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| Product | Description | |
|---|---|---|
| Temozolomide | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C6H6N6O2. CAS No. 85622-93-1. Prepack ID 31724662-1g. Molecular Weight 194.15. See USA prepack pricing. |  |
| Temozolomide | Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, Methazolastone, M&B 39831, Temodal, Temodar; CCRG 81045, TMZ; NSC 362856. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 10mg, 25mg, 100mg. US Biological Life Sciences. |  Worldwide |
| Temozolomide | Temozolomide. CAS No. 85622-93-1. Product ID: 8-04406. Molecular formula: C6H6N6O2. Mole weight: 194.15. |  |
| Temozolomide | Temozolomide Inhibitor. Uses: Scientific use. Product Category: T1178. CAS No. 85622-93-1. |  |
| Temozolomide | Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 362856; CCRG 81045; TMZ. CAS No. 85622-93-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-17364. |  |
| Temozolomide Acid | A metabolite of Temozolomide as antitumor agent. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid. Grades: Highly Purified. CAS No. 113942-30-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Temozolomide Acid | Temozolomide acid is an active metabolite of temozolomide(T017775) with anticancer activity in vitro. Temozolomide is an alkylating agent used as a treatment of some brain cancer, a second-line treatment for astrocytoma and a first-line treatment for glioblastoma multiforme.In Apr 2016, Stanford University and Merck suspended enrolment in a phase II trial for Acute myeloid leukaemia (Combination therapy, Newly diagnosed, Second-line therapy or greater) in USA. In 14 Jul 2016, Medivation planed a phase II trial for Endometrial cancer in USA (NCT02836028) After two days, M.D. Anderson Cancer Center completed a phase II trial in Malignant melanoma (Late-stage disease, Neoadjuvant therapy, Monotherapy, Combination therapy) in USA. Uses: As an antitumor agent. Synonyms: 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxylic Acid; Temozolomide-8-carboxylic Acid; TMZA. Grades: 98%. CAS No. 113942-30-6. Molecular formula: C6H5N5O3. Mole weight: 195.14. |  |
| Temozolomide Cyano Impurity | One impurity of Temozolomide, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 8-Descarboxamido-8-cyano Temozolomide; 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carbonitrile; Cyanotemozolomide; 3-methyl-4-oxoimidazo[5,1-d][1,2,3,5]tetrazine-8-carbonitrile. Grades: > 95%. CAS No. 114601-31-9. Molecular formula: C6H4N6O. Mole weight: 176.14. | |
| Temozolomide-D3 | Temozolomide-D3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 208107-14-6. Molecular Formula: C6H3D3N6O2. Mole Weight: 197.17. Catalog: APB208107146. |  |
| Temozolomide-d3 (3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3) | Labeled Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Temozolomide EP Impurity B | Temozolomide EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 113942-30-6. Molecular Formula: C6H5N5O3. Mole Weight: 195.14. Catalog: APB113942306. | |
| Temozolomide EP Impurity D | Temozolomide EP Impurity D. Uses: For analytical and research use. Group: Impurity standards. CAS No. 7008-85-7. Molecular Formula: C4H3N5O. Mole Weight: 137.1. Catalog: APB7008857. | |
| Temozolomide Impurity 1 | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 3-Amino-3-imino-2-(2-phenyldiazenyl)propanamide; 2-Amidino-2-phenylazoacetamide. Grades: > 95%. CAS No. 100607-08-7. Molecular formula: C9H11N5O. Mole weight: 205.22. | |
| Temozolomide Impurity 10 | Temozolomide Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 90801-87-9. Molecular Formula: C5H8N4O. Mole Weight: 140.15. Catalog: APB90801879. | |
| Temozolomide Impurity 11 | Temozolomide Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1007-36-9. Molecular Formula: C8H10N2O. Mole Weight: 150.18. Catalog: APB1007369. | |
| Temozolomide Impurity 12 | Temozolomide Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1822762-32-2. Molecular Formula: C10H13N3O2. Mole Weight: 207.23. Catalog: APB1822762322. | |
| Temozolomide Impurity 13 | Temozolomide Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 128191-80-0. Molecular Formula: C4H6N2O4. Mole Weight: 146.1. Catalog: APB128191800. | |
