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| Product | Description | |
|---|---|---|
| Thiocolchicoside | Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products. Apoptosis inducer.Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease. Group: Biochemicals. Alternative Names: BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchic ine. Grades: Highly Purified. CAS No. 602-41-5. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C27H33NO10S. US Biological Life Sciences. |  Worldwide |
| Thiocolchicoside | Thiocolchicoside is a competitive γ-aminobutyric acid type A (GAB A A) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 602-41-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N0301. |  |
| Thiocolchicoside | Thiocolchicoside is a semi-synthetic derivative of colchicine, an anti-inflammatory glycoside extracted from the flower seeds of superba gloriosa. Thiocolchicoside acts as a GABAA receptor antagonist exhibiting anti-inflammatory and analgesic activity. It is used as a muscle relaxant. Synonyms: N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; (S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide; Coltramyl; Coltrax; Miorel; Miotens; Muscoril. Grades: >98%. CAS No. 602-41-5. Molecular formula: C27H33NO10S. Mole weight: 563.618. |  |
| Thiocolchicoside EP Impurity B | Thiocolchicoside EP Impurity B. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2730-71-4. Molecular Formula: C22H25NO5S. Mole Weight: 415.5. Catalog: APB2730714. |  |
| Thiocolchicoside EP Impurity C | Thiocolchicoside EP Impurity C. Uses: For analytical and research use. Group: Impurity standards. CAS No. 87424-25-7. Molecular Formula: C21H23NO5S. Mole Weight: 401.48. Catalog: APB87424257. | |
| Thiocolchicoside EP Impurity G | Thiocolchicoside EP Impurity G. Uses: For analytical and research use. Group: Impurity standards. CAS No. 177991-81-0. Molecular Formula: C25H31NO9S. Mole Weight: 521.58. Catalog: APB177991810. | |
| Thiocolchicoside Impurity K | An impurity of Thiocolchicoside which has been prescribed as a muscle relaxant drug for many years. Grades: > 95%. Molecular formula: C26H31NO10S. Mole weight: 549.6. | |
| Thiocolchicoside S-Oxide (Mixture of Diastereomers) | Thiocolchicoside S-Oxide is an impurity of Thiocolchicoside, a GABA receptor antagonist that is prescribed as a muscle relaxant having analgesic effects. Synonyms: N-((7S)-1,2-Dimethoxy-10-(methylsulfinyl)-9-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide. Grades: 97%. Molecular formula: C27H33NO11S. Mole weight: 579.62. | |
| 10-S-Methylsulfonyl Thiocolchicoside | 10-S-Methylsulfonyl Thiocolchicoside is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 1359973-80-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H33NO12S. US Biological Life Sciences. | Worldwide |
| Isothiocolchicoside | Isothiocolchicoside is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: N-((S)-1,2-Dimethoxy-9-(methylthio)-10-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,10-tetrahydrobenzo[a]heptalen-7-yl)acetamide. Grades: 99%. Molecular formula: C27H33NO10S. Mole weight: 563.62. | |
| Isothiocolchicoside Tetraacetate | Isothiocolchicoside Tetraacetate is an intermediate in synthesizing Isothiocolcicoside, which is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (2S,3R,4S,5R,6R)-2-(((S)-7-Acetamido-1,2-dimethoxy-9-(methylthio)-10-oxo-5,6,7,10-tetrahydrobenzo[a]heptalen-3-yl)oxy)-6-(acetoxymethyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C35H41NO14S. Mole weight: 731.76. | |
| N-Desacetyl-2,3,4-tri-O-acetyl Thiocolchicoside-N-2,2,2-trifluoroacetaldehyde | N-Desacetyl-2,3,4-tri-O-acetyl Thiocolchicoside-N-2,2,2-trifluoroacetaldehyde is an intermediate used in the synthesis of N-Desacetyl Thiocolchicoside (D291005), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C35H38F3NO14S, Molecular Weight: 785.73. US Biological Life Sciences. | Worldwide |
| N-Desacetyl-2,3,4-tri-O-acetyl Thiocolchicoside-N-2,2,2-trifluoroacetaldehyde | N-Desacetyl-2,3,4-tri-O-acetyl Thiocolchicoside-N-2,2,2-trifluoroacetaldehyde is an intermediate used in the synthesis of N-Desacetyl Thiocolchicoside, which is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Molecular formula: C35H38F3NO14S. Mole weight: 785.73. | |
| N-Desacetyl-N-formyl Thiocolchicoside | A metabolite of Thiocolchicoside which has been used for over 35 years as a myorelaxant in the treatment of painful muscle contractions in acute and chronic rheumatic conditions, in traumatology and especially in patients with acute low back pain. Synonyms: N-[(7S)-3-(b-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]formamide. Grades: > 95%. CAS No. 219547-29-2. Molecular formula: C26H31NO10S. Mole weight: 549.59. | |
| N-Desacetyl Thiocolchicoside | N-Desacetyl Thiocolchicoside is a Thiocolchicoside impurity, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (S)-7-Amino-1,2-dimethoxy-10-(methylthio)-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydrobenzo[a]heptalen-9(5H)-one. Grades: 97%. CAS No. 177991-81-0. Molecular formula: C25H31NO9S. Mole weight: 521.58. | |
