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| Product | Description | |
|---|---|---|
| Sulfo EGS | Sulfo EGS. Pack Sizes: Milligram Quantities: 100 mg. Order Number: CL109. |  www.prochemonline.com |
| Sulfo-EGS | Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 167410-92-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117080. |  |
| BTB-1 | BTB-1 is a novel small molecule inhibitor of the mitotic motor protein Kif18A, which was identified by Catarinella et al. during a highthroughput screen against Kif18A's MT-stimulated ATPase activity, with an IC50 of 1.7-1.9 M. It is selective within the kinesin subgroup of Kif4, Eg5, MKLP-1, MKLP-2, MPP1, CENP-E and MCAK, and during in vitro motility assays Kif18A's MT gliding ability was blocked by the addition of BTB-1 in a reversible manner. BTB-1 was found to be ATP competitive and MT uncompetitive, only inhibiting the ATPase activity of the MT-bound motor protein. BTB-1 could serve as a valuable tool in disentangling the nature of Kif18A's double functionality within mitosis and assessing for potential therapeutic utilities. Synonyms: BTB 1; BTB1; 4-Chloro-2-nitro-1-(phenylsulfonyl)benzene; 4-Chloro-2-nitrodiphenyl sulfone; NSC 156750. CAS No. 86030-08-2. Molecular formula: C12H8ClNO4S. Mole weight: 297.71. |  |
| Dansyl-Glu-Gly-Arg-chloromethylketone | Dansyl-Glu-Gly-Arg-chloromethylketone, an irreversible inhibitor of plasminogen activator, Factor Xa and urokinase, allows direct monitoring of labeled enzyme interactions. Uses: Fluorescent dyes. Synonyms: dansylglutamyl-glycyl-arginine chloromethyl ketone; Dns-EGR-CMK; 1,5-Dansyl-L-glutamylglycyl-L-arginine chloromethyl ketone; Dns-Glu-Gly-Arg chloromethyl ketone; Glycinamide, N-((5-(dimethylamino)-1-naphthalenyl)sulfonyl)-L-alpha-glutamyl-N-(4-((aminoiminomethyl)amino)-1-(chloroacetyl)butyl)-, (S)-. Grade: ≥95%. CAS No. 69024-84-6. Molecular formula: C26H36ClN7O7S. Mole weight: 626.13. | |
| Dimethyl-(2-hydroxyethyl)-(3-sulfopropyl)ammonium, Inner Salt (NDSB211) | A non-detergent sulfobetaine that has been used as a mild solubilizing and stabilizing agent for halophilic malate dehydrogenase, halophilic elongation factor Tu, pig heart amylate dehydrogenase, chicken egg white lysozyme and E. coli b-galactosidase. Group: Biochemicals. Alternative Names: NDSB211. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. |  Worldwide |
| Dimethylbenzyl-(3-sulfopropyl)ammonium, Inner Salt (NDSB-256) | A non detergent sulfobetaine used as a mild solubilizing and stabilizing agent for chicken egg white lysozyme and E. coli ß-galactosidase. Group: Biochemicals. Alternative Names: NDSB-256. Grades: Highly Purified. Pack Sizes: 5g. US Biological Life Sciences. | Worldwide |
| EG01377 | EG01377 is a potent, bioavailable and selective neuropilin-1 (NRP1) inhibitor, with a Kd of 1.32 μM, and IC50s of both 609 nM for NRP1-a1 and NRP1-b1. It has antiangiogenic, antimigratory and antitumor effects. Synonyms: (3-((5-(4-(aminomethyl)phenyl)-2,3-dihydrobenzofuran)-7-sulfonamido)thiophene-2-carbonyl)-L-arginine; N2-({3-[({5-[4-(Aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl}sulfonyl)amino]-2-thienyl}carbonyl)-N5-(diaminomethylene)-L-ornithine. Grade: ≥98%. CAS No. 2227996-00-9. Molecular formula: C26H30N6O6S2. Mole weight: 586.68. | |
| EG01377 dihydrochloride | EG01377 dihydrochloride is a potent, bioavailable and selective neuropilin-1 (NRP1) inhibitor, with a Kd of 1.32 μM, and IC50s of 609 nM for both NRP1-a1 and NRP1-b1. It has antiangiogenic, antimigratory and antitumor effects. Synonyms: N2-({3-[({5-[4-(Aminomethyl)phenyl]-2,3-dihydro-1-benzofuran-7-yl}sulfonyl)amino]-2-thienyl}carbonyl)-N5-(diaminomethylene)-L-ornithine dihydrochloride; L-Ornithine, N2-[[3-[[[5-[4-(aminomethyl)phenyl]-2,3-dihydro-7-benzofuranyl]sulfonyl]amino]-2-thienyl]carbonyl]-N5-(diaminomethylene)-, hydrochloride (1:2). Grade: ≥98%. Molecular formula: C26H32Cl2N6O6S2. Mole weight: 659.60. | |
| GSK-3beta Inhibitor XXIV (2-Methyl-5- (3-[4- (methylsulfinyl) phenyl) -1-benzofuran-5-yl) -1, 3, 4-oxadiazole, Racemic) | An orally bioavailable and blood-brain-barrier permeable oxadiazolo-benzofuranyl phenyl sulfoxide compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3b (IC50=35nM, 34 and 140nM for racemic, (S)-9b eutomer and (R)-9b distomer). The (S)-9b eutomer displays excellent selectivity (IC50 > 10uM) over Cdk1/2/5, Chk1, p38a, JNK1, MEKK1, IKKb, PKCth, CK1d, EGFR, ErbB2, Src, Lck, IR, Tie2, c-Kit, c-Met, VEGFR2, FGFR3 and PDGFRa/b, and lowers tau phosphorylation at GSK-3b-Thr205 in a CWS (cold water stress) mouse model (3mg/kg, p.o.). Group: Biochemicals. Grades: Highly Purified. CAS No. 1005201-24-0. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Sulfo-Cyanine5-PEG3-Biotin | Sulfo-Cyanine5 is a far-red fluorophore widely used for biomolecule labeling, with excitation maximum at 646 nm and emission maximum at 662 nm. Far-red fluorescent tags with excitation above 600 nm and emission further than 650 nm are valuable for imaging techniques because of the lower background autofluorescence at these wavelengths. Besides, far-red fluorescent labels can be imaged simultaneously with near-red, orange, green, and blue tags, which is advantageous for multicolor imaging.,Biotin, or the water-soluble vitamin H, is well known not only for playing essential roles in various crucial metabolic cellular reactions but also for its extremely high affinity for avidin, a glycoprotein of egg white. Avidin, streptavidin (bacterial analogue of avidin), and neutravidin (deglycosylated avidin) bind non-cooperatively to biotin with high affinity. Thus, sulfo-Cyanine5 biotin conjugate can be used for detecting and quantifying biotin binding sites of avidin, streptavidin, and neutravidin in samples of different origin.,Sulfo-Cyanine5 biotin conjugate is a water-soluble reagent and its fluorescence is pH independent from pH 4 to pH 10. A flexible PEG3 linker between biotin moiety and fluorescent tag provides binding to avidin, streptavidin, or neutravidin without steric troubles.,The major applications of sulfo-Cyanine5 biotin conjugate include imaging (e.g. primary and secondary antibody labeling for Western Bl | |
| Sulforaphene | Sulforaphene, isolated from radish seeds, exhibits an ED 50 against velvetleaf seedlings approximately 2 x 10 -4 M. Sulforaphene promotes cancer cells apoptosis and inhibits migration via inhibiting EGFR , p-ERK1/2 , NF?κB and other signals [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 592-95-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-N2450. | |
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