Rolipram Suppliers USA
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Product | Description | |
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Rolipram Quick inquiry Where to buy Suppliers range | Rolipram is a selective PDE4 inhibitor that modulates cyclic AMP (cAMP) degradation. Study showed that rolipram induced neuronal differentiation of human bone marrow-mesenchymal stem cells (hBM-MSCs). It can be used as an anti-inflammatory agent. Uses: Antidepressive agents. Synonyms: ZK-62711; SB 95952; 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one. Grades: >98%. CAS No. 61413-54-5. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
Rolipram Quick inquiry Where to buy Suppliers range | Rolipram. Group: Biochemicals. Grades: Purified. CAS No. 61413-54-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
Rolipram Quick inquiry Where to buy Suppliers range | solid, ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 61413-54-5. Pack Sizes: 10MG, 25MG, 100MG. Mole weight: 275.34. EC Number: 262-771-1. Catalog: AP61413545-A. Assay: ≥98% (HPLC). | |
Rolipram Quick inquiry Where to buy Suppliers range | Rolipram. CAS No. 61413-54-5. Categories: Rolipram. | |
Rolipram (4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone) Quick inquiry Where to buy Suppliers range | A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC50=800nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-kB and NFAT activation in Jurkat and primary T cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 61413-54-5. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
Desmethyl-Rolipram Quick inquiry Where to buy Suppliers range | (-Desmethyl-Rolipram, 150519-28-1, (+)-Desmethyl-Rolipram, 4-(3-cyclopentyloxy-4-hydroxyphenyl)pyrrolidin-2-one, 4-(3-(Cyclopentyloxy)-4-hydroxyphenyl)pyrrolidin-2-one, SCHEMBL13777399. | |
(±)-Rolipram Quick inquiry Where to buy Suppliers range | (±)-Rolipram. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Pack Sizes: 10MG. Catalog: APS003596. Format: Neat. Shipping: Room Temperature. | |
(R)-(-)-Rolipram Quick inquiry Where to buy Suppliers range | (R)-(-)-Rolipram is a potent and cAMP-specific PDE4 inhibitor. It is 2.5-fold more potent than (+)-rolipram in inhibiting membrane-bound PDE 4. Grades: >98%. CAS No. 85416-75-7. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
(R)-(-)-Rolipram Quick inquiry Where to buy Suppliers range | (R)-(-)-Rolipram. Group: Biochemicals. Grades: Purified. CAS No. 85416-75-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
(S)-(+)-Rolipram Quick inquiry Where to buy Suppliers range | (S)-(+)-Rolipram. Group: Biochemicals. Grades: Purified. CAS No. 85416-73-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
(S)-(+)-Rolipram Quick inquiry Where to buy Suppliers range | (S)-(+)-Rolipram. Group: Chiral Molecules. Alternative Names: (4S)-(3-(Cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one. Grades: 97%. CAS No. 85416-73-5. Product ID: ACM85416735. Molecular formula: C16H21NO3. Mole weight: 275.34. IUPAC Name: (4S)-4-(3-Cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one. Boiling Point: 472.7±45.0 °C/760 mmHg. Flash Point: 239.7±28.7 °C. Density: 1.2±0.1 g/cm3. | |
S- (+)-Rolipram Quick inquiry Where to buy Suppliers range | S-(+)-Rolipram inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer. Synonyms: (S)-(+)-rolipram; 85416-73-5; S-(+)-Rolipram(S)-ROLIPRAMS- (+)-Rolipram. Grades: >98%. CAS No. 85416-73-5. Molecular formula: C16H21NO3. Mole weight: 275.34. | |
