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| Product | Description | |
|---|---|---|
| sphingolipid 10-desaturase | The enzyme, characterized from the marine diatom Thalassiosira pseudonana, produces an all-trans product. Similar triunsaturated sphingoid bases are found in some marine invertebrates. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. Group: Enzymes. Synonyms: desA (gene name). Enzyme Commission Number: EC 1.14.19.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0981; sphingolipid 10-desaturase; EC 1.14.19.19; desA (gene name). Cat No: EXWM-0981. |  |
| sphingolipid 4-desaturase | The enzyme, which has been characterized from plants, fungi, and mammals, generates a trans double bond at position 4 of sphinganine bases in sphingolipids. The preferred substrate is dihydroceramide, but the enzyme is also active with dihydroglucosylceramide. Unlike EC 1.14.19.29, sphingolipid 8-desaturase, this enzyme does not contain an integral cytochrome b5 domain and requires an external cytochrome b5. The product serves as an important signalling molecules in mammals and is required for spermatide differentiation. Group: Enzymes. Synonyms: dehydroceramide desaturase. Enzyme Commission Number: EC 1.14.19.17. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0979; sphingolipid 4-desaturase; EC 1.14.19.17; dehydroceramide desaturase. Cat No: EXWM-0979. | |
| sphingolipid 8-(E)-desaturase | The enzyme, characterized from the yeasts Kluyveromyces lactis and Candida albicans and from the diatom Thalassiosira pseudonana, introduces a trans double bond at the 8-position of sphingoid bases in sphingolipids. The enzyme determines the position of the double bond by its distance from the alcohol end of the sphingoid base, and contains a cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. The homologous enzymes from higher plants, EC 1.14.19.29, sphingolipid 8-(E/Z)-desaturase, act on phytosphinganine (4-hydroxysphinganine) and produces a mixture of trans and cis isomers. Group: Enzymes. Synonyms: 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.18. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0980; sphingolipid 8-(E)-desaturase; EC 1.14.19.18; 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Cat No: EXWM-0980. | |
| sphingolipid 8-(E/Z)-desaturase | The enzymes from higher plants convert sphinganine, 4E-sphing-4-enine and phytosphinganine into E/Z-mixtures of Δ8-desaturated products displaying different proportions of geometrical isomers depending on plant species. The nature of the actual desaturase substrate has not yet been studied experimentally. The enzymes contain an N-terminal cytochrome b5 domain that acts as the direct electron donor to the active site of the desaturase. The homologous enzymes from some yeasts and diatoms, EC 1.14.19.18, sphingolipid 8-(E)-desaturase, act on sphing-4-enine ceramides and produce only the trans isomer. Group: Enzymes. Synonyms: 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.29. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0992; sphingolipid 8-(E/Z)-desaturase; EC 1.14.19.29; 8-sphingolipid desaturase (ambiguous); 8 fatty acid desaturase (ambiguous); DELTA8-sphingolipid desaturase (ambiguous). Cat No: EXWM-0992. | |
| sphingolipid C4-monooxygenase | The enzyme, which belongs to the familiy of endoplasmic reticular cytochrome b5-dependent enzymes, is involved in the biosynthesis of sphingolipids in eukaryotes. Some enzymes are bifunctional and also catalyse EC 1.14.19.17, sphingolipid 4-desaturase. Group: Enzymes. Synonyms: sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH2 (gene name); DEGS2 (gene name). Enzyme Commission Number: EC 1.14.18.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0967; sphingolipid C4-monooxygenase; EC 1.14.18.5; sphinganine C4-monooxygenase; sphingolipid C4-hydroxylase; SUR2 (gene name); SBH1 (gene name); SBH2 (gene name); DEGS2 (gene name). Cat No: EXWM-0967. | |
| sphingolipid C9-methyltransferase | The enzyme, characterized from the fungi Komagataella pastoris and Fusarium graminearum, acts only on ceramides and has no activity with free sphingoid bases or glucosylceramides. Group: Enzymes. Enzyme Commission Number: EC 2.1.1.317. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1925; sphingolipid C9-methyltransferase; EC 2.1.1.317. Cat No: EXWM-1925. | |
| Sphingolipid TLC mixture-51 | Sphingolipid TLC mixture-51. Group: Others. Appearance: Liquid. Sphingolipid TLC mixture-51; TLC; Glycosphingolipid TLC Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-069. | |
| Sphingolipid TLC mixture-53 | Sphingolipid TLC mixture-53. Group: Others. Appearance: Liquid. Sphingolipid TLC mixture-53; TLC; Glycosphingolipid TLC Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-070. | |
