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| Product | Description | |
|---|---|---|
| Sphingosine 1-phosphate | ?95%, powder. Group: Fluorescence/luminescence spectroscopy. |  |
| Sphingosine 1-phosphate | Sphingosine-1-phosphate is an endogenous second messenger that inhibits cell proliferation and motility, and Ca2+ mobilization to prevent tumor cell metastasis. Sphingosine-1-phosphate acts as an agonist at sphingosine-1-phosphate receptors (S1P1-5) and as an activator of GPR3, GPR6 and GPR12. Synonyms: D-erythro-Sphingosine-1-phosphate; C18-Sphingosine 1-phosphate; Sphing-4-enine 1-phosphate; (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate. Grades: ≥98% by HPLC. CAS No. 26993-30-6. Molecular formula: C18H38NO5P. Mole weight: 379.48. |  |
| Bis(2-cyanoethoxy)-1-(N-t-boc-sphingosine-1-Phosphate-13C2,D2 | Intermediate for a labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| Caged D-erythro-sphingosine-1-phosphate (Caged SPP) | Caged SPP provides a method to elevate intracellular level of SPP upon ultraviolet irradiation and thus can be utilized as a new tool in studies of SPP-mediated intracellular events. Group: Biochemicals. Alternative Names: Caged SPP. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Dihydro-D-sphingosine-1-phosphate | May be used as a negative control for C2 Ceramide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Dihydrosphingosine 1-phosphate | Saturated analog of sphingosine 1-phosphate (1-SP1). Ligand for sphingosine 1-phosphate (S1P/EDG) receptors. Negative control for intracellular effects of sphingosine 1-phosphate. Induces chemotaxis. Antifibrotic. Group: Biochemicals. Alternative Names: (2S,3R)-Dihydro-sphingosine 1-phosphate, Dihydro-S1P, dhS1P. Grades: Highly Purified. CAS No. 19794-97-9. Pack Sizes: 1mg, 5mg. Molecular Formula: C18H40NO5P. US Biological Life Sciences. | Worldwide |
| D-Erythro-Sphingosine 1-Phosphate | D-Erythro-Sphingosine 1-Phosphate. Group: Biochemicals. Grades: Highly Purified. CAS No. 26993-30-6. Pack Sizes: 1mg, 2mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine-1-Phosphate-13C2,D2 | A labeled putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| D-erythro-Sphingosine-1-Phosphate (SPN-1-P) | A putative lipid second messenger; found to inhibit cellular mobility of melanoma cells at very low concentrati. Group: Biochemicals. Alternative Names: SPN-1-P. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| N-Biotinyl D-erythro-Sphingosine-1-phosphate | A biotinylated substrate conjugate used for performing ELISA on water-soluble ligands. Used for ceramide phosphate sphingosine synthesis. Group: Biochemicals. Alternative Names: (3aS,4S,6aR)-. Grades: Highly Purified. CAS No. 1093733-24-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1-phosphate Dicyanoethyl Ester | Intermediate in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-9-Cyano-6-(2-cyanoethoxy)-3-(1-hydroxyhexadecyl)-5,7-dioxa-2-aza-6-phosphanonanoic Acid 6-Oxide 1,1-Dimethylethyl Ester. Grades: Highly Purified. CAS No. 169528-22-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Sphingosine-1-phosphate (d17:1) | Sphingosine-1-phosphate d17:1 (D-erythro-Sphingosine-C17-1-phosphate) is a derivative of ceramide. Sphingosine-1-phosphate d17:1 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: D-erythro-Sphingosine-C17-1-phosphate. CAS No. 474923-27-8. Pack Sizes: 1 mg. Product ID: HY-141630. |  |
| (3-Carboxypropyl)triphenylphosphonium Bromide | (3-Carboxypropyl)triphenylphosphonium Bromide is a reagent used for the preparation of sphingosine 1-phosphate-1 receptor antagonists, as well as for the synthesis of mitochondrial vitamin E metabolites and other mitochondrial targets in the study of mitochodrial functions. Synonyms: (4-Hydroxy-4-oxobutyl)triphenylphosphonium Bromide; Phosphonium, (3-carboxypropyl)triphenyl-, bromide (1:1). Grades: ≥95%. CAS No. 17857-14-6. Molecular formula: C22H22BrO2P. Mole weight: 429.29. | |
