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| Product | Description | |
|---|---|---|
| Tetrahydrofolic acid | Tetrahydrofolic acid is the parent molecule of the folate derivatives that donate one-carbon units to amino acids, nucleic acids, and lipids. Tetrahydrofolate metabolites participate in the synthesis of purine and pyrimidine and in synthesis and conversion of amino acids. A recent use of tetrahydrofolate (THF) is for the studying the activation of riboswitches. Applications: A tool for studying the activation of riboswitches. Group: Coenzymes. Synonyms: 5,6,7,8-Tetrahydropteroyl-L-glutamic acid; THF. CAS No. 135-16-0. Purity: ≥65% (when packaged). Mole weight: 445.43. Appearance: powder. Form: Solid. 5,6,7,8-Tetrahydropteroyl-L-glutamic acid; THF; Tetrahydrofolic acid; 135-16-0. Cat No: COEC-089. |  |
| Tetrahydrofolic acid | Tetrahydrofolic acid (L-5,6,7,8-Tetrahydrofolic acid) is the biologically active vitamin B9 folate derivative. Tetrahydrofolic acid is a donor of one-carbon groups for amino acids, nucleic acids, and lipids. Tetrahydrofolic acid serves as an acceptor of free formaldehyde, producing 5,10-methylenetetrahydrofolate-Tetrahydrofolic acid [1]. Uses: Scientific research. Group: Natural products. Alternative Names: L-5,6,7,8-Tetrahydrofolic acid; L-Tetrahydrofolic acid. CAS No. 135-16-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14520. |  |
| 2, 5-Di methyl tetrahydrofolic Acid | 2, 5-Di methyl tetrahydrofolic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C21H27N7O6, Molecular Weight: 473.48. US Biological Life Sciences. |  Worldwide |
| 5-(Methyl-d3)tetrahydrofolic Acid (Mixture of Diastereomers) | A labeled metabolite of Folic acid; inhibits photosensitization reactions and strand breaks in DNA. Group: Biochemicals. Alternative Names: N-[4-[[ (2-Amino-3, 4, 5, 6, 7, 8-hexahydro-5- (methyl-d3) -4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid. Grades: Highly Purified. CAS No. 1356019-97-0. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| 5-Methyl tetrahydrofolic acid | 5-Methyltetrahydro folate, L-Methyl folate, 2-[[4-[(2-amino-5-methyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methyl mino]benzoyl]amino]pentanedioic acid. folic acid metabolite. CAS No. 134-35-0. Product ID: 2-08273. Molecular formula: C12H24BrN3P.F6P. Mole weight: 459.46. Purity: 0.98. Categories: 5-methyltetrahydrofolic acid. |  |
| (6S)-Tetrahydrofolic acid | (6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein [1]. Uses: Scientific research. Group: Natural products. Alternative Names: (6S)-5,6,7,8-Tetrahydrofolic acid. CAS No. 71963-69-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-14520A. | |
| (6S)-Tetrahydrofolic Acid | Folic Acid derivative. Has been shown to increase methotrexalate metabolism in humans. Group: Biochemicals. Alternative Names: (S) -N-[4-[[ (2-Amino-1, 4, 5, 6, 7, 8-hexahydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid. Grades: Highly Purified. CAS No. 71963-69-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| (6S)-Tetrahydrofolic Acid p-Toluenesulfonate Salt | Folic Acid derivative. Has been shown to increase methotrexalate metabolism in humans. Group: Biochemicals. Alternative Names: (S) -N-[4-[[ (2-Amino-1, 4, 5, 6, 7, 8-hexahydro-4-oxo-6-pteridinyl) methyl]amino]benzoyl]-L-glutamic Acid Mono (4-methyl Benzene sulfonate) . Grades: Highly Purified. CAS No. 144077-69-0. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| L-Tetrahydrofolic Acid | Tetrahydrofolic acid is a folic acid derivative. It is a cofactor in many bio-reactions, especially in the metabolism of amino acids and nucleic acids. Uses: A cofactor in many bio-reactions, especially in the metabolism of amino acids and nucleic acids. Synonyms: N-[4-[[(2-Amino-3,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; (-)-L-5,6,7,8-Tetrahydrofolic Acid; THFA; Tetrahydropteroylglutamic Acid. Grades: ≥70% (when packaged). CAS No. 135-16-0. Molecular formula: C19H23N7O6. Mole weight: 445.43. |  |
| Aminopterin | Aminopterin (4-Aminofolic acid), the 4-amino derivative of folic acid, is a folic acid antagonist. Aminopterin catalyses the reduction of folic acid to tetrahydrofolic acid, and competitively inhibits dihydrofolate reductase (DHFR) with a K i of 3.7 pM. Aminopterin has anticancer and immunosuppressive activity. Aminopterin is used in treatment of pediatric leukemia [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Aminofolic acid; APGA. CAS No. 54-62-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14518. | |