| Sphingolipid TLC mixture-54 | Sphingolipid TLC mixture-54. Group: Others. Appearance: Liquid. Sphingolipid TLC mixture-54; TLC; Glycosphingolipid TLC Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-071. | |
| Sphingolipid TLC mixture-55 | Sphingolipid TLC mixture-55. Group: Others. Appearance: Liquid. Sphingolipid TLC mixture-55; TLC; Glycosphingolipid TLC Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-072. | |
| Sphingolipid TLC mixture-56 | Sphingolipid TLC mixture-56. Group: Others. Appearance: Liquid. Sphingolipid TLC mixture-56; TLC; Glycosphingolipid TLC Mixtures; lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-073. | |
| glycosphingolipid deacylase | Does not act on sphingolipids such as ceramide. Not identical with EC 3.5.1.23 ceramidase. Group: Enzymes. Synonyms: glycosphingolipid ceramide deacylase. Enzyme Commission Number: EC 3.5.1.69. CAS No. 122544-53-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4459; glycosphingolipid deacylase; EC 3.5.1.69; 122544-53-0; glycosphingolipid ceramide deacylase. Cat No: EXWM-4459. | |
| Native Pseudomonas sp. Sphingolipid ceramide N-deacylase | Sphingolipid ceramide N-deacylase (SCDase) is derived from Pseudomonas and hydrolyzes the N-acyl linkage between fatty acids and sphingosine bases in ceramides of various sphingolipids. The enzyme also catalyzes the reverse reaction and possesses transacylation activity. SCDase acts on various acidic and neutral glycosphingolipids and sphingomyelin; however, it exhibits low activity with ceramides. Applications: Hydrolysis of n-acyl linkages between fatty acids and sphingosine bases sphingolipid hydrolysis. Group: Enzymes. Synonyms: SCDase; Sphingolipid ceramide N-deacylase. SCDase. Storage: Store at -20°C until use. Store reconstituted solution in aliquots at -20°C. Avoid freeze-thaw. Form: Solution in 50 mM sodium acetate (pH 6.0) containing 0.1% Lubrol PX. Source: Pseudomonas sp. Species: Pseudomonas sp. SCDase; Sphingolipid ceramide N-deacylase. Cat No: NATE-0896. | |
| TLC sphingolipid mixture | TLC sphingolipid mixture. Group: Others. Appearance: Liquid. Storage: -20°C. Source: Bovine. TLC sphingolipid mixture; TLC; Sphingolipid Mixture (quantitative); lipid mixture; mix; qualitive mixture; quantitive mixture; Matreya, LLC; Matyera; Larodan; lipid products. Cat No: LMIZ-102. | |
| 12-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]-3, 15-dihydroxy-cholest-5-en-26-oic Acid | 12-[[ (1, 1-Dimethylethyl) dimethylsilyl]oxy]-3, 15-dihydroxy-cholest-5-en-26-oic Acid is an intermediate in the synthesis of (25R)-3 β, 7α, 12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C33H58O5Si. US Biological Life Sciences. |  Worldwide |
| 12-Hydroxy-3-oxo-cholest-4-en-26-oic Acid | 12-Hydroxy-3-oxo-cholest-4-en-26-oic Acid is an intermediate in the synthesis of (25R)-3 β, 7α, 12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 2.5mg. Molecular Formula: C27H40O4. US Biological Life Sciences. | Worldwide |
| 25R-3α, 7α, 12α-Trihydroxy-5 β-cholestanoic Acid | 25R-3α, 7α, 12α-Trihydroxy-5 β-cholestanoic acid is an intermediate in the synthesis of (25R)-3 β, 7α, 12α-Trihydroxy-5-cholestenoic Acid (T795130), which is an oxysterol, an oxidized derivatives of cholesterol (C432501), which may be important in many biological processes, including cholesterol homeostasis, atherosclerosis, sphingolipid metabolism, platelet aggregation, apoptosis, and protein prenylation,[1] though their roles are poorly understood. Group: Biochemicals. Grades: Highly Purified. CAS No. 23740-14-9. Pack Sizes: 10mg, 25mg. Molecular Formula: C27H46O5. US Biological Life Sciences. | Worldwide |
| 3-dehydrosphinganine reductase | 3-dehydrosphinganine reductase (EC 1.1.1.102) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene. This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in sphingolipid metabolism. Group: Enzymes. Synonyms: D-3-dehydrosphinganine reductase; D-3-oxosphinganine reductase; DSR; 3-oxosphinganine reductase; 3-oxosphinganine:NADPH oxidoreductase; D-3-oxosphinganine:B-NADPH oxidoreductase. Enzyme Commission Number: EC 1.1.1.102. CAS No. 37250-36-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0005; 3-dehydrosphinganine reductase; EC 1.1.1.102; 37250-36-5; D-3-dehydrosphinganine reductase; D-3-oxosphinganine reductase; DSR; 3-oxosphinganine reductase; 3-oxosphinganine:NADPH oxidoreductase; D-3-oxosphinganine:B-NADPH oxidoreductase. Cat No: EXWM-0005. | |
| 3-Ketosphingosine | 3-Ketosphingosine is a biomarker for Niemann-Pick disease type A and B, as well as for sphingosine kinase-associated inflammatory disorders. It is also used as a research tool for studying the metabolism and signaling pathways of sphingolipids in various biological processes. Synonyms: 3-Keto Sphingosine; Ketosphingosine. CAS No. 19767-16-9. Molecular formula: C18H35NO2. Mole weight: 297.48. |  |
