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Potent competitive gamma-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist. Weak nicotinic acetylcholine receptor agonist. Muscle relaxant. Anti-inflammatory. Has analgesic properties. Shows strong epileptogenic and convulsant activity. Anticancer compound through inhibition of NF-kappaB and NF-kappaB-regulated gene products. Apoptosis inducer.Suppressed osteoclastogenesis induced by RANKL and tumor cells via the NF-kappaB signaling pathway. Therapeutic option for the management of bone metastatic disease. Group: Biochemicals. Alternative Names: BRN 0072205, NSC 147755, Coltramyl, 10-thio-Colchicoside, 2-Demethoxy-2-glucosidoxythiocolchic ine. Grades: Highly Purified. CAS No. 602-41-5. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C27H33NO10S. US Biological Life Sciences.
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Thiocolchicoside
Thiocolchicoside is a competitive γ-aminobutyric acid type A (GAB A A) receptor antagonist and glycine receptor agonist in the central nervous system. Thiocolchicoside is a semisynthetic sulfur derivative of colchicoside. Thiocolchicoside is a muscle relaxant and has anti-inflammatory, and analgesic properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 602-41-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 20 mg; 50 mg; 100 mg. Product ID: HY-N0301.
Thiocolchicoside-[13C,d3]
One of the isotopic labelled form of Thiocolchicoside, which possesses analgesic and anti-inflammatory properties observed in animal models and its good efficacy and its safety profile have been demonstrated clinically in several studies. Synonyms: Thiocolchicoside-13C-d3; N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-13C,d3; (S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-13C,d3; Coltramyl-13C,d3; Coltrax-13C,d3; Miorel-13C,d3; NSC 147755-13C,d3. Grade: >95%. Molecular formula: C26[13C]H30NO10SD3. Mole weight: 567.64.
Thiocolchicoside-[d3]
A labelled GABA receptor antagonist that is prescribed as a muscle relaxant having analgesic effects. Synonyms: N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-d3; (S)-N-[3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide-d3; Coltramyl-d3; Coltrax-d3; Miorel-d3; NSC 147755-d3. Grade: >98%. Molecular formula: C27H30D3NO10S. Mole weight: 566.64.
10-S-Methylsulfonyl Thiocolchicoside
10-S-Methylsulfonyl Thiocolchicoside is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 1359973-80-0. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C27H33NO12S. US Biological Life Sciences.
N-Desacetyl-2,3,4-tri-O-acetyl Thiocolchicoside-N-2,2,2-trifluoroacetaldehyde is an intermediate used in the synthesis of N-Desacetyl Thiocolchicoside (D291005), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C35H38F3NO14S, Molecular Weight: 785.73. US Biological Life Sciences.
Worldwide
10-Desmethoxycolchicoside
10-Desmethoxycolchicoside is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: 10-Desmethoxycolchiside; N-((S)-1,2-Dimethoxy-9-oxo-3-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide; N-[(7S)-3-(β-D-Glucopyranosyloxy)-5,6,7,9-tetrahydro-1,2-dimethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide. Molecular formula: C26H31NO10. Mole weight: 517.53.
10-Desmethoxycolchiside
10-Desmethoxycolchiside is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C26H31NO10. US Biological Life Sciences.
10-Desmethoxy Tetrahyrocolchicoside β-D-Glucopyranosyl Tetraacetate is an intermediate in the synthesis of Thiocolchicoside (T344385), which is a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C34H42NO14. US Biological Life Sciences.
Worldwide
2-Allyl-2,10-didemethyl-colchicine
2-Allyl-2,10-didemethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C23H25NO6. US Biological Life Sciences.
2-Allyl-2-demethyl 10-Tosyl-10-demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences.
Worldwide
2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine
2-Allyl-2-demethyl 9-Tosyl 10-Demethyl Colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C30H31NO8S. US Biological Life Sciences.
Worldwide
2-Allyl-2-demethyl-colchicine
2-Allyl-2-demethyl-colchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. CAS No. 104158-07-8. Pack Sizes: 10mg, 25mg. Molecular Formula: C24H27NO6. US Biological Life Sciences.
Worldwide
2-Allyl-2-demethyl Isothiocolchicine
2-Allyl-2-demethyl 10-Demethyl Isothiocolchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C24H27NO5S. US Biological Life Sciences.
Worldwide
2-Demethyl Isothiocolchicine
2-Demethyl Isothiocolchicine is an intermediate in synthesizing Isothiocolcicoside (I902755), which is an impurity of Thiocolchicoside (T344385), a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 1mg. Molecular Formula: C21H23NO5S. US Biological Life Sciences.
Protected metabolite of labeled Thiocolchicoside (TCC). Group: Biochemicals. Alternative Names: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl-d3 2,3,4-Tri-O-acetyl- β-D-glucopyranosiduronic Acid Methyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
3-Demethyl Thiocolchicine-d3 3-O- β-D-Glucuronide
The major labeled metabolite of Thiocolchicoside (TCC), a muscle relaxant drug. Group: Biochemicals. Alternative Names: 7S)-7-(Acetylamino-d3)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl β-D-Glucopyranosiduronic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
3-Desmethylthiocolchicine-3-O-D-glucuronide
3-Desmethylthiocolchicine-3-O-D-glucuronide, an intriguing and efficacious biomedicine, has garnered considerable attention due to its multifaceted therapeutic implications. Originating as an active metabolite of colchicine, a renowned remedy for gout and familial Mediterranean fever, this potent glucuronide derivative showcases substantial anti-inflammatory and anti-mitotic properties, offering a beacon of hope for therapeutic interventions. Synonyms: (7S)-7-(Acetylamino)-5,6,7,9-tetrahydro-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-3-yl β-D-glucopyranosiduronic acid; Thiocolchicoside glucuronide. CAS No. 819802-34-1. Molecular formula: C27H31NO11S. Mole weight: 577.60.
Hexa-O-benzoyl 10-Demethyl Colchicoside
Hexa-O-benzoyl 10-Demethyl Colchicoside is an intermediate in synthesizing Isothiocolcicoside, which is an impurity of Thiocolchicoside, a GABA receptor antagonist which is prescribed as a muscle relaxant having analgesic effects. Synonyms: (2S,3R,4S,5R,6R)-2-(((S)-10-(Benzoyloxy)-1,2-dimethoxy-9-oxo-7-(3-oxo-3-phenylpropanamido)-5,6,7,9-tetrahydrobenzo[a]heptalen-3-yl)oxy)-6-((benzoyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl Tribenzoate. Molecular formula: C68H55NO17. Mole weight: 1158.16.
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