences. |  Worldwide |
| Roflumilast-d3 | Roflumilast-d3 is deuterium labeled Roflumilast. Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(Cyclopropylmethoxy-d3)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; B 9302-107-d3; BY 217-d3; BYK 20869-d3. Product Category: Inhibitors. Appearance: Crystallin Solid. CAS No. 1189992-00-4. Molecular formula: C17H11D3Cl2F2N2O3. Mole weight: 406.23. Canonical SMILES: [2H]C1(CC1)C([2H])([2H])OC2=C(C=CC(C(NC3=C(Cl)C=NC=C3Cl)=O)=C2)OC(F)F. Product ID: ACM1189992004. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Roflumilast-[d3] | A deuterated Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: Daxas-d3; 3-(Cyclopropyl-d4)methoxy-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide. Grade: > 95%. CAS No. 1189992-00-4. Molecular formula: C17H11D3Cl2F2N2O3. Mole weight: 406.23. | |
| Roflumilast-d4 | Labeled selective phosphodiesterase 4(PDE4) inhibitor. Antiasthmatic; in treatment of chronic obstructive pulmonary disease. Group: Biochemicals. Alternative Names: 3- (Cyclopropyl-d4) methoxy-N- (3, 5-dichloro-4-pyridinyl) -4- (difluoromethoxy) benzamide; B 9302-107-d4; BY 217-d4; BYK 20869-d4. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. | Worldwide |
| Roflumilast-[d4] | One of the isotopic labelled form of Roflumilast, which is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: 3-(Cyclopropyl-d4)methoxy-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide; B 9302-107-d4; BY 217-d4; BYK 20869-d4; Daxas-d4. Grade: >98%. CAS No. 1398065-69-4. Molecular formula: C17H10D4Cl2F2N2O3. Mole weight: 407.23. | |
| Roflumilast-D4 | Roflumilast-D4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1398065-69-4. Molecular formula: C17H10D4Cl2F2N2O3. Mole weight: 407.23. Catalog: APB1398065694. | |
| Roflumilast N-Oxide | Roflumilast-N-oxide is the active metabolite of Roflumilast. Group: Biochemicals. Alternative Names: 3- (Cyclopropylmethoxy) -N- (3, 5-dichloro-1-oxido-4-pyridinyl) -4- (difluoromethoxy) benzamide; N-(3,5-Dichloro-1-oxopyridin-4-yl)-4-difluoromethoxy-3-cyclopropyl-methoxybenzamide. Grades: Highly Purified. CAS No. 292135-78-5. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Roflumilast N-oxide-[d4] | A deuterated impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: Roflumilast-d4 N-Oxide; 3-(Cyclopropylmethoxy-d4)-N-(3,5-dichloro-1-oxido-4-pyridinyl)-4-(difluoromethoxy)benzamide; N-(3,5-Dichloro-1-oxopyridin-4-yl)-4-difluoromethoxy-3-(cyclopropyl-d4) methoxybenzamide. Grade: > 95%. CAS No. 1794760-31-8. Molecular formula: C17H10Cl2F2N2O4D4. Mole weight: 423.24. | |
| Roflumilast Related Compound C | A metabolite of the selective phosphodiesterase 4 (PDE4) inhibitor, Roflumilast. Synonyms: 4-Amino-3,5-dichloropyridine; 4-Pyridinamine, 3,5-dichloro-; 3,5-Dichloro-4-pyridinamine; Pyridine, 4-amino-3,5-dichloro-; 3,5-Dichloro-4-aminopyridine; 3,5-Dichloropyridin-4-ylamine; 3,5-Dichloropyridine-4-amine. Grade: ≥95%. CAS No. 22889-78-7. Molecular formula: C5H4Cl2N2. Mole weight: 163.01. | |
| Roflumilast Related Compound D | An impurity and intermediate in the preparation of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: 3-Cyclopropylmethoxy-4-difluoromethoxybenzoic acid; Benzoic acid, 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-. Grade: 98%. CAS No. 162401-62-9. Molecular formula: C12H12F2O4. Mole weight: 258.22. | |
| 3,4-Bis(difluoromethoxy) Roflumilast | 3,4-Bis(difluoromethoxy) Roflumilast is an impurity of the antiasthmatic drug Roflumilast. Group: Biochemicals. Alternative Names: N- (3, 5-Dichloro-4-pyridinyl) -3, 4-bis (difluoromethoxy) benzamide. Grades: Highly Purified. CAS No. 162401-30-1. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3,4-Di(cyclopropylmethoxy) Roflumilast | 3,4-Di(cyclopropylmethoxy) Roflumilast is an impurity of Roflumilast. Group: Biochemicals. Alternative Names: 3,4-Di(cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)benzamide. Grades: Highly Purified. CAS No. 1391052-24-6. