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| Product | Description | |
|---|---|---|
| SMCC | SMCC is a heterobifunctional protein crosslinker for antibody-drug-conjugation (ADC). Synonyms: 4-(N-Maleimidomethyl)cyclohexane-1-carboxylic Acid N-Hydroxysuccinimide Ester; NSC 344483; N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate; Cyclohexanecarboxylic acid, 4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-, 2,5-dioxo-1-pyrrolidinyl ester; 1H-Pyrrole-2,5-dione, 1-[[4-[[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl]cyclohexyl]methyl]-; 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate; 4-(2,5-Dioxo-2,5-dihydro-pyrrol-1-ylmethyl)-cyclohexanecarboxylic acid 2,5-dioxo-pyrrolidin-1-yl ester; N-Hydroxysuccinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate; N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate; Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate; Succinimidyl 4-(N-maleimidomethyl)cyclohexanecarboxylate; Succinimidyl 4-[maleimidomethyl]cyclohexan-1-carboxylate. Grade: ≥95%. CAS No. 64987-85-5. Molecular formula: C16H18N2O6. Mole weight: 334.32. |  |
| SMCC | SMCC is a protein crosslinker. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 64987-85-5. Pack Sizes: 100 mg; 250 mg; 500 mg; 1 g; 5 g; 25 g; 100 g. Product ID: HY-42360. |  |
| SMCC-DM1 | SMCC-DM1 (DM1-SMCC) is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker SMCC to make antibody agent conjugate (ADC)[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DM1-SMCC. CAS No. 1228105-51-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101070. | |
| SMCC-DM1 | SMCC-DM1 is a mertansine drug (DM1) with a reactive linker SMCC to make antibody drug conjugate. DM1 (mertansine), a thiol-containing maytansinoid, is a potent microtubule-disrupting agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 1228105-51-8. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H66ClN5O16S, Molecular Weight: 1072.60999999999. US Biological Life Sciences. |  Worldwide |
| 4- (Maleimidomethyl) cyclohexane-1-carboxyl-hydrazide, Trifluoroacetic Acid (SMCC-Hydrazide) | A sulfhydryl and carbohydrate reactive, heterobifunctional crosslinking reagent. Glycoprotein reactive. Group: Biochemicals. Alternative Names: SMCC-Hydrazide. Grades: Highly Purified. CAS No. 359436-59-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| DM1-SMCC | DM1 with a reactive linker SMCC, which can react with antibody to make antibody drug conjugate, as a potent EGFR inhibitor and it overcomes resistant to EGFR. Uses: This active molecular is dm1 with a linker smcc that can react with antibody to make antibody drug conjugate. Synonyms: 2,5-dioxopyrrolidin-1-yl 4-((3-((3-(((2S)-1-(((14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl)oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carboxylate; DM1 SMCC; SMCC-DM1. Grade: 95%. CAS No. 1228105-51-8. Molecular formula: C51H66ClN5O16S. Mole weight: 1072.62. | |
| Doxorubicin-SMCC | Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 400647-59-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116063. | |
| Doxorubicin-SMCC | Doxorubicin-SMCC is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Uses: Adcs-linker. Synonyms: 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)-N-((2S,3S,4S,6R)-3-hydroxy-2-methyl-6-(((1S,3S)-3,5,12-trihydroxy-3-(2-hydroxyacetyl)-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl)oxy)tetrahydro-2H-pyran-4-yl)cyclohexanecarboxamide. Grade: >99.3%. CAS No. 400647-59-8. Molecular formula: C39H42N2O14. Mole weight: 762.76. | |
| HiCel SMCC 50M (SMCC 101) | HiCel SMCC 50M (SMCC 101). Fine particle size, microcrystalline Cellulose co-processed with Silicon Dioxide results in a free-flowing powder. It is an excellent aid that improves significantly the flow in capsule filling and tableting. Dosage Form: Capsule, Powder, Tablet. Functionality: Binder, Carrier, Capsule Filling, Compaction, Diluent, Direct Compression, Dry Granulation, Filler, Granulation, Multifunctional, Natural Origin, Powder Blends, Tablet Compressibility. Process: Capsule Filling, Direct Compression, Dry Granulation. Particle Size: 50 microns. |  Sigachi US Inc |
| HiCel SMCC 90M (SMCC 102) | HiCel SMCC 90M (SMCC 102). Medium particle size, microcrystalline Cellulose co-processed with Silicon Dioxide results in a free-flowing powder. It is an excellent aid that improves significantly the flow in capsule filling and tableting. Dosage Form: Capsule, Powder, Tablet. Functionality: Binder, Carrier, Capsule Filling, Compaction, Diluent, Direct Compression, Dry Granulation, Filler, Granulation, Multifunctional, Natural Origin, Powder Blends, Tablet Compressibility. Process: Capsule Filling, Direct Compression, Dry Granulation. Particle Size: 90 microns. | Sigachi US Inc |