| ABC294640 | ABC294640 is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. Synonyms: ABC-294640; ABC294640; ABC 294640; Opaganib; 3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide. Grades: 0.98. CAS No. 915385-81-8. Molecular formula: C23H25ClN2O. Mole weight: 380.9104. | |
| Amiselimod hydrochloride | Amiselimod (MT-1303) hydrochloride is converted to its active metabolite Amiselimod phosphate by sphingosine kinases in vivo. Amiselimod hydrochloride is an orally active and high selectivity sphingosine 1-phosphate receptor-1 ( S1P1 ) agonist, designed to reduce the bradycardia effects associated with fingolimod and other S1P receptor modulators. Amiselimod hydrochloride inhibits chronic colitis via inhibiting infiltration of colitogenic Th1 and Th17 cells into the colon. Amiselimod hydrochloride inhibits lupus nephritis by reducing the infiltration of autoreactive T cells into the kidneys. Amiselimod hydrochloride is promising for research of autoimmune diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MT-1303 hydrochloride. CAS No. 942398-84-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16734A. | |
| AUY954 | NVP-AUY954 is an orally-available, benzothiazole-based, monoselective agonist of the sphingosine-1-phosphate receptor 1 (S1P1) intended for the treatment of human autoimmune mediated inflammatory neuropathies. NVP-AUY954 efficacy has been correlated with an accumulation of plasmacytoid dendritic cells (pDC), which may have therapeutic value in the treatment of multiple sclerosis. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: AUY954; AUY-954 free base; 820240-77-5; CHEMBL4579553; 820240-77-5 (free base); 3-[[2-[4-phenyl-3-(trifluoromethyl)phenyl]-1-benzothiophen-5-yl]methylamino]propanoic acid; 3-(((2-(2-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)benzo[b]thiophen-5-yl)methyl)amino)propanoic acid; N-[[2-[2-(trifluoromethyl)[1,1'-biphenyl]-4-yl]benzo[b]thien-5-yl]methyl]-beta-alanine; AUY 954; GTPL2925; SCHEMBL2237377; BCP33492; BDBM50507187; AKOS040750638; NVP-AUY954; AUY-954; AUY 954; Q27074628; 3-{[2-(2-trifluoromethyl-biphenyl-4-yl)benzo[b]thiophen-5-ylmethyl]amino}propionic acid. Grades: ≥98%. CAS No. 820240-77-5. Molecular formula: C25H20F3NO2S. Mole weight: 455.5. | |
| C11 Ceramide-1-Phosphate | C11 Ceramide-1-Phosphate. Group: Others. Synonyms: N-[11-undecanoyl]-D-ceramide-1-phosphate (ammonium salt). Purity: >99%. Mole weight: 810.842. Stability: 6 Months. Storage: -20°C. Avanti Polar Lipids; lipid products; bioactive lipids; fluorescent lipids; singnal transduction; cell pathways; N-[11-undecanoyl]-D-ceramide-1-phosphate (ammonium salt); C11 Ceramide-1-Phosphate; N-[11-(Dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt). Cat No: FLBZ-189. |  |
| C4 Ceramide-1-phosphate | Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages. Group: Biochemicals. Alternative Names: N- [ (1S, 2R, 3E) -2-Hydroxy-1- [ (phosphonooxy) methyl] -3-heptadecenyl] butanamide; N-Butyl-D-sphingosine-1-phosphate; Butyl Ceramide-1-phosphate; N-Butanoyl-D-erythro-sphingosine-1-phosphate. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Ceralifimod | Ceralifimod (ONO-4641) is a selective agonist of sphingosine 1-phosphate (S1P) receptor 1 and 5 (EC50 = 0.0273 and 0.334?nM). In animal experiment, ONO-4641 prevented relapse of disease in a non-obese diabetic mouse model of relapsing-remitting EAE. ONO-4641 had been developed for the treatment of multiple sclerosis (MS) and undergone a phase II clinical trial by Merck KGaA and Ono, therefore, the study were terminated in Dec 2014. Uses: Ceralifimod (ono-4641) is a selective agonist of sphingosine 1-phosphate (s1p) receptor 1 and 5 (ec50 = 0.0273 and 0.334?nm) developed for the treatment of multiple sclerosis (ms). Synonyms: ONO-4641; ONO 4641; ONO4641; Ceralifimod. UNII-BZ2O8A84A4; 891859-12-4; AK173892; Ceralifimod [INN]; SCHEMBL465051; 1-[[6-[(2-methoxy-4-propylphenyl)methoxy]-1-methyl-3,4-dihydronaphthalen-2-yl]methyl]azetidine-3-carboxylic acid. Grades: ≥98%. CAS No. 891859-12-4. Molecular formula: C27H33NO4. Mole weight: 435.564. | |