| ANX-510 | ANX-510 is a folate-based biomodulator with potential antineoplastic activity. 5,10-methylenetetrahydrofolate (MTHF) stabilizes the covalent binding of the fluorouracil metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (FdUMP) to its target enzyme, thymidylate synthase, which results in inhibition of thymidylate synthase, depletion of thymidine triphosphate (TTP), a necessary constituent of DNA, and tumor cell death. Synonyms: 5,10-Methylenetetrahydrofolic acid; 5,10-Methylene-tetrahydrofolate; Tetrahydromethylenefolate; N-{4-[3-amino-1-oxo-1,2,5,6,6a,7-hexahydroimidazo[1,5-f]pteridin-8(9H)-yl]benzoyl}-L-glutamic acid. CAS No. 3432-99-3. Molecular formula: C20H23N7O6. Mole weight: 457.44. | |
| Calcium folinate 5-hydrate | Calcium folinate 5-hydrate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT;5-FORMYL-5,6,7,8-TETRAHYDROFOLIC ACID CALCIUM SALT PENTAHYDRATE;5-FORMYL-5,6,7,8-TETRAHYDROPTEROYL-L-GLUTAMIC ACID CALCIUM SA. Product Category: Heterocyclic Organic Compound. CAS No. 41927-89-3. Molecular formula: C20H21CaN7O7.5H2O. Mole weight: 601.58. Purity: 0.96. IUPACName: calcium (2S)-2-[[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioate pentahydrate. Canonical SMILES: C1C(N(C2=C(N1)NC(=NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)[O-])C(=O)[O-].O.O.O.O.O.[Ca+2]. Product ID: ACM41927893. Alfa Chemistry ISO 9001:2015 Certified. Categories: Calcium folinate pentahydrate. |  |
| Calcium Folinate Pentahydrate | When administered after methotrexate, supplies cells with tetrahydrofolate and diminishes methotrexate toxicity without abolishing the antitumor effect. Group: Biochemicals. Alternative Names: 5-Formyl-5,6,7,8-tetrahydrofolic acid, calcium salt Leucovorin. Grades: Highly Purified. CAS No. 41927-89-3. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C20H21CaN7O7·5H2O, Molecular Weight: 601.58. US Biological Life Sciences. | Worldwide |
| Dihydrofolate Reductase from human, Recombinant | Dihydrofolate reductase, or DHFR, is an enzyme that reduces dihydrofolic acid to tetrahydrofolic acid, using NADPH as electron donor, which can be converted to the kinds of tetrahydrofolate cofactors used in 1-carbon transfer chemistry. In humans, the DHFR enzyme is encoded by the DHFR gene. It is found in the q11?q22 region of chromosome 5. Bacterial species possesses distinct DHFR enzymes (based on their pattern of binding diaminoheterocyclic molecules), but mammalian DHFRs are highly similar. Human dhfr is an 186 amino acid protein with an apparent molecular weight of 25 kda. it is 30% homologous to the e. coli protein and up to 70% homologous to vertebrate protein... from mycobacterium smegmatis. human dihydrofolate reductase has been used in a study to investigate the stable expression of green fluorescent protein and the targeted disruption of thioredoxin peroxidase-1 gene in babesia bovis. human dihydrofolate reductase has also been used in a study to investigate the structural analysis of human dihydrofolate reductase as a binary complex. Group: Enzymes. Synonyms: DHFR; dihydrofolate reductase; DYR; DHFRP1; Tetrahydrofolate NADP+ oxidoreductase; EC 1.5.1.3; tetrahydrofolate dehydrogenase; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; f | |
| Folinic acid | Folinic acid is an adjuvant used in cancer chemotherapy involving the drug methotrexate. It is a 5-formyl derivative of tetrahydrofolic acid and readily converted to other reduced folic acid derivatives, thus, has vitamin activity that is equivalent to that of folic acid. Since it does not require the action of dihydrofolate reductase for its conversion, its function as a vitamin is unaffected by inhibition of this enzyme by drugs such as methotrexate. Synonyms: leucovorin. Grades: >98%. CAS No. 58-05-9. Molecular formula: C20H23N7O7. Mole weight: 473.44. | |
| Levomefolic acid | Levomefolic acid - Product ID: NST-10-222. Category: Alkaloids. Alternative Names: 5-Methyl-(6S)-tetrahydrofolic acid, L-Methylfolate, LMSR. Purity: 98%. Test method: HPLC. CAS No. 31690-09-2. Pack Sizes: 1g, 2g, 5g, 10g. Appearance: White to yellow Powder. Molecular formula: C20H25N7O6. Mole weight: 459.5. Storage: +2 +8 °C. |  |
