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(2-Bromoethyl) trimethylsilane has been used as a reactant in the synthesis of strychnine, norfluorocurarine, de hydrodesacetylretuline and valparicine. Group: Biochemicals. Grades: Highly Purified. CAS No. 18156-67-7. Pack Sizes: 250mg, 500mg. Molecular Formula: C5H13BrSi. US Biological Life Sciences.
Worldwide
2-Ethyl-2-methyl-1,3-dioxolane
2-Ethyl-2-methyl-1,3-dioxolane is used as a reagent in the synthesis of Strychnine Hydrochloride (S687710); a compound that acts as an antagonist for cholinesterases and beta amyloid aggregation. Also used as a reagent in the study of the prodrugs of peptide aldehyde as proteasome inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 126-39-6. Pack Sizes: 1g, 10g. Molecular Formula: C6H12O2, Molecular Weight: 116.16. US Biological Life Sciences.
Worldwide
3,4-Dehydro-L-proline
3,4-Dehydro-L-proline is used to prepare morpholinyl-4-piperidinylacetic acid derivatives as potent oral active VLA-4 antagonists. It is also a β-Proline analog used as agonists at the strychnine-sensitive glycine receptor. Synonyms: 3,4-Dehydro-L-Pro-OH; (S)-3,4-Dehydro-pyrrolidine-2-carboxylic acid; (S)-2,5-Dihydro-1H-pyrrole-2-carboxylic acid; L-3,4-Dehydroproline; (2S)-2,5-dihydro-1H-pyrrole-2-carboxylic acid; L-3-Pyrroline-2-carboxylic acid; (S)-3-Pyrroline-2-carboxylic acid. Grades: ≥ 99%. CAS No. 4043-88-3. Molecular formula: C5H7NO2. Mole weight: 113.11.
5,7-Dichlorokynurenic Acid, Sodium Salt (5,7-Dichloro-4-hydroxyquinoline-2-c-arboxylic Acid Sodium Salt, DCKA)
A very potent, water-soluble antagonist of thenMDA receptors complex acting at the strychnine-insensitive glycine binding site (Ki = 79nM vs. [3H]-glycine). Group: Biochemicals. Grades: Highly Purified. CAS No. 1184986-70-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
7-Chlorokynurenic acid
7-Chlorokynurenic acid is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection. Synonyms: 7CKA; 7-CKA; 7 CKA; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 18000-24-3. Molecular formula: C10H6ClNO3. Mole weight: 223.62.
7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt is the sodium salt of 7-Chlorokynurenic acid, which is a water-soluble and very potent NMDA receptor antagonist acting at the strychnine-insensitive glycine binding site with IC50 value of 0.56 μM. It is also a potent competitive inhibitor of L-glutamate transport into synaptic vesicles. It is used in studies of schizophrenia and neuroprotection. Synonyms: 7-Chloro-4-hydroxyquinoline-2-carboxylic acid sodium salt. Grades: ≥98% by HPLC. CAS No. 1263094-00-3. Molecular formula: C10H5ClNNaO3. Mole weight: 245.59.
7-Chlorokynurenic Acid Sodium Salt (7-Chloro-4-hydroxyquinoline-2-carbo-xylic Acid Sodium Salt)
A very potent, water-soluble antagonist of the nMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56uM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia. Group: Biochemicals. Grades: Highly Purified. CAS No. 1263094-00-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Gavestinel
Gavestinel is a non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM), displaying >1000-fold selectivity over NMDA, AMPA, and kainate binding sites. Gavestinel exhibits a neuroprotective property in animal models of ischaemic stroke. Uses: Glycine agents. Synonyms: 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propenyl]-; 1H-Indole-2-carboxylic acid, 4,6-dichloro-3-[3-oxo-3-(phenylamino)-1-propenyl]-, (E)-; 4,6-Dichloro-3-[(1E)-3-oxo-3-(phenylamino)-1-propen-1-yl]-1H-indole-2-carboxylic acid; GV 150526; GV 150526X; (E)-4,6-dichloro-3-(3-oxo-3-(phenylamino)prop-1-en-1-yl)-1H-indole-2-carboxylic acid. Grades: ≥95%. CAS No. 153436-22-7. Molecular formula: C18H12Cl2N2O3. Mole weight: 375.21.
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