| ACe-1 | Ac-1 is a modified ceramide with azophenyl groups used for optical control of N-acyl chains. Ceramide is a pro-apoptotic sphingolipid. Ceramide's generation can regulate the structure of the lipid rafts. Synonyms: N-[ (E) -4- (4- ( (4-butylphenyl) diazenyl) phenyl) butanoyl]-D-erythro-sphingosine; Benzenebutanamide, 4-[(1E)-2-(4-butylphenyl)diazenyl]-N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-; 4-(4-((E)-(4-butylphenyl)diazenyl)phenyl)-N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)butanamide. Grades: >99%. CAS No. 2260670-55-9. Molecular formula: C38H59N3O3. Mole weight: 605.89. | |
| a-L-galactose-1-phosphate disodium salt | a-L-galactose-1-phosphate disodium salt, a highly significant compound in the realm of biomedicine, exhibits immense potential for therapeutic application in diverse metabolic disorders. It serves as a pivotal precursor for sphingolipid synthesis, thereby facilitating the effective management of afflictions such as Gaucher disease and Farber disease. Due to its indispensable involvement in enzymatic reactions, a-L-galactose-1-phosphate disodium salt harbors substantial promise for the forefront of novel drug advancement within the biomedical industry. Synonyms: β-L-Galactopyranose, 1-(dihydrogen phosphate)?, disodium salt. CAS No. 210100-25-7. Molecular formula: C6H13O9P.2Na. Mole weight: 306.177. | |
| α-Cyclodextrin | α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Natural products. CAS No. 10016-20-3. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1513. |  |
| Bioactive Lipid Compound Library | A unique collection of 385 bioactive lipids related compounds for high throughput screening (HTS) and high content screening (HCS), including Agonists & Antagonists, Endocannabinoids, Farnesyl/geranylgeranyl derivates, HETEs deHETEs, hepoxilins, Polyunsaturated fatty acids, Leukotrienes, lipoxins, LPA & phosphatidic acids, Octadecanoids, PAFs, Prostaglandins & thromboxanes, Retinoids, vitamin D metabolites, Sphingolipids, etc. ; - Targets include GPCR, HDAC, PPAR, DNA Alkylating, EGFR, etc. ; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L7000. Categories: Bioactive Lipid Compounds Libraries. |  |
| C12 Ceramide | Ceramide is one of the simplest sphingolipids, consisting of a sphingosine base N-linked to a fatty acid, and is a membrane mediator for cell-signaling events. N-Acyl chain length of membrane ceramides can influence bidimensional transitions, condensed domain morphology, and interfacial thickness. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]dodecanamide; N- [ (1S, 2R, 3E) -2-Hydroxy-1- (hydroxymethyl) -3-heptadecenyl] dodecanamide; [R- [R*, S*- (E) ] ] -N- [2-Hydroxy-1- (hydroxymethyl) -3-heptadecenyl] dodecanamide; N-Lauroyl-D-erythro-sphingosine; N-Laurylsphingosine. Grades: Highly Purified. CAS No. 74713-60-3. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| C18 Ceramide-13C2,D2 | The sphingolipid ceramide. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide-13C2,D2. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| C18 Ceramide (N-Stearoyl-D-sphingosine, Stearoyl Ceramide) | The sphingolipid ceramide is a potent inhibitor of the mitochondrial permeability transition pore. Group: Biochemicals. Alternative Names: N-[(1S,2R,3E)-2-Hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]octadecanamide; D-erythro-1,3-Dihydroxy-2-octadecanoylamido-trans-4-octadecene; N-Stearoyl-C18-sphingosine; N-Stearoyl-D-erythro-sphingosine; N-Stearoyl-D-sphingosine; N-Stearoylsphingenine; N-Stearoylsphingosine. Grades: Highly Purified. CAS No. 2304-81-6. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C36H71NO3, Molecular Weight: 565.95. US Biological Life Sciences. | Worldwide |
| C18 L-threo Ceramide (d18:1/18:0) | C18 L-threo Ceramide is a synthetic ceramide and stereoisomer of C18 ceramide that has been used for structural characterization of natural sphingolipids. It inhibits rat brain mitochondrial ceramidase (mt-CDase) with an IC50 value of 16.8 μM. Synonyms: N-octadecanoyl-L-threo-sphingosine; L-threo Cer(d18:1/18:0); L-threo Ceramide (d18:1/18:0). Grades: ≥98%. CAS No. 95037-06-2. Molecular formula: C36H71NO3. Mole weight: 565.95. | |
| C22-Ceramide | C22-Ceramide (Cer d18:1/22:0) is an endogenous bioactive sphingolipid. C22-Ceramide reduces the propensity of C16-ceramide channel formation in isolated rat liver mitochondria and in liposomes [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Behenoyl-D-erythro-sphingosine; Cer d18:1/22:0. CAS No. 27888-44-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-154831. | |
| C24-Ceramide (d18:1/24:0) | C24-Ceramide (d18:1/24:0) is a sphingolipid that can be used for the lipid membranes composed. C24-Ceramide (d18:1/24:0) induces time-dependent changes in membrane properties. C24-Ceramide (d18:1/24:0) induces membrane reorganization [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 102917-80-6. Pack Sizes: 1 mg. Product ID: HY-134508A. | |
