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1-((2R,3R,4R,5S)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione, a powerful antimicrobial agent, is renowned for its efficacy in treating a range of bacterial and fungal infections, including those caused by Candida, Aspergillus, and Cryptococcus species. This pharmaceutical marvel works by clobbering the synthesis of crucial nucleic acids in microbes to sabotage their survival. Notably, its phenomenal antibacterial and antifungal activity renders it an essential tool in the battle against streptococcal and staphylococcal infections. Synonyms: Sofosbuvir impurity SA15432. Molecular formula: C10H13FN2O5. Mole weight: 260.22.
1-β-D-Arabinofuranosyluracil-2-C-methyl-d3,13C
1-β-D-Arabinofuranosyluracil-2-C-methyl-d3, 13C is the labeled analogue of 1-β-D-Arabinofuranosyluracil-2-C-methyl, an impurity of PSI-7977, a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Synonyms: 1-(2-C-Methyl-d3, 13C-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-((2R,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyl-d3, 13C-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; Sofosbuvir Impurity 12-d3, 13C. CAS No. 1256490-38-6. Molecular formula: C9[13C]H11D3N2O6. Mole weight: 262.24.
2-Defluro-2-hydroxy 2-epi-Sofosbuvir
2-Defluro-2-hydroxy 2-epi-Sofosbuvir is an impurity of Sofosbuvir (P839640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H30N3O10P, Molecular Weight: 527.46. US Biological Life Sciences.
Worldwide
2-Defluro-2-hydroxy 2-epi-Sofosbuvir-13Cd3
2-Defluro-2-hydroxy 2-epi-Sofosbuvir-13Cd3 is the labelled form of 2-Defluro-2-hydroxy 2-epi-Sofosbuvir (D228775), which is an impurity of Sofosbuvir (P839640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2mg. Molecular Formula: C2113CH27D3N3O10P, Molecular Weight: 531.47. US Biological Life Sciences.
Worldwide
2-Defluro-2-methylene Sofosbuvir
2-Defluro-2-methylene Sofosbuvir is an impurity of Sofosbuvir (P839640). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H28N3O9P, Molecular Weight: 509.45. US Biological Life Sciences.
Worldwide
(2'R)?-2'-?Deoxy-?2'-?fluoro-?2'-?methyl-uridine 5'-?Triphosphate Triethylammonium Salt
(2'R)?-2'-?Deoxy-?2'-?fluoro-?2'-?methyl-uridine 5'-?Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 10mg. Molecular Formula: C28H61FN5O14P3. US Biological Life Sciences.
Worldwide
(2'R)?-2'-?Deoxy-?2'-?fluoro-?2'-?methyl-uridine 5'-?Triphosphate Triethylammonium Salt
(2'R)?-2'-Deoxy-2'-fluoro-2'-methyl-uridine 5'-Triphosphate Tetrasodium Salt is an impurity of Sofosbuvir. That prodrug could be metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate. Synonyms: Sofosbuvir Impurity; RO 2433 Triphosphate Triethylammonium Salt. Grade: 95%. Molecular formula: C28H61FN5O14P3. Mole weight: 803.73.
(2'R) -2'-Deoxy-3', 5'-bis-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1393526-40-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H41FN2O5Si2. US Biological Life Sciences.
(2'R) -2'-Deoxy-3'-O-[ (1, 1-dimethylethyl) dimethylsilyl]-2'-fluoro-2'-methyl-uridine is an intermediate in the synthesis of Sofosbuvir (R)-Phosphate (S675615), which is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro- β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Group: Biochemicals. Grades: Highly Purified. CAS No. 1244762-86-4. Pack Sizes: 5mg, 10mg. Molecular Formula: C16H27FN2O5Si. US Biological Life Sciences.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: benzoic acid [(2R,3R,4R)-3-benzoyloxy-4-fluoro-4-methyl-5-oxo-2-oxolanyl]methyl ester; D-erythro-Pentonic acid, 2-deoxy-2-fluoro-2-methyl-, γ-lactone, 3,5-dibenzoate, (2R)-; (2R)-2-Deoxy-2-fluoro-2-methyl-D-erythro-pentonic acid γ-lactone 3,5-dibenzoate. Grade: ≥95%. CAS No. 874638-80-9. Molecular formula: C20H17FO6. Mole weight: 372.34.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: ((2R,3R,4R,5R)-3-(benzoyloxy)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidine-1(2H)-yl )-4-methyltetrahydrofuran-2-pyridin-3-yl)methyl benzoate. Grade: 98%. CAS No. 1496551-71-3. Molecular formula: C24H21ClN2O7. Mole weight: 484.89.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2R,3R,4R,5R)-5-(4-benzoylamino-2-oxopyrimidine-1(2H)-yl)-2-((benzoyloxy)methyl)-4-Chloro-4-methyltetrahydrofuran-3-ylbenzoate. Grade: 95%. CAS No. 1496551-70-2. Molecular formula: C31H26ClN3O7. Mole weight: 588.01.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Grade: 95%. CAS No. 863329-64-0. Molecular formula: C31H27N3O8. Mole weight: 569.56.
An impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: Propan-2-yl (2S)-2-{[pentafluorophenoxy(phenoxy)phosphoryl]amino}propanoate; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)Phenoxyphosphinyl]-L-Alanine 1-Methylethyl Ester; N-[(S)-(2,3,4,5,6-Pentafluorophenoxy)phenoxyphosphinyl]-L-alanine1-methylethyl ester. CAS No. 1256490-52-4. Molecular formula: C18H17F5NO5P. Mole weight: 453.302.
Chloro Sofosbuvir
Chloro Sofosbuvir is an impurity of Sofosbuvir; a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase. Synonyms: N-[[P(S),2'R]-2'-Chloro-2'-deoxy-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester. Grade: ≥98% (HPLC). CAS No. 1496552-51-2. Molecular formula: C22H29ClN3O9P. Mole weight: 545.91.
Sofosbuvir metabolite GS-566500-[13C,d3]
An isotope labelled impurity of Sofosbuvir. Sofosbuvir is a NS5B inhibtor used for the treatment of hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir or daclatasvir. Synonyms: (2S)-2-(((((2R,3R,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)amino)propanoic-13CD3 Acid; O-Desisopropyl O-Desphenyl Sofosbuvir-13C,D3; PSI 352707-13C,D3. Grade: > 95%. CAS No. 1256490-46-6. Molecular formula: [13C]C12H16FN3O9PD3. Mole weight: 415.29.
Sofosbuvir (R)-Phosphate
Sofosbuvir (R)-Phosphate. Uses: For analytical and research use. Group: Impurity standards. Catalog: APS003089. Format: Neat.
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