| Levomefolic Acid | A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. It has been proposed for treatment of cardiovascular disease. Group: Biochemicals. Alternative Names: N- [4- [ [ [ (6S) -2-Amino-3, 4, 5, 6, 7, 8-hexahydro-5-methyl-4-oxo-6-pteridinyl] methyl] amino] benzoyl] -L-glutamic Acid; (6S)-5-Methyltetrahydrofolic Acid; 5-Methyl-(6S)-tetrahydrofolic Acid; LMSR; l-N5; Methyl-L-tetrahydrofolic Acid. Grades: Highly Purified. CAS No. 31690-09-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| Levomefolic Acid-13C,d3 | A labeled active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supplements. It has been proposed for treatment of cardiovascular disease. Group: Biochemicals. Alternative Names: N- [4- [ [ [ (6S) -2-Amino-3, 4, 5, 6, 7, 8-hexahydro-5- (methyl-13C, d3) -4-oxo-6-pteridinyl] methyl] amino] benzoyl] -L-glutamic Acid; (6S)-5-(Methyl-13C,d3)tetrahydrofolic Acid; 5-Methyl-(6S)-tetrahydrofolic Acid-13C,d3; LMSR; l-N5-13C,d3; Methyl-L-tetrahydrofolic Acid-13C,d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Trimethoprim | Trimethoprim is a bacteriostatic antibiotic used mainly in the prophylaxis and treatment of urinary tract infections. It caused induction of DnaK, DnaJ, GroEL, ClpB, and IbpA/B Hsps. It binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). Uses: Anti-infective agents, urinary; antimalarials; antimetabolites; folic acid antagonists. Synonyms: Trimpex; Proloprim. Grades: >98%. CAS No. 738-70-5. Molecular formula: C14H18N4O3. Mole weight: 290.32. | |
| 7-Hydroxymethotrexate | 7-Hydroxymethotrexate is a major metabolite of Methotrexate (MTX; HY-14519). Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5939-37-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-130569. | |
| dihydrofolate reductase | The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. Group: Enzymes. Synonyms: tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Enzyme Commission Number: EC 1.5.1.3. CAS No. 9002-3-3. Dihydrofolate Reductase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1511; dihydrofolate reductase; EC 1.5.1.3; 9002-03-3; tetrahydrofolate dehydrogenase; DHFR; pteridine reductase:dihydrofolate reductase; dihydrofolate reductase:thymidylate synthase; thymidylate synthetase-dihydrofolate reductase; folic acid reductase; folic reductase; dihydrofolic acid reductase; dihydrofolic reductase; 7,8-dihydrofolate reductase; NADPH-dihydrofolate reductase. Cat No: EXWM-1511. | |
| Folinic acid calcium salt | Folinic acid calcium salt offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. Calcium folinate is also used in mutagenisis and cancer research. Applications: A compound that reduces the effect of folic acid antagonists. Group: Coenzymes. Synonyms: Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate. CAS No. 1492-18-8. Purity: ≥98%. Mole weight: 511.5. Appearance: Powder. Form: Solid. Leucovorin calcium salt; Citrovorum factor calcium salt; Calcium folinate; Folinic acid calcium salt; 1492-18-8. Cat No: COEC-033. | |
| Methotrexate | Methotrexate (Amethopterin), an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Amethopterin; CL14377; WR19039. CAS No. 59-05-2. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-14519. | |
| Methotrexate disodium | Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia). Synonyms: Amethopterin Sodium; Methotrexate Lederle; Metoart; Metotrexato Lederle; Sodium Methotrexate; N-[4-[[ (2, 4-Diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic Acid Disodium Salt; 4-amino-n(sup10)-methyl pteroyl glutamic acid disodium salt; amethopterin sodium. Grades: >98.0%. CAS No. 7413-34-5. Molecular formula: C20H20N8Na2O5. Mole weight: 498.40. | |
| Native Bacillus sp. Sarcosine Oxidase | Sarcosine oxidase is an enzyme (EC 1.5.3.1) that catalyzes the oxidative demethylation of sarcosine to yield glycine, H2O2, 5,10-CH2-tetrahydrofolate in a reaction requiring H4-tetrahydrofolate and oxygen. Corynebacterial sarcosine oxidase is a heterotetramer and is produced as an inducible enzyme when Corynebacterium sp.is grown with sarcosine as source of carbon and energy. Monomeric sarcosine oxidase (msox) is a flavoenzyme that catalyzes the oxidative demethylation of sarcosine (n-methylglycine) to yield glycine, formaldehyde, and hydrogen peroxide. monomeric sarcosine oxidase can oxidize other secondary amino acids such as n-methyl-l-alanine, n-ethylglycine, and l-proline. Applications: Sarcosine oxidase has been used in a study as part of a multienzyme cascade, that when immobilized constructed amperometric biosensors. sarcosine oxidase has also been used in a study to investigate oxidation of amines by flavoproteins. Group: Enzymes. Synonyms: Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Enzyme Commission Number: EC 1.5.3.1. CAS No. 9029-22-5. SAO. Activity: 25-50 units/mg solid. Storage: -20°C. Form: lyophilized powder; No stabilizers added. Source: Bacillus sp. Sarcosine oxidase; EC 1.5.3.1; 9029-22-5; sarcosine:oxygen oxidoreductase (demethylating). Cat No: NATE-0664. | |
| Pyrimethamine | Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic - folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pirimecidan; Pirimetamin; RP 4753. CAS No. 58-14-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-18062. | |
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