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| Product | Description | |
|---|---|---|
| squalene synthase | This microsomal enzyme catalyses the first committed step in the biosynthesis of sterols. The enzyme from yeast requires either Mg2+ or Mn2+ for activity. In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). High concentrations of FPP inhibit the production of squalene but not of PSPP. Group: Enzymes. Synonyms: farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Enzyme Commission Number: EC 2.5.1.21. CAS No. 9077-14-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2758; squalene synthase; EC 2.5.1.21; 9077-14-9; farnesyltransferase; presqualene-diphosphate synthase; presqualene synthase; squalene synthetase; farnesyl-diphosphate farnesyltransferase; SQS. Cat No: EXWM-2758. |  |
| Botryococcus squalene synthase | Isolated from the green alga Botryococcus braunii BOT22. Acts in the reverse direction. cf. EC 2.5.1.21, squalene synthase, where squalene is formed directly from farnesyl diphosphate. Group: Enzymes. Synonyms: SSL-2 (gene name). Enzyme Commission Number: EC 1.3.1.96. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1366; Botryococcus squalene synthase; EC 1.3.1.96; SSL-2 (gene name). Cat No: EXWM-1366. | |
| hydroxysqualene synthase | This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 1.17.8.1, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase. Group: Enzymes. Synonyms: hpnC (gene name). Enzyme Commission Number: EC 4.2.3.156. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5171; hydroxysqualene synthase; EC 4.2.3.156; hpnC (gene name). Cat No: EXWM-5171. | |
| presqualene diphosphate synthase | Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase). Group: Enzymes. Synonyms: SSL-1 (gene name); hpnD (gene name). Enzyme Commission Number: EC 2.5.1.103. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2719; presqualene diphosphate synthase; EC 2.5.1.103; SSL-1 (gene name); hpnD (gene name). Cat No: EXWM-2719. | |
| 2-(3-Butynyloxy)tetrahydro-2H-pyran | 2-(3-Butynyloxy)tetrahydro-2H-pyran is used as a reagent in the synthesis of Phomoidride D, a bridged, polycyclic, natural compound that has the ability to inhibit squalene synthase and can be used as an antihypercholesterolem ic agent. 2-(3-Butynyloxy)tetrahydro-2H-pyran is also used as a reagent to prepare Rugulactone, a natural compound that is isolated from Cryptocarya rugulosa. Group: Biochemicals. Grades: Highly Purified. CAS No. 40365-61-5. Pack Sizes: 1g, 2.5g. Molecular Formula: C9H14O2. US Biological Life Sciences. |  Worldwide |
| 2-Bromodibenzo[b, d]thiophene | 2-Bromodibenzo[b, d]thiophene acts as a reagent in the synthesis and biological evaluation of quinuclidines as squalene synthase inhibitors, properties and device performance of electron transport materials. Group: Biochemicals. Grades: Highly Purified. CAS No. 22439-61-8. Pack Sizes: 5g, 10g. Molecular Formula: C12H7BrS. US Biological Life Sciences. | Worldwide |
| 2-Chloro-3-fluorobenzoic Acid | 2-Chloro-3-fluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize aminobenzhydrol derivatives containing pendant cyclic amines as inhibitors of squalene synthase and cholesterol synthase. It can also be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists. Group: Biochemicals. Grades: Highly Purified. CAS No. 102940-86-3. Pack Sizes: 2.5g, 5g. Molecular Formula: C7H4ClFO2, Molecular Weight: 174.56. US Biological Life Sciences. | Worldwide |
| arabidiol synthase | The reaction occurs in the reverse direction. Group: Enzymes. Synonyms: PEN1 (gene name); (S)-squalene-2,3-epoxide hydro-lyase (arabidiol forming). Enzyme Commission Number: EC 4.2.1.124. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4965; arabidiol synthase; EC 4.2.1.124; PEN1 (gene name); (S)-squalene-2,3-epoxide hydro-lyase (arabidiol forming). Cat No: EXWM-4965. | |
