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Sacubitril (AHU-377) is a potent and orally active NEP (neprilysin) inhibitor with an IC 50 of 5 nM. Sacubitril is a component of the heart failure medicine LCZ696. Sacubitril can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377. CAS No. 149709-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407.
Sacubitrilat
Sacubitrilat (Desethyl Sacubitril) is an active neprilysin ( NEP ) inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Desethyl Sacubitril; LBQ-657. CAS No. 149709-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17620.
An isotope labelled AHU377, a methyl ester prodrug form of the neprilysin inhibitor LBQ657. Synonyms: AHU377-d4; (alphaR,gammaS)-gamma-[(3-carboxy-1-oxopropyl-2,2,3,3-d4)amino]-alpha-methyl-[1,1'-biphenyl]-4-pentanoicacid,alpha-ethylester. Grade: ≥99% atom D. CAS No. 1884269-07-1. Molecular formula: C24H25D4NO5. Mole weight: 415.5.
Sacubitril impurity 11
Sacubitril impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038924-70-7. Molecular formula: C18H19NO. Mole weight: 265.36. Catalog: APB1038924707.
Sacubitril impurity 12
Sacubitril impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038924-71-8. Molecular formula: C18H22ClNO2. Mole weight: 319.83. Catalog: APB1038924718.
Sacubitril impurity 31
Sacubitril impurity 31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153037-40-2. Molecular formula: C20H25NO3. Mole weight: 327.42. Catalog: APB153037402.
Sacubitril sodium
Sacubitril sodium is a potent and orally active NEP (neprilysin) inhibitor, with an IC 50 of 5 nM. Sacubitril sodium enhances the tone of the natriuretic peptide (NP) system and exerts significant antihypertensive effects. Sacubitril sodium is a component of the heart failure medicine LCZ696. Sacubitril sodium can be used for the research of heart failure, hypertension and COVID-19 [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHU-377 sodium. CAS No. 149690-05-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15407B.
Sacubitril/Valsartan
Sacubitril/Valsartan (LCZ696), comprised Valsartan and Sacubitril (AHU377) in 1:1 molar ratio, is a first-in-class, orally bioavailable, and dual-acting angiotensin receptor-neprilysin (ARN) inhibitor for hypertension and heart failure [1] [2] [3]. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation, oxidative stress and apoptosis [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LCZ696. CAS No. 936623-90-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18204A.
2,5-Dioxopyrrolidine Sacubitril
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Synonyms: (2R,4S)-5-Biphenyl-4-yl-4-(2,5-dioxopyrrolidin-1-yl)-2-methylpentanoic acid ethyl ester. CAS No. 1038924-97-8. Molecular formula: C24H27NO4. Mole weight: 393.483.
2,5-Dioxopyrrolidine Sacubitril
Sacubitril Impurity 2 is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 1038924-97-8. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H27NO4, Molecular Weight: 393.48. US Biological Life Sciences.
Worldwide
(2R,4R)-Sacubitril
(2R,4R)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 766480-48-2. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H29NO5. US Biological Life Sciences.
Worldwide
(2R,4R)-Sacubitril
(2R,4R)-Sacubitril. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (?R,?R)-rel-?-[(3-Carboxy-1-oxopropyl)amino]-?-methyl-[1,1'-biphenyl]-4-pentanoic Acid 4-Ethyl Ester, Sacubitril-(2R,4R) Isomer,Impurity B,(R*,R*)-?-[(3-Carboxy-1-oxopropyl)amino]-?-methyl-[1,1'-biphenyl]-4-pentanoic Acid ?-Ethyl Ester. CAS No. 766480-48-2. IUPAC Name: (4Z)-4-[4-ethoxy-3-methyl-4-oxo-1-[(4-phenylphenyl)methyl]butyl]imino-4-hydroxy-butanoic acid. Molecular formula: C24H29NO5. Mole weight: 411.49. Catalog: APS766480482. SMILES: CCOC(=O)C(C)CC(Cc1ccc(cc1)c2ccccc2)\N=C(/O)\CCC(=O)O. Format: Neat.
2R,4R-Sacubitril
An isomer of Sacubitril. Sacubitril is a neprilysin inhibitor that is commonly used in combination with valsartan (an angiotensin II receptor blocker) to form a dual-acting medication known as sacubitril/valsartan. Synonyms: (2R,4R)-Sacubitril; LCZ 696 Impurity B; 4-((rel-(2R,4R)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid; Sacubitril-(2R,4R) Isomer. Grade: 90%. CAS No. 766480-48-2. Molecular formula: C24H29NO5. Mole weight: 411.49.
