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| Product | Description | |
|---|---|---|
| Simeprevir | Simeprevir (TMC435; TMC435350) is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a K i of 0.36 nM. Simeprevir inhibits HCV replication with an EC 50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (M pro ) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses [1] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TMC435; TMC435350. CAS No. 923604-59-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10241. |  |
| [(2R,3R,4R)-3-(Benzoyloxy)-4-fluoro-4-methyl-5-oxotetrahydrofuran-2-yl]methyl Benzoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: benzoic acid [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-2-oxolanyl]methyl ester; D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, 3,5-dibenzoate, (2R)-; (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate. Grade: ≥95%. CAS No. 874638-80-9. Molecular formula: C20H17FO6. Mole weight: 372.34. |  |
| ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methyltetrahydrofuran-2-yl)methyl benzoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl )-4-methyltetrahydrofuran-2-pyridin-3-yl)methyl benzoate. Grade: 98%. CAS No. 1496551-71-3. Molecular formula: C24H21ClN2O7. Mole weight: 484.89. | |
| (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-chloro-4-methyltetrahydrofuran-3-yl benzoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Chloro-4-methyltetrahydrofuran-3-ylbenzoate. Grade: 95%. CAS No. 1496551-70-2. Molecular formula: C31H26ClN3O7. Mole weight: 588.01. | |
| (2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((benzoyloxy)methyl)-4-hydroxy-4-methyltetrahydrofuran-3-yl benzoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grade: 95%. CAS No. 863329-64-0. Molecular formula: C31H27N3O8. Mole weight: 569.56. | |
| (2S)-Isopropyl 2-(((perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate | An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)Phenoxyphosphinyl]-L-Alanine 1-Methylethyl Ester; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-methylethyl ester. CAS No. 1256490-52-4. Molecular formula: C18H17F5NO5P. Mole weight: 453.302. | |
| Sofosbuvir-[13C,d3] | Sofosbuvir-[13C,d3] is the labelled analogue of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Sofosbuvir 13CD3. Grade: 95% by HPLC; 95% atom 13C; 95% atom D. CAS No. 2070009-25-3. Molecular formula: C21[13C]H26D3FN3O9P. Mole weight: 533.46. | |
| Sofosbuvir metabolite GS-566500-[13C,d3] | An isotope labelled impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic-13CD3 Acid; O-Desisopropyl O-Desphenyl Sofosbuvir-13C,D3; PSI 352707-13C,D3. Grade: > 95%. CAS No. 1256490-46-6. Molecular formula: [13C]C12H16FN3O9PD3. Mole weight: 415.29. | |
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