| C2 Adamantanyl Galactosylceramide (d18:1/2:0) | C2 Adamantanyl Galactosylceramide (d18:1/2:0) is a bioactive sphingolipid. It reduces globotriaosylceramide 3 synthesis from exogenous lactosylceramide in microsomes. AdaGalCer stimulates recombinant glucocerebrosidase activity in a pH-dependent manner. It activates glucocerebrosidase to decrease glucosylceramide accumulation in fibroblasts and lymphoblasts isolated from patients with Gaucher and Fabry disease, respectively. Synonyms: [(2S,3R,4E)-2-[(1-Adamantyl)acetylamino]-3-hydroxy-4-octadecenyl]beta-D-galactopyranoside; N-(1-Adamantaneacetyl)-galactosylceramide; Adamantanyl Galactosyl(β) Ceramide; AdaGalCer(d18:1/2:0). Grades: ≥98%. CAS No. 574738-16-2. Molecular formula: C36H63NO8. Mole weight: 637.89. | |
| C2 Adamantanyl Glucosylceramide (d18:1/2:0) | C2 Adamantanyl glucosylceramide (AdaGluCer) is a bioactive sphingolipid. It increases levels of glycosphingolipids in Vero cells at low concentrations (≤20 μM) but decreases them at high concentrations (≥40 μM). Pretreatment of microsomes with AdaGluCer increases production of adamantanyl lactosylceramide (AdaLacCer) and reduces synthesis of LacCer from exogenous GlcCer. AdaGluCer inhibits glucocerebrosidase activity in vitro in a pH-dependent manner. Synonyms: N-(1-Adamantaneacetyl) Glucosylceramide; Adamantanyl GluCer(d18:1/2:0); Adamantanyl Glucosylceramide (d18:1/2:0); AdaGluCer(d18:1/2:0). Grades: ≥98%. Molecular formula: C36H61NO8. Mole weight: 635.87. | |
| C6 NBD Ceramide | C6 NBD Ceramide is a Golgi apparatus fluorescent probe with cell membrane permeability. C6 NBD Ceramide can be used for fast and convenient green fluorescent labeling of Golgi in living and fixed cells, and can be used to observe changes in Golgi morphology in living cells (Ex=466 nm, Em=536 nm). C6-NBD-ceramide is metabolized to fluorescent sphingomyelin and glucosylceramide, can be used for the study of sphingolipid transport and metabolic mechanism [1] [2] [3]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Nbd-ceramide. CAS No. 94885-02-6. Pack Sizes: 1 mg. Product ID: HY-W356116. | |
| CAY10621 | Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. The two known kinases, sphingosine kinase 1 (SphK1) and sphingosine kinase 2 (SphK2), have different developmental and tissue expression patterns, suggesting that they have distinct physiological functions. CAY10621 is an inhibitor of SPHK1 with IC50 of 3.3 μM. It is selective for SphK1 over Sph2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SphK1 activity by 70% in U937 cells at 5 μM. Synonyms: SKI 5C; SPHK1 Inhibitor 5C; CAY 10621; CAY-10621. Grades: ≥98%. CAS No. 120005-55-2. Molecular formula: C26H45NO4. Mole weight: 435.6. | |
| Ceramide 1-phosphate | Ceramide 1-phosphate is a bioactive lipid and one of the key components of sphingolipids. Ceramide 1-phosphate playing diverse roles in cellular behaviors such as cell differentiation, migration, proliferation and death [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 128543-23-7. Pack Sizes: 1 mg. Product ID: HY-P2982. | |
| Ceramide 3 | C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer(t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer(t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer(t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: N-Stearoyl phytosphingosine. CAS No. 34354-88-6. Pack Sizes: 1 mg; 5 mg. Product ID: HY-141582. | |
| ceramide cholinephosphotransferase | This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:N-acylsphingosine cholinephosphotransferase. This enzyme is also called phosphorylcholine-ceramide transferase. This enzyme participates in sphingolipid metabolism. Group: Enzymes. Synonyms: phosphorylcholine-ceramide transferase. Enzyme Commission Number: EC 2.7.8.3. CAS No. 9026-14-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3329; ceramide cholinephosphotransferase; EC 2.7.8.3; 9026-14-6; phosphorylcholine-ceramide transferase. Cat No: EXWM-3329. | |
| ceramide kinase | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:ceramide 1-phosphotransferase. This enzyme is also called acylsphingosine kinase. This enzyme participates in sphingolipid metabolism. Group: Enzymes. Synonyms: acylsphingosine kinase. Enzyme Commission Number: EC 2.7.1.138. CAS No. 123175-68-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2969; ceramide kinase; EC 2.7.1.138; 123175-68-8; acylsphingosine kinase. Cat No: EXWM-2969. | |
| Cetyl-PG hydroxyethyl palmitamide | Cetyl-PG hydroxyethyl palmitamide. Uses: Designed for use in research and industrial production. CAS No. 110483-07-3. Purity: 0.95. Product ID: ACM110483073. Alfa Chemistry ISO 9001:2015 Certified. Categories: Sphingolipid E. |  |