| HiCel SMCC HD 90M (SMCC 102) | HiCel SMCC HD 90M (SMCC 102). High density, medium particle size, microcrystalline Cellulose co-processed with Silicon Dioxide results in a free-flowing powder. It is an excellent aid that improves significantly the flow in capsule filling and tableting, resulting in less volume. Dosage Form: Capsule, Powder, Tablet. Functionality: Binder, Carrier, Capsule Filling, Compaction, Diluent, Direct Compression, Dry Granulation, Filler, Granulation, Multifunctional, Natural Origin, Powder Blends, Tablet Compressibility. Process: Capsule Filling, Direct Compression, Dry Granulation. Particle Size: 90 microns. | Sigachi US Inc |
| HiCel SMCC LM 90M (SMCC 102) | HiCel SMCC LM 90M (SMCC 102). Low moisture (<1.5%), medium particle size, microcrystalline Cellulose co-processed with Silicon Dioxide results in a free-flowing powder. It is an excellent aid that improves significantly the flow in capsule filling and tableting, for processing moisture-sensitive active ingredients. Dosage Form: Capsule, Powder, Tablet. Functionality: Binder, Carrier, Capsule Filling, Compaction, Diluent, Direct Compression, Dry Granulation, Filler, Granulation, Moisture-Sensitive Active Ingredient, Multifunctional, Natural Origin, Powder Blends, Tablet Compressibility. Process: Capsule Filling, Direct Compression, Dry Granulation. Particle Size: 90 microns. | Sigachi US Inc |
| Lys-SMCC-DM1 | Lys-SMCC-DM1 (Lys-N?-MCC-DM1) is a agent-linker conjugates for ADC that can inhibit tubulin polymerization. Lys-SMCC-DM1 is the active metabolite of T-DM1. T-DM1 is a HER2-targeting ADC with a tubulin polymerization inhibitor DM1. Lys-SMCC-DM1 can be used in the research of breast cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lys-N?-MCC-DM1. CAS No. 1281816-04-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-101982. | |
| N-Succinimidyl 4- (Maleimidomethyl) cyclohexane-1-carboxylate (SMCC) | A heterobifunctional cross-linking reagent incorporating an extended spacer with amine and sulfhydryl reactivity. Typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates. Contains 9 atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers. Group: Biochemicals. Alternative Names: 4- (N-Maleimidomethyl) cyclohexane-1-carboxylic Acid N-Hydroxysuccinimide Ester; NSC 344483; SMCC. Grades: Highly Purified. CAS No. 64987-85-5. Pack Sizes: 25mg, 100mg, 250mg, 500mg. US Biological Life Sciences. | Worldwide |
| Sulfo-N-Succinimidyl 4- (Maleimidomethyl) cyclohexane-1-carboxylate, Sodium Salt (Sulfo-SMCC) | A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 11.6 Angstroms. Group: Biochemicals. Alternative Names: Sulfo-SMCC. Grades: Highly Purified. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Sulfo-SMCC sodium | Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. Synonyms: Sulfo-SMCC; Sodium 1-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarbonyl)oxy)-2,5-dioxopyrrolidine-3-sulfonate. Grade: >98.0%. CAS No. 92921-24-9. Molecular formula: C16H17N2NaO9S. Mole weight: 436.37. | |
| Sulfo-SMCC sodium | Sulfo-SMCC sodium is a commonly used hetero-bifunctional, noncleavable ADC crosslinker bearing N-hydroxysuccinimide (NHS) ester and maleimide groups to react with primary amines and sulfhydryl groups, respectively. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 92921-24-9. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-D0975. | |
| 4- (Maleimidomethyl) cyclohexane-1-carboxyl-hydrazide trifluoroacetic acid | 4- (Maleimidomethyl) cyclohexane-1-carboxyl-hydrazide trifluoroacetic acid. Group: Biochemicals. Alternative Names: SMCC hydrazide. Grades: Highly Purified. CAS No. 181148-00-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| 4- (Maleimidomethyl) cyclohexane-1-carboxyl-hydrazide, trifluoroacetic acid | 4- (Maleimidomethyl) cyclohexane-1-carboxyl-hydrazide, trifluoroacetic acid. Group: Biochemicals. Alternative Names: SMCC-hydrazide, MMCCH; 4- [ (2, 5-Dihydro-2, 5-dioxo-1H-pyrrol-1-yl) methyl] cyclohexanecarboxylic acid hydrazide, 2,2,2-trifluoroacetate. Grades: Highly Purified. CAS No. 359436-59-2. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C12H17N3O3·CF3CO2H. US Biological Life Sciences. | Worldwide |