| CS-0777-P | CS-0777 is a selective sphingosine 1-phosphate receptor modulator agonist. It is in clinical trials for the treatment of multiple sclerosis, but no recent development was reported. Uses: Multiple sclerosis. Synonyms: CS-0777; CS0777; CS 0777. 1-(5-((3R)-3-amino-3-methyl-4-(phosphonooxy)butyl)-1-methyl-1H-pyrrol-2-yl)-4-(4-methylphenyl)-1-Butanone. Grades: 98%. CAS No. 840523-39-9. Molecular formula: C21H31N2O5P. Mole weight: 422.45. | |
| Ex26 | Ex26 (S1P1-IN-Ex26) is a potent and selective sphingosine 1-phosphate receptor 1 ( S1P 1 ) antagonist ( IC 50=0.93 nM). Ex26 shows >3,000-fold selectivity for S1P 1 over other Sphingosine 1-phosphate receptors. Ex26 can be used in experimental autoimmune encephalomyelitis reseach [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: S1P1-IN-Ex26. CAS No. 1233332-37-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-117213. | |
| Fingolimod | Fingolimod (FTY720 free base) is a sphingosine 1-phosphate ( S1P ) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720 free base. CAS No. 162359-55-9. Pack Sizes: 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-11063. | |
| Fingolimod-d4 | Fingolimod-d 4 is the deuterium labeled Fingolimod. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: FTY720 free based-d4. CAS No. 1346747-38-3. Pack Sizes: 500 μg; 1 mg. Product ID: HY-11063S. | |
| Fingolimod-d4 hydrochloride | Fingolimod-d 4 (hydrochloride) is the deuterium labeled Fingolimod hydrochloride. Fingolimod hydrochloride (FTY720) is a sphingosine 1-phosphate (S1P) antagonist with an IC50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride (FTY720) also is a pak1 activator, a immunosuppressant[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: FTY720-d4. CAS No. 1346604-90-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-11063S1. | |
| Fingolimod hydrochloride | Fingolimod (FTY720) hydrochloride is a sphingosine 1-phosphate ( S1P ) antagonist with IC 50 of 0.033 nM in K562 and NK cells. Fingolimod hydrochloride is also a pak1 activator and immunosuppressant [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720. CAS No. 162359-56-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg; 500 mg; 1 g; 5 g. Product ID: HY-12005. | |
| Fingolimod Hydrochloride (FTY-720A, FTY720, D04187, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Hydrochloride) | Fingolimod (FTY720), a sphingosine 1-phosphate (S1P) analog, is a novel immunosuppressant drug that induces lymphopenia by preventing emergence of lymphocytes from lymph nodes. Fingolimod is a sphingosine-1-phosphate receptor 1 modulator and is in phase III clinical trials for relapsing-remitting multiple sclerosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Fingolimod phosphate | Fingolimod phosphate (FTY720 phosphate) is an orally active sphingosine 1-phosphate (S1P) receptor agonist. Fingolimod phosphate can promote the neuroprotective effects of microglia. Fingolimod phosphate can be used for the research of multiple sclerosis and neurologic diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FTY720 phosphate. CAS No. 402615-91-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15381. | |
| Fingolimod (Standard) | Fingolimod (Standard) is the analytical standard of Fingolimod. This product is intended for research and analytical applications. Fingolimod (FTY720 free base) is a sphingosine 1-phosphate (S1P) antagonist with an IC 50 of 0.033 nM in K562 and NK cells. Fingolimod also is a pak1 activator, a immunosuppressant [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162359-55-9. Pack Sizes: 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11063R. | |
| FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol. HCl, Fingolimod) | Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Group: Biochemicals. Grades: Highly Purified. CAS No. 162359-56-0. Pack Sizes: 1mg, 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Mocravimod hydrochloride | Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KRP-203. CAS No. 509088-69-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13660. | |
| NIBR0213 | NIBR0213 is an orally bioavailable and selective antagonist of sphingosine-1-phosphate receptor-1 (S1P1). NIBR0213 is identified as a promising agent for autoimmune disease therapy. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: NIBR-0213; NIBR 0213; GTPL6997; (2S)-2-[[4-[3-[[(1R)-1-(4-chloro-3-methylphenyl)ethyl]amino]phenyl]-2,6-dimethylbenzoyl]amino]propanoic acid. Grades: ≥98%. CAS No. 1233332-14-3. Molecular formula: C27H29ClN2O3. Mole weight: 465. | |
| N-tert-Butyloxycarbonyl-D-erythro-dihydro-D-sphingosine-1,3-di-O-(phosphate Dicyanoethyl Ester) | Side product in the preparation of sphingosine 1-phosphate analogs. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Ozanimod | Ozanimod (RPC-1063), a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod has modulate effect for hS1P 1 and hS1P 5 receptor with EC 50 s of 1.03 nM and 8.6 nM, respectively. Ozanimod can be used for the research of relapsing multiple sclerosis (MS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RPC-1063. CAS No. 1306760-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12288. | |
| Ozanimod hydrochloride | Ozanimod (RPC-1063) hydrochloride, a sphingosine 1-phosphate (S1P) receptor modulator that binds with high affinity selectively to S1P receptor subtypes 1 (S1P1) and 5 (S1P5). Ozanimod hydrochloride has modulate effect for hS1P 1 and hS1P 5 receptor with EC 50 s of 1.03 nM and 8.6 nM, respectively. Ozanimod hydrochloride can be used for the research of relapsing multiple sclerosis (MS) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RPC-1063 hydrochloride. CAS No. 1618636-37-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12288A. | |
| PF-543 | PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II. CAS No. 1415562-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15425. | |
| PF-543 Citrate | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 Citrate induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II Citrate. CAS No. 1415562-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15425A. | |
| rac FTY720 Phosphate | rac FTY720 is a sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. Group: Biochemicals. Alternative Names: 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol 1-(Dihydrogen Phosphate); 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester; FTY720-P; FTY-P; Fingolimod phosphate. Grades: Highly Purified. CAS No. 402615-91-2. Pack Sizes: 1mg, 2mg, 5mg. US Biological Life Sciences. | Worldwide |
| SEW 2871 | SEW 2871 is a potent, cell-permeable and selective sphingosine-1-phosphate type 1 receptor agonist (EC50= 13 nM). SEW 2871 suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia. Uses: Sphingosine 1 phosphate receptor modulators. Synonyms: 5-[4-Phenyl-5-(trifluoromethyl)thiophen-2-yl]-3-[3-(trifluoromethyl)phenyl]1,2,4-oxadiazole; SEW2871; SEW2871; SEW2871. Grades: >98%. CAS No. 256414-75-2. Molecular formula: C20H16N2OS. Mole weight: 332.419. | |