| Bisabosqual A | Bisabosqual A is a squalene synthase inhibitor produced by Stach-ybotrys sp. RF-7260. Bisabosqual A has broad-spectrum antifungal activity. Synonyms: (3S,3aR,9S,9aR,9bS)-2,3,3a,9,9a,9b-Hexahydro-3-hydroxy-3,9-dimethyl-9-(4-methyl-3-pentenyl)-1H-benzofuro[4,3,2-cde][1]benzopyran-5,6-dicarbaldehyde. Molecular formula: C23H28O5. Mole weight: 384.46. |  |
| Bisabosqual B | Bisabosqual B is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia. Bisabosqual B Antifungal activity is weak. Synonyms: (3S,3aR,9S,9aR,9bS)-2,3,3a,9,9a,9b-Hexahydro-3-hydroxy-6-(hydroxymethyl)-3,9-dimethyl-9-(4-methyl-3-pentenyl)-1H-benzofuro[4,3,2-cde][1]benzopyran-5-carbaldehyde. Molecular formula: C23H30O5. Mole weight: 386.48. | |
| Bisabosqual C | Bisabosqual C is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia. Synonyms: (3S,3aS,9S,9aR,9bR)-2,3,3a,9,9a,9b-Hexahydro-3,9b-dihydroxy-3,9-dimethyl-9-(4-methyl-3-pentenyl)-1H-benzofuro[4,3,2-cde][1]benzopyran-5,6-dicarbaldehyde. Molecular formula: C23H28O6. Mole weight: 400.46. | |
| Bisabosqual D | Bisabosqual D is a squalene synthase inhibitor produced by Stachybotry ruwenzoriensia. Molecular formula: C23H30O7. Mole weight: 418.49. | |
| BMS-188494 | BMS-188494 is the prodrug of BMS-187745, a squalene synthase inhibitor used as an anticholesterol drug. Synonyms: 1-[bis (2, 2-dimethylpropanoyloxymethoxy) phosphoryl]-4- (3-phenoxyphenyl) butane-1-sulfonic acid; BMS-188494; BMS 188494; BMS188494; UNII-F4W2579G7P. Grades: >98%. CAS No. 191866-32-7. Molecular formula: C28H39O11PS. Mole weight: 614.645. | |
| chrysanthemyl diphosphate synthase | Requires a divalent metal ion for activity, with Mg2+ being better than Mn2+. Chrysanthemyl diphosphate is a monoterpene with a non-head-to-tail linkage. It is unlike most monoterpenoids, which are derived from geranyl diphosphate and have isoprene units that are linked head-to-tail. The mechanism of its formation is similar to that of the early steps of squalene and phytoene biosynthesis. Chrysanthemyl diphosphate is the precursor of chrysanthemic acid, the acid half of the pyrethroid insecticides found in chrysanthemums. Group: Enzymes. Synonyms: CPPase. Enzyme Commission Number: EC 2.5.1.67. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2804; chrysanthemyl diphosphate synthase; EC 2.5.1.67; CPPase. Cat No: EXWM-2804. | |
| CP-225917 | CP-225917 inhibits Ras farnesyl transferase from the mouse brain and Squalene synthase. Molecular formula: C31H38O10. Mole weight: 570.63. | |
| CP-263114 | CP-263114 inhibits Ras farnesyl transferase from the mouse brain and Squalene synthase. CAS No. 186700-09-4. Molecular formula: C31H36O9. Mole weight: 552.61. | |
| cycloartenol synthase | This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. This enzyme participates in biosynthesis of steroids. Group: Enzymes. Synonyms: 2,3-epoxysqualene cycloartenol-cyclase; squalene-2,3-epoxide-cycloartenol cyclase; 2,3-epoxysqualene-cycloartenol cyclase; 2,3-oxidosqualene-cycloartenol cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming). Enzyme Commission Number: EC 5.4.99.8. CAS No. 9075-25-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5608; cycloartenol synthase; EC 5.4.99.8; 9075-25-6; 2,3-epoxysqualene cycloartenol-cyclase; squalene-2,3-epoxide-cycloartenol cyclase; 2,3-epoxysqualene-cycloartenol cyclase; 2,3-oxidosqualene-cycloartenol cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming). Cat No: EXWM-5608. | |
