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| Product | Description | |
|---|---|---|
| Tetrodotoxin Citrate | Tetrodotoxin Citrate is a highly selective, reversible sodium channel blocker. Group: Biochemicals. Grades: Highly Purified. CAS No. 18660-81-6. Pack Sizes: 1mg, 10mg. Molecular Formula: C17H25N3O15. US Biological Life Sciences. |  Worldwide |
| Tetrodotoxin, citrate (1:1) (salt) | Tetrodotoxin, citrate (1:1) (salt), also called as TTX citrate, is the citrate salt of tetrodotoxin. Tetrodotoxin is a neurotoxin that reversibly and selectively blocks sodium channel. Synonyms: TETRODOTOXIN;TETRODOTOXIN CITRATE;OCTAHYDRO-12-(HYDROXYMETHYL)-2-IMINO-5,9:7,10A-DIMETHANO-10AH-[1,3]DIOXOCINO[6,5-D]PYRIMIDINE-4,7,10,11,12-PENTOL CITRATE; citratodetetrodotoxina; tetrodotoxin, citrate(1:1)(salt); Octahydro-12-(hydroxymethyl)-2-imino-5, 9:7. Grades: 95%. CAS No. 18660-81-6. Molecular formula: C17H25N3O15. Mole weight: 511.39. |  |
| 4,9-Anhydrotetrodotoxin | 4,9-Anhydrotetrodotoxin is a derivative of tetrodotoxin, which is a potent neurotoxin and can be isolated from pufferfish. It is also a selective and potent Nav1.6 channel blocker with IC50 value of 7.8 nM. It selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels. It may be a useful compound for treating diseases related to the voltage-gated sodium channel α subunit Nav1.6. Synonyms: (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol; (4β,9β)-4,9-Dideoxy-4,9-epoxy-tetrodotoxin; Anhydro-tetrodotoxin; Anhydroepitetrodotoxin; 4,9-anhydro-TTX. Grades: ≥98% by HPLC. CAS No. 13072-89-4. Molecular formula: C11H15N3O7. Mole weight: 301.25. | |
| A-803467 | A-803467 is a sodium channel blocker that potently blocks tetrodotoxin-resistant currents (IC50=140 nM). Synonyms: A-803467; A 803467; A803467. Grades: >98%. CAS No. 944261-79-4. Molecular formula: C19H16ClNO4. Mole weight: 357.79. | |
| Aconitine | Neurotoxin. Activates tetrodotoxin-sensitive Na+ channels, inducing presynaptic depolarization, thus blocking the nerve action potential which, in turn, blocks the release of neurotransmitters and decreases the end plate potential at the neuromuscular junction. Aconitine also blocks norepinephrine reuptake. In the heart, aconitine induces ventricular tachycardia after intracoronary injection. In cultured ventricular myocytes, aconitine increases the duration of the action potential and induces the appearance of early after depolarization. Group: Biochemicals. Alternative Names: (1α, 3α, 6α, 14α, 15α, 16 β ) -20-Ethyl-1, 6, 16-trimethoxy-4- (methoxymethyl) aconitane-3, 8, 13, 14, 15-pentol 8-Acetate 14-Benzoate. Grades: Highly Purified. CAS No. 302-27-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| alpha,beta-methylene ATP (ab-MeATP, ab-methylene ATP, P2X Purinergic Receptor Agonist, a,b-methylene ATP, a,b-Methyleneadenosine 5?-triphosphate Lithium Salt) | A metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200nM to 4uM) that reaches a peak within 2-3 min after application and then decays to a steady level. CAS No:104809-20-3. Group: Biochemicals. Grades: Highly Purified. CAS No. 104809-20-3. Pack Sizes: 5mg. Molecular Formula: C??H??N?O??P?; xLi+. US Biological Life Sciences. | Worldwide |
| Brevetoxin A | Brevetoxin A is a polyacyl toxoid produced by Ptychodiscus brevis (Gymnodiniuin bervis). It has a strong effect of activating cell membrane sodium channels, and Tetrodotoxin can counteract its activity. Uses: Adcs cytotoxin. Synonyms: Brevetoxin PbTx 1; Ptychodiscus brevis toxin 1. Grades: 98%. CAS No. 98112-41-5. Molecular formula: C49H70O13. Mole weight: 867.06. | |
| Brevetoxin B | Brevetoxin B is a polyacyl toxoid produced by Ptychodiscus brevis (Gymnodiniuin bervis). It has a strong effect of activating cell membrane sodium channels, and Tetrodotoxin can counteract its activity. Synonyms: PbTx-2. Grades: ≥95%. CAS No. 79580-28-2. Molecular formula: C50H70O14. Mole weight: 895.08. | |
| Nifenalol hydrochloride | Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5704-60-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100952. |  |
| Ralfinamide mesylate | Ralfinamide mesylate is a mixed sodium and N-type calcium channel protein inhibitor. Ralfinamide is two fold selective for tetrodotoxin (TTX)-resistant sodium channels compared with TTX-sensitive currents. It displays analgesic effects in animal models of inflammatory and neuropathic pain. Synonyms: (2S) -2-[[[4-[ (2-Fluorophenyl) methoxy]phenyl]methyl]amino]-propanamide methanesulfonate. Grades: ≥99% by HPLC. CAS No. 202825-45-4. Molecular formula: C17H19FN2O2.CH3SO3H. Mole weight: 398.45. | |
| TC-N 1752 | TC-N 1752 is a state-dependent human NaV channel inhibitor (IC50 = 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9, respectively). TC-N 1752 inhibits Nav1.7 and exhibits analgesic efficacy in the formalin pain model. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. Synonyms: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide; Nav1.7 blocker 52. Grades: ≥99% by HPLC. CAS No. 1211866-85-1. Molecular formula: C25H27F3N6O3. Mole weight: 516.52. | |
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