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| Product | Description | |
|---|---|---|
| Terpendole C | Inhibitor for Acyl-CoA, cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2, Tremorgenic and Cholesteryl ester (CE) synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug. US Biological Life Sciences. |  Worldwide |
| Terpendole C | Isolated from Albophoma yamanashiensis. An acyl-CoA:cholesterol acyltransferase (ACAT) isozymes ACAT1 and ACAT2 inhibitor. Also acts as a tremorgen and cholesteryl ester (CE) synthesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 156967-65-6. Pack Sizes: 250ug, 1mg. US Biological Life Sciences. | Worldwide |
| Terpendole C | Terpendole C is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.46 μmol/L, and the CD50 that causes 50% cell damage is greater than 24.1 μmol/L. Synonyms: (3S, 4aR, 4bR, 5aS, 5bS, 7aS, 13bS, 13cR, 15aS, 16aS)-1, 1, 13b, 13c-tetramethyl-3-(2-methylprop-1-en-1-yl)-1, 4a, 4b, 6, 7, 7a, 8, 13, 13b, 13c, 14, 15, 15a, 16a-tetradecahydro-5bH-[1, 3]dioxino[5'', 4'':2', 3']oxireno[2'', 3'':4', 4a']chromeno[5', 6':6, 7]indeno[1, 2-b]indol-5b-ol; (-)-terpendole C. Grades: >98%. CAS No. 156967-65-6. Molecular formula: C32H41NO5. Mole weight: 519.67. |  |
| Terpendole A | Terpendole A is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 μmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 μmol/L. Molecular formula: C32H41NO6. Mole weight: 535.67. | |
| Terpendole E | Terpendole E is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 μmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 μmol/L. Synonyms: (2S, 4R, 4aR, 4bR, 6aS, 12bS, 12cS, 14aS)-2-(2-Hydroxypropan-2-yl)-4a, 12b, 12c-trimethyl-3, 4, 4a, 4b, 5, 6, 6a, 7, 12, 12b, 12c, 13, 14, 14a-tetradecahydro-2H-chromeno[5', 6':6, 7]indeno[1, 2-b]indol-4-ol. Grades: >98%. CAS No. 167427-23-8. Molecular formula: C28H39NO3. Mole weight: 437.61. | |
| Terpendole I | Terpendole I is a fungal metabolite originally isolated from A. yamanashiensis. It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50=145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml). It is also cytotoxic to HeLa cells with an IC50 value of 52.6 μM. Synonyms: Terpendole I; 167612-17-1; (1S, 2R, 5S, 7S, 8R, 9R, 11S, 12S, 15S)-7-(2-hydroxypropan-2-yl)-1, 2-dimethyl-6, 10-dioxa-24-azaheptacyclo[13.10.0.02, 12.05, 11.09, 11.017, 25.018, 23]pentacosa-17(25), 18, 20, 22-tetraene-8, 12-diol; (2S, 3R, 3aR, 4aS, 4bS, 6aS, 12bS, 12cR, 14aS)-3, 3a, 5, 6, 6a, 7, 12, 12b, 12c, 13, 14, 14a-dodecahydro-2-(1-hydroxy-1-methylethyl)-12b, 12c-dimethyl-2H, 4bH-oxireno[4', 4'a]-1-benzopyrano[5', 6':6, 7]indeno[1, 2-b]indole-3, 4b-diol; SCHEMBL20869892. Grades: >95% by HPLC. CAS No. 167612-17-1. Molecular formula: C27H35NO5. Mole weight: 453.57. | |
| Terpendole L | Terpendole F is an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor produced by Albophoma yamenashiensis. The IC50 that inhibits ACAT in macrophages is 0.29 μmol/L, and the CD50 that causes 50% cell damage is greater than 23.4 μmol/L. Synonyms: (3S, 4aR, 4bR, 5aS, 5bS, 7aS, 13bS, 13cR, 15aS, 16aS)-1, 1, 13b, 13c-tetramethyl-9-(3-methylbut-2-en-1-yl)-3-(2-methylprop-1-en-1-yl)-1, 4a, 4b, 6, 7, 7a, 8, 13, 13b, 13c, 14, 15, 15a, 16a-tetradecahydro-5bH-[1, 3]dioxino[5'', 4'':2', 3']oxireno[4', 4a']chromeno[5', 6':6, 7]indeno[1, 2-b]indol-5b-ol. Molecular formula: C37H49NO5. Mole weight: 587.79. | |
| Terpendole E | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| Terpendole E (1'alpha-Hydroxy-Paspaline) | Inhibitor to Acyl-CoA: Cholesterol acyltransferase (ACAT), Mitotic kinesin Eg5 (Mitotic Kinesin Spindle Protein; KSP) and Specific M phase. Group: Biochemicals. Alternative Names: 1'alpha-Hydroxy-Paspaline. Grades: Highly Purified. CAS No. 167427-23-8. Pack Sizes: 250ug. US Biological Life Sciences. | Worldwide |
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