| dammarenediol II synthase | The reaction occurs in the reverse direction. Group: Enzymes. Synonyms: dammarenediol synthase; 2,3-oxidosqualene (20S)-dammarenediol cyclase; DDS; (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming). Enzyme Commission Number: EC 4.2.1.125. CAS No. 189354-84-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4966; dammarenediol II synthase; EC 4.2.1.125; 189354-84-5; dammarenediol synthase; 2,3-oxidosqualene (20S)-dammarenediol cyclase; DDS; (S)-squalene-2,3-epoxide hydro-lyase (dammarenediol-II forming). Cat No: EXWM-4966. | |
| hydroxysqualene dehydroxylase | This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC 2.5.1.103, presqualene diphosphate synthase, and EC 4.2.3.156, hydroxysqualene synthase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC 2.5.1.21, squalene synthase. Group: Enzymes. Synonyms: hpnE (gene name). Enzyme Commission Number: EC 1.17.8.1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1100; hydroxysqualene dehydroxylase; EC 1.17.8.1; hpnE (gene name). Cat No: EXWM-1100. | |
| lanosterol synthase | Lanosterol synthase is an oxidosqualene cyclase (OSC) enzyme that converts (S)-2,3-oxidosqualene to a protosterol cation and finally to lanosterol. Lanosterol is a key four-ringed intermediate in cholesterol biosynthesis. In humans, lanosterol synthase is encoded by the LSS gene. Group: Enzymes. Synonyms: 2,3-epoxysqualene lanosterol cyclase; squalene-2,3-oxide-lanosterol cyclase; lanosterol 2,3-oxidosqualene cyclase; squalene 2,3-epoxide:lanosterol cyclase; 2,3-oxidosqualene sterol cyclase; oxidosqualene cyclase; 2,3-oxidosqualene cyclase; 2,3-oxidosqualene-lanosterol cyclase; oxidosqualene-lanosterol cyclase; squalene epoxidase-cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming). Enzyme Commission Number: EC 5.4.99.7. CAS No. 9032-71-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5607; lanosterol synthase; EC 5.4.99.7; 9032-71-7; 2,3-epoxysqualene lanosterol cyclase; squalene-2,3-oxide-lanosterol cyclase; lanosterol 2,3-oxidosqualene cyclase; squalene 2,3-epoxide:lanosterol cyclase; 2,3-oxidosqualene sterol cyclase; oxidosqualene cyclase; 2,3-oxidosqualene cyclase; 2,3-oxidosqualene-lanosterol cyclase; oxidosqualene-lanosterol cyclase; squalene epoxidase-cyclase; (S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming). Cat No: EXWM-5607. | |
| Lapaquistat acetate | Lapaquistat acetate, also referred as TAK475, is a squalene synthase inhibitor. As a cholesterol-lowering drug, Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Uses: A novel squalene synthase inhibitor. Synonyms: 2-[1-[2-[(3R,5S)-1-(3-acetyloxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid; (1-(2-(1-(2-carboxyoxy-1,1-dimethylethyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid; 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid; lapaquistat; TAK 475; TAK-475; TAK475. Grades: >98%. CAS No. 189060-13-7. Molecular formula: C33H41ClN2O9. Mole weight: 645.14. | |
| RPR113228 | RPR113228 is a farnesyl-protein transferase inhibitor produced by Chrysosporium lobatum. It has no inhibitory effect on squalene synthase. Synonyms: RPR-113228; RPR113228. Molecular formula: C30H49O9P. Mole weight: 584.7. | |
| Schizostatin | It is a squalene synthase inhibitor produced by the strain of Schizophyllum commune SANK 17785. It inhibits squalene synthase with IC50 of 0.84 μmol/L. 1000 μg/mL of Schizostatin has no antibacterial effect on the tested bacteria, mycobacteria, yeast and mycoplasma. Synonyms: schizostatin E; 2-Butenedioic acid, 2-[(3E,7E)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2E)-; 2-Butenedioic acid, 2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (E,E,E)-. CAS No. 163564-55-4. Molecular formula: C20H30O4. Mole weight: 334.45. | |
