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| Product | Description | |
|---|---|---|
| Siomycin A | A macrocyclic antibiotic first isolated from S. sioyaensis with potent and selective antibacterial activity. It is a potent inhibitor of the oncogenic transcription factor, foxm1. It inhibits foxm1-induced cell growth on soft agar and selectively kills transformed but not normal cells in vitro. Synonyms: Mutabilycin; Sporangiomycin; 6741-21; NSC 285116; Antibiotic 6741-21; (1-L-valine)-[2-(2,3-didehydro-alanine)]-thiostrepton; Thiostrepton, 1-Valine-2-(2,3-didehydroalanine)-. Grades: >95% by HPLC. CAS No. 12656-09-6. Molecular formula: C71H81N19O18S5. Mole weight: 1648.84. |  |
| Siomycin A | from Streptomyces sioyaensis, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin) | Siomycin A (Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin). Group: Biochemicals. Alternative Names: Mutabilycin, Sporangiomycin, Antibiotic 6741-21, Mutabillicin. Grades: Highly Purified. CAS No. 12656-09-6. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Berninamycin A (Berninamycin, Antibiotic U27810) | Berninamycin A is an antibiotic discovered in 1976 from a strain of Streptomyces. Berninamycin A is a macrocyclic "peptide" comprising atypical amino acids linked to thiazole and oxazoles. Chemically very complex, berninamycin A is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistence. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1. Group: Biochemicals. Alternative Names: Berninamycin, Antibiotic U27810. Grades: Highly Purified. CAS No. 58798-97-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Geninthiocin | A thiopeptide antibiotic isolated from a streptomyces sp.; a potent activator of the tipa gene; a bacterial transcription regulator involved in multidrug resistance; displays a 10-fold selectivity for bacteria over mammalian cells lines; closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, foxm1. Synonyms: NSC676674; 14-Demethylberinamycin. Grades: >95% by HPLC. CAS No. 158792-27-9. Molecular formula: C50H49N15O15S. Mole weight: 1132.08. | |
| Siomycin | Siomycin is a peptide antibiotic that interacts with the 50S ribosomal subunit and inhibits binding of factor G and aminoacyl-tRNA. It exhibits antitumor activity against certain cancer cell lines. CAS No. 11017-43-9. Molecular formula: C64H88N16O22S4. Mole weight: 1561.73. | |
| Thiostrepton (Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31) | Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S riobsomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, members of the MerR proteins that are central regulators in multidrug resistance. Closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor-FoxM1. Group: Biochemicals. Alternative Names: Bryamycin, Thiactin, Alaninamide, Antibiotic X 146, Antibiotic A 8506, Antibiotic 6761-31. Grades: Highly Purified. CAS No. 1393-48-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
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