CHF-6001 Quick inquiry Where to buy Suppliers range | This active molecular is a Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor originated by Chiesi Farmaceutici with IC50 value of 0.026 ± 0.006 nM. CHF6001 inhibited PDE4 isoforms A to D with equal potency, showed an elevated ratio of high-affinity rolipram binding site versus low-affinity rolipram binding site and displayed >20,000-fold selectivity versus PDE4 compared with a panel of PDEs. In May 2016, Chiesi completed a phase I trial in Chronic Obstructive Pulmonary Disease (In volunteers) in United Kingdom (Inhalation). In Oct 2016, Phase-II clinical trials in Chronic obstructive pulmonary disease (Adjunctive treatment) in Hungary (Inhalation) was on-going. Uses: Allergic asthma; chronic obstructive pulmonary disease. Synonyms: CHF-6001; CHF 6001; CHF6001. UNII-0984EU6E2F; 0984EU6E2F; CHEMBL3113974; SCHEMBL12096092; CHF6001; VCFBPAOSTLMYIV-SANMLTNESA-N;[(1S)-1-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)ethyl] 3-(cyclopropylmethoxy)-4-(methanesulfonamido)benzoate. Grades: 98%. CAS No. 1239278-59-1. Molecular formula: C30H30Cl2F2N2O8S. Mole weight: 687.53. | |
CI-1044 Quick inquiry Where to buy Suppliers range | CI-1044, a selective PDE4 inhibitor, inhibits in vitro LPS-induced TNF-alpha release in whole blood from COPD patients better than rolipram and cilomilast and suggested that it could be a useful anti-inflammatory therapy in COPD. Synonyms: CI-1044; CI 1044; CI1044; UNII-O4T475XIIY; PD-189659; PD 189659; PD189659; N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro(1,4)diazepino(6,7,1-hi)indol-3-yl)nicotinamide. Grades: >98%. CAS No. 197894-84-1. Molecular formula: C23H19N5O2. Mole weight: 397.43. | |
Ethyl 3-Methyl-2-butenoate Quick inquiry Where to buy Suppliers range | Ethyl 3-Methyl-2-butenoate is used in the synthesis of Endothelin-A antagonist ABT-546 used in the preparation of antidepressant Rolipram. Also used in the synthesis of potent inhibitors of human inducible nitric oxide synthases, important enzymes in cellular signaling. Group: Biochemicals. Alternative Names: 3-Methyl-2-butenoic Acid Ethyl Ester; 3-Methyl-2-butenoic Acid Ethyl Ester; Ethyl 3,3-Dimethylacrylate; Ethyl 3-Methyl-2-butenoate; Ethyl 3-Methylcrotonate; Ethyl Dimethylacrylate; Ethyl Isobutenoate; Ethyl Isopropylideneacetate; Ethyl Senecioate; Ethyl β, β-Dimethylacrylate; Ethyl β-Methylcrotonate; NSC 61853; NSC 99208. Grades: Highly Purified. CAS No. 638-10-8. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
Filaminast Quick inquiry Where to buy Suppliers range | Filaminast is a Type 4 cyclic nucleotide phosphodiesterase inhibitor. It is an analog of rolipram which served as a prototype molecule for several development efforts. In Oct 1999, phase II clinical trials for Asthma in European Union was discontinued. Uses: Asthma. Synonyms: UNII-CDD69JC61J; Way-pda-641; WAY-PDA 641; WAY-PDA-641; CDD69JC61J; SCHEMBL73843; 1-(3-(Cyclopentyloxy)-4-methoxyphenyl)ethanone-(E)-O-(aminocarbonyl)oxime. Grades: 98%. CAS No. 141184-34-1. Molecular formula: C15H20N2O4. Mole weight: 292.33. | |
ICI 63197 Quick inquiry Where to buy Suppliers range | ICI 63197 is a specific and potent cAMP phosphodiesterase IV (PDE 4) inhibitor. Its IC50 value is 35 nM for inhibition of [3H]-rolipram binding to rat brain. It is potent in anatagonizing reserpine-induced hypothermia. It has an antidepressant effect following systemic administration in vivo. Synonyms: ICI 63197; ICI63197; ICI-63197; 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one; 2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo[1,5-a]pyrimidin-5-one. Grades: ≥99% by HPLC. CAS No. 27277-00-5. Molecular formula: C9H13N5O. Mole weight: 207.23. | |
PDE4D Inhibitor, GEBR-7b ((E)-3-(cyclopentyloxy)-4-methoxybenzaldehyde, O-2-(2,6-dimethylmorpholino)-2-oxoethyl oxime, GEBR-7b) Quick inquiry Where to buy Suppliers range | A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50=0.67uM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100uM, but has no effect on Ab levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |