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| Product | Description | |
|---|---|---|
| Ruxolitinib | Ruxolitinib (INCB18424) is an orally active and selective JAK1/2 inhibitor with IC 50 s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3 [1]. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB18424. CAS No. 941678-49-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50856. |  |
| Ruxolitinib | Ruxolitinib (INCB18424) is a potent and selective JAK1/2 inhibitor with IC50s of 3.3 nM and 2.8 nM in cell-free assays, and has 130-fold selectivity for JAK1/2 over JAK3. Ruxolitinib induces autophagy and kills tumor cells through toxic mitophagy. Group: Inhibitors. Alternative Names: Ruxolitinib; (R)-3-(4-(7H-Pyrrolo[2, 3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile; (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2, 3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; 1H-Pyrazole-1-propanenitrile. beta.-cyclopentyl-4-(7H-pyrrolo[2, 3-d]pyriMidin-4-yl)-, (.beta.R)-; (3R)-3-(4-(7H-pyrrolo[2, 3-d]pyriMidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile; (3R)-3-cyclopentyl-3-(4-{7H-pyrrolo[2, 3-d]pyriMidin-4-yl}-1H-pyrazol-1-yl)propanenitrile; INCB018424 (Ruxolitinib);Jakafi. CAS No. 941678-49-5. Molecular formula: C17H18N6. Mole weight: 306.371. Purity: 0.9997. Density: 1.4. Catalog: ACM941678495. |  |
| Ruxolitinib | Ruxolitinib Inhibitor. Uses: Scientific use. Product Category: T1829. CAS No. 941678-49-5. |  |
| Ruxolitinib | Ruxolitinib Inhibitor. Uses: Scientific use. Product Category: T3043. CAS No. 1092939-17-7. | |
| Ruxolitinib | Ruxolitinib is a potent and selective JAK1/2 inhibitor with IC50 values of 3.3 nM and 2.8 nM respectively in cell-free assays, and has > 130-fold selectivity for JAK1/2 versus JAK3. Synonyms: (R)-Ruxolitinib; INCB018424; R-INCB018424; (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile. Grades: >98%. CAS No. 941678-49-5. Molecular formula: C17H18N6. Mole weight: 306.37. |  |
| Ruxolitinib-alkyne | Ruxolitinib-alkyne is a derivative of Ruxolitinib (R702000), which is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Ruxolitinib-alkyne is prepared as a racemic mixture. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H19N5, Molecular Weight: 305.38. US Biological Life Sciences. |  Worldwide |
| Ruxolitinib-azide | Ruxolitinib-azide is a derivative of Ruxolitinib (R702000), which is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C17H20N8, Molecular Weight: 336.39. US Biological Life Sciences. | Worldwide |
| Ruxolitinib, Free Base | Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with with IC50's of 2.7 and 4.5nm for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis. Group: Biochemicals. Alternative Names: (b-R)-b-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile; INCB018424, INC18424, NCB018424, NCB18424. Grades: Purified. CAS No. 941678-49-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences. | Worldwide |
| Ruxolitinib impurity 1 | Ruxolitinib impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2606144-44-7. Molecular Formula: C16H18N6O2. Mole Weight: 326.36. Catalog: APB2606144447. |  |
| Ruxolitinib impurity 3 | Ruxolitinib impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 941685-37-6. Molecular Formula: C17H18N6. Mole Weight: 306.37. Catalog: APB941685376. | |
| Ruxolitinib impurity 4 | Ruxolitinib impurity 4. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C35H34N12. Mole Weight: 622.74. Catalog: APB11154. | |
| Ruxolitinib impurity 5 | Ruxolitinib impurity 5. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C13H23BN2O3. Mole Weight: 266.15. Catalog: APB11153. | |
| Ruxolitinib Impurity 5 (Lithium) | Ruxolitinib Impurity 5 (Lithium). Uses: For analytical and research use. Group: Impurity standards. Alternative Names: lithium (R)-4-amino-6-(1-(2-cyano-1-cyclopentylethyl)-1H-pyrazol-4-yl)pyrimidine-5-carboxylate. Molecular Formula: C16H17LiN6O2. Mole Weight: 332.29. Catalog: APB01761. | |
| Ruxolitinib impurity 6 | Ruxolitinib impurity 6. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C17H18N6O. Mole Weight: 322.37. Catalog: APB11156. | |
| Ruxolitinib impurity 7 | Ruxolitinib impurity 7. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C17H18N6O. Mole Weight: 322.37. Catalog: APB11155. | |
| Ruxolitinib impurity 8 | Ruxolitinib impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2606144-45-8. Molecular Formula: C16H18N6O. Mole Weight: 310.36. Catalog: APB2606144458. | |
| Ruxolitinib impurity 9 | Ruxolitinib impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1315607-85-2. Molecular Formula: C17H18N6O. Mole Weight: 322.37. Catalog: APB1315607852. | |
| Ruxolitinib phosphate | Ruxolitinib phosphate (INCB018424 phosphate) is a potent JAK1/2 inhibitor with IC 50 s of 3.3 nM/2.8 nM, respectively, showing more than 130-fold selectivity over JAK3. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB018424 phosphate. CAS No. 1092939-17-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-50858. | |
| Ruxolitinib phosphate | Ruxolitinib phosphate is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: INCB018424 phosphate; INCB 018424 phosphate; INCB-018424 phosphate. Grades: >98%. CAS No. 1092939-17-7. Molecular formula: C17H21N6O4P. Mole weight: 404.36. | |
| Ruxolitinib sulfate | Ruxolitinib sulfate (INCB018424) is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. Synonyms: Ruxolitinib sulfate; 1092939-16-6; INCB018424 sulfate; beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-(betaR)-1H-pyrazole-1-propanenitrile, (2Z)-2-butenedioate); SCHEMBL22127335; BCP27733; FT-0770538; 1092939-15-5; A921922; INCB018424 sulfate; INCB 018424 sulfate; INCB-018424 sulfate; 3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile; sulfuric acid. Grades: >98%. CAS No. 1092939-16-6. Molecular formula: C17H20N6O4S. Mole weight: 404.44. | |
| Deuruxolitinib | Deuruxolitinib, a deuterated Ruxolitinib (HY-50856), is an orally active JAK1 and JAK2 inhibitor. Deuruxolitinib demonstrates significant hair regrowth effects. Deuruxolitinib can be used for the research of alopecia areata [1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: CTP-543; Ruxolitinib d8; Deuterated Ruxolitinib. CAS No. 1513883-39-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-50856S. | |
| (S)-Ruxolitinib | Ruxolitinib S enantiomer, the chirality of INCB018424, is a potent and selective small-molecule Janus kinase 1 (JAK1) and JAK2 inhibitor to enter the clinic. It was initially developed to target the constitutive activation of the JAK-STAT pathway. It maintains its anti-JAK activity by competitive inhibition of the ATP-binding catalytic site of the kinase domain. It is well absorbed at above 95%. Synonyms: (S)-INCB018424; S-Ruxolitinib; SRuxolitinib; S Ruxolitinib; INCB-18424. Grades: >98%. CAS No. 941685-37-6. Molecular formula: C17H18N6. Mole weight: 306.37. | |
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