| Temozolomide Impurity 14 | Temozolomide Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 100-34-5. Molecular Formula: C6H5ClN2. Mole Weight: 140.57. Catalog: APB100345. | |
| Temozolomide Impurity 16 | Temozolomide Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 71749-37-6. Molecular Formula: C5H5N5. Mole Weight: 135.13. Catalog: APB71749376. | |
| Temozolomide Impurity 18 | Temozolomide Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4919-4-4. Molecular Formula: C4H5N3O2. Mole Weight: 127.1. Catalog: APB4919044. | |
| Temozolomide Impurity 2 | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 3-Amino-2-(formylamino)-3-iminopropanamide; 2-Amidino-2-formamidoacetamide. Grades: > 95%. Molecular formula: C4H8N4O2. HCl. Mole weight: 180.59. | |
| Temozolomide Impurity 20 | Temozolomide Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18514-52-8. Molecular Formula: C4H4N4. Mole Weight: 108.1. Catalog: APB18514528. | |
| Temozolomide Impurity 21 | Temozolomide Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 20344-79-0. Molecular Formula: C4H4N4. Mole Weight: 108.1. Catalog: APB20344790. | |
| Temozolomide Impurity 23 | Temozolomide Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 57052-92-3. Molecular Formula: C4HN5. Mole Weight: 119.09. Catalog: APB57052923. | |
| Temozolomide Impurity 24 | Temozolomide Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 287964-59-4. Molecular Formula: C6H4N6O4. Mole Weight: 224.14. Catalog: APB287964594. | |
| Temozolomide Impurity 4 | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 5-Amino-N1-methyl-1H-imidazole-1,4-dicarboxamide. Grades: > 95%. CAS No. 188612-53-5. Molecular formula: C6H9N5O2. Mole weight: 183.17. | |
| Temozolomide Impurity 4 | Temozolomide Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 188612-53-5. Molecular Formula: C6H9N5O2. Mole Weight: 183.17. Catalog: APB188612535. | |
| Temozolomide Impurity 8 | Temozolomide Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 196806-10-7. Molecular Formula: C11H9N5O5. Mole Weight: 291.22. Catalog: APB196806107. | |
| Temozolomide Impurity 9 | Temozolomide Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 3413-72-7. Molecular Formula: C5H8N6O. Mole Weight: 168.16. Catalog: APB3413727. | |
| Temozolomide Intermediate | Temozolomide Intermediate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6285-64-9. Molecular Formula: C9H12ClN5O. Mole Weight: 241.68. Catalog: APB6285649. | |
| Temozolomide Metabolite - MTIC | One metabolite of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Grades: > 95%. CAS No. 1232679-46-7. Molecular formula: C5H8N6O. Mole weight: 168.16. | |
| TemozoloMide Metabolite-MTIC | TemozoloMide Metabolite-MTIC. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1232679-46-7. Molecular Formula: C5H8N6O. Mole Weight: 168.16. Catalog: APB1232679467. | |
| Temozolomide Related Compound A | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 5-Diazoimidazole-4-carboxamide; 4-Diazo-4H-imidazole-5-carboxamide. Grades: > 95%. CAS No. 7008-85-7. Molecular formula: C4H3N5O. Mole weight: 137.1. | |
| 3-Amino-2-(formylamino)-3-iminopropanamide | 3-Amino-2-(formylamino)-3-iminopropanamide is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 100191-43-3. Pack Sizes: 10mg, 100mg. Molecular Formula: C4H8N4O2, Molecular Weight: 144.13. US Biological Life Sciences. | Worldwide |
| 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide-d5 Hydrochloride | Isotope labelled 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C9D5H7ClN5O, Molecular Weight: 246.71. US Biological Life Sciences. | Worldwide |
| 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride | 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 6285-64-9. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H12ClN5O, Molecular Weight: 241.68. US Biological Life Sciences. | Worldwide |
| 3-Methyl-1,1-diphenylurea | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 3-methyl-1,1-diphenylurea. Grades: 98.0 % (GC). CAS No. 13114-72-2. Molecular formula: C14H14N2O. Mole weight: 226.27. | |
| 5-Amino-4-imidazolecarboxamide Hydrochloride | 5-Amino-4-imidazolecarboxamide hydrochloride is the hydrochloride salt of 5-Amino-4-imidazolecarboxamide, a metabolite of Temozolomide. It is also an impurity in the synthesis of Dacarbazine. Synonyms: 4-amino-1H-imidazole-5-carboxamide;hydrochloride; 4-amino-1H-imidazole-5-carboxamide;hydrochloride. Grades: > 95 %. CAS No. 72-40-2. Molecular formula: C4H7ClN4O. Mole weight: 162.58. | |