| 4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide,trifluoroacetic acid | 4-(Maleimidomethyl)cyclohexane-1-carboxyl-hydrazide,trifluoroacetic acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SMCC-Hydrazide, MMCCH; 4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic Acid Hydrazide, 2,2,2-Trifluoroacetate. Product Category: Heterocyclic Organic Compound. Appearance: White to Off-White. CAS No. 359436-59-2. Molecular formula: C12H17N3O3?CF3CO2H. Mole weight: 365.31. Purity: 0.96. IUPACName: 4-[(2,5-dioxopyrrol-1-yl)methyl]cyclohexane-1-carbohydrazide;2,2,2-trifluoroacetic acid. Canonical SMILES: C1CC(CCC1CN2C(=O)C=CC2=O)C(=O)NN.C(=O)(C(F)(F)F)O. Product ID: ACM359436592. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Biotin-LC-LC-NHS | Biotin-LC-LC-NHS is a SMCC cross-linking reagent that can be used to mark antibody and other small molecules, such as Paclitaxel [1] [2]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 89889-52-1. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-W040254. | |
| Cyclohexanecarboxylicacid,4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-1-pyrrolidinyl ester,trans- | Cyclohexanecarboxylicacid,4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-,2,5-dioxo-1-pyrrolidinyl ester,trans-. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SMCC, 64987-85-5, TRANS-4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHS, UNII-B357P1G1IF, 71875-81-5, 1-[(4-{[(2,5-dioxo-1-pyrrolidinyl)oxy]carbonyl}cyclohexyl)methyl]-1h-pyrrole-2,5-dione, 4-(Maleimidomethyl)cyclohexanecarboxylicAcid-NHS(SMCC), 4-(MALEIMIDOMETHYL)CYCLOHEXANECARBOXYLIC ACID-NHS, N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate, N-Succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Succinimidyl 4-[N-maleimidomethyl]-cyclohexane-1-carboxylate, N-(4-Carboxycyclohexylmethyl)maleimide N-hydroxysuccinimide ester, Succinimidyl-trans-4-(N-maleimidylmethyl)cyclohexane-1-carboxylate, N-Hydroxysuccinimidyl 4-(N-maleimidomethylcyclohexane)-1-carboxylate, 2,5-Dioxopyrrolidin-1-yl 4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexanecarboxylate, N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate, 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, N-Smc-carboxylate, AmbotzMAA1000, PubChem11734. Product Category: Heterocyclic Organic Compound. CAS No. 71875-81-5. Molecular formula: C16H18N2O6. Mole weight: 334.323920 [g/mol]. Purity: 97+%. IUPACName: (2,5-dioxo | |
| Mertansine | Mertansine, the cytotoxic component in antibody-drug conjugates, is attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4-(2-pyridyldithio)) linker or SMCC (4-(3-mercapto-2,5-dioxo-1 pyrrolidinylmethyl)-cylohexanecarboxylic acid) linkerto create an antibody-drug conjugate. It derives from a maytansine. Synonyms: (14S,16S,33S,2R,4R,10E,12Z,14R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl N-(3-mercaptopropanoyl)-N-methyl-L-alaninate; N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; DM 1; Maytansinoid DM 1; N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine; DM-1; DM1; DM1 Compound; DM1 [Maytansinoid]. Grade: ≥95%. CAS No. 139504-50-0. Molecular formula: C35H48ClN3O10S. Mole weight: 738.29. | |
| N-Succinimidyl 4- (maleimidomethyl) cyclohexane-1-carboxylate | N-Succinimidyl 4- (maleimidomethyl) cyclohexane-1-carboxylate. Group: Biochemicals. Alternative Names: 4- (N-Maleimidomethyl) cyclohexane-1-carboxylic acid N-hydroxysuccinimide ester; NSC 344483; SMCC. Grades: Highly Purified. CAS No. 64987-85-5. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C16H18N2O6. US Biological Life Sciences. | Worldwide |
| N-Succinimidyl 6- [ [4- (maleimidomethyl) cyclohexyl] carboxamido] caproate | N-Succinimidyl 6- [ [4- (maleimidomethyl) cyclohexyl] carboxamido] caproate. Group: Biochemicals. Alternative Names: 6- [ [ [4- [ (2, 5-Dihydro-2, 5-dioxo-1H-pyrrol-1-yl) methyl] cyclohexyl] carbonyl] amino] hexanoic acid 2,5-dioxo-1-pyrrolidinyl ester; LC-SMCC. Grades: Highly Purified. CAS No. 125559-00-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C22H29N3O7. US Biological Life Sciences. | Worldwide |
| Sulfo-N-succinimidyl 4- (maleimidomethyl) cyclohexane-1-carboxylate, sodium salt, 90% | Sulfo-N-succinimidyl 4- (maleimidomethyl) cyclohexane-1-carboxylate, sodium salt, 90%. Group: Biochemicals. Alternative Names: 4- [ (2, 5-Dihydro-2, 5-dioxo-1H-pyrrol-1-yl) methyl] cyclohexanecarboxylic acid 2,5-dioxo-3-sulfo-1-pyrrolidinyl ester, sodium salt; Sulfo-SMCC. Grades: Highly Purified. CAS No. 92921-24-9. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C16H17N2O9SNa. US Biological Life Sciences. | Worldwide |
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