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| Product | Description | |
|---|---|---|
| Simocyclinone D8 | Antibiotic. Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50=1.45uM), E. coli (IC50=0.41uM). Human topoisomerase II (Topo II) inhibitor (IC50=100uM). Antibacterial (Gram-positive). Antitumor compound. Group: Biochemicals. Grades: Highly Purified. CAS No. 301845-97-6. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Simocyclinone D8 | It is produced by the strain of Streptomyces antibioticus Tu 6040. It has moderate anti-gram-positive bacteria activity and has inhibitory effect on a variety of tumor cells. It inhibits HMO2, MCF7 and HEP G2 cells with GI50 (μmol/L) of 0.50, 0.95 and >50, respectively. Synonyms: 9-[4-O-Acetyl-3-O-[10-[(8-chloro-4,7-dihydroxy-2-oxo-2H-1-benzopyran-3-yl)amino]-1,10-dioxo-2,4,6,8-decatetraenyl]-2,6-dideoxy-beta-D-arabino-hexopyranosyl]-4a,5,6,12b-tetrahydro-4a,6,7,8,12b-pentahydroxy-3-methyl-6a,12a-epoxybenz[a]anthracene-1,12(4H,7H)-dione; (1R)-4-O-acetyl-1,5-anhydro-3-O-{(2E,4E,6E,8E)-10-[(8-chloro-4,7-dihydroxy-2-oxo-2H-chromen-3-yl)amino]-10-oxodeca-2,4,6,8-tetraenoyl}-2,6-dideoxy-1-[(4aR,6S,6aS,7S,12aS,12bR)-4a,6,7,8,12b-pentahydroxy-3-methyl-1,12-dioxo-1,4,4a,5,6,7,12,12b-octahydro-6a,12a-epoxytetraphen-9-yl]-D-arabino-hexitol. Grades: ≥95%. CAS No. 301845-97-6. Molecular formula: C46H42ClNO18. Mole weight: 932.27. |  |
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