| 5-Aminoimidazole-4-carboxamide (AICA, 4-Amino-5-carbamoylimidazole) | A metabolite of Temozolomide. Group: Biochemicals. Alternative Names: AICA, 4-Amino-5-carbamoylimidazole. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 5-Aminoimidazole-4-carboxamide Lactose Adduct | 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide, a metabolite of Temozolomide. Synonyms: Dacarbazine Lactose Adduct Impurity. Grades: 98%. Molecular formula: C16H26N4O11. Mole weight: 450.4. | |
| α-Cyano-4-hydroxycinnamic acid | CHC is a monocarboxylic acid transport (MCT) inhibitor, displaying antitumoral and antiangiogenic activity in gliomas in vivo. It decreases glycolytic metabolism, migration and invasion in U251 cells, enhances the effect of temozolomide. Synonyms: (E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enoic acid. Grades: ≥ 98 % by HPLC. CAS No. 28166-41-8. Molecular formula: C10H7NO3. Mole weight: 189.17. | |
| KRX-0402 | KRX-0402 (O6-benzyl guanine or O6-BG) is a small molecule that was specifically designed to block the DNA repair protein, MGMT. MGMT confers resistance to certain alkylating agents, such as temozolomide and BCNU, that are commonly used to treat brain cancer, melanoma and non-Hodgkin's lymphoma. Recent research has shown that KRX-0402 can also potentiate the activity of other alkylating agents, such as cyclophosphamide, ifosphamide, cisplatinum and carboplatinum. These drugs are some of the most widely used chemotherapy drugs and are commonly used to treat breast cancer, non-small cell lung cancer and ovarian cancer. Accordingly, It is believed that KRX-0402 may have an important role in making cells more susceptible to the damaging effects of alkylating agents, and that KRX-0402 may have utility in the treatment of multiple forms of cancer. KRX-0402 is administered intravenously. To date, approximately 400 patients have received KRX-0402 in multiple clinical studies. Dose limiting toxicity for KRX-0402 in combination with chemotherapy was bone marrow suppression. KRX-0402 alone has no identified dose limiting toxicity. Two company-sponsored, Phase II clinical trials for KRX-0402 are ongoing. Uses: Enzyme inhibitors. Synonyms: KRX 0402; KRX0402; 6-O-Benzylguanine; 6-(Benzyloxy)-7H-purin-2-amine; O(6)-Benzylguanine; 2-Amino-6-(benzyloxy)purine; NSC-637037; O6-BG. CAS No. 1000874-21-4. Molecular formula: C12H11N5O. Mole weight: 241.254. | |
| Levetiracetam | Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT , thus increasing Temozolomide effectiveness. A chemosensitizer agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UCB L059. CAS No. 102767-28-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0106. | |
| Lomeguatrib | Lomeguatrib, also known as PaTrin-2, is a potent Inhibitor of O6-Alkylguanine-DNA-Alkyltransferase. Lomeguatrib is also a nontoxic low-molecular weight pseudosubstrate that has the ability to inactivate MGMT. Lomeguatrib can be used with temozolomide (TMZ) for GBM treatment. Synonyms: PaTrin 2; PaTrin2; PaTrin-2; Lomeguatrib; Patrin. O6-(4-bromothenyl)guanine; 6-(4-Bromothenyloxy)-7H-purin-2-amine. CAS No. 192441-08-0. Molecular formula: C10H8BrN5OS. Mole weight: 326.172. | |
| Lomeguatrib | Lomeguatrib is an inhibitor of O6-methylguanine-DNA methyltransferase (MGMT). Lomeguatrib attenuates MGMT activity in vitro and in vivo. Lomeguatrib enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts. Group: Biochemicals. Alternative Names: 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine; 6-[(4-Bromo-2-thienyl)methoxy]-1H-purin-2-amine; 2-Amino-6-(4-bromothiophen-2-ylmethoxy)-9H-purine; PaTrin 2. Grades: Highly Purified. CAS No. 192441-08-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| MTIC | MTIC is a metabolite Temozolomide, which is an alkylating drug. Synonyms: 5-(3-Methyl-1-triazeno)imidazole-4-carboxamide. CAS No. 3413-72-7. Molecular formula: C5H8N6O. Mole weight: 168.16. | |
| MTIC | MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3413-72-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119696. | |
