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| Product | Description | |
|---|---|---|
| Tazemetostat | Tazemetostat (EPZ-6438) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat inhibits the activity of human polycomb repressive complex 2 (PRC2)-containing wild-type EZH2 with a K i value of 2.5 nM. Tazemetostat inhibits EZH2 with IC 50 s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat inhibits rat EZH2 with an IC 50 of 4 nM. Tazemetostat also inhibits EZH1 with an IC 50 of 392 nM. Tazemetostat induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EPZ-6438; E-7438. CAS No. 1403254-99-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-13803. |  |
| Tazemetostat | Tazemetostat Inhibitor. Uses: Scientific use. Product Category: T1788. CAS No. 1403254-99-8. |  |
| 1,2,3,6-Tetrahydro-2,2,6,6-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine | 1,2,3,6-Tetrahydro-2,2,6,6-tetramethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is used as a reagent in the synthesis process of tazemetostat, an EHZ2 inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1257651-11-8. Pack Sizes: 10mg, 50mg. Molecular Formula: C15H28BNO2, Molecular Weight: 265.2. US Biological Life Sciences. |  Worldwide |
| EPZ-6438 | EPZ-6438 is a potent, selective, and orally bioavailable small-molecule inhibitor of EZH2 enzymatic activity. EPZ-6438 induces apoptosis and differentiation specifically in SMARCB1-deleted MRT cells. Treatment of xenograft-bearing mice with EPZ-6438 leads to dose-dependent regression of MRTs with correlative diminution of intratumoral trimethylation levels of lysine 27 on histone H3, and prevention of tumor regrowth after dosing cessation. These data demonstrate the dependency of SMARCB1 mutant MRTs on EZH2 enzymatic activity and portend the utility of EZH2-targeted drugs for the treatment of these genetically defined cancers. EPZ-6438 is currently in clinical trials. Synonyms: EPZ-6438; EPZ 6438; EPZ6438; E7438; E-7438; E 7438; Tazemetostat. Grades: 98%. CAS No. 1403254-99-8. Molecular formula: C34H44N4O4. Mole weight: 572.75. |  |
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