(2R,4S)-Sacubitril-O-isobutane
(2R,4S)-Sacubitril-O-isobutane is an intermediate in the synthesis of (2S,4S)-Sacubitril (S080915). (2S,4S)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 149709-64-8. Pack Sizes: 500ug, 1mg. Molecular Formula: C28H37NO5. US Biological Life Sciences.
Worldwide
(2S,4R)-Sacubitril
(2S,4R)-Sacubitril is the enantiomer and an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 761373-05-1. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C24H29NO5. US Biological Life Sciences.
(2S,4S)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 149709-63-7. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H29NO5. US Biological Life Sciences.
Worldwide
(2S,4S)-Sacubitril
(2S,4S)-Sacubitril. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid),4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic acid,[S-(R*,R*)]-?-[(3-Carboxy-1-oxopropyl)amino]-?-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester, 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic Acid, Sacubitril-(2S,4S) Isomer. CAS No. 149709-63-7. IUPAC Name: (4Z)-4-[(1S)-4-ethoxy-3-methyl-4-oxo-1-[(4-phenylphenyl)methyl]butyl]imino-4-hydroxy-butanoic acid. Molecular formula: C24H29NO5. Mole weight: 411.49. Catalog: APS149709637. SMILES: CCOC(=O)C(C)C[C@@H](Cc1ccc(cc1)c2ccccc2)\N=C(/O)\CCC(=O)O. Format: Neat.
(2S,4S)-Sacubitril-[d4]
A deuterated sacubitril. Sacubitril is an antihypertensive drug used in combination with valsartan. Synonyms: 4-(((2S,4S)-1-([1,1'-Biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoic-2,2,3,3-d4 acid; (2S,4S)-Sacubitril D4; (2S,4S)-Sacubitril-d4; 3-{[(2S,4S)-1-{[1,1'-biphenyl]-4-yl}-5-ethoxy-4-methyl-5-oxopentan-2-yl]carbamoyl}(D4)propanoic acid; 4-[[(2S,4S)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]amino]-4-oxobutanoic-d4 acid. Grade: >95%. Molecular formula: C24H25NO5D4. Mole weight: 415.53.
(2S,4S)-Sacubitril-O-isobutane
(2S,4S)-Sacubitril-O-isobutane is an intermediate in the synthesis of (2S,4S)-Sacubitril (S080915). (2S,4S)-Sacubitril is an impurity of Sacubitril (S080895) which is an antihypertensive drug used in combination with valsartan. Group: Biochemicals. Grades: Highly Purified. CAS No. 149709-65-9. Pack Sizes: 500ug, 1mg. Molecular Formula: C28H37NO5. US Biological Life Sciences.
Worldwide
Desethyl Sacubitril
Desethyl Sacubitril. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS001486. Format: Neat.
Desethyl Sacubitril-d4
Desethyl Sacubitril-d4. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS001487. Format: Neat.
LCZ696 (valsartan + sacubitril) impurity 19
LCZ696 (valsartan + sacubitril) impurity 19. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-54-6. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341546.
LCZ696 (valsartan + sacubitril) impurity 20
LCZ696 (valsartan + sacubitril) impurity 20. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2R,4R)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-56-8. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341568.
LCZ696 (valsartan + sacubitril) impurity 21
LCZ696 (valsartan + sacubitril) impurity 21. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (2S,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid. CAS No. 1012341-52-4. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB1012341524.
Valsartan impurity 16 (sacubitril impurity 1)
Valsartan impurity 16 (sacubitril impurity 1). Uses: For analytical and research use. Group: Impurity standards. CAS No. 102341-56-8. Molecular formula: C23H29NO4. Mole weight: 383.48. Catalog: APB102341568.
Valsartan Impurity 40 (Sacubitril impurity 40)
Valsartan Impurity 40 (Sacubitril impurity 40). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1038924-97-8. Molecular formula: C24H27NO4. Mole weight: 393.48. Catalog: APB1038924978.
Valsartan Impurity 48 (Sacubitril impurity 48)
Valsartan Impurity 48 (Sacubitril impurity 48). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1012341-48-8. Molecular formula: C23H27NO4. Mole weight: 381.46. Catalog: APB1012341488.
Valsartan Impurity49 (Sacubitril impurity 49)
Valsartan Impurity49 (Sacubitril impurity 49). Uses: For analytical and research use. Group: Impurity standards. CAS No. 1012341-50-2. Molecular formula: C23H29NO4. Mole weight: 383.49. Catalog: APB1012341502.