| dihydroceramide fatty acyl 2-hydroxylase | The enzyme, characterized from plants, catalyses the hydroxylation of carbon 2 of long- or very-long-chain fatty acids attached to sphinganine during de novo ceramide synthesis. The enzyme requires an external cytochrome b5 as the electron donor. The newly introduced 2-hydroxyl group has R-configuration. cf. EC 1.14.18.6, 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase. Group: Enzymes. Synonyms: FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Enzyme Commission Number: EC 1.14.18.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0969; dihydroceramide fatty acyl 2-hydroxylase; EC 1.14.18.7; FAH1 (gene name); FAH2 (gene name); plant sphingolipid fatty acid 2-hydroxylase. Cat No: EXWM-0969. | |
| Dm-AMP1 | DmAMP1, an antifungal plant defensin from dahlia (Dahlia merckII), interacts with sphingolipids from Saccharomyces cerevisiae. | |
| Fmoc-L-serine | N-Fmoc-L-serine is an N-Fmoc-protected form of L-Serine. L-Serine is a non-essential amino acid that is required for the synthesis of sphingolipids and phosphatidylserine, compounds that are important for central nervous system neuronal survival. L-Serine is also important in intermediary metabolism in eukaryotic cells. Synonyms: Fmoc-L-Ser-OH; Fmoc-L-β-hydroxyalanine(S)-Fmoc-2-amino-3-hydroxypropionic acid; FMOC-SER-OH; N-Fmoc-L-serine-OH; N-FMOC-L-SERINE; FMOC-SERINE; FMOC-SER. Grades: ≥ 99.5% (Chiral HPLC). CAS No. 73724-45-5. Molecular formula: C18H17NO5. Mole weight: 327.30. | |
| Fumonisin B1 | Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 116355-83-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N6719. | |
| Fumonisin B2 | Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of sphingosine N-acyltransferase (ceramide synthase) and disrupts de novo sphingolipid biosynthesis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 116355-84-1. Pack Sizes: 1 mg. Product ID: HY-N6723. | |
| Ginsenoside CK | Ginsenoside compound K (C-K) is a metabolite of the protopanaxadiol-type saponins of Panax ginseng C.A. Meyer (Araliaceae), has long been used to treat against the development of cancer, inflammation, allergies, and diabetes; C-K acts as a unique HUVEC migration inhibitor by regulating MMP expression, as well as the activity of SPHK1 and its related sphingolipid metabolites. [1]Ginsenoside compound K, the intestinal metabolite of ginseng saponin, has various chemopreventive and chemotherapeutic activities, including anti-tumor activity; C-K suppresses the activation of the NF-κB pathway, may become a potential cytotoxic drug in the prevention and treatment of hepatocellular carcinoma( HCC).[2]Ginsenoside compound K shows significant anti-proliferative effects and pro-apoptotic effects in HCT-116 and SW-480 cells at concentrations of 30-50 uM, suggests that C-K could be potentially effective anti-colorectal cancer agent.[3]Ginsenoside CK has anti-cancer effect on NPC cells, C-K-induced apoptosis of HK-1 cells was mediated by the mitochondrial pathway and could significantly inhibit tumor growth in vivo.[4]. Group: Biochemicals. Alternative Names: (3 β,12 β)-3,12-Dihydroxydammar-24-en-2. Grades: Highly Purified. CAS No. 39262-14-1. Pack Sizes: 10mg, 20mg, 50mg, 100mg. Molecular Formula: C??H??O?, Molecular Weight: 622.87. US Biological Life Sciences. | Worldwide |
| Glucosyl-C18-sphingosine | A sphingosine derivative. A sphingolipid compound found in the the umbilical cord artery of women with preeclampsia. Group: Biochemicals. Alternative Names: Glucosylsphingosine; 2-Amino-3-hydroxy-4-octadecenyl β-D-Glucopyranoside; (2S,3R,4E)-2-Amino-3-hydroxy-4-octadecenyl β-D-Glucopyranoside. Grades: Highly Purified. CAS No. 52050-17-6. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| K6PC-5 | K6PC-5 is a Sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, an active metabolite of sphingolipid. S1P can modulate multiple cellular responses including [Ca2+] signaling, growth, survival, and differentiation. K6PC-5 regulates both differentiation and proliferation of keratinocytes via [Ca2+]i responses through S1P production, which may be used for the treatment of skin disorders characterized by abnormal differentiation and proliferation, such as atopic dermatitis and psoriasis. Uses: Potential treatment of skin disorders with abnormal differentiation and proliferation. Synonyms: K6PC-5; K6PC 5; K6PC5; Dihydroxyisopropyl capryloylcaprylamide; Decanamide, 2-hexyl-N-(2-hydroxy-1-(hydroxymethyl)ethyl)-3-oxo. Grades: 98%. CAS No. 756875-51-1. Molecular formula: C19H37NO4. Mole weight: 343.5. | |