| (S) FTY720 Phosphate (2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester, (S)-FTY720-P) | A sphingosine 1-phosphate receptor modular, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration. It is the active metabolite of FTY720-phosphate. Group: Biochemicals. Alternative Names: 2-(S)-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol Mono(dihydrogen phosphate) Ester; (S)-FTY720-P. Grades: Highly Purified. CAS No. 402616-26-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| SKI-I, Sphingosine Kinase Inhibitor (5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide) | Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy. Group: Biochemicals. Grades: Highly Purified. CAS No. 306301-68-8. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| SLM6031434 hydrochloride | SLM6031434 hydrochloride is a highly selective sphingosine kinase 2 (SphK2) inhibitor with K i s of 0.4 μM, 0.5 μM, >20 μM, 22 μM for mSphK2, rSphK2, mSphK1 and rSphK1, respectively. SLM6031434 hydrochloride decrease Sphingosine 1-phosphate (S1P) levels in U937 monocytic leukemia cells. SLM6031434 hydrochloride has the potential for renal fibrosis research [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1897379-34-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120268A. | |
| Sphinganine-1-phosphate (d18:0) | Sphinganine-1-phosphate is an antagonist of the sphingosine-1-phosphate (S1P1/EDG-1) receptor with Ki value of 15 nM. It is a lipid mediator particularly for HDL. Synonyms: D-erythro-sphinganine-1-phosphate; C18-dihydro Sphingosine-1-phosphate; Dihydro-D-erythro-Sphingosine-1-phosphate; D-erythro-Dihydro-D-sphingosine-1-phosphate; [R-(R*,S*)]-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate); (2S,3R)-Sphinganine 1-Phosphate; C18-Dihydrosphingosine 1-Phosphate; Dihydrosphingosine-1-phosphate; (2S,3R)-2-Amino-1,3-octadecanediol 1-(Dihydrogen Phosphate). Grades: ≥95%. CAS No. 19794-97-9. Molecular formula: C18H40NO5P. Mole weight: 381.49. | |
| (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride | (1R)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307231-02-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
| (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine Hydrochloride | (1S)-4-Bromo-2,3-dihydro-1H-inden-1-amine is used to prepare sphingosine 1 phosphate receptor modulators useful in treatment of S1P1-associated diseases. Group: Biochemicals. Grades: Highly Purified. CAS No. 1307873-37-5. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H11BrClN, Molecular Weight: 248.55. US Biological Life Sciences. | Worldwide |
| Amiselimod HCl | Amiselimod, formerly known as MT-1303, is a prodrug that is converted to (S)-amiselimod phosphate by sphingosine kinases. And it also is a potent and selective immunosuppressant and sphingosine 1 phosphate receptor modulator, as an investigational therapy for people with relapsing-remitting muscular sclerosis (RRMS), inflammatory bowel disease (IBD), and other autoimmune diseases. Synonyms: 2-amino-2-{2-[4- (heptyloxy) -3- (trifluoromethyl) phenyl]ethyl}propane-1, 3-diol hydrochloride; MT-1303; MT1303; MT 1303; Amiselimod HCl. CAS No. 942398-84-7. Molecular formula: C19H31ClF3NO3. Mole weight: 413.91. | |
| APD334 | This active moleclar is a Sphingosine 1 Phosphate Receptor antagonists for treatment of multiple sclerosis (MS) and other autoimmune diseases originated by Arena Pharmaceuticals. APD334 was efficacious in a mouse EAE (experimental autoimmune encephalomyelitis ) model of MS and a rat CIA (collagen induced arthritis) model. It was found to have appreciable central exposure. In Sep 2015, Arena Pharmaceuticals planed a phase II extension trial for Ulcerative colitis in USA was on-going. In Mar 2016, Arena Pharmaceuticals had patent protection for APD 334 in USA, Japan, China, Australia and Russia. Uses: Multiple sclerosis (ms) and other autoimmune diseases. Synonyms: APD334; APD 334; APD-334; Etrasimod; UNII-6WH8495MMH; 6WH8495MMH; CHEMBL3358920;2-[(3R)-7-[[4-cyclopentyl-3-(trifluoromethyl)phenyl]methoxy]-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid. Grades: 98%. CAS No. 1206123-37-6. Molecular formula: C26H26F3NO3. Mole weight: 457.49. | |
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