| MTIC-d3 (Monomethyl-d3 Triaizeno Imidazole Carboxamide, 3-Methyl-d3-(triazenyl)imidazole-4-carboxamide, 5-(3-Methyl-d3-triazen-1-yl)imidazole-4-carboxamide, NSC 407347-d3) | A labeled metabolite of Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: Monomethyl-d3 Triaizeno Imidazole Carboxamide; 3-Methyl-d3-(triazenyl)imidazole-4-carboxamide; 5-(3-Methyl-d3-triazen-1-yl)imidazole-4-carboxamide; NSC 407347-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MTIC (Monomethyl Triaizeno Imidazole Carboxamide) | A metabolite of Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: Monomethyl Triaizeno Imidazole Carboxamide; 3-Methyl (triazenyl)imidazole-4-carboxamide; 5- (3-Methyltriazen-1-yl)imidazole-4-carboxamide, NSC 407347. Grades: Highly Purified. CAS No. 3413-72-7. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| NEO 212 | NEO 212 is a novel DNA alkylating agent that causes DNA damage and cancer cell apoptosis. It has the potent activity against breast cancer cells in vitro and intracranial triple-negative tumor growth in vivo (IC50 values 5-50 μM for cytotoxicity on glioma cell lines). NEO212 is a conjugate of temozolomide (TMZ) with the natural product perillyl alcohol (POH) and circumvents TMZ-resistance in multiple cancer cell lines and gliomas. Uses: Dna alkylating agent. Synonyms: NEO 212; NEO212; NEO-212; [(4S)-4-Isopropenyl-1-cyclohexen-1-yl]methyl [(3-methyl-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazin-8-yl)carbonyl]carbamate. Grades: 99%. CAS No. 1361198-79-9. Molecular formula: C17H20N6O4. Mole weight: 372.38. | |
| NU6027 | NU6027 is a potent inhibitor of cellular ATR activity (IC(50)=6.7 μM) and enhanced hydroxyurea and cisplatin cytotoxicity in an ATR-dependent manner. NU6027 attenuated G2/M arrest following DNA damage, inhibited RAD51 focus formation and increased the cytotoxicity of the major classes of DNA-damaging anticancer cytotoxic therapy but not the antimitotic, paclitaxel. In A2780 cells sensitisation to cisplatin was greatest in cells with functional p53 and mismatch repair (MMR) and sensitisation to temozolomide was greatest in p53 mutant cells with functional MMR. Importantly, NU6027 was synthetically lethal when DNA single-strand break repair is impaired either through poly(ADP-ribose) polymerase (PARP) inhibition or defects in XRCC1. NU6027 inhibits ATR, impairing G2/M arrest and homologous recombination thus increasing sensitivity to DNA-damaging agents and PARP inhibitors. It provides proof of concept data for clinical development of ATR inhibitors. Synonyms: NU-6027; NU 6027; 2,6-Diamino-4-(cyclohexylmethoxy)-5-nitrosopyrimidine; 6-(Cyclohexylmethoxy)-5-nitroso-2,4-pyrimidinediamine; 4-Cyclohexylmethoxy-2,6-diamino-5-nitrosopyrimidine; 4-Cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine. Grades: ≥98%. CAS No. 220036-08-8. Molecular formula: C11H17N5O2. Mole weight: 251.29. | |
| Regadenoson (2-[4-[ (Methylamino)carbonyl]-1H-pyrazol-1-yl]-adenosine) | Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinsons and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3). Group: Biochemicals. Alternative Names: 2-[4-[ (Methylamino)carbonyl]-1H-pyrazol-1-yl]-adenosine. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H18N8O5, Molecular Weight: 390.35. US Biological Life Sciences. | Worldwide |
| STX-0119 | STX-0119 is a potent STAT3 inhibitor. STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors, and could be the next promising compound leading to survival prolongation. STX-0119 demonstrated strong inhibition of the expression of STAT3 target genes and stem cell-associated genes as well as the induction of apoptosis in one stem-like cell line. STX-0119 may serve as a novel therapeutic compound against GBM-SCs even in temozolomide-resistant GBM patients and has the potential for GBM-SC-specific therapeutics in combination with temozolomide plus radiation therapy. Synonyms: STX 0119; STX0119. Grades: 98%. CAS No. 851095-32-4. Molecular formula: C22H14N4O3. Mole weight: 382.38. | |
| Triacetin | Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Glyceryl triacetate; 1,2,3-Triacetoxypropane. CAS No. 102-76-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0896. | |
| Veliparib | ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Group: Biochemicals. Alternative Names: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide; A 861695; ABT 888. Grades: Purified. CAS No. 912444-00-9. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
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