| KRP-203 | KRP-203 is a selective Sphingosine-1-phosphate receptor agonist that has been shown to reduce peripheral lymphocyte infiltration and to prolong survival in rat transplant models. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite involved in many critical cellular processes including proliferation, survival, and migration, as well as angiogenesis and immune responses. Activation of sphingosine kinase by a variety of agonists increases intracellular S1P, which in turn can function intracellularly as a second messenger or be secreted out of the cell and act extracellularly by signaling through S1P (S1P1-5) receptors. The phosphorylated form of KRP 203 demonstrates a high affinity for the S1P1 receptor with an ED50 value in the nM range and an ED50 value >1 μM for the S1P3 receptor. Synonyms: Mocravimod hydrochloride; 2-Amino-2-(4-((3-(benzyloxy)phenyl)thio)-2-chlorophenethyl)propane-1,3-diol hydrochloride; 1,3-Propanediol, 2-amino-2-[2-[2-chloro-4-[[3- (phenylmethoxy) phenyl]thio]phenyl]ethyl]-, hydrochloride (1:1). Grades: ≥98%. CAS No. 509088-69-1. Molecular formula: C24H27Cl2NO3S. Mole weight: 480.45. | |
| Lactosylsphingosine | Lactosylsphingosine, a sphingolipid, is a vital biomarker characterizing diverse lysosomal storage disorders such as Niemann-Pick disease and Gaucher disease due to its accumulation within the tissues and blood of affected people. Detection through blood examination or imaging studies makes identification possible. Therapy options include substrate reduction and enzyme replacement therapy. Furthermore, tracking variations in lactosylsphingosine may be employed to monitor therapy response and trace disease advancement, imparting substantial clinical value in disease management. Synonyms: D-lactosyl-beta1-1'-D-erythro-sphingosine; Lactosyl(beta) Sphingosine (d18:1); 2S,3R1-beta-lactosyl-sphing-4-enine; lyso-Lactosylceramide; 1-b-Lactosyl-sphing-4-enine; lyso-LC. Grades: >99%. CAS No. 109785-20-8. Molecular formula: C30H57NO12. Mole weight: 623.77. | |
| L-threo Lysosphingomyelin (d18:1) | L-threo Lysosphingomyelin (d18:1) is an endogenous bioactive sphingolipid and an agonist of sphingosine-1-phosphate (S1P) receptors 1-3. Synonyms: L-threo Lyso SM (18:1); L-threo Lysosphingomyelin (18:1); L-threo Sphingosine-1-Phosphocholine (d18:1); L-threo-Sphingosylphosphorylcholine; [(E,2S,3S)-2-amino-3-hydroxyoctadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate. Grades: ≥98%. CAS No. 105615-55-2. Molecular formula: C23H49N2O5P. Mole weight: 464.62. | |
| Myriocin | Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids. Group: Biochemicals. Alternative Names: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R*,3S*,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Myriocin | Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces , Isaria sinclairi and Mycelia sterilia , is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC 50 of 3.5 μg/mL for inhibiting HCV infection [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Thermozymocidin; ISP-I. CAS No. 35891-70-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N6798. | |
| Myriocin | Myriocin (Thermozymocidin), a fungal metabolite could be isolated from Myriococcum albomyces, Isaria sinclairi and Mycelia sterilia, is a potent inhibitor of serine-palmitoyl-transferase (SPT) and a key enzyme in de novo synthesis of sphingolipids. Myriocin suppresses replication of both the subgenomic HCV-1b replicon and the JFH-1 strain of genotype 2a infectious HCV, with an IC50 of 3.5 μg/mL for inhibiting HCV infection. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid. Product Category: Inhibitors. Appearance: Off-white solid. CAS No. 35891-70-4. Molecular formula: C21H39NO6. Mole weight: 401.54. Purity: >98%. IUPACName: (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid. Canonical SMILES: CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O. Density: 1.123±0.06 g/cm3(Predicted). Product ID: ACM35891704. Alfa Chemistry ISO 9001:2015 Certified. | |
| Myriocin (Thermozymocidin, ISP) | Myriocin is an a-amino fatty acid derived from species of several genera of fungi, notably Myriococcum, Melanconis and Isaria. Myriocin is a potent inhibitor of sphingosine biosynthesis by blocking the first enzyme in the pathway, serine palmitoyltransferase. Myriocin induces apoptosis by depletion of cellular sphingolipids, inhibits proliferation of IL-2-dependent mouse cytotoxic cells and is a potent immunosuppressant. Group: Biochemicals. Grades: Highly Purified. CAS No. 35891-70-4. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| N-(4,4-Difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoyl)sphingosyl 1-b-D-galactopyranoside | N-(4,4-Difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-dodecanoyl)sphingosyl 1-b-D-galactopyranoside is an experimental compound, enabling the exploration of intricate phenomena regarding cell membrane dynamics and lipid trafficking. As an illuminating fluorogenic compound, it possesses the remarkable ability to precisely mark sphingolipids and glycosphingolipids. Molecular formula: C47H78BF2N3O8. Mole weight: 861.95. | |
