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| Product | Description | |
|---|---|---|
| Temozolomide | 1g Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C6H6N6O2. CAS No. 85622-93-1. Prepack ID 31724662-1g. Molecular Weight 194.15. See USA prepack pricing. |  |
| Temozolomide | Imidazotetrazine alkylating agent. An antineoplastic. A cell-permeable, orally bioavailable, blood-brain barrier-permeant MTIC [5-(3-methyltriazen-1-yl-)-imidazole-4-carboxamide] prodrug whose in vivo DNA alkylating activity is employed in anticancer therapy. MGMT (O6-methylguanine DNA methyl transferase) repairs TMZ-damaged DNA lesion by covalently transferring O6-methylation on guanine residues to a cysteine residue on the MGMT, forming the basis of TMZ-resistance in cancer treatment. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, Methazolastone, M&B 39831, Temodal, Temodar; CCRG 81045, TMZ; NSC 362856. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 10mg, 25mg, 100mg. US Biological Life Sciences. |  Worldwide |
| Temozolomide | Temozolomide Inhibitor. Uses: Scientific use. Product Category: T1178. CAS No. 85622-93-1. |  |
| Temozolomide | Temozolomide is an oral chemotherapy drug.The therapeutic benefit of temozolomide depends on its ability to alkylate/methylate DNA, which most often occurs at the N-7 or O-6 positions of guanine residues. This methylation damages the DNA and triggers the death of tumor cells. Uses: Antineoplastic agents, alkylating. Synonyms: Org3770; Org 3770; Org-3770; SCH-52365; SCH52365; SCH 52365; MB39831; MB-39831; MB 39831; RP46161; RP 46161; R-P46161; CCRG81045; TMZ. US brand names: Methazolastone; Temodar. Foreign brand name: Temodal. Grade: >98%. CAS No. 85622-93-1. Molecular formula: C6H6N6O2. Mole weight: 194.15. |  |
| Temozolomide | Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: NSC 362856; CCRG 81045; TMZ. CAS No. 85622-93-1. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g. Product ID: HY-17364. |  |
| Temozolomide Acid | A metabolite of Temozolomide as antitumor agent. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxo-imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxylic Acid. Grades: Highly Purified. CAS No. 113942-30-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Temozolomide-[d3] | Temozolomide-[d3] is the labelled analogue of Temozolomide, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: Temozolomide D3. Grade: 95% by HPLC; 95% atom D. CAS No. 208107-14-6. Molecular formula: C6H3D3N6O2. Mole weight: 197.17. | |
| Temozolomide-d3 (3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3) | Labeled Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one-d3. Grades: Highly Purified. CAS No. 85622-93-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Temozolomide EP Impurity B | Temozolomide EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 113942-30-6. Molecular formula: C6H5N5O3. Mole weight: 195.14. Catalog: APB113942306. |  |
| Temozolomide Impurity 11 | Temozolomide Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1007-36-9. Molecular formula: C8H10N2O. Mole weight: 150.18. Catalog: APB1007369. | |
| Temozolomide Impurity 14 | Temozolomide Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 100-34-5. Molecular formula: C6H5ClN2. Mole weight: 140.57. Catalog: APB100345. | |
| Temozolomide Impurity 20 | Temozolomide Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 18514-52-8. Molecular formula: C4H4N4. Mole weight: 108.1. Catalog: APB18514528. | |
| TemozoloMide Metabolite-MTIC | TemozoloMide Metabolite-MTIC. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1232679-46-7. Molecular formula: C5H8N6O. Mole weight: 168.16. Catalog: APB1232679467. | |
| Temozolomide Metabolite-MTIC-[d3] | An isotope labelled metabolite of Temozolomide. Temozolomide is a chemotherapy drug as an alkylating agent that can be used for the treatment of some brain cancers. Synonyms: 5-[(1E)-3-(D3)methyltriaz-1-en-1-yl]-1H-imidazole-4-carboxamide. Grade: 95% by HPLC; 98% atom D. CAS No. 1185242-69-6. Molecular formula: C5H5D3N6O. Mole weight: 171.18. | |
| Temozolomide Related Compound A | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Temozolomide Related Compound B | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| Temozolomide Related Compound C | United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards. | |
| 3-Amino-2-(formylamino)-3-iminopropanamide | 3-Amino-2-(formylamino)-3-iminopropanamide is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 100191-43-3. Pack Sizes: 10mg, 100mg. Molecular Formula: C4H8N4O2, Molecular Weight: 144.13. US Biological Life Sciences. | Worldwide |
| 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide-d5 Hydrochloride | Isotope labelled 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C9D5H7ClN5O, Molecular Weight: 246.71. US Biological Life Sciences. | Worldwide |
| 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride | 3-Amino-3-imino-2- (2-phenyldiazenyl) propanamide Hydrochloride is a Temozolomide (T017775) impurity. Temozolomide acts as a imidazotetrazine alkylating agent. An antineoplastic. Group: Biochemicals. Grades: Highly Purified. CAS No. 6285-64-9. Pack Sizes: 100mg, 500mg. Molecular Formula: C9H12ClN5O, Molecular Weight: 241.68. US Biological Life Sciences. | Worldwide |
| 3-Methyl-1,1-diphenylurea | One impurity of Temozolomidee, which is an imidazotetrazine derivative and has been found to be a DNA methylating agent and could be used as an antineoplastic. Synonyms: 3-methyl-1,1-diphenylurea. Grade: 98.0 % (GC). CAS No. 13114-72-2. Molecular formula: C14H14N2O. Mole weight: 226.27. | |
| 5-Amino-4-imidazolecarboxamide Hydrochloride | 5-Amino-4-imidazolecarboxamide hydrochloride is the hydrochloride salt of 5-Amino-4-imidazolecarboxamide, a metabolite of Temozolomide. It is also an impurity in the synthesis of Dacarbazine. Synonyms: 4-amino-1H-imidazole-5-carboxamide; hydrochloride; 4-amino-1H-imidazole-5-carboxamide; hydrochloride. Grade: > 95 %. CAS No. 72-40-2. Molecular formula: C4H7ClN4O. Mole weight: 162.58. | |
| 5-Aminoimidazole-4-carboxamide-[13C2,15N] Hydrochloride Salt | A labelled metabolite of Temozolomide, a medication used for the treatment of some brain tumors. Synonyms: AICA-13C2,15N; 4-Amino-5-carbamoylimidazole-13C2,15N2 Hydrochloride Salt; 5-Aminoimidazole-4-carboxamide-13C2,15N Hydrochloride Salt; AIC-13C2,15N; Ba 2756-13C2,15N; NSC 7784-13C2,15N. Grade: 95%. CAS No. 1246816-45-4. Molecular formula: C2[13C]2H7ClN3[15N]O. Mole weight: 165.56. | |
| 5-Aminoimidazole-4-carboxamide (AICA, 4-Amino-5-carbamoylimidazole) | A metabolite of Temozolomide. Group: Biochemicals. Alternative Names: AICA, 4-Amino-5-carbamoylimidazole. Grades: Highly Purified. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 5-Aminoimidazole-4-carboxamide Lactose Adduct | 5-Aminoimidazole-4-carboxamide Lactose Adduct is a lactose adduct of 5-Aminoimidazole-4-carboxamide, a metabolite of Temozolomide. Synonyms: Dacarbazine Lactose Adduct Impurity; 4-(((2R,3R,4R,5S,6R)-3,4-Dihydroxy-6-(hydroxymethyl)-5-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)amino)-1H-imidazole-5-carboxamide. Grade: 98%. Molecular formula: C16H26N4O11. Mole weight: 450.40. | |
| 5-Aminoimidazole-4-carboxamide Lactose Adduct-13C2,15N | 5-Aminoimidazole-4-carboxamide Lactose Adduct-13C2,15N is a labelled 5-Aminoimidazole-4-carboxamide Lactose Adduct, a lactose adduct of 5-Aminoimidazole-4-carboxamide which is a metabolite of Temozolomide. Synonyms: Dacarbazine Lactose Adduct Impurity-13C2,15N. Molecular formula: C14[13C]2H26N3[15N]O11. Mole weight: 453.38. | |