| 10-Desmethoxycolchiside | 10-Desmethoxycolchiside is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (S)-7-Amino-1,2-dimethoxy-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6,7-dihydrobenzo[a]heptalen-9(5H)-one. Molecular formula: C26H31NO10. Mole weight: 517.53. | |
| 10-Desmethoxycolchiside | 10-Desmethoxycolchiside is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C26H31NO10. US Biological Life Sciences. | Worldwide |
| 10-Desmethoxy Tetrahyrocolchicoside β-D-Glucopyranosyl Tetraacetate | 10-Desmethoxy Tetrahyrocolchicoside β-D-Glucopyranosyl Tetraacetate is an intermediate in the synthesis of Thiocolchicoside (T344385), which is a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C34H42NO14. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2,10-didemethyl-colchicine | 2-Allyl-2,10-didemethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H25NO6. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl 10-Tosyl-10-demethyl Colchicine | 2-Allyl-2-demethyl 10-Tosyl-10-demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine | 2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl-colchicine | 2-Allyl-2-demethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 104158-07-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C24H27NO6. US Biological Life Sciences. | Worldwide |
| 2-Allyl-2-demethyl Isothiocolchicine | 2-Allyl-2-demethyl 10-Demethyl Isothiocolchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H27NO5S. US Biological Life Sciences. | Worldwide |
| 2-Demethyl Isothiocolchicine | 2-Demethyl Isothiocolchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H23NO5S. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Thiocolchicine 2-O-(2,3,4-Tri-O-acetyl- β-D-glucuronide Methyl Ester) | Protected metabolite of Thiocolchicoside (TCC). Group: Biochemicals. Alternative Names: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl 2,3,4-Tri-O-acetyl- β-D-glucopyranosiduronic Acid Methyl Ester. Grades: Highly Purified. CAS No. 250662-47-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Thiocolchicine-d3 2-O-(2,3,4-Tri-O-acetyl- β-D-glucuronide Methyl Ester) | Protected metabolite of labeled Thiocolchicoside (TCC). Group: Biochemicals. Alternative Names: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl-d3 2,3,4-Tri-O-acetyl- β-D-glucopyranosiduronic Acid Methyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 3-Demethyl Thiocolchicine-d3 3-O- β-D-Glucuronide | The major labeled metabolite of Thiocolchicoside (TCC), a muscle relaxant drug. Group: Biochemicals. Alternative Names: 7S)-7-(Acetylamino-d3)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl β-D-Glucopyranosiduronic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences. | Worldwide |
| 3-Desmethylthiocolchicine-3-O-D-glucuronide | 3-Desmethylthiocolchicine-3-O-D-glucuronide, an intriguing and efficacious biomedicine, has garnered considerable attention due to its multifaceted therapeutic implications. Originating as an active metabolite of colchicine, a renowned remedy for gout and familial Mediterranean fever, this potent glucuronide derivative showcases substantial anti-inflammatory and anti-mitotic properties, offering a beacon of hope for therapeutic interventions. Synonyms: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl b-D-glucopyranosiduronic acid Thiocolchicoside glucuronide. CAS No. 819802-34-1. Molecular formula: C27H31NO11S. Mole weight: 577.60. | |
| Hexa-O-benzoyl 10-Demethyl Colchicoside | Hexa-O-benzoyl 10-Demethyl Colchicoside is an intermediate in synthesizing Isothiocolcicoside, which is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (2S,3R,4S,5R,6R)-2-(((S)-10-(Benzoyloxy)-1,2-dimethoxy-9-oxo-7-(3-oxo-3-phenylpropanamido)-5,6,7,9-tetrahydrobenzo[a]heptalen-3-yl)oxy)-6-((benzoyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl Tribenzoate. Molecular formula: C68H55NO17. Mole weight: 1158.16. | |
| Penta-O-benzoyl 10-Demethyl Colchicoside | Penta-O-benzoyl 10-Demethyl Colchicoside, an intermediate in the synthesis of Isothiocolcicoside, is an impurity of Thiocolchicoside, a GABA receptor antagonist that is prescribed as a muscle relaxant having analgesic effects. Synonyms: (2S,3R,4S,5R,6R)-2-(((S)-7-Acetamido-10-(benzoyloxy)-1,2-dimethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-3-yl)oxy)-6-((benzoyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl Tribenzoate. Molecular formula: C61H51NO16. Mole weight: 1054.05. | |
| R 428 dihydrochloride | R 428 dihydrochloride is a potent and selective inhibitor of Axl receptor tyrosine kinases (IC50 = 14 nM). R428 inhibits Axl kinase and Axl-dependent events, including Akt phosphorylation, breast cancer cell invasion, and proinflammatory cytokine production. Synonyms: R 428 dihydrochloride; R428 dihydrochloride; R-428 dihydrochloride; 1-(6,7-dihydro-5H-benzo[2,3]cyclohepta[2,4-d]pyridazin-3-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine dihydrochloride; Thiocolchicoside dihydrochloride. Grades: 99%. CAS No. 2108833-51-6. Molecular formula: C30H34N8.2HCl. Mole weight: 579.57. | |
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