| N-acylsphingosine galactosyltransferase | This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. This enzyme participates in sphingolipid metabolism. Group: Enzymes. Synonyms: UDP galactose-N-acylsphingosine galactosyltransferase; uridine diphosphogalactose-acylsphingosine galactosyltransferase; UDP-galactose:N-acylsphingosine D-galactosyltransferase. Enzyme Commission Number: EC 2.4.1.47. CAS No. 37277-56-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2593; N-acylsphingosine galactosyltransferase; EC 2.4.1.47; 37277-56-8; UDP galactose-N-acylsphingosine galactosyltransferase; uridine diphosphogalactose-acylsphingosine galactosyltransferase; UDP-galactose:N-acylsphingosine D-galactosyltransferase. Cat No: EXWM-2593. | |
| Native Bacillus cereus Sphingomyelinase | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Applications: Sphingomyelinase has been used in a study to assess the interaction of actin with the hiv-1 accessory protein nef. sphingomyelinase has also been used in a study to investigate x-ray scattering as a quality-control tool for liposomal drug-delivery systems. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Activity: > 100 units/mg protein. Storage: 2-8°C. Form: Type I, buffered aqueous glycerol solution, Solution in 50% glycerol containing 50 mM Tris-HCl, pH 7.5; Type II, Lyophilized powder containing potassium phosphate buffer salts and stabilizer. Source: Bacillus cereus. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Cat No: NATE-0672. | |
| Native Sphingomyelinase from Streptomyces sp. | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Applications: This enzyme is useful for enzymatic determination of sphingomyelin when coupled with alkaline phosphatase and choline oxidase. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; Smase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Mole weight: 37.5 kDa (SDS-PAGE). Activity: > 500 U/mg. Stability: At least one year at ?20°C. Appearance: White to brownish amorphous powder?lyophilized. Storage: Storage at ?20°C in the presence of a desiccant is recommended. Form: Freeze dried powder. Source: Streptomyces sp. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; Smase. Cat No: NATE-1160. | |
| Native Staphylococcus aureus Sphingomyelinase | Sphingomyelin phosphodiesterase is a hydrolase enzyme that is involved in sphingolipid metabolism reactions. SMase is a member of the DNase I superfamily of enzymes and is responsible for breaking sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses. Group: Enzymes. Synonyms: Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Enzyme Commission Number: EC 3.1.4.12. CAS No. 9031-54-3. SMase. Activity: 100-300 units/mg protein (Lowry). Storage: 2-8°C. Form: buffered aqueous glycerol solution; Solution in 50% glycerol containing 0.25 M phosphate buffer, pH 7.5. Source: Staphylococcus aureus. Sphingomyelin phosphodiesterase; EC 3.1.4.12; neutral sphingomyelinase; 9031-54-3; sphingomyelin cholinephosphohydrolase; sphingomyelinase; SMase. Cat No: NATE-0673. | |
| Nervonic Acid | Nervonic acid is a fatty acid. It is particularly abundant in the white matter of animal brains and in peripheral nervous tissue where nervonyl sphingolipids are enriched in the myelin sheath of nerve fibers. It is one of the major fatty acids in brain sphingolipids, normally accounting for approximately 40% of the total fatty acids in sphingolipids. Group: Biochemicals. Grades: Highly Purified. CAS No. 506-37-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C24H46O2. US Biological Life Sciences. | Worldwide |
| Palmitic Acid-?13C16 | Palmitic Acid-?13C16 is an analytical agent for analysis of sphingolipid biosynthesis by tandem mass spectrometry. Group: Biochemicals. Grades: Highly Purified. CAS No. 56599-85-0. Pack Sizes: 1mg, 5mg. Molecular Formula: 13C16H32O2, Molecular Weight: 272.31. US Biological Life Sciences. | Worldwide |
| Phosphorylethanolamine | Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane. Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer?s and Huntington?s disease. Group: Biochemicals. Alternative Names: 2-Aminoethanol 1-(Dihydrogen Phosphate); 2-Aminoethanol Dihydrogen Phosphate Ester; 2-Aminoethanol Phosphate; Phosphoric Acid 2-Aminoethyl Ester; 2-Aminoethanol O-Phosphate; 2-Aminoethyl Dihydrogen Phosphate; Colamine phosphate; Ethanolamine O-Phosphate; Mono(2-aminoethyl) phosphate; Monoaminoethyl Phosphate; NSC 254167; O-Phosphoethanolamine; O-Phosphoryl ethanolamine; Phosphoethanolamine; Phosphonoethanolamine. Grades: Highly Purified. CAS No. 1071-23-4. Pack Sizes: 10g, 25g. Molecular Formula: C2H8NO4P, Molecular Weight: 141.06. US Biological Life Sciences. | Worldwide |
