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Simeprevir plays an important role in HCV replication. Data from phase I and II clinical trials of TMC-435350 (TMC 435350; TMC 435; TMC-435350) to date have shown that this agent is well tolerated as a once-daily oral therapy and provides potent antiviral activity in HCV genotype 1-infected subjects, with restoration of liver enzymes and no evidence of viral breakthrough. Synonyms: TMC435; TMC 435; TMC-435; TMC435350; TMC-435350; TMC 435350. Grades: 98%. CAS No. 923604-59-5. Molecular formula: C38H47N5O7S2. Mole weight: 749.942.
Simeprevir
Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K i of 0.36 nM. Simeprevir inhibits HCV replication with an EC 50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro ) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC435; TMC435350. CAS No. 923604-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10241.
Simeprevir sodium salt
Simeprevir is an orally bioavailable inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It has been approved in combination with peginterferon-alfa and ribavirin for the treatment of HCV and HBV infections. Uses: Antiviral agents. Synonyms: TMC 435 sodium salt; TMC 435 sodium. Grades: ≥98%. CAS No. 1241946-89-3. Molecular formula: C38H47N5O7S2·xNa. Mole weight: 749.94.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: benzoic acid [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-2-oxolanyl]methyl ester; [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxooxolan-2-yl]methyl benzoate. Grades: 99 %. CAS No. 874638-80-9. Molecular formula: C20H17FO6. Mole weight: 372.34.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl )-4-methyltetrahydrofuran-2-pyridin-3-yl)methyl benzoate. Grades: 98%. CAS No. 1496551-71-3. Molecular formula: C24H21ClN2O7. Mole weight: 484.89.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Chloro-4-methyltetrahydrofuran-3-ylbenzoate. Grades: 95%. CAS No. 1496551-70-2. Molecular formula: C31H26ClN3O7. Mole weight: 588.01.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: 95%. CAS No. 863329-64-0. Molecular formula: C31H27N3O8. Mole weight: 569.56.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Propan-2-yl (2S) -2-{[pentafluorophenoxy (phenoxy) phosphoryl]amino}propanoate; N-[ (S) - (2, 3, 4, 5, 6-Pentafluorophenoxy) Phenoxyphosphinyl]-L-Alanine 1-Methylethyl Ester; N-[ (S) - (2, 3, 4, 5, 6-Pentafluorophenoxy) phenoxyphosphinyl]-L-alanine1-methylethyl ester. CAS No. 1256490-52-4. Molecular formula: C18H17F5NO5P. Mole weight: 453.302.
Sofosbuvir Impurity 1
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2R,3R,4S,5R)-5-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-fluoro-4-methyltetrahydrofuran-3-yl Benzoate; N4,3',5'-Tribenzoyl,2'-deoxy-2'β-fluoro-2'C-α-methyl Cytidine. Grades: > 95%. Molecular formula: C31H26FN3O7. Mole weight: 571.55.
Sofosbuvir Impurity 10
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Uridine, 2'-deoxy-2'-methylene-, 3',?5'-dibenzoate. Grades: > 95%. CAS No. 1910099-17-0. Molecular formula: C24H20N2O7. Mole weight: 448.42.
Sofosbuvir Impurity 11
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 2'-epi-Sofosbuvir Desphosphate. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 12
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 2'-c-methyl arabino-uridine; 1-(2-C-Methyl-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione. Grades: > 95%. CAS No. 114262-49-6. Molecular formula: C10H14N2O6. Mole weight: 258.23.
Sofosbuvir Impurity 13
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 2'-Methylene-2'-deoxyuridine; 2'-Methylidene-2'-deoxyuridine; 2'-Deoxy-2'-methyleneuridine. Grades: > 95%. CAS No. 119410-95-6. Molecular formula: C10H12N2O5. Mole weight: 240.22.
Sofosbuvir Impurity 14
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C22H29FN3O9P. Mole weight: 529.46.
Sofosbuvir Impurity 15
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 2'-Defluro-2'-hydroxy 2'-epi-Sofosbuvir. Grades: > 95%. Molecular formula: C22H30N3O10P. Mole weight: 527.46.
Sofosbuvir Impurity 16
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 2'-Defluro-2'-methylene Sofosbuvir. Grades: > 95%. Molecular formula: C22H28N3O9P. Mole weight: 509.45.
Sofosbuvir Impurity 17
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C34H45FN4O13P2. Mole weight: 798.7.
Sofosbuvir Impurity 2
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Benzamide, N-[1-(3,5-di-O-benzoyl-2-C-methyl-beta-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]-. Grades: > 95%. CAS No. 863329-62-8. Molecular formula: C31H27N3O8. Mole weight: 569.56.
Sofosbuvir Impurity 20
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2S)-Isopropyl 2- ( ( ( ( (2R, 3R, 4R, 5R) -5- (2, 4-Dioxo-3, 4-dihydropyrimidin-1 (2H) -yl) -4-fluoro-2- (hydroxymethyl) -4-methyltetrahydrofuran-3-yl) oxy) (phenoxy) phosphoryl) amino) propanoate; Sofosbuvir 5'-Desphosphate 3'-O-[(S)-Phosphate]. Grades: > 95%. CAS No. 1337482-15-1. Molecular formula: C22H29FN3O9P. Mole weight: 529.46.