| Levetiracetam | Levetiracetam, an antiepileptic agent, binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis. Levetiracetam modulates HDAC levels ultimately silencing MGMT , thus increasing Temozolomide effectiveness. A chemosensitizer agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UCB L059. CAS No. 102767-28-2. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-B0106. | |
| Lomeguatrib | Lomeguatrib is an inhibitor of O6-methylguanine-DNA methyltransferase (MGMT). Lomeguatrib attenuates MGMT activity in vitro and in vivo. Lomeguatrib enhances the antitumor activity of temozolomide in both human melanoma and MCF-7 xenografts. Group: Biochemicals. Alternative Names: 6-[(4-Bromo-2-thienyl)methoxy]-9H-purin-2-amine; 6-[(4-Bromo-2-thienyl)methoxy]-1H-purin-2-amine; 2-Amino-6-(4-bromothiophen-2-ylmethoxy)-9H-purine; PaTrin 2. Grades: Highly Purified. CAS No. 192441-08-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| MTIC | MTIC, the active metabolite of Temozolomide (TMZ), is a DNA alkylating agent. MTIC has antitumor activity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3413-72-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119696. | |
| MTIC-d3 (Monomethyl-d3 Triaizeno Imidazole Carboxamide, 3-Methyl-d3-(triazenyl)imidazole-4-carboxamide, 5-(3-Methyl-d3-triazen-1-yl)imidazole-4-carboxamide, NSC 407347-d3) | A labeled metabolite of Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: Monomethyl-d3 Triaizeno Imidazole Carboxamide; 3-Methyl-d3-(triazenyl)imidazole-4-carboxamide; 5-(3-Methyl-d3-triazen-1-yl)imidazole-4-carboxamide; NSC 407347-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MTIC (Monomethyl Triaizeno Imidazole Carboxamide) | A metabolite of Temozolomide, an antineoplastic. Group: Biochemicals. Alternative Names: Monomethyl Triaizeno Imidazole Carboxamide; 3-Methyl (triazenyl)imidazole-4-carboxamide; 5- (3-Methyltriazen-1-yl)imidazole-4-carboxamide, NSC 407347. Grades: Highly Purified. CAS No. 3413-72-7. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| Regadenoson (2-[4-[ (Methylamino)carbonyl]-1H-pyrazol-1-yl]-adenosine) | Regadenoson is a selective and potent A2A adenosine receptor agonist (1). The adenosine A2A receptor is a G-protein-coupled receptor and a key therapeutic target for oncologic, inflammatory, Parkinsons and cardiovascular diseases (2). In rodent studies, it has been shown that co-administration of Regadenoson with Temozolomide (T017775) can increase Temozolomide concentration in the brain (3). Group: Biochemicals. Alternative Names: 2-[4-[ (Methylamino)carbonyl]-1H-pyrazol-1-yl]-adenosine. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H18N8O5, Molecular Weight: 390.35. US Biological Life Sciences. | Worldwide |
| Triacetin | Triacetin (Glyceryl triacetate) is a synthetic compound that is a triester of glycerol and acetic acid, orally active. Triacetin increases acetate bioavailability in glioma cells. Triacetin induces glioma cell growth arrest and Apoptosis. Triacetin freely crosses the blood brain barrier/plasma membrane. Triacetin increases histone acetylation and enhances Temozolomide (HY-17364) (TMZ) chemotherapeutic efficacy [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: Glyceryl triacetate; 1,2,3-Triacetoxypropane. CAS No. 102-76-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g; 5 g. Product ID: HY-B0896. | |
| Veliparib | ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Group: Biochemicals. Alternative Names: 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamide; A 861695; ABT 888. Grades: Purified. CAS No. 912444-00-9. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences. | Worldwide |
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