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: (2R,4S)-5-(4-Biphenylyl)-4-(2,5-dioxo-1-pyrrolidinyl)-2-methylpentanoic acid. Grade: 98%. CAS No. 1639970-62-9. Molecular formula: C22H23NO4. Mole weight: 365.422.
(2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: Sacubitril impurity 16; Valsartan Impurity; (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoic acid. CAS No. 149709-49-9. Molecular formula: C24H29NO5. Mole weight: 411.49.
(2R,4S)-4-Amino-5-(biphenyl-4-yl)-2-methylpentanoic acid ethyl ester hydrochloride is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: Ethyl (2R,4S)-4-amino-5-(4-biphenylyl)-2-methylpentanoate hydrochloride; (αR,γS)-γ-Amino-α-methyl-[1,1'-biphenyl]-4-pentanoic Acid Ethyl Ester Hydrochloride; (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoate hydrochloride. CAS No. 149690-12-0. Molecular formula: C20H26ClNO2. Mole weight: 347.88.
An impurity of Sacubitril, a neprilysin inhibitor that is used in combination with valsartan to treat high blood pressure. Synonyms: 1038924-71-8; (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid hydrochloride(2R,4S)-4-amino-2-methyl-5-(4-phenylphenyl)pentanoic acid; hydrochloride; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid hydrochloride; SCHEMBL597864. CAS No. 1038924-71-8. Molecular formula: C18H22ClNO2. Mole weight: 319.8.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Synonyms: 1012341-50-2; (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid(2R,4S)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methylpentanoic acid; FJ7AWX8DMFUNII-FJ7AWX8DMF. CAS No. 1012341-50-2. Molecular formula: C23H29NO4. Mole weight: 383.488.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. Synonyms: 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)-. CAS No. 1038924-70-7. Molecular formula: C18H19NO. Mole weight: 265.356.
(3S,5R)-4-[5-([1,1'-Biphenyl]-4-ylmethyl)-3-methyl-2-oxopyrrolidin-1-yl]-4-oxobutanoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: 4-[(3R,5S)-5-(4-Biphenylylmethyl)-3-methyl-2-oxo-1-pyrrolidinyl]-4-oxobutanoic acid. CAS No. 2216746-87-9. Molecular formula: C22H23NO4. Mole weight: 365.422.
6-Chloro 3-Methyl Uracil
6-Chloro 3-Methyl Uracil is an impurity of Sacubitril. Sacubitril is a prodrug neprilysin inhibitor used in combination with valsartan to reduce the risk of cardiovascular events in patients with chronic heart failure (NYHA Class II-IV) and reduced ejection fraction. Synonyms: 6-Chloro-3-methyluracil; 6-Chloro-3-methyl-2,4(1H,3H)-pyrimidinedione; 3-Methyl-6-chlorouracil; 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione; 6-Chloro-3-methylpyrimidine-2,4-dione; 6-Chloro-2-hydroxy-3-methylpyrimidin-4(3H)-one. CAS No. 4318-56-3. Molecular formula: C5H5ClN2O2. Mole weight: 160.56.
AHU-377 hemicalcium salt
LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms. Synonyms: calcium 4-(((2S,4R)-1-([1,1'-biphenyl]-4-yl)-5-ethoxy-4-methyl-5-oxopentan-2-yl)amino)-4-oxobutanoate; AHU337; AHU-337; AHU 337; LCZ696; LCZ 696; LCZ696; Sacubitril. Grade: >98%. CAS No. 1369773-39-6. Molecular formula: C24H28NO5-. Mole weight: 410.48.
Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-4-(4-ethoxy-4-oxobutanamido)-2-methylbutanoate is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. CAS No. 2376611-98-0. Molecular formula: C26H33NO5. Mole weight: 439.54.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-58-0. Molecular formula: C20H23NO3. Mole weight: 325.408.
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid is an impurity of Sacubitril, an endopeptidase inhibitor that is effective in the treatment of hypertension and heart failure. Synonyms: (2E,4R)-5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoicacid; 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoicacid; 2-Pentenoicacid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]aminChemicalbooko]-2-methyl-, (2E,4R)-; (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid; SCHEMBL18765. Grade: 95%. CAS No. 1012341-48-8. Molecular formula: C23H27NO4. Mole weight: 381.46.
An impurity of Sacubitril, which is an antihypertensive. The combination drug of sacubitril and valsartan is used for heart failure. CAS No. 149709-59-1. Molecular formula: C25H31NO4. Mole weight: 409.526.
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