Sofosbuvir Impurity 21
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Chloro (R)-Phosphoryl Sofosbuvir. Grades: > 95%. CAS No. 1496552-50-1. Molecular formula: C22H29ClN3O9P. Mole weight: 545.92.
Sofosbuvir Impurity 22 (GS-491241)
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C22H29FN3O9P. Mole weight: 529.46.
Sofosbuvir Impurity 23
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: α-Sofosbuvir Desphosphate. Grades: 98%. CAS No. 2041584-99-8. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 24
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 25
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 26
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 27
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 28
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 29
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: ent-Sofosbuvir Desphosphate. Grades: 98%. CAS No. 1946820-96-7. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
Sofosbuvir Impurity 3
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C38H31N3O9. Mole weight: 673.69.
Sofosbuvir Impurity 32
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, 3,?5-dibenzoate, (2S)?-. Grades: > 95%. CAS No. 1157884-58-6. Molecular formula: C20H17FO6. Mole weight: 372.34.
Sofosbuvir Impurity 33
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: D-erythro-Pentonic acid, 2-chloro-2-deoxy-2-methyl-, γ-lactone, 3,?5-dibenzoate, (2R)?-. Grades: > 95%. CAS No. 1496551-65-5. Molecular formula: C20H17ClO6. Mole weight: 388.8.
Sofosbuvir Impurity 34 (GS-606965)
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: 5'-Uridylic acid, 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)?-; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic acid; PSI 7411. Grades: > 95%. CAS No. 1015073-43-4. Molecular formula: C10H14FN2O8P. Mole weight: 340.2.
Sofosbuvir Impurity 35
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2'R)-2'-Chloro-2'-deoxy-2'-methyl-uridine; Chloro Sofosbuvir Desphosphate. Grades: > 95%. CAS No. 1496551-72-4. Molecular formula: C10H13ClN2O5. Mole weight: 276.68.
Sofosbuvir Impurity 36
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C10H15FN2O11P2. Mole weight: 420.18.
Sofosbuvir Impurity 37 ( Sofosbuvir Isomer)
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C22H29FN3O9P. Mole weight: 529.46.
Sofosbuvir Impurity 38
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C22H29FN3O9P. Mole weight: 529.46.
Sofosbuvir Impurity 39
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Benzamide, N-[1-[(2R)?-3,?5-di-O-benzoyl-2-deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranosyl]?-1,?2-dihydro-2-oxo-4-pyrimidinyl]?-; N-[1-[(2R)-3,5-Di-O-benzoyl-2-deoxy-2-fluoro-2-methyl-α-D-erythro-pentofuranosyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]benzamide. Grades: 98%. CAS No. 874638-94-5. Molecular formula: C31H26FN3O7. Mole weight: 571.55.
Sofosbuvir Impurity 4
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: N-Benzoyl-2'-deoxy-2'-methylenecytidine 3',5'-Dibenzoate; N4,3',5'-Tribenzoyl,2'-deoxy-2'-methylene Cytidine. Grades: > 95%. CAS No. 863329-63-9. Molecular formula: C31H25N3O7. Mole weight: 551.56.
Sofosbuvir Impurity 40
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Des-alanyl Sofosbuvir. Grades: > 95%. Molecular formula: C16H18FN2O8P. Mole weight: 416.29.
Sofosbuvir Impurity 41
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-1-(1-methylethyl) Ester L-Alanine; O-Desphenyl Sofosbuvir. Grades: > 95%. CAS No. 1233335-82-4. Molecular formula: C16H25FN3O9P. Mole weight: 453.36.
Sofosbuvir Impurity 42
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C16H25FN3O9P. Mole weight: 453.36.
Sofosbuvir Impurity 43
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt; (2S)-Isopropyl 2- ( (Hydroxy (phenoxy)phosphoryl)amino)propanoate Sodium Salt; Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt. Grades: > 95%. Molecular formula: C12H17NO5P. Na. Mole weight: 286.25 22.99.
Sofosbuvir Impurity 5
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C24H22FN3O6. Mole weight: 467.46.
Sofosbuvir Impurity 6
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C24H22FN3O6. Mole weight: 467.46.
Sofosbuvir Impurity 7
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grades: > 95%. Molecular formula: C24H21FN2O7. Mole weight: 468.44.
Sofosbuvir Impurity 8
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Uridine, 2'-C-methyl-, 3',?5'-dibenzoate. Grades: > 95%. CAS No. 944476-44-2. Molecular formula: C24H22N2O8. Mole weight: 466.44.
Sofosbuvir Impurity (GS-566500)
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: L-Alanine, N-[(2'R)?-2'-deoxy-2'-fluoro-2'-methyl-5'-uridylyl]?-; N-[(2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylyl]-L-alanine; PSI 352707. Grades: > 95%. CAS No. 1233335-78-8. Molecular formula: C13H19FN3O9P. Mole weight: 411.28.
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