| Phosphorylethanolamine-d4 | Labeled analogue of Phosphoryl ethanolamine. Phosphorylethanolamine is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane. Group: Biochemicals. Alternative Names: 2-Aminoethanol-d4 1-(Dihydrogen Phosphate); 2-Aminoethanol-d4 Dihydrogen Phosphate Ester; 2-Aminoethanol-d4 Phosphate; Phosphoric Acid 2-Aminoethy-d4 Ester; 2-Aminoethanol-d4 O-Phosphate2-Aminoethyl-d4 Dihydrogen Phosphate; Colamine phosphate; Ethanolamine-d4 O-Phosphate; Mono(2-aminoethyl-d4) phosphate; Monoaminoethyl-d4 Phosphate; NSC 254167-d4; O-Phosphoethanolamine-d4; O-Phosphorylethanolamine-d4; Phosphoethanolamine-d4; Phosphonoethanolamine-d4. Grades: Highly Purified. CAS No. 1169692-38-9. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Safingol | Safingol is a lyso-sphingolipid protein kinase C (PKC) inhibitor. It binds to and inhibits the regulatory phorbol-binding domain of PKC. It has the potential for the treatment of solid tumors. Synonyms: L-threo-Dihydrosphingosine; L-threo-Sphinganine; L-threo-2-Amino-1,3-octadecanediol; (2S,3S)-2-aminooctadecane-1,3-diol. Grades: ≥98%. CAS No. 15639-50-6. Molecular formula: C18H39NO2. Mole weight: 301.51. | |
| Safingol - CAS 15639-50-6 | A cell-permeable and reversible lyso-sphingolipid protein kinase C (PKC) inhibitor that competitively interacts at the regulatory phorbol binding domain of PKC. Group: Fluorescence/luminescence spectroscopy. |  |
| Sphinganine 1-phosphate | Sphinganine 1-phosphate (D-erythro-Dihydrosphingosine 1-phosphate) is a polar sphingolipid metabolite that regulates cell migration, differentiation, survival and complex physiological processes [1]. Uses: Scientific research. Group: Natural products. Alternative Names: D-erythro-Dihydrosphingosine 1-phosphate. CAS No. 19794-97-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-113116. | |
| Sphingomyelin | Sphingomyelin is a eukaryotic sphingolipid and one of the major constituents of cell membranes and particularly abundant in the myelin sheath that surrounds neuronal axons. Sphingomyelin plays an important role in cell processes, the regulation of inflammatory responses, and signal transduction. Sphingomyelin metabolism is associated with various central nervous system diseases and Niemann - Pick disease [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 85187-10-6. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113498. | |
| sphingomyelin deacylase | The enzyme is involved in the sphingolipid metabolism in the epidermis. Group: Enzymes. Synonyms: SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Enzyme Commission Number: EC 3.5.1.109. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4388; sphingomyelin deacylase; EC 3.5.1.109; SM deacylase; GcSM deacylase; glucosylceramide sphingomyelin deacylase; sphingomyelin glucosylceramide deacylase; SM glucosylceramide GCer deacylase; SM-GCer deacylase; SMGCer deacylase. Cat No: EXWM-4388. | |
| Sphingomyelins, milk | Sphingomyelins, milk (SMs (buttermilk)) are compounds studied in sphingolipids, which play important roles in various biological processes. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SMs (buttermilk). CAS No. 475662-40-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-165136. | |
| sphingomyelin synthase | The reaction can occur in both directions. This enzyme occupies a central position in sphingolipid and glycerophospholipid metabolism. Up- and down-regulation of its activity has been linked to mitogenic and pro-apoptotic signalling in a variety of mammalian cell types. Unlike EC 2.7.8.3, ceramide cholinephosphotransferase, CDP-choline cannot replace phosphatidylcholine as the donor of the phosphocholine moiety of sphingomyelin. Group: Enzymes. Synonyms: SM synthase; SMS1; SMS2. Enzyme Commission Number: EC 2.7.8.27. CAS No. 58703-97-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3326; sphingomyelin synthase; EC 2.7.8.27; 58703-97-2; SM synthase; SMS1; SMS2. Cat No: EXWM-3326. | |
| sphingosine cholinephosphotransferase | This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in sphingolipid metabolism. Group: Enzymes. Synonyms: CDP-choline-sphingosine cholinephosphotransferase; phosphorylcholine-sphingosine transferase; cytidine diphosphocholine-sphingosine cholinephosphotransferase; sphingosine choline phosphotransferase. Enzyme Commission Number: EC 2.7.8.10. CAS No. 9027-12-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3310; sphingosine cholinephosphotransferase; EC 2.7.8.10; 9027-12-7; CDP-choline-sphingosine cholinephosphotransferase; phosphorylcholine-sphingosine transferase; cytidine diphosphocholine-sphingosine cholinephosphotransferase; sphingosine choline phosphotransferase. Cat No: EXWM-3310. | |
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