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| Product | Description | |
|---|---|---|
| Streptonigrin | Bruneomycin is a benzoquinone antibiotic produced by Auiw-myces albus van bruneomycini and Act. echinatus. It has anti-gram-positive bacteria, negative bacteria, and mycobacterial activity. It has inhibitory effect on lymphosarcoma Lio-1, lymphocytic leukemia NK/L1 and L-5178, Ehrlich ascites carcinoma, sarcoma-180, and has inhibitory effect on sarcoma-37 invalid. Synonyms: Bruneomycin; Rufocromomycin; Nigrin; Streptonigran. Grades: >95% by HPLC. CAS No. 3930-19-6. Molecular formula: C25H22N4O8. Mole weight: 506.46. |  |
| Streptonigrin | Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus , possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC 50 s of 48.3±34.2 μM, 26.1±0.3 μM, 0.43±0.03 μM, and 2.5±0.4 μM for PAD1 , PAD2 , PAD3 , and PAD4 , respectively [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Bruneomycin. CAS No. 3930-19-6. Pack Sizes: 500 μg; 1 mg. Product ID: HY-124586. |  |
| Streptonigrin (Bruneomycin, Nigrin, Rufocromomycin, Valacidin, Antibiotic RP 5278) | Streptonigrin is an unusual aminoquinone with broad biological activity against bacteria, fungi, nematodes, viruses and tumor cells. Streptonigrin acts as a bioreductive agent, highly dependent on interactions with metal ions, notably iron, and plays an important role in free radical production through redox cycling of NAD(P)H:quinone oxidoreductase (NQO1). Streptonigrin from Streptomyces flocculus is an aminoquinone antitumor antibiotic. Its antineoplastic activity requires reductive activation by Xanthine-converting enzymes. It induces apoptosis by a mechanism involving NF-κB. DNA cleavage reaction and chromosome damage by Streptonigrin are influenced by the nature of the metal ion present and dependent on the production of free radicals. Its antibiotic activity is iron-activated. Group: Biochemicals. Alternative Names: EC Number 223-501-8; 5278RP; AO 50165L302; Abbott Crystalline antibiotic; Bruneomycin; NSC 45383; NSC 56748; NSC 83950; Nigrin; Rufocromomycin; SN; STP; Streptonigran; Streptonigrin; 5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid; (4R)-5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid; (R)-Streptonigrin. Grades: Highly Purified. CAS No. 3930-19-6. Pack Sizes: 1mg. Molecular Formula: C??H??N?O?, Molecular Weight: 506.46. US Biological Life Sciences. |  Worldwide |
| Streptonigrin from Streptomyces flocculus | ?98%. Group: Fluorescence/luminescence spectroscopy. |  |
| 10'-Desmethoxystreptonigrin | It is a close analogue of streptonigrin produced by selected streptomyces species. It is a moderately potent inhibitor of farnesylation of RAS P21 protein, 3-fold more active than streptonigrin. It has potent and broad spectrum antibacterial and antitumour activity. Synonyms: 2-Pyridinecarboxylic acid, 5-amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolinyl)-4-(2-hydroxy-3-methoxyphenyl)-3-methyl-; 10-Desmethoxystreptonigrin. Grades: >95% by HPLC. CAS No. 136803-89-9. Molecular formula: C24H20N4O7. Mole weight: 476.44. | |
| Lavendamycin | It is produced by the strain of Str. lavendulae C-22030. It's a quinone antibiotic. It has anti-bacterial and fungal effect, but the anti-bacterial effect is weaker than Streptonigrin, while the anti-fungal effect is stronger than Streptonigrin. Synonyms: 9H-Pyrido(3,4-b)indole-3-carboxylic acid, 1-(7-amino-5,8-dihydro-5,8-dioxo-2-quinolinyl)-4-methyl-; Antibiotic K 82A. CAS No. 81645-09-2. Molecular formula: C22H14N4O4. Mole weight: 398.38. | |
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