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 3-O-Decyclopropyl Roflumilast | O-Decyclopropyl Roflumilast is an impurity of Roflumilast. Group: Biochemicals. Alternative Names: 3- (Hydroxy) -N- (3, 5-dichloro-4-pyridinyl) -4- (difluoromethoxy) benzamide. Grades: Highly Purified. CAS No. 1391052-76-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast | 4-(Cyclopropylmethoxy)-3-(difluoromethoxy) Roflumilast is a positional isomeric impurity of Roflumilast. Group: Biochemicals. Alternative Names: 4- (Cyclopropylmethoxy) -N- (3, 5-dichloro-4-pyridinyl) -3- (difluoromethoxy) benzamide. Grades: Highly Purified. CAS No. 162401-43-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 4-O-Des(difluoromethyl) Roflumilast | 4-O-Des(difluoromethyl) Roflumilast is an impurity in the preparation of Roflumilast. Group: Biochemicals. Alternative Names: 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-hydroxybenzamide. Grades: Highly Purified. CAS No. 475271-62-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 5-Dechloro Roflumilast | 5-Dechloro Roflumilast is an impurity of Roflumilast. Group: Biochemicals. Alternative Names: N- (3-Chloropyridin-4-yl) -3- (cyclopropylmethoxy) -4- (difluoromethoxy) benzamide. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5-Dechloro Roflumilast | An impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: Benzamide, N-(3-chloro-4-pyridinyl)-3-(cyclopropylmethoxy)-4-(difluoromethoxy)-. Grade: > 95%. CAS No. 1391053-75-0. Molecular formula: C17H15ClF2N2O3. Mole weight: 368.77. | |
| 3, 4-Bis (difluoromethoxy) benzaldehyde | 3, 4-Bis (difluoromethoxy) benzaldehyde is an impurity of the antiasthmatic drug Roflumilast. 3, 4-Bis (difluoromethoxy) benzaldehyde is used in the preparation of diphenylethylene compounds as PDE4 (phosphodiesterase-4) inhibitors for treatment of cancer, CNS disorders, and inflammatory disorders. Group: Biochemicals. Grades: Highly Purified. CAS No. 127842-54-0. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 3-(But-3-en-1-yloxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide | An impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: Roflumilast Impurity 6. CAS No. 2368178-29-2. Molecular formula: C17H14Cl2F2N2O3. Mole weight: 403.20. | |
| 3-(Cyclopropylmethoxy)-3-hydroxybenzoic Acid Methyl Ester | 3-(Cyclopropylmethoxy)-3-hydroxybenzoic Acid Methyl Ester is an intermediate in the synthesis of Roflumilast (R639700), an selective phosphodiesterase 4(PDE4) inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 848574-60-7. Pack Sizes: 100mg, 1g. Molecular Formula: C12H14O4. US Biological Life Sciences. | Worldwide |
| 3- (Cyclopropylmethoxy) -4- (methoxymethoxy) benzoic Acid | 3- (Cyclopropylmethoxy) -4- (methoxymethoxy) benzoic Acid is an impurity formed in the synthesis of Roflumilast (R639700), an selective phosphodiesterase 4(PDE4) inhibitor. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg, 250mg. Molecular Formula: C13H16O5. US Biological Life Sciences. | Worldwide |
| 4-(Cyclopropylmethoxy)-3-(difluoromethoxy)benzaldehyde | An impurity of Roflumilast. Roflumilast is a selective, long-acting inhibitor of the enzyme phosphodiesterase-4 (PDE-4). Synonyms: 4-Cyclopropylmethoxy-3-difluoromethoxy-benzaldehyde. CAS No. 162401-78-7. Molecular formula: C12H12F2O3. Mole weight: 242.22. | |
| Catechol Dimethylether-[d6] | Catechol Dimethylether-[d6] is the labelled analogue of Catechol Dimethylether, which is a common organic synthesis reagent used in the synthesis of arizonins B1 and C1, and also in the synthesis of pharmacophores of salmeterol and roflumilast. Synonyms: Catechol Dimethylether D6; 1,2-Di(methoxy-d3)benzene; Veratrole-d6; 1,2-Dimethoxybenzene-d6; 2-Methoxyanisole-d6; Methylguaiacol-d6; NSC 16934-d6; O,O-Dimethylcatechol-d6; Pyrocatechol Dimethyl Ether-d6; Veratrol-d6; o-Dimethoxybenzene-d6; o-Hydroquinone Dimethyl Ether-d6; o-Methoxyanisole-d6. Grade: 98%; 99% atom D. CAS No. 24658-24-0. Molecular formula: C8H4D6O2. Mole weight: 144.20. | |
| Veratrole | Veratrole is common reagent in organic synthesis such as the synthesis of arizonins B1 and C1. Also used in the synthesis of pharmacophores of salmeterol and roflumilast as dual β2-adrenoreceptor agonists-PDE4 inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 91-16-7. Pack Sizes: 10g, 25 g. Molecular Formula: C8H10O2. US Biological Life Sciences. | Worldwide |
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