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| Product | Description | |
|---|---|---|
| TGR5 Receptor Agonist | TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC 50 s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca 2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CCDC. CAS No. 1197300-24-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14229. |  |
| TGR5 Receptor Agonist (3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide) | Cell-permeable, small molecule agonist of TGR5 G-protein coupled receptor. This agonist has shown to increase glucagon like peptide-1 (GLP-1) secretion from primary intestinal cells. Group: Biochemicals. Alternative Names: 3-(2-Chlorophenyl)-N-(4-chlorophenyl)-N,5-dimethylisoxazole-4-carboxamide. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| TGR5 Receptor Agonist, Cpd23g ( (4-cyclopropyl-3, 4-dihydroquinoxalin-1 (2H) -yl) (4- (2, 5-dimethylphenoxy) pyridin-3-yl) methanone, Bile Acid Receptor GPBAR-1 Agonist, Bile Acid Receptor Agonist, G Protein-coupled Bile Acid Receptor 1 Agonist) | A cell-permeable, orally available, phenoxypyrimidine carboxamide derivative that acts as a highly potent and selective agonist of Protein coupled receptor TGR5 (EC50 = 720 pM and 6.2nM for human and mouse TGR5, respectively). Does not exhibit any significant affinity towards other related targets such as GPR40, GPR119, and GPR120. Shown to increase glucagon-like peptide-1 (GLP-1) secretion in a dose-dependent manner and significantly reduce blood glucose levels in db/db mice following a single oral dose (50mg/kg). Exhibits desirable pharmacokinetic properties in rodent models (t½ = 1.5h, Cmax = 56ng/ml; and AUC = 147ng.h/ml following an oral dose of 5mg/kg). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Cholic acid 7-sulfate | Cholic acid 7-sulfate (7-Sulfocholic acid), a metabolite of Cholic acid, is a Takeda G-protein receptor 5 (TGR5) agonist. Cholic acid 7-sulfate can increase Tgr5 expression and induce GLP-1 secretion [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 7-Sulfocholic acid. CAS No. 60320-05-0. Pack Sizes: 500 μg; 1 mg; 5 mg. Product ID: HY-126855. | |
| EP-024297 | EP-024297 is a novel agonist of farnesoid X receptor (FXR). Study in Chinese hamster ovary cells showed that it is 20000-fold more potent than obeticholic acid (OCA). EP-024297 is selective for FXR over TGR5. It promisingly becomes a new treatment of NASH. Uses: The potential treatment of nash. Synonyms: EP-024297; EP 024297; EP024297. |  |
| TC-G 1005 | TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5) that selectively activates TGR5 over FXR (farnesoid X receptor). TC-G 1005 has been shown to increase plasma GLP-1 level and lower blood glucose level in mice. Synonyms: TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005; (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone. Grades: ≥98% by HPLC. CAS No. 1415407-60-1. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| TGR5 | A potent TGR5(GPCR19) agonist that showed improved potency in the U2-OS cell assay (pEC50 = 6.8) and in melanophore cells (pEC50 = 7.5). Synonyms: TGR5; TGR 5; TGR-5; TGR5 Receptor Agonist; MDK00245; MDK-00245; MDK 00245. CAS No. 1197300-24-5. Molecular formula: C18H14Cl2N2O2. Mole weight: 361.222. | |
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