| squalene monooxygenase | A flavoprotein (FAD). This enzyme, together with EC 5.4.99.7 lanosterol synthase, was formerly known as squalene oxidocyclase. The electron donor is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Enzyme Commission Number: EC 1.14.14.17. CAS No. 9029-62-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0914; squalene monooxygenase; EC 1.14.14.17; 9029-62-3; squalene epoxidase; squalene-2,3-epoxide cyclase; squalene 2,3-oxidocyclase; squalene hydroxylase; squalene oxydocyclase; squalene-2,3-epoxidase. Cat No: EXWM-0914. | |
| Squalestatin A | It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: Zaragozic acid A; squalestatin 1; Squalestatin; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-(4,6-dimethyl-2-octenoate), (5(2E,4S,6S),7S)-; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-; Squalestatin S1. Grades: >98% by HPLC. CAS No. 142561-96-4. Molecular formula: C35H46O14. Mole weight: 690.73. | |
| Squalestatin B | It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 5-[(2E,4S,6S)-4,6-dimethyl-2-octenoate], (7S)-; L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 5-(4,6-dimethyl-2-octenoate), [5(2E,4S,6S),7S]-; Squalestatin 2; Squalestatin S2. CAS No. 142505-91-7. Molecular formula: C33H44O13. Mole weight: 648.70. | |
| Squalestatin C | It is a squalene synthase inhibitor produced by the strain of Phoma sp. C2932. It inhibits squalene synthase in mammalian (rat liver) and Candida albicans, and has a broad-spectrum antifungal effect. Synonyms: L-erythro-L-glycero-D-altro-7-Trideculo-7,4-furanosonic acid, 2,7-anhydro-3,4-di-C-carboxy-8,9,10,12,13-pentadeoxy-10-methylene-12-(phenylmethyl)-, 11-acetate, (7S)-; Squalestatin 3; Squalestatin H1. CAS No. 142505-92-8. Molecular formula: C25H30O13. Mole weight: 538.50. | |
| tetrahymanol synthase | The reaction occurs in the reverse direction. Group: Enzymes. Synonyms: squalene?tetrahymanol cyclase. Enzyme Commission Number: EC 4.2.1.123. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4964; tetrahymanol synthase; EC 4.2.1.123; squalene?tetrahymanol cyclase. Cat No: EXWM-4964. | |
| Ym-53601 | YM-53601, a squalene synthase inhibitor, reduces plasma cholesterol and triglyceride levels in vivo. YM-53601 inhibits squalene synthase derived from human hepatoma cells with an IC50 of 79 nM. Lipid-lowering agent. YM-53601 is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and abrogates HCV propagation. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. Appearance: Solid. CAS No. 182959-33-7. Molecular formula: C21H21FN2O. Mole weight: 372.86. Purity: 0.9926. Canonical SMILES: F/C(COC1=CC(NC2=C3C=CC=C2)=C3C=C1)=C4CN5CCC/4CC5.[H]Cl. Product ID: ACM182959337. Alfa Chemistry ISO 9001:2015 Certified. |  |
| YM-53601 | YM-53601 is a squalene synthase inhibitor with IC50s of 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively. It is a lipid lowering agent that can reduce plasma cholesterol and triglyceride levels in vivo and inhibit cholesterol biosynthesis in rats (ED50 = 32 mg/kg). It is also an inhibitor of farnesyl-diphosphate farnesyltransferase 1 (FDFT1) enzyme activity and can inhibit the proliferation of HCV. Synonyms: 9H-Carbazole, 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-, hydrochloride (1:1); (E)-3-[2-(Carbazol-2-yloxy)-1-fluoroethylidene]quinuclidine hydrochloride; 2-[(2E)-2-(1-azabicyclo[2.2.2]oct-3-ylidene)-2-fluoroethoxy]-9H-carbazole, monohydrochloride. Grades: ≥98%. CAS No. 182959-33-7. Molecular formula: C21H21FN2O.HCl. Mole weight: 372.86. | |
| Zaragozic acid A | Zaragozic acid A is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Squalestatin S1. CAS No. 142561-96-4. Pack Sizes: 1 mg. Product ID: HY-116290. |  |
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